Abstract:
:The primary source for evaluating treatment outcome in alcoholism is usually verbal self-report. Because the validity of self-report is often doubted, more objective markers for treatment outcome are needed. In this study, we compared self-report data from 238 male alcohol-dependent patients participating in a combined 6-week inpatient followed by a 1-year outpatient treatment program with the biological markers carbohydrate-deficient transferrin (CDT) and gamma-glutamyl transferase (GGT). According to self-report, over 70% of the patients had a positive treatment outcome (57% abstinence, 16% intermediate relapse). These results are supported by the general reduction of CDT and GGT during the treatment period (p < 0. 001). When we performed a cross-sectional analysis at 6 months during the outpatient program, there was a high consistency of self-report data with the biological markers (CDT 93%, GGT 91%, CDT/GGT 85%). Our results support the hypothesis that in abstinence- oriented treatment programs, self-reports are valid and can be used as the basis of measurement for treatment outcome.
journal_name
Eur Addict Resjournal_title
European addiction researchauthors
Mundle G,Ackermann K,Günthner A,Munkes J,Mann Kdoi
10.1159/000018972keywords:
subject
Has Abstractpub_date
1999-06-01 00:00:00pages
91-6issue
2eissn
1022-6877issn
1421-9891pii
18972journal_volume
5pub_type
杂志文章abstract:OBJECTIVE:Evaluation of the Addiction Severity Index (ASI) as a screen for identifying sexual and physical assault histories. METHOD:The sensitivity and specificity of the ASI assault items were examined in 146 alcoholic patients with the assault questions of the Composite International Diagnostic Interview posttrauma...
journal_title:European addiction research
pub_type: 杂志文章
doi:10.1159/000050740
更新日期:2001-12-01 00:00:00
abstract::Engaging in online games has become increasingly important as a part of leisure activity in adolescents and adults. While the majority of people use these games in a healthy way, epidemiological studies show that some develop excessive use and symptoms that are related to those of substance-related addictions. Despite...
journal_title:European addiction research
pub_type: 杂志文章
doi:10.1159/000355832
更新日期:2014-01-01 00:00:00
abstract:AIMS:The aim of this paper is to illustrate how Switzerland was able to play such a pioneering role in the field of addiction treatment, in creating a drug policy that includes the medical prescription of diacetylmorphine (heroin). The paper will also describe the role of knowledge brokering processes and coalition bui...
journal_title:European addiction research
pub_type: 杂志文章
doi:10.1159/000357234
更新日期:2014-01-01 00:00:00
abstract::The aim of this study was to investigate to what extent alcohol-specific parenting practices relate to adolescents' alcohol use, binge drinking, and alcohol-related problems, and whether these associations are moderated by socioeconomic status (SES), i.e. parents' education level and family income. The present data we...
journal_title:European addiction research
pub_type: 杂志文章
doi:10.1159/000110408
更新日期:2008-01-01 00:00:00
abstract::There is a long-recognized association between alcohol consumption and aggressive behavior. This study was designed to examine aggression in a group of socially well-adapted recovered alcoholics (RA). The question addressed was whether the treatment, together with long-term abstinence from alcohol, could reduce aggres...
journal_title:European addiction research
pub_type: 杂志文章
doi:10.1159/000097938
更新日期:2007-01-01 00:00:00
abstract::Sixty-one percent (138/226) of Swiss inpatient and outpatient alcohol treatment programmes responded to a postal survey designed to assess the definition and acceptance of controlled drinking (CD) as a treatment objective, the degree to which a client's severity of dependence and finality of CD as an outcome goal were...
journal_title:European addiction research
pub_type: 杂志文章
doi:10.1159/000210041
更新日期:2009-01-01 00:00:00
abstract:AIMS:The issue of leptin as a putative state marker of alcohol use and its role in craving has been raised in the last few years. Recently, a strong GABA-ergic modulation of leptin was postulated. The aim of the pilot study was to examine leptin levels in correlation with the strongly GABA-mimetic active substance clom...
journal_title:European addiction research
pub_type: 杂志文章
doi:10.1159/000331017
更新日期:2012-01-01 00:00:00
abstract::Alcohol and illicit drug use has a significant impact on global health. Alcohol consumption is increasing worldwide, particularly in developing countries and countries in transition, leading to an increasing number of health and social problems, both acute and chronic. Illicit drug use is also increasing, particularly...
journal_title:European addiction research
pub_type: 杂志文章
doi:10.1159/000050727
更新日期:2001-08-01 00:00:00
abstract::Treatment of alcohol-dependent patients was primarily focused on inpatient settings in the past decades. The efficacy of these treatment programs has been evaluated in several studies and proven to be sufficient. However, with regard to the increasing costs in public healthcare systems, questions about alternative tre...
journal_title:European addiction research
pub_type: 杂志文章
doi:10.1159/000085548
更新日期:2005-01-01 00:00:00
abstract:BACKGROUND/AIMS:In recent years, quality of life (QoL) assessments have proved useful for evaluating and comparing drug treatment programs. To compare QoL of patients maintained on methadone versus slow-release morphine, a prospective, randomized, double-blind, double-dummy, cross-over study was conducted. METHODS:Ove...
journal_title:European addiction research
pub_type: 杂志文章,随机对照试验
doi:10.1159/000113724
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND:In France, most patients with opioid use disorder (OUD) have been treated by buprenorphine, prescribed by general practitioners (GP) in private practice since 1996. This has contributed to building a 'French model' facilitating access to treatment based on the involvement of GPs in buprenorphine prescription...
journal_title:European addiction research
pub_type: 杂志文章
doi:10.1159/000506630
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND/AIMS:Opioid substitution treatment (OST) improves outcomes in opioid dependence. However, controlled drugs used in treatment may be misused or diverted, resulting in negative treatment outcomes. This review defines a framework to assess the impact of misuse and diversion. METHODS:A systematic review of publ...
journal_title:European addiction research
pub_type: 杂志文章,评审
doi:10.1159/000438988
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:Consumption of natural cannabis (NC) and synthetic cannabinoids (SCs) has been associated with psychotic disorders. We compared the prevalence of use, consumer profiles, and psychosis-inducing potential of NC and SCs in a specific high-risk population. METHODS:This prospective pilot study included 332 patie...
journal_title:European addiction research
pub_type: 杂志文章
doi:10.1159/000479554
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND/AIMS:To determine whether there is a dose-response relationship between maternal dose of buprenorphine at delivery and neonatal outcomes. METHODS:This retrospective cohort study of 155 maternal-infant dyads exposed to buprenorphine during pregnancy examines the relationship between maternal dose of buprenor...
journal_title:European addiction research
pub_type: 杂志文章
doi:10.1159/000441220
更新日期:2016-01-01 00:00:00
abstract::In Europe, adolescent substance misuse increased during the 1990s. Ireland has among the highest rates of substance misuse among schoolchildren in Europe. We sought to describe the socio-demographic and drug misuse profile of children presenting to addiction treatment services in Dublin during the 1990s. Of the 9,874 ...
journal_title:European addiction research
pub_type: 杂志文章
doi:10.1159/000076116
更新日期:2004-01-01 00:00:00
abstract::This longitudinal study of 600 families concentrates on the influence of parental anti-smoking socialization by examining both (a) the effects of eight indicators of anti-smoking socialization on adolescent smoking and (b) the influence of parental smoking on the effectiveness of their anti-smoking socialization. Robu...
journal_title:European addiction research
pub_type: 杂志文章
doi:10.1159/000088580
更新日期:2006-01-01 00:00:00
abstract:AIMS:Qualitative studies find that men and women in Russia have different preferences for alcoholic beverages, but quantitative evidence for gender differences in beverage type choice remains scarce. The purpose of this article is to test numerically whether and to what extent men and women in Russia differ in terms of...
journal_title:European addiction research
pub_type: 杂志文章
doi:10.1159/000342313
更新日期:2013-01-01 00:00:00
abstract::In the article the growing interest of studies on treatment systems rather than specific treatment modalities is taken as a starting point for a discussion and outlook on how the research agenda of drug treatment research will develop in the near future. The relative absence of research that provides substantial guida...
journal_title:European addiction research
pub_type: 杂志文章
doi:10.1159/000018984
更新日期:1999-09-01 00:00:00
abstract:BACKGROUND:Alcohol consumption is one of the most important factors for disease and disability in Europe. In clinical trials, nalmefene has resulted in a significant reduction in the number of heavy-drinking days (HDDs) per month and total alcohol consumption (TAC) among alcohol-dependent patients versus placebo. METH...
journal_title:European addiction research
pub_type: 杂志文章
doi:10.1159/000362408
更新日期:2014-01-01 00:00:00
abstract::The programme of prescribing amphetamines and opiates to drug users in Stockholm carried out from 1965 to 1967 has frequently been referred to in the European drug policy debate. In this article, originally presented at the Conference on Drug Use and Drug Policy in Amsterdam in September 1996, the programme is describ...
journal_title:European addiction research
pub_type: 杂志文章
doi:10.1159/000018951
更新日期:1998-12-01 00:00:00
abstract:UNLABELLED:This report presents findings of a community survey of 3,021 adolescents and young adults aged 14-24 years in Munich, Germany, carried out to determine the prevalence of use and abuse of and dependence on ecstasy, amphetamines and hallucinogens. The response rate was 71%. RESULTS:(1) In 1995, 4% of the male...
journal_title:European addiction research
pub_type: 杂志文章
doi:10.1159/000018925
更新日期:1998-03-01 00:00:00
abstract::In the UK, few doctors prescribe diamorphine for the treatment of opiate dependence to a small number of patients. A retrospective case note review of patients receiving diamorphine in 2000 was conducted in the UK to determine how and why these patients came to receive a prescription for diamorphine. Patient eligibili...
journal_title:European addiction research
pub_type: 杂志文章
doi:10.1159/000101550
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND:Two forms of institutionalized pressure to treatment can be distinguished in Switzerland: civil commitment and court referral. In court referral, the referred patient has the right to refuse treatment. OBJECTIVES:To compare court referrals for inpatient treatment to voluntary therapy. METHODS:Comparison of...
journal_title:European addiction research
pub_type: 杂志文章
doi:10.1159/000052058
更新日期:2002-04-01 00:00:00
abstract:AIMS:To describe and assess trends in the use of hallucinogens and other adjunct drugs over a 5-year period. DESIGN:Repeated-measures cross-sectional survey. SETTING AND PARTICIPANTS:Annual magazine-based survey targeting people who use drugs in dance contexts. MEASUREMENTS:Lifetime use prevalence (ever used); age o...
journal_title:European addiction research
pub_type: 杂志文章
doi:10.1159/000095816
更新日期:2007-01-01 00:00:00
abstract::Data were collected on 1,074 opiate detoxifications conducted with lofexidine, from 40 drug dependency units in the United Kingdom. 671 patients (62.5%) attempted a detoxification in the community, with the remainder attempting an inpatient detoxification. Patients completing the detoxification started on a mean dose ...
journal_title:European addiction research
pub_type: 杂志文章
doi:10.1159/000018962
更新日期:1999-03-01 00:00:00
abstract:BACKGROUND:There is increasing interest in naltrexone, an opiate antagonist, in the treatment of opiate addicts. The effects of naltrexone are often compromised by a lack of compliance and drop-out. The effects of this compound are probably more favorable when combined with a psychosocial intervention such as the Commu...
journal_title:European addiction research
pub_type: 杂志文章
doi:10.1159/000068808
更新日期:2003-04-01 00:00:00
abstract:BACKGROUND:The community reinforcement approach (CRA) with vouchers is a well-established program developed for the treatment of cocaine addiction. It involves an incentive program in which patients earn vouchers that can be exchanged for goods or services contingent upon abstinence from cocaine use. AIM:To examine th...
journal_title:European addiction research
pub_type: 杂志文章,随机对照试验
doi:10.1159/000324848
更新日期:2011-01-01 00:00:00
abstract:BACKGROUND/AIM:Heroin dependence is a chronic relapsing disorder characterized by the compulsion to seek and use heroin. Stress and craving are seen as key factors for heroin use. Moreover, altered hypothalamic-pituitary-adrenal (HPA) axis function has been frequently reported. However, the acute effects of diacetylmor...
journal_title:European addiction research
pub_type: 杂志文章,随机对照试验
doi:10.1159/000334411
更新日期:2012-01-01 00:00:00
abstract::In Spain, detoxification in general hospitals plays an important role in the medical care of patients. We aim to provide clinicians with information on the prevalence and correlates of psychiatric co-morbidity in drug abusers in detoxification. A sample of 115 substance-abuse inpatients (mean age 31.9 +/- 6.4 years) i...
journal_title:European addiction research
pub_type: 杂志文章
doi:10.1159/000104881
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND:In 2003, Denmark lowered its tax on spirits, and in 2004, Sweden increased its traveller import quotas. AIM:The aim of the study was to determine whether these two changes increased self-reported alcohol consumption in southern Sweden, which is located near Denmark. METHOD:Data were collected through telep...
journal_title:European addiction research
pub_type: 杂志文章
doi:10.1159/000314358
更新日期:2010-01-01 00:00:00