Abstract:
AIMS:The issue of leptin as a putative state marker of alcohol use and its role in craving has been raised in the last few years. Recently, a strong GABA-ergic modulation of leptin was postulated. The aim of the pilot study was to examine leptin levels in correlation with the strongly GABA-mimetic active substance clomethiazole. The main hypothesis was that higher doses of the strong GABA-mimetic clomethiazole are positively correlated with higher leptin levels. METHODS:Twenty-eight alcohol-dependent patients (3 females, median age 36 years) undergoing alcohol withdrawal were included. In 18 patients with and 10 without clomethiazole, serum leptin was analyzed at day 1 and day 7 of alcohol withdrawal. Both groups did not differ by age, BMI, or alcohol use characteristics. RESULTS:In the clomethiazole group, significant correlations were found between leptin levels at day 1 and clomethiazole dose (p = 0.004), clomethiazole and leptin at day 1/BMI (p = 0.009) and leptin at day 1 and clomethiazole/body surface (p = 0.006). Furthermore, patients with higher clomethiazole doses demonstrated significant higher leptin levels at day 1 (p = 0.044) and day 7 (p = 0.046). CONCLUSIONS:Our pilot data show a strong association between leptin levels and clomethiazole doses, thus supporting further research.
journal_name
Eur Addict Resjournal_title
European addiction researchauthors
Dammann G,Walter M,Gremaud-Heitz D,Wolfersdorf M,Hartmann S,Wurst FMdoi
10.1159/000331017subject
Has Abstractpub_date
2012-01-01 00:00:00pages
12-5issue
1eissn
1022-6877issn
1421-9891pii
000331017journal_volume
18pub_type
杂志文章abstract::There is a long-recognized association between alcohol consumption and aggressive behavior. This study was designed to examine aggression in a group of socially well-adapted recovered alcoholics (RA). The question addressed was whether the treatment, together with long-term abstinence from alcohol, could reduce aggres...
journal_title:European addiction research
pub_type: 杂志文章
doi:10.1159/000097938
更新日期:2007-01-01 00:00:00
abstract:AIMS:To explore previously unreported rates and trends in opioid-related mortality in Israel, 2005-2014. METHODS:Data was obtained from the national database on causes of death. Drug poisoning deaths were divided into opioid-related deaths and deaths related to other drugs according to International Classification of ...
journal_title:European addiction research
pub_type: 杂志文章
doi:10.1159/000485033
更新日期:2017-01-01 00:00:00
abstract:UNLABELLED:This report presents findings of a community survey of 3,021 adolescents and young adults aged 14-24 years in Munich, Germany, carried out to determine the prevalence of use and abuse of and dependence on ecstasy, amphetamines and hallucinogens. The response rate was 71%. RESULTS:(1) In 1995, 4% of the male...
journal_title:European addiction research
pub_type: 杂志文章
doi:10.1159/000018925
更新日期:1998-03-01 00:00:00
abstract:BACKGROUND:Alcohol use among medical specialists remains a delicate topic. However, the number of prevalence studies remains very limited in Western European countries. AIMS:To explore alcohol use and hazardous drinking among male and female medical specialists. METHODS:All medical specialists in Belgium--a typical W...
journal_title:European addiction research
pub_type: 杂志文章
doi:10.1159/000341993
更新日期:2013-01-01 00:00:00
abstract::In the article the growing interest of studies on treatment systems rather than specific treatment modalities is taken as a starting point for a discussion and outlook on how the research agenda of drug treatment research will develop in the near future. The relative absence of research that provides substantial guida...
journal_title:European addiction research
pub_type: 杂志文章
doi:10.1159/000018984
更新日期:1999-09-01 00:00:00
abstract::This study investigates whether antismoking peer pressure and/or nonsmoking peers are protective factors and decrease young adults' likelihood to smoke. An experiment was conducted among 59 daily-smoking young adults aged 16-24 years. The experiment consisted of four conditions. During the session, the confederate and...
journal_title:European addiction research
pub_type: 杂志文章,随机对照试验
doi:10.1159/000330318
更新日期:2011-01-01 00:00:00
abstract:BACKGROUND/AIMS:In recent years, quality of life (QoL) assessments have proved useful for evaluating and comparing drug treatment programs. To compare QoL of patients maintained on methadone versus slow-release morphine, a prospective, randomized, double-blind, double-dummy, cross-over study was conducted. METHODS:Ove...
journal_title:European addiction research
pub_type: 杂志文章,随机对照试验
doi:10.1159/000113724
更新日期:2008-01-01 00:00:00
abstract::We tested the use of some subscales of the psychiatric symptom checklist SCL-90-R in predicting relapse within a 1-year follow-up period after a combined detoxification- and abstinence-focused day patient psychotherapy program in 20 men and 13 women with alcohol dependence. Scores of the SCL-90-R subscales interperson...
journal_title:European addiction research
pub_type: 杂志文章
doi:10.1159/000066131
更新日期:2002-11-01 00:00:00
abstract:OBJECTIVES:The study presents data about age of onset of alcohol, cigarette and cannabis use and investigates the association between age of onset and later drug use patterns. METHODS:Using a sample from a cross-sectional multi-site study, personal interviews were conducted with 3,503 individuals aged 12-49 years. Las...
journal_title:European addiction research
pub_type: 杂志文章
doi:10.1159/000083038
更新日期:2005-01-01 00:00:00
abstract::Depression is a common co-morbid disorder in substance use disorder (SUD) patients. Hence, valid instruments are needed to screen for depression in this subpopulation. In this study, the predictive validity of the Depression, Anxiety and Stress Scale (DASS-21) for the presence of a depressive disorder was investigated...
journal_title:European addiction research
pub_type: 杂志文章
doi:10.1159/000485182
更新日期:2017-01-01 00:00:00
abstract::This longitudinal study of 600 families concentrates on the influence of parental anti-smoking socialization by examining both (a) the effects of eight indicators of anti-smoking socialization on adolescent smoking and (b) the influence of parental smoking on the effectiveness of their anti-smoking socialization. Robu...
journal_title:European addiction research
pub_type: 杂志文章
doi:10.1159/000088580
更新日期:2006-01-01 00:00:00
abstract:BACKGROUND/AIMS:We investigated the psychometric properties of a German translation of the 12-item Autonomy over Tobacco Scale (AUTOS) among 1,195 eighth-grade students. METHODS:Data for this study were collected as part of the fourth wave of data collection of the Smokefree Class Competition intervention in the Saxon...
journal_title:European addiction research
pub_type: 杂志文章
doi:10.1159/000334410
更新日期:2012-01-01 00:00:00
abstract::A number of studies point at platelet monoamine oxidase (MAO) activity being reduced in alcoholics with a family history of drinking, this being a possible vulnerability marker for alcoholism. To test this hypothesis, we examined a group of recently detoxified alcoholics with high (n = 25) and low genetic loading for ...
journal_title:European addiction research
pub_type: 杂志文章
doi:10.1159/000019011
更新日期:2000-06-01 00:00:00
abstract:BACKGROUND:The community reinforcement approach (CRA) with vouchers is a well-established program developed for the treatment of cocaine addiction. It involves an incentive program in which patients earn vouchers that can be exchanged for goods or services contingent upon abstinence from cocaine use. AIM:To examine th...
journal_title:European addiction research
pub_type: 杂志文章,随机对照试验
doi:10.1159/000324848
更新日期:2011-01-01 00:00:00
abstract:AIMS:To investigate the gender differences in the patterns of cannabis use (CU), namely frequency, times of day, social context and methods and in their association with DSM-IV cannabis dependence. METHODS:A sample of 3,904 students from German universities was recruited via an internet survey. Logistic regressions an...
journal_title:European addiction research
pub_type: 杂志文章
doi:10.1159/000333338
更新日期:2011-01-01 00:00:00
abstract:UNLABELLED:This study evaluated automated techniques including personalized normative feedback and protective behavioral strategies, for brief interventions intended to reduce peak alcohol concentrations in university students. After completing baseline assessment, a total of 1,678 hazardous-drinking consumers were ran...
journal_title:European addiction research
pub_type: 杂志文章,随机对照试验
doi:10.1159/000381017
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND/AIMS:Methylphenidate (MPH) has been the most commonly used intravenous (i.v.) substance in Iceland in recent years. In Iceland, MPH is available in 3 forms: immediate-release (IR) tablets (MPH IR, short-acting), sustainable-release (SR) capsules (MPH SR, long-acting) and osmotic-release (OROS) tablets (MPH O...
journal_title:European addiction research
pub_type: 杂志文章
doi:10.1159/000446428
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND/AIMS:Opioid substitution treatment (OST) improves outcomes in opioid dependence. However, controlled drugs used in treatment may be misused or diverted, resulting in negative treatment outcomes. This review defines a framework to assess the impact of misuse and diversion. METHODS:A systematic review of publ...
journal_title:European addiction research
pub_type: 杂志文章,评审
doi:10.1159/000438988
更新日期:2016-01-01 00:00:00
abstract:OBJECTIVE:To assess smoking habit and awareness of smoking as a potential cause of disease among relatives of patients with serious smoking-related disorders. DESIGN AND SETTING:A survey using a face-to-face interview-assisted questionnaire at the Ege University Hospital between October 1998 and March 1999. SUBJECTS:...
journal_title:European addiction research
pub_type: 杂志文章
doi:10.1159/000059380
更新日期:2002-06-01 00:00:00
abstract:BACKGROUND:The aim of the study was to examine the practicability and implementation efficacy of an alcohol outpatient detoxification model and the concomitant 'motivational' psychotherapeutic approach. METHOD:This was an open prospective study to examine the implementation efficacy, practicability and medical safety ...
journal_title:European addiction research
pub_type: 杂志文章
doi:10.1159/000079840
更新日期:2004-01-01 00:00:00
abstract::Both heroin abuse and early life stress (ELS) affect the immune system and the hypothalamic-pituitary-adrenal (HPA) axis. Additionally, accelerated aging due to mild inflammation has been indicated in these conditions. The present study aims to compare plasma levels of apoptosis markers, inflammatory markers, and stre...
journal_title:European addiction research
pub_type: 杂志文章
doi:10.1159/000503880
更新日期:2020-01-01 00:00:00
abstract::In France, during the 1990s, there have been some rapid developments in the treatment of opioid addiction with the introduction of legal substitution agents. Originally, some patients were treated with morphine sulfate, but this was superseded by high dose buprenorphine (Subutex(R)) and methadone. This resulted in tho...
journal_title:European addiction research
pub_type: 临床试验,杂志文章
doi:10.1159/000052035
更新日期:1998-01-01 00:00:00
abstract:BACKGROUND:A pre-post pilot study was conducted to test the feasibility, acceptability, and potential effectiveness of a fully automatized computer-based intervention targeting hazardous drinking and depressiveness in proactively recruited health care patients (HCPs). To address the importance of the sample selection w...
journal_title:European addiction research
pub_type: 杂志文章
doi:10.1159/000499040
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND/AIM:Heroin dependence is a chronic relapsing disorder characterized by the compulsion to seek and use heroin. Stress and craving are seen as key factors for heroin use. Moreover, altered hypothalamic-pituitary-adrenal (HPA) axis function has been frequently reported. However, the acute effects of diacetylmor...
journal_title:European addiction research
pub_type: 杂志文章,随机对照试验
doi:10.1159/000334411
更新日期:2012-01-01 00:00:00
abstract::The combination of intoxication and criminal responsibility has been a problem field for legal theory and practice for quite some time. While it has been argued in certain contexts that intoxication reduces or denies criminal responsibility, elsewhere it has been reasoned that intoxicated offenders should be held as (...
journal_title:European addiction research
pub_type: 杂志文章,评审
doi:10.1159/000018931
更新日期:1998-09-01 00:00:00
abstract:BACKGROUND:In France, most patients with opioid use disorder (OUD) have been treated by buprenorphine, prescribed by general practitioners (GP) in private practice since 1996. This has contributed to building a 'French model' facilitating access to treatment based on the involvement of GPs in buprenorphine prescription...
journal_title:European addiction research
pub_type: 杂志文章
doi:10.1159/000506630
更新日期:2020-01-01 00:00:00
abstract:OBJECTIVES:Smoking is a highly prevalent addictive behavior with severe and life-shortening health consequences. This is the first study to evaluate the efficacy of a newly developed imaginal variant of approach bias modification (ABM) (i.e., imaginal retraining) for the reduction of craving for tobacco and actual smok...
journal_title:European addiction research
pub_type: 杂志文章
doi:10.1159/000509823
更新日期:2020-01-01 00:00:00
abstract:INTRODUCTION:There is a high prevalence of smoking among heavy drinkers, which is often forgotten even though it has important health consequences. AIM:To evaluate the effects that providing an intensive tobacco cessation treatment simultaneously with alcohol dependence treatment versus delayed treatment (first alcoho...
journal_title:European addiction research
pub_type: 杂志文章,随机对照试验
doi:10.1159/000321256
更新日期:2011-01-01 00:00:00
abstract:AIM:The purpose of this study was to investigate the role of serotonergic genes in the development of alcohol dependence. The manifestation of alcohol withdrawal symptoms related to serotonergic polymorphisms in alcoholics was also examined. METHODS:The role of polymorphisms in the serotonin receptor 1A (5-HT1A), sero...
journal_title:European addiction research
pub_type: 杂志文章
doi:10.1159/000173008
更新日期:2009-01-01 00:00:00
abstract::In this paper, the effectiveness of the treatment program developed by Proyecto Hombre ('Project Mankind') in Asturias, Spain, is evaluated. In a long-term follow-up (range from 73 days to 8 years) with a sample of 249 subjects, the results obtained by subjects completing the treatment (194) were compared with pre-tre...
journal_title:European addiction research
pub_type: 杂志文章
doi:10.1159/000049484
更新日期:2002-01-01 00:00:00