Viruses, dendritic cells and the lung.

abstract：BACKGROUND:Pentraxin 3 (PTX3) regulates multiple aspects of innate immunity and tissue inflammation. Recently, it has been reported that PTX3 deficiency enhances interleukin (IL)-17A-dominant pulmonary inflammation in an ovalbumin (OVA)-induced mouse asthma model. However, whether PTX3 treatment would provide protectio...

journal_title：Respiratory research

authors： Gao P,Tang K,Lu Y,Huang Z,Wang S,Wang M,Wang J,Zhao J,Xie J

更新日期：2020-09-16 00:00:00

abstract：BACKGROUND:Family history of asthma and other allergic diseases have been linked to the risk of childhood asthma previously, but little is known about their effect on the age-of-onset and persistency of asthma until young adulthood. METHODS:We assessed the effect of the family history of asthma and allergic diseases o...

journal_title：Respiratory research

authors： Paaso EM,Jaakkola MS,Rantala AK,Hugg TT,Jaakkola JJ

更新日期：2014-11-27 00:00:00

abstract：BACKGROUND:Cigarette smoke induced oxidative stress has been shown to reduce silent information regulator 1 (Sirt1) levels in lung tissue from smokers and patients with COPD patients. Sirt1 is known to inhibit endothelial senescence and may play a protective role in vascular cells. Endothelial progenitor cells (EPCs) a...

journal_title：Respiratory research

authors： Kato R,Mizuno S,Kadowaki M,Shiozaki K,Akai M,Nakagawa K,Oikawa T,Iguchi M,Osanai K,Ishizaki T,Voelkel NF,Toga H

更新日期：2016-10-27 00:00:00

abstract：BACKGROUND:Exposure to ozone activates innate immune function and causes neutrophilic (PMN) airway inflammation that in some individuals is robustly elevated. The interplay between immuno-inflammatory function and genomic signaling in those with heightened inflammatory responsiveness to ozone is not well understood. O...

journal_title：Respiratory research

authors： Fry RC,Rager JE,Zhou H,Zou B,Brickey JW,Ting J,Lay JC,Peden DB,Alexis NE

更新日期：2012-10-03 00:00:00

abstract：BACKGROUND:Pulmonary sarcoidosis is an inflammatory disease, characterized by an accumulation of CD4+ lymphocytes and the formation of non-caseating epithelioid cell granulomas in the lungs. The disease either resolves spontaneously or develops into a chronic disease with fibrosis. The neurotrophins nerve growth factor...

journal_title：Respiratory research

authors： Dagnell C,Grunewald J,Kramar M,Haugom-Olsen H,Elmberger GP,Eklund A,Olgart Höglund C

更新日期：2010-11-08 00:00:00

abstract：BACKGROUND:Mechanical ventilation can cause ventilator-induced lung injury (VILI) and lung fibrosis; however, the underlying mechanisms are still not fully understood. RNA sequencing is a powerful means for detecting vitally important protein-coding transcripts and long non-coding RNAs (lncRNAs) on a genome-wide scale,...

journal_title：Respiratory research

authors： Wang L,Zhang N,Zhang Y,Xia J,Zhan Q,Wang C

更新日期：2018-06-22 00:00:00

abstract：BACKGROUND:ATP-regulated potassium channels (KATP) regulate pulmonary vascular tone and are involved in hypoxic pulmonary vasoconstriction (HPV). In patients with inflammation like sepsis or ARDS, HPV is impaired, resulting in a ventilation-perfusion mismatch and hypoxia. Since increase of vascular KATP channel Kir6.1 ...

journal_title：Respiratory research

authors： Turzo M,Vaith J,Lasitschka F,Weigand MA,Busch CJ

更新日期：2018-02-13 00:00:00

abstract：BACKGROUND:Systemic sclerosis (SSc) is a rare connective tissue disease with a heterogeneous clinical course. Interstitial lung disease (ILD) is a common manifestation of SSc and a leading cause of death. MAIN BODY:All patients newly diagnosed with SSc should receive a comprehensive clinical evaluation, including asse...

journal_title：Respiratory research

authors： Cottin V,Brown KK

更新日期：2019-01-18 00:00:00

abstract：BACKGROUND:Proteomic studies of respiratory disorders have the potential to identify protein biomarkers for diagnosis and disease monitoring. Utilisation of sensitive quantitative proteomic methods creates opportunities to determine individual patient proteomes. The aim of the current study was to determine if quantita...

journal_title：Respiratory research

authors： O'Neil SE,Sitkauskiene B,Babusyte A,Krisiukeniene A,Stravinskaite-Bieksiene K,Sakalauskas R,Sihlbom C,Ekerljung L,Carlsohn E,Lötvall J

更新日期：2011-09-22 00:00:00

abstract：BACKGROUND:An imbalance in the generation of pro-inflammatory leukotrienes, and counter-regulatory lipoxins is present in severe asthma. We measured leukotriene B4 (LTB4), and lipoxin A4 (LXA4) production by alveolar macrophages (AMs) and studied the impact of corticosteroids. METHODS:AMs obtained by fiberoptic bronch...

journal_title：Respiratory research

authors： Bhavsar PK,Levy BD,Hew MJ,Pfeffer MA,Kazani S,Israel E,Chung KF

更新日期：2010-06-07 00:00:00

abstract：BACKGROUND:Chronic obstructive pulmonary disease (COPD) is characterized by expiratory flow limitation, causing air trapping and lung hyperinflation. Hyperinflation leads to reduced exercise tolerance and poor quality of life in COPD patients. Total lung capacity (TLC) is an indicator of hyperinflation particularly in ...

journal_title：Respiratory research

authors： Lee JH,McDonald ML,Cho MH,Wan ES,Castaldi PJ,Hunninghake GM,Marchetti N,Lynch DA,Crapo JD,Lomas DA,Coxson HO,Bakke PS,Silverman EK,Hersh CP,COPDGene and ECLIPSE Investigators.

更新日期：2014-08-20 00:00:00

abstract：BACKGROUND:Evidence suggests that dendritic cells accumulate in the lungs of COPD patients and correlate with disease severity. We investigated the importance of IL-1R1 and its ligands IL-1α and β to dendritic cell accumulation and maturation in response to cigarette smoke exposure. METHODS:Mice were exposed to cigare...

journal_title：Respiratory research

authors： Botelho FM,Nikota JK,Bauer CM,Morissette MC,Iwakura Y,Kolbeck R,Finch D,Humbles AA,Stämpfli MR

更新日期：2012-09-19 00:00:00

abstract：BACKGROUND:Obstructive sleep apnoea (OSA) and morbid obesity (MO), defined by a body mass index ≥35 kg/m2, are two closely related conditions. Recent studies suggest that circulating microRNA (miRNA) plays a potential role in the physiopathology of both conditions. To date, circulating miRNA expression has been studied...

journal_title：Respiratory research

authors： Lázaro J,Clavería P,Cabrejas C,Fernando J,Daga B,Ordoñez B,Segura S,Sanz-Rubio D,Marín JM

更新日期：2020-02-04 00:00:00

abstract：BACKGROUND:Skeletal muscle weakness in chronic obstructive pulmonary disease (COPD) is an important predictor of poor prognosis, but the molecular mechanisms of muscle weakness in COPD have not been fully elucidated. The aim of this study was to investigate the role of histone deacetylases(HDAC) in skeletal muscle weak...

journal_title：Respiratory research

authors： To M,Swallow EB,Akashi K,Haruki K,Natanek SA,Polkey MI,Ito K,Barnes PJ

更新日期：2017-05-19 00:00:00

abstract：BACKGROUND:In idiopathic pulmonary fibrosis loss of alveolar epithelium induces inflammation of the pulmonary tissue followed by accumulation of pathogenic myofibroblasts leading eventually to respiratory failures. In animal models inflammatory and resident cells have been demonstrated to contribute to pulmonary fibros...

journal_title：Respiratory research

authors： Blyszczuk P,Germano D,Stein S,Moch H,Matter CM,Beck-Schimmer B,Lüscher TF,Eriksson U,Kania G

更新日期：2011-09-26 00:00:00

abstract：BACKGROUND:Alpha-1-Antitrypsin (AAT) deficiency (AATD) is a hereditary disorder that manifests primarily as pulmonary emphysema and liver cirrhosis. The clinically most relevant mutation causing AATD is a single nucleotide polymorphism Glu342Lys (Z-mutation). Despite the recommendation to test every COPD patient, the c...

journal_title：Respiratory research

authors： Greulich T,Rodríguez-Frias F,Belmonte I,Klemmer A,Vogelmeier CF,Miravitlles M

更新日期：2018-08-13 00:00:00

abstract：BACKGROUND:The common cold is the most widespread viral infection in humans. Iota-carrageenan has previously shown antiviral effectiveness against cold viruses in clinical trials. This study investigated the efficacy of a carrageenan-containing nasal spray on the duration of the common cold and nasal fluid viral load i...

journal_title：Respiratory research

authors： Ludwig M,Enzenhofer E,Schneider S,Rauch M,Bodenteich A,Neumann K,Prieschl-Grassauer E,Grassauer A,Lion T,Mueller CA

更新日期：2013-11-13 00:00:00

abstract：BACKGROUND:Platelet-derived growth factor A (PDGF-A) signals solely through PDGF-Ralpha, and is required for fibroblast proliferation and transdifferentiation (fibroblast to myofibroblast conversion) during alveolar development, because pdgfa-null mice lack both myofibroblasts and alveoli. However, these PDGF-A-mediate...

journal_title：Respiratory research

authors： Kimani PW,Holmes AJ,Grossmann RE,McGowan SE

更新日期：2009-11-25 00:00:00

abstract：BACKGROUND:Extended culture of monocytes and fibroblasts in three-dimensional collagen gels leads to degradation of the gels (see linked study in this issue, "Fibroblasts and monocytes contract and degrade three-dimensional collagen gels in extended co-culture"). The current study, therefore, was designed to evaluate p...

journal_title：Respiratory research

authors： Zhu Y,Liu X,Sköld CM,Wang H,Kohyama T,Wen FQ,Ertl RF,Rennard SI

更新日期：2001-01-01 00:00:00

abstract：BACKGROUND:Generalized hypoxic pulmonary vasoconstriction (HPV) occurring during exposure to hypoxia is a detrimental process resulting in an increase in lung vascular resistance. Nebulization of sodium nitrite has been shown to inhibit HPV. The aim of this project was to investigate and compare the effects of nebuliza...

journal_title：Respiratory research

authors： Egemnazarov B,Schermuly RT,Dahal BK,Elliott GT,Hoglen NC,Surber MW,Weissmann N,Grimminger F,Seeger W,Ghofrani HA

更新日期：2010-06-21 00:00:00

abstract：BACKGROUND:Asthma is a disease of varying severity and differing disease mechanisms. To date, studies aimed at stratifying asthma into clinically useful phenotypes have produced a number of phenotypes that have yet to be assessed for stability and to be validated in independent cohorts. The aim of this study was to def...

journal_title：Respiratory research

authors： Loza MJ,Djukanovic R,Chung KF,Horowitz D,Ma K,Branigan P,Barnathan ES,Susulic VS,Silkoff PE,Sterk PJ,Baribaud F,ADEPT (Airways Disease Endotyping for Personalized Therapeutics) and U-BIOPRED (Unbiased Biomarkers for the Prediction

更新日期：2016-12-15 00:00:00

abstract：BACKGROUND:Idiopathic pulmonary fibrosis (IPF) is a progressive, fatal disorder with a variable disease course. The recent advancement of antifibrotic therapy has increased the need for reliable and specific biomarkers. This study aimed to assess alveolar epithelial biomarkers as predictors for the efficacy of the anti...

journal_title：Respiratory research

authors： Ikeda K,Chiba H,Nishikiori H,Azuma A,Kondoh Y,Ogura T,Taguchi Y,Ebina M,Sakaguchi H,Miyazawa S,Suga M,Sugiyama Y,Nukiwa T,Kudoh S,Takahashi H,Pirfenidone Clinical Study Group in Japan.

更新日期：2020-11-30 00:00:00

abstract：BACKGROUND:While glucocorticoids are currently the most effective therapy for asthma, associated side effects limit enthusiasm for their use. Peroxisome proliferator-activated receptor-gamma (PPAR-gamma) activators include the synthetic thiazolidinediones (TZDs) which exhibit anti-inflammatory effects that suggest usef...

journal_title：Respiratory research

authors： Narala VR,Ranga R,Smith MR,Berlin AA,Standiford TJ,Lukacs NW,Reddy RC

更新日期：2007-12-04 00:00:00

abstract：BACKGROUND:Airway epithelial barrier function is maintained by the formation of tight junctions (TJs) and adherens junctions (AJs). Inhalation of cigarette smoke causes airway epithelial barrier dysfunction and may contribute to the pathogenesis of chronic lung diseases such as asthma and chronic obstructive pulmonary ...

journal_title：Respiratory research

authors： Tatsuta M,Kan-O K,Ishii Y,Yamamoto N,Ogawa T,Fukuyama S,Ogawa A,Fujita A,Nakanishi Y,Matsumoto K

更新日期：2019-11-09 00:00:00

abstract：BACKGROUND:Anxiety in patients with chronic obstructive pulmonary disease (COPD) is associated with self-reported disability. The purpose of this study is to determine whether there is an association between anxiety and functional measures, quality of life and dyspnea. METHODS:Data from 1828 patients with moderate to ...

journal_title：Respiratory research

authors： Giardino ND,Curtis JL,Andrei AC,Fan VS,Benditt JO,Lyubkin M,Naunheim K,Criner G,Make B,Wise RA,Murray SK,Fishman AP,Sciurba FC,Liberzon I,Martinez FJ,NETT Research Group.

更新日期：2010-03-09 00:00:00

abstract：BACKGROUND:Influenza virus binds to cell receptors via sialic acid (SA) linked glycoproteins. They recognize SA on host cells through their haemagglutinins (H). The distribution of SA on cell surfaces is one determinant of host tropism and understanding its expression on human cells and tissues is important for underst...

journal_title：Respiratory research

authors： Nicholls JM,Bourne AJ,Chen H,Guan Y,Peiris JS

更新日期：2007-10-25 00:00:00

abstract：:In the present study, we used tumor necrosis factor-R1 knock out mice (TNF-alpha R1KO) to understand the roles of TNF-alpha on epithelial function in models of carrageenan-induced acute lung inflammation. In order to elucidate whether the observed anti-inflammatory status is related to the inhibition of TNF-alpha, we ...

journal_title：Respiratory research

authors： Mazzon E,Cuzzocrea S

更新日期：2007-10-30 00:00:00

abstract：BACKGROUND:For decades, there is an unresolved debate about adequate prescription of antibiotics for patients suffering from exacerbations of chronic obstructive pulmonary disease (COPD). The aim of this systematic review was to analyse randomised controlled trials investigating the clinical benefit of antibiotics for ...

journal_title：Respiratory research

authors： Puhan MA,Vollenweider D,Latshang T,Steurer J,Steurer-Stey C

更新日期：2007-04-04 00:00:00

abstract：BACKGROUND:In order to find novel noninvasive biomarkers with high accuracy for the screening of early-stage non-small cell lung cancer (NSCLC), we investigate the predictive power of 5 microRNAs (miR-20a, miR-145, miR-21, miR223 and miR-221) as potential biomarkers in early-stage NSCLC. METHODS:In training set, 25 ea...

journal_title：Respiratory research

authors： Geng Q,Fan T,Zhang B,Wang W,Xu Y,Hu H

更新日期：2014-11-25 00:00:00

abstract：BACKGROUND:Programming a mechanical ventilator with a biologically variable or fractal breathing pattern (an example of 1/f noise) improves gas exchange and respiratory mechanics. Here we show that fractal ventilation increases respiratory sinus arrhythmia (RSA) -- a mechanism known to improve ventilation/perfusion mat...

journal_title：Respiratory research

authors： Mutch WA,Graham MR,Girling LG,Brewster JF

更新日期：2005-05-09 00:00:00