Abstract：
:Bacillus Calmette-Guérin (BCG) vaccination is routine and near-universal in many low- and middle-income countries (LMIC). It has been suggested that BCG can have a protective effect on COVID-19 morbidity and mortality. This commentary discusses the limitations of the evidence around BCG and COVID-19. We argue that higher-quality evidence is necessary to understand the protective effect of the BCG vaccine from existing, secondary data, while we await results from clinical trials currently conducted in different settings.
journal_name
Respir Resjournal_title
Respiratory researchauthors
Pereira M,Paixão E,Trajman A,de Souza RA,da Natividade MS,Pescarini JM,Pereira SM,Barreto FR,Ximenes R,Dalcomo M,Ichihara MY,Nunes C,Barral-Netto M,Barreto MLdoi
10.1186/s12931-020-01439-4subject
Has Abstractpub_date
2020-07-11 00:00:00pages
178issue
1eissn
1465-9921issn
1465-993Xpii
10.1186/s12931-020-01439-4journal_volume
21pub_type
信件,评审abstract：:The nervous system mediates key airway protective behaviors, including cough, mucus secretion, and airway smooth muscle contraction. Thus, its involvement and potential involvement in several airway diseases has become increasingly recognized. In the current review, we focus on the contribution of select neuropeptides...
journal_title：Respiratory research
pub_type： 杂志文章,评审
doi：10.1186/s12931-018-0846-4
更新日期：2018-08-06 00:00:00
abstract：BACKGROUND:The discrepancy between functional and inflammatory airway response to ozone has been reported in normal subjects, but few data are available for stable asthmatics regularly treated with inhaled corticosteroids. METHODS:Twenty-three well controlled, regularly treated, mild-to-moderate asthmatic patients und...
journal_title：Respiratory research
pub_type： 杂志文章,随机对照试验
doi：10.1186/1465-9921-11-5
更新日期：2010-01-19 00:00:00
abstract：BACKGROUND:Generally, structural destruction of lung parenchyma, such as pulmonary emphysema, is considered to be related to the low diagnostic yields and high complication rates of lung biopsies of peripheral lung lesions. Currently, little is known about the clinical outcomes of using endobronchial ultrasound with a ...
journal_title：Respiratory research
pub_type： 杂志文章
doi：10.1186/s12931-019-1149-0
更新日期：2019-08-06 00:00:00
abstract：BACKGROUND:Several previously healthy young adults have developed Coronavirus Disease 2019 (COVID-19), and a few of them progressed to the severe stage. However, the factors are not yet determined. METHOD:We retrospectively analyzed 123 previously healthy young adults diagnosed with COVID-19 from January to March 2020...
journal_title：Respiratory research
pub_type： 杂志文章
doi：10.1186/s12931-020-01412-1
更新日期：2020-06-22 00:00:00
abstract：BACKGROUND:Obesity augments pulmonary responses to ozone. We have reported that IL-33 contributes to these effects of obesity in db/db mice. The purpose of this study was to determine whether IL-33 also contributes to obesity-related changes in the response to ozone in mice with diet-induced obesity. METHODS:Male wild...
journal_title：Respiratory research
pub_type： 杂志文章
doi：10.1186/s12931-020-01361-9
更新日期：2020-04-23 00:00:00
abstract：BACKGROUND:Using guinea pig tracheal preparations, we have recently shown that endogenous arginase activity attenuates inhibitory nonadrenergic noncholinergic (iNANC) nerve-mediated airway smooth muscle relaxation by reducing nitric oxide (NO) production--due to competition with neuronal NO-synthase (nNOS) for the comm...
journal_title：Respiratory research
pub_type： 杂志文章
doi：10.1186/1465-9921-7-6
更新日期：2006-01-12 00:00:00
abstract：BACKGROUND:Airway clearance techniques (ACTs) are an important aspect of the treatment of children with chronic obstructive lung diseases. Unfortunately, a sound evidence base is lacking and airway clearance strategies are largely based on clinical expertise. One of the reasons for the limited evidence is the lack of a...
journal_title：Respiratory research
pub_type： 杂志文章,评审
doi：10.1186/s12931-020-01484-z
更新日期：2020-08-17 00:00:00
abstract：BACKGROUND:In utero exposure to particulate matter with an aerodynamic diameter of less than 2.5 μm (PM2.5) has been linked to child lung function. Overlapping evidence suggests that child sex and exposure timing may modify effects and associations may be mediated through glutathione S-transferase P1 (GSTP1) methylatio...
journal_title：Respiratory research
pub_type： 杂志文章
doi：10.1186/s12931-018-0774-3
更新日期：2018-04-27 00:00:00
abstract：BACKGROUND:The relative contributions of the cytotoxic phenotype of P. aeruginosa expressing type III secretory toxins and an immunocompromised condition lacking normal Toll-like receptor 4 (TLR4) signaling in the pathogenesis of acute lung injury and sepsis were evaluated in a mouse model for Pseudomonas aeruginosa pn...
journal_title：Respiratory research
pub_type： 杂志文章
doi：10.1186/1465-9921-5-1
更新日期：2004-02-12 00:00:00
abstract：BACKGROUND:Lung inflammation in COPD is poorly controlled by inhaled corticosteroids (ICS). Strategies to improve ICS efficacy or the search of biomarkers who may select those patients candidates to receive ICS in COPD are needed. Recent data indicate that MUC1 cytoplasmic tail (CT) membrane mucin can mediate corticost...
journal_title：Respiratory research
pub_type： 杂志文章
doi：10.1186/s12931-018-0927-4
更新日期：2018-11-20 00:00:00
abstract：BACKGROUND:Systemic sclerosis (SSc) is a rare connective tissue disease with a heterogeneous clinical course. Interstitial lung disease (ILD) is a common manifestation of SSc and a leading cause of death. MAIN BODY:All patients newly diagnosed with SSc should receive a comprehensive clinical evaluation, including asse...
journal_title：Respiratory research
pub_type： 杂志文章,评审
doi：10.1186/s12931-019-0980-7
更新日期：2019-01-18 00:00:00
abstract：BACKGROUND:Recent meta-analyses of genome-wide association studies have identified single nucleotide polymorphisms (SNPs) within/near 54 genes associated with lung function measures. Current understanding of the contribution of these genes to human lung development is limited. We set out to further define i) the expres...
journal_title：Respiratory research
pub_type： 杂志文章
doi：10.1186/s12931-016-0410-z
更新日期：2016-07-29 00:00:00
abstract：BACKBROUND:COPD is a common, highly debilitating disease of the airways, primarily caused by smoking. Chronic inflammation and structural remodelling are key pathological features of this disease caused, in part, by the aberrant function of airway smooth muscle (ASM). We have previously demonstrated that hydrogen sulfi...
journal_title：Respiratory research
pub_type： 杂志文章
doi：10.1186/s12931-018-0788-x
更新日期：2018-05-09 00:00:00
abstract：BACKGROUND:Chronic obstructive pulmonary disease (COPD) is a progressive and irreversible chronic inflammatory disease of the lung. The nature of the immune reaction in COPD raises the possibility that IL-17 and related cytokines may contribute to this disorder. This study analyzed the expression of IL-17A and IL-17F a...
journal_title：Respiratory research
pub_type： 杂志文章
doi：10.1186/1465-9921-12-43
更新日期：2011-04-10 00:00:00
abstract：:The interaction between viruses and dendritic cells (DCs) is varied and complex. DCs are key elements in the development of a host response to pathogens such as viruses, but viruses have developed survival tactics to either evade or diminish the immune system that functions to kill and eliminate these micro-organisms....
journal_title：Respiratory research
pub_type： 杂志文章,评审
doi：10.1186/rr63
更新日期：2001-01-01 00:00:00
abstract：BACKGROUND:Lung cancer is one of the leading cause of cancer-related death in the world. Recently, many clinical researches have reported that COL6A3 had strong role in many diseases. The aim of this study was to evaluate the association between single nucleotide polymorphisms (SNPs) in COL6A3 and lung cancer susceptib...
journal_title：Respiratory research
pub_type： 杂志文章
doi：10.1186/s12931-019-1114-y
更新日期：2019-07-08 00:00:00
abstract：BACKGROUND:25-hydroxycholesterol (25-HC) is one of the oxysterols, which are oxidized derivatives of cholesterol, and has been reported to be involved in the pathogenesis of atherosclerosis and Alzheimer's disease. In lung, the possible involvement of 25-HC in airway diseases has been revealed. In the present study, we...
journal_title：Respiratory research
pub_type： 杂志文章
doi：10.1186/1465-9921-13-63
更新日期：2012-07-31 00:00:00
abstract：BACKGROUND:Real-world evidence (RWE) can inform patient management decisions, but RWE studies are associated with limitations. Linkage of different RWE data types could address such limitations by enriching data and improving scientific quality. Using the example of chronic obstructive pulmonary disease (COPD) in Germa...
journal_title：Respiratory research
pub_type： 杂志文章
doi：10.1186/s12931-018-0865-1
更新日期：2018-08-30 00:00:00
abstract：:The aim was to compare the diagnosis of COPD among smokers according to different international guidelines and to compare the outcome when using slow (SVC) and forced vital capacity (FVC). In order to find current smokers a questionnaire was sent to persons who had been on sick leave for more than two weeks. Those who...
journal_title：Respiratory research
pub_type： 杂志文章
doi：10.1186/1465-9921-8-89
更新日期：2007-12-04 00:00:00
abstract：BACKGROUND:Organ regeneration in mammals is hypothesized to require a functional pool of stem or progenitor cells, but the role of these cells in lung regeneration is unknown. METHODS:Based on the fact that postnatal regeneration of alveolar tissue has been attributed to alveolar epithelial cells, we established a hem...
journal_title：Respiratory research
pub_type： 杂志文章
doi：10.1186/s12931-016-0480-y
更新日期：2016-12-07 00:00:00
abstract：RATIONALE:Pulmonary Alveolar Proteinosis (PAP) patients exhibit an acquired deficiency of biologically active granulocyte-macrophage colony stimulating factor (GM-CSF) attributable to GM-CSF specific autoantibodies. PAP alveolar macrophages are foamy, lipid-filled cells with impaired surfactant clearance and markedly r...
journal_title：Respiratory research
pub_type： 临床试验,杂志文章
doi：10.1186/1465-9921-13-46
更新日期：2012-06-14 00:00:00
abstract：BACKGROUND:Surfactant protein D (SP-D) and Mannose Binding Lectin (MBL) are collectins that have opsonic and immunoregulatory functions, are found in lung fluid and interact with the human immunodeficiency virus (HIV). We compared collectin levels in lung fluid and serum from HIV infected and normal subjects to determi...
journal_title：Respiratory research
pub_type： 杂志文章
doi：10.1186/1465-9921-8-42
更新日期：2007-06-13 00:00:00
abstract：BACKGROUND:Inflammation may contribute to the pathogenesis of various forms of pulmonary hypertension (PH). Recent studies in patients with idiopathic PH or PH associated with underlying diseases suggest a role for interleukin-6 (IL-6). METHODS:To determine whether endogenous IL-6 contributes to mediate hypoxic PH and...
journal_title：Respiratory research
pub_type： 杂志文章
doi：10.1186/1465-9921-10-6
更新日期：2009-01-27 00:00:00
abstract：: ...
journal_title：Respiratory research
pub_type： 社论
doi：10.1186/s12931-018-0929-2
更新日期：2018-11-26 00:00:00
abstract：BACKGROUND:The home is the predominant environment for exposure to many environmental irritants such as air pollutants and allergens. Exposure to common indoor irritants including volatile organic compounds, formaldehyde and nitrogen dioxide, may increase the risk of snoring for children. The aim of this study was to i...
journal_title：Respiratory research
pub_type： 杂志文章,随机对照试验
doi：10.1186/1465-9921-5-19
更新日期：2004-11-04 00:00:00
abstract：BACKGROUND:The role of the microbiota in the pathogenesis of chronic obstructive pulmonary disease (COPD) following exposure to ambient particulate matter (PM) is largely unknown. METHODS:Fifty-four male Sprague-Dawley rats were exposed to clean air, biomass fuel (BMF), or motor vehicle exhaust (MVE) for 4, 12, and 24...
journal_title：Respiratory research
pub_type： 杂志文章
doi：10.1186/s12931-020-01529-3
更新日期：2020-10-19 00:00:00
abstract：BACKGROUND:Mutations in the DNAI1 gene, encoding a component of outer dynein arms of the ciliary apparatus, are the second most important genetic cause of primary ciliary dyskinesia (PCD), the genetically heterogeneous recessive disorder with the prevalence of ~1/20,000. The estimates of the DNAI1 involvement in PCD pa...
journal_title：Respiratory research
pub_type： 杂志文章
doi：10.1186/1465-9921-11-174
更新日期：2010-12-08 00:00:00
abstract：:There is increasing focus on understanding the nature of chronic obstructive pulmonary disease (COPD) during the earlier stages. Mild COPD (Global Initiative for Chronic Obstructive Lung Disease [GOLD] stage 1 or the now-withdrawn GOLD stage 0) represents an early stage of COPD that may progress to more severe disease...
journal_title：Respiratory research
pub_type： 杂志文章,评审
doi：10.1186/s12931-019-1108-9
更新日期：2019-07-08 00:00:00
abstract：BACKGROUND:Cigarette smoke (CS) is the main cause in the development of chronic obstructive pulmonary disease (COPD), the pathogenesis of which is related to an extended inflammatory response. In this study, we investigated the effect of low and high doses of gas phase cigarette smoke (GPS) on cultured lymphocyte proge...
journal_title：Respiratory research
pub_type： 杂志文章
doi：10.1186/1465-9921-10-82
更新日期：2009-09-10 00:00:00
abstract：BACKGROUND:The identification of smoking-related lung disease in current and former smokers with normal FEV1 is complex, leading to debate regarding using a ratio of forced expiratory volume in 1 s to forced vital capacity (FEV1/FVC) of less than 0.70 versus the predicted lower limit of normal (LLN) for diagnosis of ai...
journal_title：Respiratory research
pub_type： 杂志文章,多中心研究
doi：10.1186/s12931-018-0911-z
更新日期：2018-11-20 00:00:00
