Abstract:
BACKGROUND:The long average incubation time from HIV infection to AIDS makes it difficult to estimate recent HIV transmission from AIDS incidence data. Age-period-cohort (APC) analysis can separate out the effects of age, calendar time and birth cohort to provide a clearer picture of transmission trends. METHODS:AIDS incidence data from 1981 to 1994 among intravenous drug users (IDU) for 12 Western European countries were used. Yearly incidences per 100,000 population or 100,000 person-years were calculated by age at diagnosis and 5-year birth cohort (1950-1954, 1955-1959, 1960-1964, 1965-1969 and 1970-1974), and corrected for reporting delay. Incidence patterns were compared between birth cohorts and countries. RESULTS:For most countries the impact was greatest on the cohort born 1960-1964. Comparing incidence patterns in the 1965-1969 to 1960-1964 cohorts suggest the epidemic has plateaued at low to intermediate levels in Austria, Greece and the North-Western European countries, and at high levels in France, Italy and Switzerland. For most countries transmission amongst the 1970-1974 as compared to the 1965-1969 cohorts could not be assessed due to small numbers and short follow-up time. In Spain the epidemic was uncontrolled with a high incidence among recent birth cohorts. In Portugal the epidemic was still at an early and expanding phase. CONCLUSIONS:The APC analysis revealed large country differences in the dynamics of the HIV/AIDS epidemic among IDU. Full interpretation of these differences is dependent on information from other sources about the local public health response and trends in drug injecting behaviours. Earlier introduction of the virus and higher prevalence of injecting drug use may explain some of the generally higher incidence in Southern European countries, but the larger part of it is most likely explained by local characteristics of drug users, such as younger age and more frequent sharing of needles and syringes, and a less effective public health response.
journal_name
Int J Epidemioljournal_title
International journal of epidemiologyauthors
Houweling H,Wiessing LG,Hamers FF,Termorshuizen F,Gill ON,Sprenger MJdoi
10.1093/ije/28.6.1141keywords:
subject
Has Abstractpub_date
1999-12-01 00:00:00pages
1141-8issue
6eissn
0300-5771issn
1464-3685journal_volume
28pub_type
杂志文章abstract:OBJECTIVE:This was to describe and analyse incidence and survival data on childhood leukaemias. SAMPLE:Incident leukaemia cases aged 0-19 from the cancer registry holdings of the province of Saskatchewan for the 60-year period 1932-1991 are the subject of this descriptive report. METHODS:Age-adjusted, age-specific, h...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/24.6.1100
更新日期:1995-12-01 00:00:00
abstract::Recent developments in statistics have produced powerful methods that facilitate the analysis of longitudinal studies. These methods are illustrated by an analysis of a longitudinal study of blood pressure in children. The results of the study show a clear tendency for blood pressure to increase with age, and Asian ch...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/8.1.15
更新日期:1979-03-01 00:00:00
abstract:BACKGROUND:Studies suggest that increased levels of physical activity might decrease the risk of prostate cancer. We ascertained lifetime measures of activity in a population-based case-control study of prostate cancer in Shanghai, China to investigate physical activity in a population where the incidence of prostate c...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/30.2.341
更新日期:2001-04-01 00:00:00
abstract:BACKGROUND:Predictions of primary liver cancer (PLC) incidence rates and case numbers are critical to understand and plan for PLC disease burden. METHODS:Data on PLC incidence rates and case numbers from 1990 to 2017 were retrieved from the Global Burden of Disease database. The estimated average percentage change (EA...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/dyaa196
更新日期:2020-12-08 00:00:00
abstract::In a questionnaire administered to a general population sample of 1673 adults, a 14-item scale of social desirability was divided into two groups of questions, almost evenly divided between desirable and undesirable behaviour, the percentage answering 'true' was higher when the question was asked early than when it wa...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/5.2.125
更新日期:1976-06-01 00:00:00
abstract:BACKGROUND:Previous studies have shown an inconsistency in the association between maternal education and child nutritional status across socioeconomic levels. This may be because the beneficial effects of education are only significant when resources are sufficient but not abundant. METHODS:Associations were examined...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/25.3.585
更新日期:1996-06-01 00:00:00
abstract::A generalized least squares regression approach is proposed for the analysis of data arising from experimental studies involving cluster randomization and non-experimental studies in which the major treatment factor corresponds to a characteristic which applies at the cluster level. This approach is more flexible than...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/14.2.322
更新日期:1985-06-01 00:00:00
abstract:BACKGROUND:France has the second highest number of variant Creutzfeldt-Jakob disease (vCJD) cases worldwide. Imports of bovine carcasses from the UK probably constituted the main source of exposure of the French population to the bovine spongiform encephalopathy (BSE) agent. Meat products consumed whilst visiting the U...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/dyh374
更新日期:2005-02-01 00:00:00
abstract:BACKGROUND:A central pattern of body fat is recognized as a risk indicator of cardiovascular diseases in adulthood. The development of this body fat pattern from childhood into adulthood however, remains to be explored. METHODS:The development of two trunk skinfolds (subscapular; supra-iliac), two extremity skinfolds ...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/25.6.1162
更新日期:1996-12-01 00:00:00
abstract:Background:The Obstetrics and Periodontal Therapy (OPT) study, a randomized controlled trial, reported no effect of periodontal treatment on preterm birth. Even though there were more spontaneous abortions or stillbirths in the control group, sensitivity analyses using conventional approaches did not change the results...
journal_title:International journal of epidemiology
pub_type: 杂志文章,随机对照试验
doi:10.1093/ije/dyy089
更新日期:2018-10-01 00:00:00
abstract:OBJECTIVE:To examine age- and sex-specific mortality rates and trends in water traffic accidents (WTA), and their association with alcohol, in Finland. MATERIALS AND METHODS:National mortality and population data from Finland, 1969-1995, are used to analyse rates and trends. The mortality rates are calculated on the b...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/27.6.1038
更新日期:1998-12-01 00:00:00
abstract:BACKGROUND:Previous studies have shown that the serum level of sialic acid is associated positively with mortality from coronary disease and stroke. In this study its relation with carotid atherosclerosis was evaluated. METHODS:From the Atherosclerosis Risk in Communities (ARIC) Study, 323 cases with carotid intima-me...
journal_title:International journal of epidemiology
pub_type: 杂志文章,多中心研究
doi:10.1093/ije/25.5.953
更新日期:1996-10-01 00:00:00
abstract:BACKGROUND:Extended breastfeeding is known to benefit the health of children in developing countries and despite widespread expectations of a decline in breastfeeding in these countries, it has been demonstrated that the incidence and duration of breastfeeding are in fact increasing many countries. METHODS:In this pap...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/25.1.94
更新日期:1996-02-01 00:00:00
abstract:Background:Associations of adult height with cardiometabolic and pulmonary traits have been studied in majority European ancestry populations using Mendelian randomization and polygenic risk score (PRS) analysis. The standard PRS approach entails creating a PRS for height using variants identified in prior genome-wide ...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/dyy177
更新日期:2018-12-01 00:00:00
abstract:BACKGROUND:High maternal pre-pregnancy body mass index (BMI) is associated with increased risk of offspring attention deficit hyperactivity disorder (ADHD). However, the role of unmeasured familial confounding for this association remains unclear. METHODS:We conducted a population-based cohort study via linkage of Swe...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/dyt152
更新日期:2014-02-01 00:00:00
abstract::Until recently, botulism was not recognized as an important public health problem in Taiwan. In 1986, an outbreak of type A foodborne botulism resulted in nine cases, two of them fatal. The vehicle in this outbreak was commercially preserved peanuts processed by an improperly equipped, unlicensed cannery. A single bat...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/17.4.899
更新日期:1988-12-01 00:00:00
abstract:BACKGROUND:Predictions concerning people and their health are influenced by many factors and have many sources of uncertainty. Even so predictions can give useful guidelines for health care planning. We present a Bayesian model based on past observations and prior knowledge to predict coronary heart disease (CHD) morta...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/dyl128
更新日期:2006-10-01 00:00:00
abstract::Several conditions, whose timely and appropriate therapy should decrease case fatality, have been proposed as indicators of medical care quality for the National Health Service. Mortality rates for these diseases vary widely within the UK. To evaluate the contribution of varying incidence rates to these mortality diff...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/15.3.408
更新日期:1986-09-01 00:00:00
abstract:BACKGROUND:The relationship between income and health is usually thought to be curvilinear, but previous studies have yielded inconsistent results. We therefore examined the shape of the relationship between household equivalent income and self-assessed health in seven European countries. METHODS:Data were obtained fr...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/dyh338
更新日期:2005-04-01 00:00:00
abstract:Background:In administrative database research, misclassification bias can result from diagnostic codes that imperfectly represent the condition being studied. It is unclear how to correct for this bias. Methods:Severe renal failure and Colles' fracture status were determined in two distinct cohorts using gold standar...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/dyx253
更新日期:2018-04-01 00:00:00
abstract:BACKGROUND:Type 2 diabetes (T2D) results from a complex interplay between genetics and the environment. Several epigenome-wide association studies (EWAS) have found DNA methylation loci associated with T2D in European populations. However, data from African populations are lacking. We undertook the first EWAS for T2D a...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/dyy171
更新日期:2019-02-01 00:00:00
abstract::We have studied cytosolic low molecular weight phosphotyrosine phosphatase (cLMWPTP or ACP1) in 364 healthy puerperae from the population of Penne, in 155 diabetic puerperae from the population of Rome and in 349 consecutive normal newborn infants from the population of Rome. The data from these independent samples po...
journal_title:International journal of epidemiology
pub_type: 杂志文章,多中心研究
doi:10.1093/ije/30.2.400
更新日期:2001-04-01 00:00:00
abstract::Two controlled, double blind field trials of a non-living promastigote vaccine against New World Cutaneous Leishmaniasis (NWCL) were conducted in 1981 and 1983 in Brazil. Brazilian Army conscripts were randomly assigned to the vaccine or placebo groups and tested during their training in the Amazon jungle, a high risk...
journal_title:International journal of epidemiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1093/ije/15.4.572
更新日期:1986-12-01 00:00:00
abstract:BACKGROUND:Undernutrition is associated with an increased risk of death among young children in developing countries. Infant and child nutritional status and mortality were monitored in a rural area of Casamance, Senegal. METHODS:Analysis of weight measurements taken at 3-24 months of age during routine growth monitor...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/dyh174
更新日期:2004-12-01 00:00:00
abstract:BACKGROUND:Although individual studies have been inconsistent, meta-analyses of epidemiological data suggest that high folate and vitamin B12 levels may be associated with increased prostate cancer risk. METHODS:Within JANUS, a prospective cohort in Norway (n = 317 000) with baseline serum samples, we conducted a nest...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/dys199
更新日期:2013-02-01 00:00:00
abstract:BACKGROUND:Epidemiology's role as the 'diagnostic' arm of public health has submitted epidemiological reasoning and practice to the crossfire of oppositional social values and demands. In Latin America, the visible signs of extreme social and political authoritarianism and inequity, as well as the growing unfairness of...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/dyn135
更新日期:2008-08-01 00:00:00
abstract::Parental occupational exposures to chemical carcinogens have been associated with malignancies in offspring. Recent studies have raised the issue that electromagnetic fields may play a role in carcinogenesis. We conducted a population-based case-control study testing for an association between the occurrence of a nerv...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/18.4.756
更新日期:1989-12-01 00:00:00
abstract:OBJECTIVE:To examine the effects, by income group, of targeted food taxes and subsidies on nutrition, health and expenditure in the UK. METHODS:A model based on consumption data and demand elasticity was constructed to predict the effects of four food taxation-subsidy regimens. Resulting changes in demand, expenditure...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/dyp214
更新日期:2009-10-01 00:00:00
abstract:BACKGROUND:Endometriosis has been associated with a higher risk of cutaneous melanoma, but the mechanisms underlying this association are unknown.Some constitutional factors known to influence melanoma risk have been associated with endometriosis in some retrospective studies. However, prospective data are scarce, and ...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/dyt235
更新日期:2014-02-01 00:00:00
abstract:BACKGROUND:The incidence of hepatitis C (HCV) infection among injecting drug users (IDUs) in Dublin is particularly high by international standards. The most robust predictor of an IDU's HCV status is his or her total number of lifetime injecting episodes. It has been proposed that participation in specific unsafe inje...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/dyh347
更新日期:2005-02-01 00:00:00