Association between leptin levels and doses of clomethiazole during alcohol withdrawal: a pilot study.

Abstract:

AIMS:The issue of leptin as a putative state marker of alcohol use and its role in craving has been raised in the last few years. Recently, a strong GABA-ergic modulation of leptin was postulated. The aim of the pilot study was to examine leptin levels in correlation with the strongly GABA-mimetic active substance clomethiazole. The main hypothesis was that higher doses of the strong GABA-mimetic clomethiazole are positively correlated with higher leptin levels. METHODS:Twenty-eight alcohol-dependent patients (3 females, median age 36 years) undergoing alcohol withdrawal were included. In 18 patients with and 10 without clomethiazole, serum leptin was analyzed at day 1 and day 7 of alcohol withdrawal. Both groups did not differ by age, BMI, or alcohol use characteristics. RESULTS:In the clomethiazole group, significant correlations were found between leptin levels at day 1 and clomethiazole dose (p = 0.004), clomethiazole and leptin at day 1/BMI (p = 0.009) and leptin at day 1 and clomethiazole/body surface (p = 0.006). Furthermore, patients with higher clomethiazole doses demonstrated significant higher leptin levels at day 1 (p = 0.044) and day 7 (p = 0.046). CONCLUSIONS:Our pilot data show a strong association between leptin levels and clomethiazole doses, thus supporting further research.

journal_name

Eur Addict Res

authors

Dammann G,Walter M,Gremaud-Heitz D,Wolfersdorf M,Hartmann S,Wurst FM

doi

10.1159/000331017

subject

Has Abstract

pub_date

2012-01-01 00:00:00

pages

12-5

issue

1

eissn

1022-6877

issn

1421-9891

pii

000331017

journal_volume

18

pub_type

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