Abstract:
BACKGROUND/AIMS:In recent years, quality of life (QoL) assessments have proved useful for evaluating and comparing drug treatment programs. To compare QoL of patients maintained on methadone versus slow-release morphine, a prospective, randomized, double-blind, double-dummy, cross-over study was conducted. METHODS:Over two 7-week study phases, participants received either oral slow-release morphine capsules followed by methadone oral solution or vice versa. QoL status was assessed at baseline, week 7, and week 14 using the German version of the Lancashire Quality of Life Profile. RESULTS:No statistically significant difference was found between methadone and slow-release morphine in any QoL domain. A significant time effect for nearly all QoL domains was observed after 14 weeks of opioid medication, independent of the chosen drug (general well-being, p < 0.001; mental health, p = 0.001; general state of health, p = 0.018; leisure time at home, p = 0.034; leisure time out of the home, p = 0.008). Furthermore, this study revealed that even short-term maintenance yields significantly higher QoL scores in the important domain of general well-being. CONCLUSION:These results indicate that slow-release morphine has effects comparable to methadone on patient-reported QoL data and is thus a promising option for treatment of opioid-dependent subjects.
journal_name
Eur Addict Resjournal_title
European addiction researchauthors
Winklbaur B,Jagsch R,Ebner N,Thau K,Fischer Gdoi
10.1159/000113724subject
Has Abstractpub_date
2008-01-01 00:00:00pages
99-105issue
2eissn
1022-6877issn
1421-9891pii
000113724journal_volume
14pub_type
杂志文章,随机对照试验abstract:BACKGROUND/AIMS:We investigated the psychometric properties of a German translation of the 12-item Autonomy over Tobacco Scale (AUTOS) among 1,195 eighth-grade students. METHODS:Data for this study were collected as part of the fourth wave of data collection of the Smokefree Class Competition intervention in the Saxon...
journal_title:European addiction research
pub_type: 杂志文章
doi:10.1159/000334410
更新日期:2012-01-01 00:00:00
abstract::Both heroin abuse and early life stress (ELS) affect the immune system and the hypothalamic-pituitary-adrenal (HPA) axis. Additionally, accelerated aging due to mild inflammation has been indicated in these conditions. The present study aims to compare plasma levels of apoptosis markers, inflammatory markers, and stre...
journal_title:European addiction research
pub_type: 杂志文章
doi:10.1159/000503880
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND/AIMS:Methylphenidate (MPH) has been the most commonly used intravenous (i.v.) substance in Iceland in recent years. In Iceland, MPH is available in 3 forms: immediate-release (IR) tablets (MPH IR, short-acting), sustainable-release (SR) capsules (MPH SR, long-acting) and osmotic-release (OROS) tablets (MPH O...
journal_title:European addiction research
pub_type: 杂志文章
doi:10.1159/000446428
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND/AIM:Heroin dependence is a chronic relapsing disorder characterized by the compulsion to seek and use heroin. Stress and craving are seen as key factors for heroin use. Moreover, altered hypothalamic-pituitary-adrenal (HPA) axis function has been frequently reported. However, the acute effects of diacetylmor...
journal_title:European addiction research
pub_type: 杂志文章,随机对照试验
doi:10.1159/000334411
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND:Alcohol consumption is one of the most important factors for disease and disability in Europe. In clinical trials, nalmefene has resulted in a significant reduction in the number of heavy-drinking days (HDDs) per month and total alcohol consumption (TAC) among alcohol-dependent patients versus placebo. METH...
journal_title:European addiction research
pub_type: 杂志文章
doi:10.1159/000362408
更新日期:2014-01-01 00:00:00
abstract:AIMS:There is a scarcity of clinical trials on psychological treatments for concurrent borderline personality disorder (BPD) and substance use disorder (SUD). Mentalization-based treatment (MBT) have shown efficacy in several trials on BPD. The aim of the present study was to examine the feasibility and effectiveness o...
journal_title:European addiction research
pub_type: 杂志文章,随机对照试验
doi:10.1159/000485564
更新日期:2018-01-01 00:00:00
abstract:OBJECTIVE:Evaluation of the Addiction Severity Index (ASI) as a screen for identifying sexual and physical assault histories. METHOD:The sensitivity and specificity of the ASI assault items were examined in 146 alcoholic patients with the assault questions of the Composite International Diagnostic Interview posttrauma...
journal_title:European addiction research
pub_type: 杂志文章
doi:10.1159/000050740
更新日期:2001-12-01 00:00:00
abstract:AIMS:To explore previously unreported rates and trends in opioid-related mortality in Israel, 2005-2014. METHODS:Data was obtained from the national database on causes of death. Drug poisoning deaths were divided into opioid-related deaths and deaths related to other drugs according to International Classification of ...
journal_title:European addiction research
pub_type: 杂志文章
doi:10.1159/000485033
更新日期:2017-01-01 00:00:00
abstract::The aim of this study was to investigate to what extent alcohol-specific parenting practices relate to adolescents' alcohol use, binge drinking, and alcohol-related problems, and whether these associations are moderated by socioeconomic status (SES), i.e. parents' education level and family income. The present data we...
journal_title:European addiction research
pub_type: 杂志文章
doi:10.1159/000110408
更新日期:2008-01-01 00:00:00
abstract::Adult attention deficit/hyperactivity disorder (ADHD) often co-occurs with substance use disorders (SUD) and is associated with early onset and more severe development of SUD and with reduced treatment effectiveness. Screening tools allow for a good recognition of possible ADHD in adults with SUD and should be used ro...
journal_title:European addiction research
pub_type: 杂志文章
doi:10.1159/000487767
更新日期:2018-01-01 00:00:00
abstract::γ-Butyrolactone (GBL) is a popular drug of abuse which is easily available over the internet. Following a UK classification change to a class C drug in January 2010, internet supply has become difficult. Some of the effects have resulted in sourcing GBL from industrial solvents. We report a case of a 24-year-old man w...
journal_title:European addiction research
pub_type: 杂志文章
doi:10.1159/000324343
更新日期:2011-01-01 00:00:00
abstract:UNLABELLED:This study evaluated automated techniques including personalized normative feedback and protective behavioral strategies, for brief interventions intended to reduce peak alcohol concentrations in university students. After completing baseline assessment, a total of 1,678 hazardous-drinking consumers were ran...
journal_title:European addiction research
pub_type: 杂志文章,随机对照试验
doi:10.1159/000381017
更新日期:2015-01-01 00:00:00
abstract::Depression is a common co-morbid disorder in substance use disorder (SUD) patients. Hence, valid instruments are needed to screen for depression in this subpopulation. In this study, the predictive validity of the Depression, Anxiety and Stress Scale (DASS-21) for the presence of a depressive disorder was investigated...
journal_title:European addiction research
pub_type: 杂志文章
doi:10.1159/000485182
更新日期:2017-01-01 00:00:00
abstract::The combination of intoxication and criminal responsibility has been a problem field for legal theory and practice for quite some time. While it has been argued in certain contexts that intoxication reduces or denies criminal responsibility, elsewhere it has been reasoned that intoxicated offenders should be held as (...
journal_title:European addiction research
pub_type: 杂志文章,评审
doi:10.1159/000018931
更新日期:1998-09-01 00:00:00
abstract:BACKGROUND:Consumption of natural cannabis (NC) and synthetic cannabinoids (SCs) has been associated with psychotic disorders. We compared the prevalence of use, consumer profiles, and psychosis-inducing potential of NC and SCs in a specific high-risk population. METHODS:This prospective pilot study included 332 patie...
journal_title:European addiction research
pub_type: 杂志文章
doi:10.1159/000479554
更新日期:2017-01-01 00:00:00
abstract::The primary source for evaluating treatment outcome in alcoholism is usually verbal self-report. Because the validity of self-report is often doubted, more objective markers for treatment outcome are needed. In this study, we compared self-report data from 238 male alcohol-dependent patients participating in a combine...
journal_title:European addiction research
pub_type: 杂志文章
doi:10.1159/000018972
更新日期:1999-06-01 00:00:00
abstract::There is a long-recognized association between alcohol consumption and aggressive behavior. This study was designed to examine aggression in a group of socially well-adapted recovered alcoholics (RA). The question addressed was whether the treatment, together with long-term abstinence from alcohol, could reduce aggres...
journal_title:European addiction research
pub_type: 杂志文章
doi:10.1159/000097938
更新日期:2007-01-01 00:00:00
abstract::In Spain, detoxification in general hospitals plays an important role in the medical care of patients. We aim to provide clinicians with information on the prevalence and correlates of psychiatric co-morbidity in drug abusers in detoxification. A sample of 115 substance-abuse inpatients (mean age 31.9 +/- 6.4 years) i...
journal_title:European addiction research
pub_type: 杂志文章
doi:10.1159/000104881
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND/AIMS:Opioid substitution treatment (OST) improves outcomes in opioid dependence. However, controlled drugs used in treatment may be misused or diverted, resulting in negative treatment outcomes. This review defines a framework to assess the impact of misuse and diversion. METHODS:A systematic review of publ...
journal_title:European addiction research
pub_type: 杂志文章,评审
doi:10.1159/000438988
更新日期:2016-01-01 00:00:00
abstract:OBJECTIVE:To assess smoking habit and awareness of smoking as a potential cause of disease among relatives of patients with serious smoking-related disorders. DESIGN AND SETTING:A survey using a face-to-face interview-assisted questionnaire at the Ege University Hospital between October 1998 and March 1999. SUBJECTS:...
journal_title:European addiction research
pub_type: 杂志文章
doi:10.1159/000059380
更新日期:2002-06-01 00:00:00
abstract::The impact on the motivation to treatment of a qualified alcohol withdrawal programme was evaluated in a pre/post setting. Over a period of 2 years we compared the results of replacing the last week of an inpatient setting by day-clinic treatment. In the first year, 202 patients were treated in a 3-week inpatient sett...
journal_title:European addiction research
pub_type: 杂志文章
doi:10.1159/000050717
更新日期:2001-07-01 00:00:00
abstract:AIMS:To analyse correlates of anabolic androgenic steroids (AAS) use in the general male population. DESIGN:A national household survey. PARTICIPANTS:Individuals aged 15-64 years in Sweden. MEASUREMENTS:AAS use and potential correlates of AAS use, including demographic data, financial situation, physical training, a...
journal_title:European addiction research
pub_type: 杂志文章
doi:10.1159/000333037
更新日期:2012-01-01 00:00:00
abstract:UNLABELLED:This report presents findings of a community survey of 3,021 adolescents and young adults aged 14-24 years in Munich, Germany, carried out to determine the prevalence of use and abuse of and dependence on ecstasy, amphetamines and hallucinogens. The response rate was 71%. RESULTS:(1) In 1995, 4% of the male...
journal_title:European addiction research
pub_type: 杂志文章
doi:10.1159/000018925
更新日期:1998-03-01 00:00:00
abstract:BACKGROUND:A pre-post pilot study was conducted to test the feasibility, acceptability, and potential effectiveness of a fully automatized computer-based intervention targeting hazardous drinking and depressiveness in proactively recruited health care patients (HCPs). To address the importance of the sample selection w...
journal_title:European addiction research
pub_type: 杂志文章
doi:10.1159/000499040
更新日期:2019-01-01 00:00:00
abstract:AIMS:Qualitative studies find that men and women in Russia have different preferences for alcoholic beverages, but quantitative evidence for gender differences in beverage type choice remains scarce. The purpose of this article is to test numerically whether and to what extent men and women in Russia differ in terms of...
journal_title:European addiction research
pub_type: 杂志文章
doi:10.1159/000342313
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND:The aim of the study was to examine the practicability and implementation efficacy of an alcohol outpatient detoxification model and the concomitant 'motivational' psychotherapeutic approach. METHOD:This was an open prospective study to examine the implementation efficacy, practicability and medical safety ...
journal_title:European addiction research
pub_type: 杂志文章
doi:10.1159/000079840
更新日期:2004-01-01 00:00:00
abstract:BACKGROUND:Therapeutic communities (TCs) are drug-free residential settings, focused on psychosocial rehabilitation. While TCs are considered an effective method, the bulk of the research evidence is from poorly controlled studies. The goal of this study was to evaluate TC effectiveness in terms of abstinence and to de...
journal_title:European addiction research
pub_type: 杂志文章,评审
doi:10.1159/000331007
更新日期:2012-01-01 00:00:00
abstract::Engaging in online games has become increasingly important as a part of leisure activity in adolescents and adults. While the majority of people use these games in a healthy way, epidemiological studies show that some develop excessive use and symptoms that are related to those of substance-related addictions. Despite...
journal_title:European addiction research
pub_type: 杂志文章
doi:10.1159/000355832
更新日期:2014-01-01 00:00:00
abstract:AIM:Little is known about whether heroin-dependent individuals receiving methadone maintenance treatment (MMT) who were discharged involuntarily and against medical advice (DAMA) get benefits before they left. The aims of this 12-month follow-up study were to examine whether the effects of MMT on depressive symptoms, h...
journal_title:European addiction research
pub_type: 杂志文章
doi:10.1159/000342309
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND:Personality disorders (PD) are related to negative outcome in substance abuse treatment, and in the general population, personality disorders are related to negative outcome in overall functioning. Little is known about the impact of PD on adjustment following substance abuse treatment. METHODS:A cohort of ...
journal_title:European addiction research
pub_type: 杂志文章
doi:10.1159/000173006
更新日期:2009-01-01 00:00:00