Viruses, dendritic cells and the lung.


:The interaction between viruses and dendritic cells (DCs) is varied and complex. DCs are key elements in the development of a host response to pathogens such as viruses, but viruses have developed survival tactics to either evade or diminish the immune system that functions to kill and eliminate these micro-organisms. In the present review we summarize current concepts regarding the function of DCs in the immune system, our understanding of how viruses alter DC function to attenuate both the virus-specific and global immune response, and how we may be able to exploit DC function to prevent or treat viral infections.


Respir Res


Respiratory research


Peebles RS Jr,Graham BS





Has Abstract


2001-01-01 00:00:00












  • Heterogeneous burden of lung disease in smokers with borderline airflow obstruction.

    abstract:BACKGROUND:The identification of smoking-related lung disease in current and former smokers with normal FEV1 is complex, leading to debate regarding using a ratio of forced expiratory volume in 1 s to forced vital capacity (FEV1/FVC) of less than 0.70 versus the predicted lower limit of normal (LLN) for diagnosis of ai...

    journal_title:Respiratory research

    pub_type: 杂志文章,多中心研究


    authors: Pirozzi CS,Gu T,Quibrera PM,Carretta EE,Han MK,Murray S,Cooper CB,Tashkin DP,Kleerup EC,Barjaktarevic I,Hoffman EA,Martinez CH,Christenson SA,Hansel NN,Graham Barr R,Bleecker ER,Ortega VE,Martinez FJ,Kanner RE,Paine

    更新日期:2018-11-20 00:00:00

  • Rac2 is involved in bleomycin-induced lung inflammation leading to pulmonary fibrosis.

    abstract:BACKGROUND:Pulmonary fibrotic diseases induce significant morbidity and mortality, for which there are limited therapeutic options available. Rac2, a ras-related guanosine triphosphatase expressed mainly in hematopoietic cells, is a crucial molecule regulating a diversity of mast cell, macrophage, and neutrophil functi...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Arizmendi N,Puttagunta L,Chung KL,Davidson C,Rey-Parra J,Chao DV,Thebaud B,Lacy P,Vliagoftis H

    更新日期:2014-06-27 00:00:00

  • Primary data, claims data, and linked data in observational research: the case of COPD in Germany.

    abstract:BACKGROUND:Real-world evidence (RWE) can inform patient management decisions, but RWE studies are associated with limitations. Linkage of different RWE data types could address such limitations by enriching data and improving scientific quality. Using the example of chronic obstructive pulmonary disease (COPD) in Germa...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Mueller S,Gottschalk F,Groth A,Meeraus W,Driessen M,Kohlmann T,Wilke T

    更新日期:2018-08-30 00:00:00

  • Higher serum CCL17 may be a promising predictor of acute exacerbations in chronic hypersensitivity pneumonitis.

    abstract:BACKGROUND:Recent research has suggested that the Th1 and Th2 chemokine/cytokine axis contributes to the development of chronic hypersensitivity pneumonitis (HP). Acute exacerbations (AE) are significant factors in the prognosis of chronic HP. Little is known, however, about these biomarkers in association with AE in c...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Miyazaki Y,Unoura K,Tateishi T,Akashi T,Takemura T,Tomita M,Inase N,Yoshizawa Y

    更新日期:2013-05-25 00:00:00

  • Neutrophil cannibalism--a back up when the macrophage clearance system is insufficient.

    abstract:BACKGROUND:During a lipopolysaccharide-induced lung inflammation, a massive accumulation of neutrophils occurs, which is normally cleared by macrophage phagocytosis following neutrophil apoptosis. However, in cases of extensive apoptosis the normal clearance system may fail, resulting in extensive neutrophil secondary ...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Rydell-Törmänen K,Uller L,Erjefält JS

    更新日期:2006-12-14 00:00:00

  • Gene therapy-emulating small molecule treatments in cystic fibrosis airway epithelial cells and patients.

    abstract:BACKGROUND:Several small molecule corrector and potentiator drugs have recently been licensed for Cystic Fibrosis (CF) therapy. However, other aspects of the disease, especially inflammation, are less effectively treated by these drugs. We hypothesized that small molecule drugs could function either alone or as an adju...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Yang Q,Soltis AR,Sukumar G,Zhang X,Caohuy H,Freedy J,Dalgard CL,Wilkerson MD,Pollard HB,Pollard BS

    更新日期:2019-12-21 00:00:00

  • Quantitative CT analysis using functional imaging is superior in describing disease progression in idiopathic pulmonary fibrosis compared to forced vital capacity.

    abstract:BACKGROUND:Idiopathic pulmonary fibrosis (IPF) is chronic fibrosing pneumonia with an unpredictable natural disease history. Functional respiratory imaging (FRI) has potential to better characterize this disease. The aim of this study was to identify FRI parameters, which predict FVC decline in patients with IPF. METH...

    journal_title:Respiratory research

    pub_type: 临床试验,杂志文章


    authors: Clukers J,Lanclus M,Mignot B,Van Holsbeke C,Roseman J,Porter S,Gorina E,Kouchakji E,Lipson KE,De Backer W,De Backer J

    更新日期:2018-11-06 00:00:00

  • AIDS patients have increased surfactant protein D but normal mannose binding lectin levels in lung fluid.

    abstract:BACKGROUND:Surfactant protein D (SP-D) and Mannose Binding Lectin (MBL) are collectins that have opsonic and immunoregulatory functions, are found in lung fluid and interact with the human immunodeficiency virus (HIV). We compared collectin levels in lung fluid and serum from HIV infected and normal subjects to determi...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Jambo KC,French N,Zijlstra E,Gordon SB

    更新日期:2007-06-13 00:00:00

  • Superoxide dismutase A antigens derived from molecular analysis of sarcoidosis granulomas elicit systemic Th-1 immune responses.

    abstract:BACKGROUND:Sarcoidosis is an idiopathic granulomatous disease with pathologic and immunologic features similar to tuberculosis. Routine histologic staining and culture fail to identify infectious agents. An alternative means for investigating a role of infectious agents in human pathogenesis involves molecular analysis...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Allen SS,Evans W,Carlisle J,Hajizadeh R,Nadaf M,Shepherd BE,Pride DT,Johnson JE,Drake WP

    更新日期:2008-04-25 00:00:00

  • Sialic acid receptor detection in the human respiratory tract: evidence for widespread distribution of potential binding sites for human and avian influenza viruses.

    abstract:BACKGROUND:Influenza virus binds to cell receptors via sialic acid (SA) linked glycoproteins. They recognize SA on host cells through their haemagglutinins (H). The distribution of SA on cell surfaces is one determinant of host tropism and understanding its expression on human cells and tissues is important for underst...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Nicholls JM,Bourne AJ,Chen H,Guan Y,Peiris JS

    更新日期:2007-10-25 00:00:00

  • Gender and respiratory factors associated with dyspnea in chronic obstructive pulmonary disease.

    abstract:RATIONALE:We had shown that COPD women expressed more dyspnea than men for the same degree of airway obstruction. OBJECTIVES:Evaluate gender differences in respiratory factors associated with dyspnea in COPD patients. METHODS:In a FEV1 % matched population of 100 men and women with COPD we measured: age, MMRC, FEV1, ...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: de Torres JP,Casanova C,Montejo de Garcini A,Aguirre-Jaime A,Celli BR

    更新日期:2007-03-06 00:00:00

  • Regulation of ATP binding cassette transporter A1 (ABCA1) expression: cholesterol-dependent and - independent signaling pathways with relevance to inflammatory lung disease.

    abstract::The role of the ATP binding cassette transporter A1 (ABCA1) in maintaining cellular lipid homeostasis in cardiovascular disease is well established. More recently, the important beneficial role played by ABCA1 in modulating pathogenic disease mechanisms, such as inflammation, in a broad range of chronic conditions has...

    journal_title:Respiratory research

    pub_type: 杂志文章,评审


    authors: He P,Gelissen IC,Ammit AJ

    更新日期:2020-09-25 00:00:00

  • Thiolated chitosan nanoparticles enhance anti-inflammatory effects of intranasally delivered theophylline.

    abstract:BACKGROUND:Chitosan, a polymer derived from chitin, has been used for nasal drug delivery because of its biocompatibility, biodegradability and bioadhesiveness. Theophylline is a drug that reduces the inflammatory effects of allergic asthma but is difficult to administer at an appropriate dosage without causing adverse...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Lee DW,Shirley SA,Lockey RF,Mohapatra SS

    更新日期:2006-08-24 00:00:00

  • Pharmacological inhibition of GSK-3 in a guinea pig model of LPS-induced pulmonary inflammation: II. Effects on skeletal muscle atrophy.

    abstract:BACKGROUND:Chronic obstructive pulmonary disease (COPD) is accompanied by pulmonary inflammation and associated with extra-pulmonary manifestations, including skeletal muscle atrophy. Glycogen synthase kinase-3 (GSK-3) has been implicated in the regulation of muscle protein- and myonuclear turnover; two crucial process...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Verhees KJ,Pansters NA,Baarsma HA,Remels AH,Haegens A,de Theije CC,Schols AM,Gosens R,Langen RC

    更新日期:2013-11-01 00:00:00

  • Macrophage CD74 contributes to MIF-induced pulmonary inflammation.

    abstract:BACKGROUND:MIF is a critical mediator of the host defense, and is involved in both acute and chronic responses in the lung. Neutralization of MIF reduces neutrophil accumulation into the lung in animal models. We hypothesized that MIF, in the alveolar space, promotes neutrophil accumulation via activation of the CD74 r...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Takahashi K,Koga K,Linge HM,Zhang Y,Lin X,Metz CN,Al-Abed Y,Ojamaa K,Miller EJ

    更新日期:2009-05-04 00:00:00

  • Chitinase-like protein YKL-40 correlates with inflammatory phenotypes, anti-asthma responsiveness and future exacerbations.

    abstract:BACKGROUND:Asthma is a heterogeneous chronic airway disease, which may be classified into different phenotypes. YKL-40 is a chitin-binding glycoprotein with unclear functions, but its expression is associated with inflammation and tissue remodeling. However, few studies have explored whether YKL-40 is associated with i...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Liu L,Zhang X,Liu Y,Zhang L,Zheng J,Wang J,Hansbro PM,Wang L,Wang G,Hsu AC

    更新日期:2019-05-22 00:00:00

  • Successful establishment of primary small airway cell cultures in human lung transplantation.

    abstract:BACKGROUND:The study of small airway diseases such as post-transplant bronchiolitis obliterans syndrome (BOS) is hampered by the difficulty in assessing peripheral airway function either physiologically or directly. Our aims were to develop robust methods for sampling small airway epithelial cells (SAEC) and to establi...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Banerjee B,Kicic A,Musk M,Sutanto EN,Stick SM,Chambers DC

    更新日期:2009-10-26 00:00:00

  • Prevention of bronchial hyperreactivity in a rat model of precapillary pulmonary hypertension.

    abstract:BACKGROUND:The development of bronchial hyperreactivity (BHR) subsequent to precapillary pulmonary hypertension (PHT) was prevented by acting on the major signalling pathways (endothelin, nitric oxide, vasoactive intestine peptide (VIP) and prostacyclin) involved in the control of the pulmonary vascular and bronchial t...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Habre W,Albu G,Janosi TZ,Fontao F,von Ungern-Sternberg BS,Beghetti M,Petak F

    更新日期:2011-04-27 00:00:00

  • Health care resource utilization and cost for asthma patients regularly treated with oral corticosteroids - a Swedish observational cohort study (PACEHR).

    abstract:BACKGROUND:Patients with severe uncontrolled asthma may receive oral corticosteroid (OCS) treatment regularly. The present study investigated the health care resource utilization and cost in regularly OCS treated Swedish asthma patients. METHODS:Primary care medical records data were linked to data from Swedish nation...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Janson C,Lisspers K,Ställberg B,Johansson G,Telg G,Thuresson M,Nordahl Christensen H,Larsson K

    更新日期:2018-09-03 00:00:00

  • Critical combination of initial markers for predicting refractory Mycoplasma pneumoniae pneumonia in children: a case control study.

    abstract:BACKGROUND:It is unclear whether the responses of refractory and common Mycoplasma pneumoniae (MP) pneumonia to macrolides differ. Hence, this study aimed to identify biomarkers that may be used to distinguish refractory and common pneumonias caused by MP in children at hospital admission. METHODS:The study included 1...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Choi YJ,Jeon JH,Oh JW

    更新日期:2019-08-23 00:00:00

  • Psychometric properties and minimal important differences of SF-36 in Idiopathic Pulmonary Fibrosis.

    abstract:BACKGROUND:Idiopathic pulmonary fibrosis (IPF) is a rare disease with a median survival of 3-5 years after diagnosis with limited treatment options. The aim of this study is to assess the psychometric characteristics of the Short Form 36 Health Status Questionnaire (SF-36) in IPF and to provide disease specific minimal...

    journal_title:Respiratory research

    pub_type: 临床试验,杂志文章


    authors: Witt S,Krauss E,Barbero MAN,Müller V,Bonniaud P,Vancheri C,Wells AU,Vasakova M,Pesci A,Klepetko W,Seeger W,Crestani B,Leidl R,Holle R,Schwarzkopf L,Guenther A

    更新日期:2019-03-01 00:00:00

  • LPS induces IL-10 production by human alveolar macrophages via MAPKinases- and Sp1-dependent mechanisms.

    abstract:BACKGROUND:IL-10 is a cytokine mainly produced by macrophages that plays key roles in tolerance to inhaled antigens and in lung homeostasis. Its regulation in alveolar macrophages (HAM), the resident lung phagocytes, remains however unknown. METHODS:The present study investigated the role of intracellular signalling a...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Chanteux H,Guisset AC,Pilette C,Sibille Y

    更新日期:2007-10-04 00:00:00

  • Impaired survival of regulatory T cells in pulmonary sarcoidosis.

    abstract:BACKGROUND:Impaired regulatory T cell (Treg) function is thought to contribute to ongoing inflammatory responses in sarcoidosis, but underlying mechanisms remain unclear. Moreover, it is not known if increased apoptotic susceptibility of Tregs may contribute to an impaired immunosuppressive function in sarcoidosis. The...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Broos CE,van Nimwegen M,Kleinjan A,ten Berge B,Muskens F,in 't Veen JC,Annema JT,Lambrecht BN,Hoogsteden HC,Hendriks RW,Kool M,van den Blink B

    更新日期:2015-09-16 00:00:00

  • Effect of COPD severity and comorbidities on the result of the PHQ-9 tool for the diagnosis of depression: results from the COSYCONET cohort study.

    abstract::The diagnosis of depression, a frequent comorbidity of chronic obstructive pulmonary disease (COPD), is often supported by questionnaires, such as the Patient Health Questionnaire 9 (PHQ-9). It is unknown to which extent its single questions are affected by the clinical characteristics of COPD patients.We addressed th...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: von Siemens SM,Jörres RA,Behr J,Alter P,Lutter J,Lucke T,Söhler S,Welte T,Watz H,Vogelmeier CF,Trudzinski F,Rief W,Herbig B,Kahnert K,COSYCONET study group.

    更新日期:2019-02-11 00:00:00

  • Recent advances in our understanding of human host responses to tuberculosis.

    abstract::Tuberculosis remains one of the world's greatest public health challenges: 2 billion persons have latent infection, 8 million people develop active tuberculosis annually, and 2-3 million die. Recently, significant advances in our understanding of the human immune response against tuberculosis have occurred. The presen...

    journal_title:Respiratory research

    pub_type: 杂志文章,评审


    authors: Schluger NW

    更新日期:2001-01-01 00:00:00

  • Validated and longitudinally stable asthma phenotypes based on cluster analysis of the ADEPT study.

    abstract:BACKGROUND:Asthma is a disease of varying severity and differing disease mechanisms. To date, studies aimed at stratifying asthma into clinically useful phenotypes have produced a number of phenotypes that have yet to be assessed for stability and to be validated in independent cohorts. The aim of this study was to def...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Loza MJ,Djukanovic R,Chung KF,Horowitz D,Ma K,Branigan P,Barnathan ES,Susulic VS,Silkoff PE,Sterk PJ,Baribaud F,ADEPT (Airways Disease Endotyping for Personalized Therapeutics) and U-BIOPRED (Unbiased Biomarkers for the Prediction

    更新日期:2016-12-15 00:00:00

  • 25-Hydroxycholesterol enhances cytokine release and Toll-like receptor 3 response in airway epithelial cells.

    abstract:BACKGROUND:25-hydroxycholesterol (25-HC) is one of the oxysterols, which are oxidized derivatives of cholesterol, and has been reported to be involved in the pathogenesis of atherosclerosis and Alzheimer's disease. In lung, the possible involvement of 25-HC in airway diseases has been revealed. In the present study, we...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Koarai A,Yanagisawa S,Sugiura H,Ichikawa T,Kikuchi T,Furukawa K,Akamatsu K,Hirano T,Nakanishi M,Matsunaga K,Minakata Y,Ichinose M

    更新日期:2012-07-31 00:00:00

  • Cleaved cytokeratin-18 is a mechanistically informative biomarker in idiopathic pulmonary fibrosis.

    abstract:BACKGROUND:Stress of the endoplasmic reticulum (ER) leading to activation of the unfolded protein response (UPR) and alveolar epithelial cell (AEC) apoptosis may play a role in the pathogenesis of idiopathic pulmonary fibrosis (IPF). Our objectives were to determine whether circulating caspase-cleaved cytokeratin-18 (c...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Cha SI,Ryerson CJ,Lee JS,Kukreja J,Barry SS,Jones KD,Elicker BM,Kim DS,Papa FR,Collard HR,Wolters PJ

    更新日期:2012-11-20 00:00:00

  • Relation of exaggerated cytokine responses of CF airway epithelial cells to PAO1 adherence.

    abstract::In many model systems, cystic fibrosis (CF) phenotype airway epithelial cells in culture respond to P. aeruginosa with greater interleukin (IL)-8 and IL-6 secretion than matched controls. In order to test whether this excess inflammatory response results from the reported increased adherence of P. aeruginosa to the CF...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Kube DM,Fletcher D,Davis PB

    更新日期:2005-07-11 00:00:00

  • Artificial intelligence accuracy in detecting pathological breath sounds in children using digital stethoscopes.

    abstract:BACKGROUND:Manual auscultation to detect abnormal breath sounds has poor inter-observer reliability. Digital stethoscopes with artificial intelligence (AI) could improve reliable detection of these sounds. We aimed to independently test the abilities of AI developed for this purpose. METHODS:One hundred and ninety two...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Kevat A,Kalirajah A,Roseby R

    更新日期:2020-09-29 00:00:00