Abstract:
:Respiratory diseases including asthma and chronic obstructive pulmonary disease (COPD) are characterised by excessive and persistent inflammation. Current treatments are often inadequate for symptom and disease control, and hence new therapies are warranted. Recent emerging research has implicated dyslipidaemia in pulmonary inflammation. Three ATP-binding cassette (ABC) transporters are found in the mammalian lung - ABCA1, ABCG1 and ABCA3 - that are involved in movement of cholesterol and phospholipids from lung cells. The aim of this review is to corroborate the current evidence for the role of ABC lipid transporters in pulmonary lipid homeostasis and inflammation. Here, we summarise results from murine knockout studies, human diseases associated with ABC transporter mutations, and in vitro studies. Disruption to ABC transporter activity results in lipid accumulation and elevated levels of inflammatory cytokines in lung tissue. Furthermore, these ABC-knockout mice exhibit signs of respiratory distress. ABC lipid transporters appear to have a crucial and protective role in the lung. However, our knowledge of the underlying molecular mechanisms for these benefits requires further attention. Understanding the relationship between cholesterol and inflammation in the lung, and the role that ABC transporters play in this may illuminate new pathways to target for the treatment of inflammatory lung diseases.
journal_name
Respir Resjournal_title
Respiratory researchauthors
Chai AB,Ammit AJ,Gelissen ICdoi
10.1186/s12931-017-0526-9subject
Has Abstractpub_date
2017-02-28 00:00:00pages
41issue
1eissn
1465-9921issn
1465-993Xpii
10.1186/s12931-017-0526-9journal_volume
18pub_type
杂志文章,评审abstract:BACKGROUND:Idiopathic pulmonary fibrosis (IPF) is a rare disease with a median survival of 3-5 years after diagnosis with limited treatment options. The aim of this study is to assess the psychometric characteristics of the Short Form 36 Health Status Questionnaire (SF-36) in IPF and to provide disease specific minimal...
journal_title:Respiratory research
pub_type: 临床试验,杂志文章
doi:10.1186/s12931-019-1010-5
更新日期:2019-03-01 00:00:00
abstract:BACKGROUND:Aim of this prospective study was to compare clinical and genetic findings in children with idiopathic or heritable pulmonary arterial hypertension (I/HPAH) with children affected with congenital heart defects associated PAH (CHD-APAH). METHODS:Prospectively included were 40 consecutive children with invasi...
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pub_type: 杂志文章
doi:10.1186/1465-9921-14-3
更新日期:2013-01-09 00:00:00
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journal_title:Respiratory research
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1186/s12931-016-0498-1
更新日期:2017-01-11 00:00:00
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journal_title:Respiratory research
pub_type: 杂志文章,评审
doi:10.1186/1465-9921-8-30
更新日期:2007-04-04 00:00:00
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pub_type: 杂志文章
doi:10.1186/s12931-017-0570-5
更新日期:2017-05-08 00:00:00
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pub_type: 杂志文章
doi:10.1186/s12931-019-1206-8
更新日期:2019-12-18 00:00:00
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pub_type: 杂志文章
doi:10.1186/1465-9921-14-57
更新日期:2013-05-25 00:00:00
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journal_title:Respiratory research
pub_type: 杂志文章
doi:10.1186/s12931-018-0786-z
更新日期:2018-05-25 00:00:00
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journal_title:Respiratory research
pub_type: 杂志文章,评审
doi:10.1186/s12931-020-01516-8
更新日期:2020-10-09 00:00:00
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journal_title:Respiratory research
pub_type: 杂志文章
doi:10.1186/1465-9921-6-69
更新日期:2005-07-11 00:00:00
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journal_title:Respiratory research
pub_type: 杂志文章
doi:10.1186/s12931-020-01350-y
更新日期:2020-04-15 00:00:00
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pub_type: 杂志文章,多中心研究
doi:10.1186/s12931-019-1020-3
更新日期:2019-03-15 00:00:00
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pub_type: 杂志文章
doi:10.1186/s12931-020-01600-z
更新日期:2021-01-06 00:00:00
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pub_type: 杂志文章
doi:10.1186/s12931-018-0774-3
更新日期:2018-04-27 00:00:00
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journal_title:Respiratory research
pub_type: 杂志文章
doi:10.1186/s12931-018-0822-z
更新日期:2018-06-22 00:00:00
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pub_type: 杂志文章
doi:10.1186/s12931-020-1302-9
更新日期:2020-02-04 00:00:00
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journal_title:Respiratory research
pub_type: 杂志文章
doi:10.1186/1465-9921-13-81
更新日期:2012-09-19 00:00:00
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journal_title:Respiratory research
pub_type: 杂志文章
doi:10.1186/1465-9921-10-80
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pub_type: 杂志文章,评审
doi:10.1186/s12931-019-1017-y
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pub_type: 杂志文章,评审
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更新日期:2016-06-01 00:00:00
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pub_type: 杂志文章,多中心研究
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更新日期:2007-06-13 00:00:00
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pub_type: 杂志文章,多中心研究
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更新日期:2014-03-04 00:00:00
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更新日期:2014-04-11 00:00:00
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pub_type: 临床试验,杂志文章
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更新日期:2013-07-30 00:00:00
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pub_type: 杂志文章
doi:10.1186/1465-9921-7-50
更新日期:2006-03-29 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2011-11-09 00:00:00
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pub_type: 杂志文章
doi:10.1186/1465-9921-9-23
更新日期:2008-02-28 00:00:00
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pub_type: 杂志文章
doi:10.1186/s12931-020-01475-0
更新日期:2020-08-08 00:00:00