Dynamics of Helicobacter pylori colonization in relation to the host response.

abstract：:Development of the nervous system in the amphibian embryo is initiated during gastrulation by an inductive interaction between chordamesoderm and dorsal ectoderm. The induced ectoderm forms the neural plate while uninduced ectoderm generates epidermis. We screened for genes activated during gastrulation and expressed ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Richter K,Grunz H,Dawid IB

更新日期：1988-11-01 00:00:00

abstract：:Components in cerebrospinal fluid that are antigenically related to myelin basic protein have been identified by a technique described recently [Barbarese, E., Braun, P. E. & Carson, J. H. (1977) Proc. Natl. Acad. Sci. USA 74, 3360-3364] involving separating the cerebrospinal fluid proteins by sodium dodecyl sulfate/p...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Carson JH,Barbarese E,Braun PE,McPherson TA

更新日期：1978-04-01 00:00:00

abstract：:The multifunctional DNA-binding protein (DBP) encoded by human adenovirus binds RNA. The association of purified DBP with RNA in vitro was demonstrated by using either a gel filtration or a filter binding assay. This association is sensitive to ionic strength and exhibits no apparent sequence specificity. DBP also int...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cleghon VG,Klessig DF

更新日期：1986-12-01 00:00:00

abstract：:Receptors for platelet-derived growth factor (PDGF) have previously only been found on cells of mesenchymal and glial origin. This study shows PDGF receptors on an anaplastic thyroid carcinoma cell line, C 643, that was found to express thyroglobulin mRNA, confirming its origin from thyroid epithelium. Northern blot a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Heldin NE,Gustavsson B,Claesson-Welsh L,Hammacher A,Mark J,Heldin CH,Westermark B

更新日期：1988-12-01 00:00:00

abstract：:Cerebral organization during sentence processing in English and in American Sign Language (ASL) was characterized by employing functional magnetic resonance imaging (fMRI) at 4 T. Effects of deafness, age of language acquisition, and bilingualism were assessed by comparing results from (i) normally hearing, monolingua...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Neville HJ,Bavelier D,Corina D,Rauschecker J,Karni A,Lalwani A,Braun A,Clark V,Jezzard P,Turner R

更新日期：1998-02-03 00:00:00

abstract：:Two-dimensional 1H NMR investigations were used to locate elements of regular secondary structure in the human complement protein C3a (the des-Arg77 derivative) in solution. The results were compared to a refined crystal structure based on the 3.2-A resolution structure of des-Arg77-C3a [Huber, R., Scholze, H., Paques...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nettesheim DG,Edalji RP,Mollison KW,Greer J,Zuiderweg ER

更新日期：1988-07-01 00:00:00

abstract：:The ability to modulate the collective properties of correlated electron systems at their interfaces and surfaces underpins the burgeoning field of "designer" quantum materials. Here, we show how an electronic reconstruction driven by surface polarity mediates a Stoner-like magnetic instability to itinerant ferromagne...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mazzola F,Sunko V,Khim S,Rosner H,Kushwaha P,Clark OJ,Bawden L,Marković I,Kim TK,Hoesch M,Mackenzie AP,King PDC

更新日期：2018-12-18 00:00:00

abstract：:The mammalian anx7 gene codes for a Ca(2+)-activated GTPase, which supports Ca(2+)/GTP-dependent secretion events and Ca(2+) channel activities in vitro and in vivo. To test whether anx7 might be involved in Ca(2+) signaling in secreting pancreatic beta cells, we knocked out the anx7 gene in the mouse and tested the i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Srivastava M,Atwater I,Glasman M,Leighton X,Goping G,Caohuy H,Miller G,Pichel J,Westphal H,Mears D,Rojas E,Pollard HB

更新日期：1999-11-23 00:00:00

abstract：:In yeast meiosis, crossing-over between homologues is dependent upon double-strand breaks. We demonstrate that the occurrence of these breaks is independent of pairing between homologues by showing that they occur with normal frequency, timing, and position in the absence of a homologue. This observation supports mode...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gilbertson LA,Stahl FW

更新日期：1994-12-06 00:00:00

abstract：:Developmental genetic studies of evolved differences in morphology have led to the hypothesis that cis-regulatory changes often underlie morphological evolution. However, because most of these studies focus on evolved loss of traits, the genetic architecture and possible association with cis-regulatory changes of gain...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cleves PA,Ellis NA,Jimenez MT,Nunez SM,Schluter D,Kingsley DM,Miller CT

更新日期：2014-09-23 00:00:00

abstract：:Lineage specification is thought to be largely regulated at the level of transcription, where lineage-specific transcription factors drive specific cell fates. MicroRNAs (miR), vital to many cell functions, act posttranscriptionally to decrease the expression of target mRNAs. MLL-AF4 acute lymphocytic leukemia exhibit...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Okuyama K,Ikawa T,Gentner B,Hozumi K,Harnprasopwat R,Lu J,Yamashita R,Ha D,Toyoshima T,Chanda B,Kawamata T,Yokoyama K,Wang S,Ando K,Lodish HF,Tojo A,Kawamoto H,Kotani A

更新日期：2013-08-13 00:00:00

abstract：:Laser-polarized gases (3He and 129Xe) are currently being used in magnetic resonance imaging as strong signal sources that can be safely introduced into the lung. Recently, researchers have been investigating other tissues using 129Xe. These studies use xenon dissolved in a carrier such as lipid vesicles or blood. Sin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chawla MS,Chen XJ,Möller HE,Cofer GP,Wheeler CT,Hedlund LW,Johnson GA

更新日期：1998-09-01 00:00:00

abstract：:The potential involvement of ceramide-related signaling processes in the induction of apoptosis by tumor necrosis factor alpha was assessed by multiple biochemical strategies in the human leukemic cell lines HL-60 and U937 and the murine fibrosarcoma cell lines L929/LM and WEHI 164/13. Exposure of these cells to tumor...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jarvis WD,Kolesnick RN,Fornari FA,Traylor RS,Gewirtz DA,Grant S

更新日期：1994-01-04 00:00:00

abstract：:Poly(A)+ mRNA was isolated from the brains of C57BL/6J (B6), DBA/2J (D2), and F1 hybrid mice (B6 X D2) of 16-17 days of age. The yield of polysomal RNA, both poly(A)+ and poly(A)-, from the three strains of mice was comparable. When translated in vitro in a reticulocyte lysate system, the mRNA preparations had the sam...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Miskimins R,Ebato H,Seyfried TN,Yu RK

更新日期：1986-03-01 00:00:00

abstract：:Pancreatic ductal adenocarcinoma (PDAC) cells (PCC) have an exceptional propensity to metastasize early into intratumoral, chemokine-secreting nerves. However, we hypothesized the opposite process, that precancerous pancreatic cells secrete chemokines that chemoattract Schwann cells (SC) of nerves and thus induce read...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Demir IE,Kujundzic K,Pfitzinger PL,Saricaoglu ÖC,Teller S,Kehl T,Reyes CM,Ertl LS,Miao Z,Schall TJ,Tieftrunk E,Haller B,Diakopoulos KN,Kurkowski MU,Lesina M,Krüger A,Algül H,Friess H,Ceyhan GO

更新日期：2017-01-03 00:00:00

abstract：:Ovine pulmonary surfactant is bactericidal for Pasteurella haemolytica when surfactant and bacteria mixtures are incubated with normal ovine serum. To isolate this component, surfactant (1 mg/ml) was centrifuged at 100,000 x gav, and the supernatant was fractionated by HPLC. Fractions were eluted with acetonitrile (10...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Brogden KA,De Lucca AJ,Bland J,Elliott S

更新日期：1996-01-09 00:00:00

abstract：:Recent genome-wide nucleosome mappings along with bioinformatics studies have confirmed that the DNA sequence plays a more important role in the collective organization of nucleosomes in vivo than previously thought. Yet in living cells, this organization also results from the action of various external factors like D...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Milani P,Chevereau G,Vaillant C,Audit B,Haftek-Terreau Z,Marilley M,Bouvet P,Argoul F,Arneodo A

更新日期：2009-12-29 00:00:00

abstract：:Results on the subcellular localization of the mineralocorticoid receptor (MR) have been controversial. To determine the subcellular distribution and trafficking of the MR in living cells after binding of agonists and antagonists, we expressed a MR-green fluorescent protein (GFP) chimera in mammalian cells lacking end...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fejes-Tóth G,Pearce D,Náray-Fejes-Tóth A

更新日期：1998-03-17 00:00:00

abstract：:The functional unit molecular size of the intestinal brush border membrane-bound Na+/glucose cotransporter was determined by radiation inactivation. Purified brush border membrane vesicles preserved in cryoprotectant buffer were irradiated (-135 degrees C) with high-energy electrons from a 13-MeV (1 eV = 1.602 x 10(-1...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stevens BR,Fernandez A,Hirayama B,Wright EM,Kempner ES

更新日期：1990-02-01 00:00:00

abstract：:Stimulation of antitumor immune mechanisms is the primary goal of cancer immunotherapy, and accumulating evidence suggests that effective alteration of the host-tumor relationship involves immunomodulating cytokines and also the presence of costimulatory molecules. To examine the antitumor effect of direct in vivo gen...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pützer BM,Hitt M,Muller WJ,Emtage P,Gauldie J,Graham FL

更新日期：1997-09-30 00:00:00

abstract：:All available complete mitochondrial genomes (21 species) are evaluated for dinucleotide over- and under-representation. The CpG dinucleotide is pervasively under-represented in all animal mitochondria, but it is of variable relative abundance in fungal, protist, and plant mitochondrial genomes. Interpretations and hy...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cardon LR,Burge C,Clayton DA,Karlin S

更新日期：1994-04-26 00:00:00

abstract：:Recent advances in cell-free expression protocols have opened a new avenue toward high-resolution structural investigations of membrane proteins by x-ray crystallography and NMR spectroscopy. One of the biggest challenges for liquid-state NMR-based structural investigations of membrane proteins is the significant peak...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Reckel S,Sobhanifar S,Schneider B,Junge F,Schwarz D,Durst F,Löhr F,Güntert P,Bernhard F,Dötsch V

更新日期：2008-06-17 00:00:00

abstract：:The economic and ecological costs of wildfire in the United States have risen substantially in recent decades. Although climate change has likely enabled a portion of the increase in wildfire activity, the direct role of people in increasing wildfire activity has been largely overlooked. We evaluate over 1.5 million g...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Balch JK,Bradley BA,Abatzoglou JT,Nagy RC,Fusco EJ,Mahood AL

更新日期：2017-03-14 00:00:00

abstract：:The ability to predictably control the coassembly of multiple nanoscale building blocks, especially those with disparate chemical and physical properties such as biomolecules and inorganic nanoparticles, has far-reaching implications in catalysis, sensing, and photonics, but a generalizable strategy for engineering sp...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Brodin JD,Auyeung E,Mirkin CA

更新日期：2015-04-14 00:00:00

abstract：:The plant photoreceptor phytochrome plays an important role in the nucleus as a regulator of transcription. Numerous studies imply, however, that phytochromes in both higher and lower plants mediate physiological reactions within the cytoplasm. In particular, the tip cells of moss protonemal filaments use phytochrome ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mittmann F,Brücker G,Zeidler M,Repp A,Abts T,Hartmann E,Hughes J

更新日期：2004-09-21 00:00:00

abstract：:The human genome is made up of long DNA segments, the isochores, which are compositionally homogeneous and can be subdivided into a small number of families characterized by different G+C levels. Chromosome in situ suppression hybridization (in which excess unlabeled human DNA is added to suppress hybridization of rep...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Saccone S,De Sario A,Wiegant J,Raap AK,Della Valle G,Bernardi G

更新日期：1993-12-15 00:00:00

abstract：:Gliogenesis in animal development is spatiotemporally regulated so that correct numbers of glia are present to support various neuronal functions. During Drosophila embryonic development, the glial regulatory gene, glial cell missing/glial cell deficient (gcm/glide), promotes glial cell fate and differentiation. Here ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ho MS,Chen H,Chen M,Jacques C,Giangrande A,Chien CT

更新日期：2009-04-21 00:00:00

abstract：:Metal-catalyzed oxidation results in loss of function and structural alteration of proteins. The oxidative process affects a variety of side amino acid groups, some of which are converted to carbonyl compounds. Spectrophotometric measurement of these moieties, after their reaction with 2,4-dinitrophenylhydrazine, is a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Requena JR,Chao CC,Levine RL,Stadtman ER

更新日期：2001-01-02 00:00:00

abstract：:We present a theory, and its computer implementation, of how mental simulations underlie the abductions of informal algorithms and deductions from these algorithms. Three experiments tested the theory's predictions, using an environment of a single railway track and a siding. This environment is akin to a universal Tu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Khemlani SS,Mackiewicz R,Bucciarelli M,Johnson-Laird PN

更新日期：2013-10-15 00:00:00

abstract：:In 2009 we reported that depletion of Dicer-1, the enzyme that catalyzes the final step of miRNA biosynthesis, prevents metamorphosis in Blattella germanica. However, the precise regulatory roles of miRNAs in the process have remained elusive. In the present work, we have observed that Dicer-1 depletion results in an ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lozano J,Montañez R,Belles X

更新日期：2015-03-24 00:00:00