Factors affecting exhaled nitric oxide measurements: the effect of sex.

abstract：:Respiratory diseases including asthma and chronic obstructive pulmonary disease (COPD) are characterised by excessive and persistent inflammation. Current treatments are often inadequate for symptom and disease control, and hence new therapies are warranted. Recent emerging research has implicated dyslipidaemia in pul...

journal_title：Respiratory research

authors： Chai AB,Ammit AJ,Gelissen IC

更新日期：2017-02-28 00:00:00

abstract：OBJECTIVE:We aimed to identify the prevalence and distribution patterns of allergens among Chinese children with asthma/asthma-like symptoms (ALS). METHODS:A total of 3479 children with asthma/ALS were enrolled. Skin prick test (SPT) was used to test the allergen-specific IgE. We analysed allergens prevalence and dist...

journal_title：Respiratory research

authors： Mao S,Wu L,Shi W

更新日期：2020-02-18 00:00:00

abstract：:Important paradigms of pulmonary disease with nontuberculous mycobacteria (NTM) are currently shifting based on an increasing attention within the field of cystic fibrosis (CF). These shifts are likely to benefit the management of all patients with pulmonary NTM, regardless of underlying pathology. Currently several k...

journal_title：Respiratory research

authors： Qvist T,Pressler T,Høiby N,Katzenstein TL

更新日期：2014-04-11 00:00:00

abstract：BACKGROUND:Mechanical ventilation can cause ventilator-induced lung injury (VILI) and lung fibrosis; however, the underlying mechanisms are still not fully understood. RNA sequencing is a powerful means for detecting vitally important protein-coding transcripts and long non-coding RNAs (lncRNAs) on a genome-wide scale,...

journal_title：Respiratory research

authors： Wang L,Zhang N,Zhang Y,Xia J,Zhan Q,Wang C

更新日期：2018-06-22 00:00:00

abstract：RATIONALE:Gastroesophageal reflux disease (GERD) is a common comorbidity in chronic obstructive pulmonary disease (COPD) and has been associated with increased risk of acute exacerbations, hospitalization, emergency room visits, costs, and quality-of-life impairment. However, it remains unclear whether GERD contributes...

journal_title：Respiratory research

authors： Baldomero AK,Wendt CH,Petersen A,Gaeckle NT,Han MK,Kunisaki KM,COPDGene Investigators.

更新日期：2020-08-03 00:00:00

abstract：BACKGROUND:Generalized hypoxic pulmonary vasoconstriction (HPV) occurring during exposure to hypoxia is a detrimental process resulting in an increase in lung vascular resistance. Nebulization of sodium nitrite has been shown to inhibit HPV. The aim of this project was to investigate and compare the effects of nebuliza...

journal_title：Respiratory research

authors： Egemnazarov B,Schermuly RT,Dahal BK,Elliott GT,Hoglen NC,Surber MW,Weissmann N,Grimminger F,Seeger W,Ghofrani HA

更新日期：2010-06-21 00:00:00

abstract：: ...

journal_title：Respiratory research

authors：

更新日期：2018-12-20 00:00:00

abstract：BACKGROUND:Mutations in the eukaryotic translation initiation factor 2α kinase 4 (EIF2AK4) gene have recently been identified in recessively inherited veno-occlusive disease. In this study we assessed if EIF2AK4 mutations occur also in a family with autosomal dominantly inherited pulmonary arterial hypertension (HPAH) ...

journal_title：Respiratory research

authors： Eichstaedt CA,Song J,Benjamin N,Harutyunova S,Fischer C,Grünig E,Hinderhofer K

更新日期：2016-11-04 00:00:00

abstract：BACKGROUND:Cigarette smoke (CS) is the main cause in the development of chronic obstructive pulmonary disease (COPD), the pathogenesis of which is related to an extended inflammatory response. In this study, we investigated the effect of low and high doses of gas phase cigarette smoke (GPS) on cultured lymphocyte proge...

journal_title：Respiratory research

authors： Sdralia ND,Patmanidi AL,Velentzas AD,Margaritis LH,Baltatzis GE,Hatzinikolaou DG,Stavridou A

更新日期：2009-09-10 00:00:00

abstract：BACKGROUND:Programming a mechanical ventilator with a biologically variable or fractal breathing pattern (an example of 1/f noise) improves gas exchange and respiratory mechanics. Here we show that fractal ventilation increases respiratory sinus arrhythmia (RSA) -- a mechanism known to improve ventilation/perfusion mat...

journal_title：Respiratory research

authors： Mutch WA,Graham MR,Girling LG,Brewster JF

更新日期：2005-05-09 00:00:00

abstract：BACKGROUND:Progestins as respiratory stimulants in chronic obstructive pulmonary disease (COPD) have been investigated in males and during wakefulness. However, sleep and gender may influence therapeutic responses. We investigated the effects of a 2-week medroxyprogesterone acetate (MPA) therapy on sleep and nocturnal ...

journal_title：Respiratory research

authors： Saaresranta T,Aittokallio T,Utriainen K,Polo O

更新日期：2005-04-04 00:00:00

abstract：:A proportion of patients with certain types of interstitial lung disease (ILD), including chronic hypersensitivity pneumonitis and ILDs associated with autoimmune diseases, develop a progressive fibrosing phenotype that shows similarities in clinical course to idiopathic pulmonary fibrosis. Irrespective of the clinica...

journal_title：Respiratory research

authors： Kolb M,Vašáková M

更新日期：2019-03-14 00:00:00

abstract：:Bacillus Calmette-Guérin (BCG) vaccination is routine and near-universal in many low- and middle-income countries (LMIC). It has been suggested that BCG can have a protective effect on COVID-19 morbidity and mortality. This commentary discusses the limitations of the evidence around BCG and COVID-19. We argue that hig...

journal_title：Respiratory research

authors： Pereira M,Paixão E,Trajman A,de Souza RA,da Natividade MS,Pescarini JM,Pereira SM,Barreto FR,Ximenes R,Dalcomo M,Ichihara MY,Nunes C,Barral-Netto M,Barreto ML

更新日期：2020-07-11 00:00:00

abstract：:Pre-bronchodilator lung function including forced vital capacity (FVC), forced expiratory flow in 1 second (FEV1), their ratio (FEV1/FVC), and forced expiratory flow 25-75% (FEF25-75) measured at age 10, 18, and 26 years in the Isle of Wight birth cohort was analyzed for developmental patterns (trajectories). Early li...

journal_title：Respiratory research

authors： Karmaus W,Mukherjee N,Janjanam VD,Chen S,Zhang H,Roberts G,Kurukulaaratchy RJ,Arshad H

更新日期：2019-05-22 00:00:00

abstract：RATIONALE:We had shown that COPD women expressed more dyspnea than men for the same degree of airway obstruction. OBJECTIVES:Evaluate gender differences in respiratory factors associated with dyspnea in COPD patients. METHODS:In a FEV1 % matched population of 100 men and women with COPD we measured: age, MMRC, FEV1, ...

journal_title：Respiratory research

authors： de Torres JP,Casanova C,Montejo de Garcini A,Aguirre-Jaime A,Celli BR

更新日期：2007-03-06 00:00:00

abstract：BACKGROUND:Idiopathic pulmonary fibrosis (IPF) is a rapid progressive fibro-proliferative disorder with poor prognosis similar to lung cancer. The pathogenesis of IPF is uncertain, but loss of epithelial cells and fibroblast proliferation are thought to be central processes. Previous reports have shown that BARD1 expre...

journal_title：Respiratory research

authors： André PA,Prêle CM,Vierkotten S,Carnesecchi S,Donati Y,Chambers RC,Pache JC,Crestani B,Barazzone-Argiroffo C,Königshoff M,Laurent GJ,Irminger-Finger I

更新日期：2015-09-29 00:00:00

abstract：BACKGROUND:We have previously shown that vitamin D deficiency has a detrimental impact on lung development. In this study, we aimed to identify the mechanisms linking vitamin D with lung development using a mouse model of dietary manipulation. METHODS:Female offspring were euthanized at different time-points; embryoni...

journal_title：Respiratory research

authors： Chen L,Wilson R,Bennett E,Zosky GR

更新日期：2016-04-27 00:00:00

abstract：:Pulmonary surfactant is a complex fluid that comprises phospholipids and four proteins (SP-A, SP-B, SP-C, and SP-D) with different biological functions. SP-B, SP-C, and SP-D are essential for the lungs' surface tension function and for the organization, stability and metabolism of lung parenchyma. SP-A and SP-D, which...

journal_title：Respiratory research

authors： Carreto-Binaghi LE,Aliouat el M,Taylor ML

更新日期：2016-06-01 00:00:00

abstract：BACKGROUND:Identifying genetic determinants for lung function is important in providing insight into the pathophysiology of asthma. Signal transducer and activator of transcription 3 is a transcription factor latent in the cytoplasm; the gene (STAT3) is activated by a wide range of cytokines, and may play a role in lun...

journal_title：Respiratory research

authors： Litonjua AA,Tantisira KG,Lake S,Lazarus R,Richter BG,Gabriel S,Silverman ES,Weiss ST

更新日期：2005-06-03 00:00:00

abstract：BACKGROUND:Family history of asthma and other allergic diseases have been linked to the risk of childhood asthma previously, but little is known about their effect on the age-of-onset and persistency of asthma until young adulthood. METHODS:We assessed the effect of the family history of asthma and allergic diseases o...

journal_title：Respiratory research

authors： Paaso EM,Jaakkola MS,Rantala AK,Hugg TT,Jaakkola JJ

更新日期：2014-11-27 00:00:00

abstract：BACKGROUND:Platelet-derived growth factor A (PDGF-A) signals solely through PDGF-Ralpha, and is required for fibroblast proliferation and transdifferentiation (fibroblast to myofibroblast conversion) during alveolar development, because pdgfa-null mice lack both myofibroblasts and alveoli. However, these PDGF-A-mediate...

journal_title：Respiratory research

authors： Kimani PW,Holmes AJ,Grossmann RE,McGowan SE

更新日期：2009-11-25 00:00:00

abstract：STUDY OBJECTIVE:The primary aim of this study was to investigate whether IMA levels are helpful in the diagnosis of pulmonary embolism (PE). The secondary aim was to determine whether IMA was more effective alone or in combination with clinical probability scores in the diagnosis of PE. Thirdly, the sensitivity and spe...

journal_title：Respiratory research

authors： Turedi S,Gunduz A,Mentese A,Topbas M,Karahan SC,Yeniocak S,Turan I,Eroglu O,Ucar U,Karaca Y,Turkmen S,Russell RM

更新日期：2008-05-30 00:00:00

abstract：:The interaction between viruses and dendritic cells (DCs) is varied and complex. DCs are key elements in the development of a host response to pathogens such as viruses, but viruses have developed survival tactics to either evade or diminish the immune system that functions to kill and eliminate these micro-organisms....

journal_title：Respiratory research

authors： Peebles RS Jr,Graham BS

更新日期：2001-01-01 00:00:00

abstract：BACKGROUND:Cigarette smoke induced oxidative stress has been shown to reduce silent information regulator 1 (Sirt1) levels in lung tissue from smokers and patients with COPD patients. Sirt1 is known to inhibit endothelial senescence and may play a protective role in vascular cells. Endothelial progenitor cells (EPCs) a...

journal_title：Respiratory research

authors： Kato R,Mizuno S,Kadowaki M,Shiozaki K,Akai M,Nakagawa K,Oikawa T,Iguchi M,Osanai K,Ishizaki T,Voelkel NF,Toga H

更新日期：2016-10-27 00:00:00

abstract：BACKGROUND:The long-term efficacy and safety of aclidinium bromide, a novel, long-acting muscarinic antagonist, were investigated in patients with moderate to severe chronic obstructive pulmonary disease (COPD). METHODS:In two double-blind, 52-week studies, ACCLAIM/COPD I (n=843) and II (n=804), patients were randomis...

journal_title：Respiratory research

authors： Jones PW,Rennard SI,Agusti A,Chanez P,Magnussen H,Fabbri L,Donohue JF,Bateman ED,Gross NJ,Lamarca R,Caracta C,Gil EG

更新日期：2011-04-26 00:00:00

abstract：BACKGROUND:Inspiratory activity is a prerequisite for successful application of patient triggered ventilation such as proportional assist ventilation (PAV). It has recently been reported that surfactant instillation increases the activity of slowly adapting pulmonary stretch receptors (PSRs) followed by a shorter inspi...

journal_title：Respiratory research

authors： Sindelar R,Rieger-Fackeldey E,Jonzon A,Schaller P,Schulze A,Sedin G

更新日期：2006-03-10 00:00:00

abstract：BACKGROUND:Exacerbations of chronic obstructive pulmonary disease (COPD) are associated with loss of lung function and poor outcomes for patients. However, there are limited data on the time course of changes in forced expiratory volume in 1 s (FEV1) preceding the first reported symptom and after the start of an exacer...

journal_title：Respiratory research

authors： Watz H,Tetzlaff K,Magnussen H,Mueller A,Rodriguez-Roisin R,Wouters EFM,Vogelmeier C,Calverley PMA

更新日期：2018-12-13 00:00:00

abstract：BACKGROUND:Legionella pneumophila (LPN) can cause a lethal infectious disease with a marked inflammatory response in humans. However, the mechanism of this severe inflammation remains poorly understood. Since necrosis is known to induce inflammation, we investigated whether LPN induces necrosis in macrophages. We also ...

journal_title：Respiratory research

authors： Morinaga Y,Yanagihara K,Nakamura S,Hasegawa H,Seki M,Izumikawa K,Kakeya H,Yamamoto Y,Yamada Y,Kohno S,Kamihira S

更新日期：2010-11-22 00:00:00

abstract：BACKGROUND:Mutations in the DNAI1 gene, encoding a component of outer dynein arms of the ciliary apparatus, are the second most important genetic cause of primary ciliary dyskinesia (PCD), the genetically heterogeneous recessive disorder with the prevalence of ~1/20,000. The estimates of the DNAI1 involvement in PCD pa...

journal_title：Respiratory research

authors： Ziętkiewicz E,Nitka B,Voelkel K,Skrzypczak U,Bukowy Z,Rutkiewicz E,Humińska K,Przystałowska H,Pogorzelski A,Witt M

更新日期：2010-12-08 00:00:00

abstract：BACKGROUND:Nintedanib is an approved therapy for idiopathic pulmonary fibrosis (IPF). Some patients treated with nintedanib experience weight loss. Exploratory data suggest that low body mass index or weight loss are associated with worse outcomes in patients with IPF. We investigated whether BMI at baseline or weight ...

journal_title：Respiratory research

authors： Jouneau S,Crestani B,Thibault R,Lederlin M,Vernhet L,Valenzuela C,Wijsenbeek M,Kreuter M,Stansen W,Quaresma M,Cottin V

更新日期：2020-11-25 00:00:00