The use of lofexidine by drug dependency units in the United Kingdom.

Abstract:

:Data were collected on 1,074 opiate detoxifications conducted with lofexidine, from 40 drug dependency units in the United Kingdom. 671 patients (62.5%) attempted a detoxification in the community, with the remainder attempting an inpatient detoxification. Patients completing the detoxification started on a mean dose of 0.8 mg/day (median 0.6 mg/day), titrating to a mean dose of 2.2 mg/day (median 1.6 mg/day) and detoxifying in a mean of 10 days (median 10 days). Overall 614 patients (60.4%) successfully completed the detoxification. The most frequently recorded adverse events were dry mouth (5.3%), dizziness (8.5%) and sedation (6.6%). In conclusion, lofexidine is widely and successfully used to rapidly detoxify patients from a range of opiates.

journal_name

Eur Addict Res

authors

Akhurst JS

doi

10.1159/000018962

keywords:

subject

Has Abstract

pub_date

1999-03-01 00:00:00

pages

43-9

issue

1

eissn

1022-6877

issn

1421-9891

pii

18962

journal_volume

5

pub_type

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