DNAH5 is associated with total lung capacity in chronic obstructive pulmonary disease.

abstract：BACKGROUND:The pathogenesis of allergic airway inflammation in asthmatic patients is complex and characterized by cellular infiltrates and activity of many cytokines and chemokines. Both the transcription factor hypoxia inducible factor-1 (HIF-1) and chemokine CCL2 have been shown to play pivotal roles in allergic airw...

journal_title：Respiratory research

authors： Baay-Guzman GJ,Bebenek IG,Zeidler M,Hernandez-Pando R,Vega MI,Garcia-Zepeda EA,Antonio-Andres G,Bonavida B,Riedl M,Kleerup E,Tashkin DP,Hankinson O,Huerta-Yepez S

更新日期：2012-07-23 00:00:00

abstract：:The aim was to compare the diagnosis of COPD among smokers according to different international guidelines and to compare the outcome when using slow (SVC) and forced vital capacity (FVC). In order to find current smokers a questionnaire was sent to persons who had been on sick leave for more than two weeks. Those who...

journal_title：Respiratory research

authors： Nathell L,Nathell M,Malmberg P,Larsson K

更新日期：2007-12-04 00:00:00

abstract：BACKGROUND:In asthma, higher chymase positive mast cell (MC-C) numbers are associated with less airway obstruction. In COPD, the distribution of MC-C and tryptase positive mast cells (MC-T) in central and peripheral airways, and their relation with lung function, is unknown. We compared MC-T and MC-C distributions in C...

journal_title：Respiratory research

authors： Gosman MM,Postma DS,Vonk JM,Rutgers B,Lodewijk M,Smith M,Luinge MA,Ten Hacken NH,Timens W

更新日期：2008-09-10 00:00:00

abstract：BACKGROUND:Exposure to ozone activates innate immune function and causes neutrophilic (PMN) airway inflammation that in some individuals is robustly elevated. The interplay between immuno-inflammatory function and genomic signaling in those with heightened inflammatory responsiveness to ozone is not well understood. O...

journal_title：Respiratory research

authors： Fry RC,Rager JE,Zhou H,Zou B,Brickey JW,Ting J,Lay JC,Peden DB,Alexis NE

更新日期：2012-10-03 00:00:00

abstract：BACKGROUND:Bronchiectasis (BE) is a chronic structural lung disease with frequent exacerbations, some of which require hospital admission though no clear associated factors have been identified. We aimed to evaluate factors associated with hospitalization due to exacerbations during a 1-year follow-up period. METHODS:...

journal_title：Respiratory research

authors： Menéndez R,Méndez R,Polverino E,Rosales-Mayor E,Amara-Elori I,Reyes S,Posadas T,Fernández-Barat L,Torres A

更新日期：2017-09-30 00:00:00

abstract：BACKGROUND:Little is known about the association between cigarette smoking and asthma severity. We assessed smoking as a determinant of disease severity and control in a cohort of clinic-referred allergic subjects who developed new onset asthma. METHODS:Allergic rhinitis subjects with no asthma (n = 371) were followed...

journal_title：Respiratory research

authors： Polosa R,Russo C,Caponnetto P,Bertino G,Sarvà M,Antic T,Mancuso S,Al-Delaimy WK

更新日期：2011-01-24 00:00:00

abstract：BACKGROUND:Steroid resistant (SR) asthma is characterized by persistent airway inflammation that fails to resolve despite treatment with high doses of corticosteroids. Furthermore, SR patient airways show increased numbers neutrophils, which are less responsive to glucocorticoid. The present study seeks to determine wh...

journal_title：Respiratory research

authors： Wang M,Gao P,Wu X,Chen Y,Feng Y,Yang Q,Xu Y,Zhao J,Xie J

更新日期：2016-11-16 00:00:00

abstract：BACKGROUND:The development of bronchial hyperreactivity (BHR) subsequent to precapillary pulmonary hypertension (PHT) was prevented by acting on the major signalling pathways (endothelin, nitric oxide, vasoactive intestine peptide (VIP) and prostacyclin) involved in the control of the pulmonary vascular and bronchial t...

journal_title：Respiratory research

authors： Habre W,Albu G,Janosi TZ,Fontao F,von Ungern-Sternberg BS,Beghetti M,Petak F

更新日期：2011-04-27 00:00:00

abstract：BACKGROUND:Preserved Ratio Impaired Spirometry (PRISm), defined as a reduced FEV1 in the setting of a preserved FEV1/FVC ratio, is highly prevalent and is associated with increased respiratory symptoms, systemic inflammation, and mortality. Studies investigating quantitative chest tomographic features, genetic associat...

journal_title：Respiratory research

authors： Wan ES,Castaldi PJ,Cho MH,Hokanson JE,Regan EA,Make BJ,Beaty TH,Han MK,Curtis JL,Curran-Everett D,Lynch DA,DeMeo DL,Crapo JD,Silverman EK,COPDGene Investigators.

更新日期：2014-08-06 00:00:00

abstract：BACKGROUND:Although feelings of anxiety and depression are common in patients with chronic obstructive pulmonary disease (COPD), little is known about the estimates of their incidence in patients with asthma-COPD overlap (ACO), which has been described and acknowledged as a distinct clinical entity. We aimed to estimat...

journal_title：Respiratory research

authors： Kang HR,Hong SH,Ha SY,Kim TB,Lee EK

更新日期：2019-04-30 00:00:00

abstract：BACKGROUND:Hypoxia-induced mitogenic factor (HIMF) is developmentally regulated and plays an important role in lung pathogenesis. We initially found that HIMF promotes vascular tubule formation in a matrigel plug model. In this study, we investigated the mechanisms which HIMF enhances expression of vascular endothelial...

journal_title：Respiratory research

authors： Tong Q,Zheng L,Lin L,Li B,Wang D,Huang C,Li D

更新日期：2006-03-02 00:00:00

abstract：BACKGROUND:Low muscle mass is associated with increased mortality in the general population but its prognostic value in at-risk smokers, those without expiratory airflow obstruction, is unknown. We aimed to test the hypothesis that reduced muscle mass is associated with increased mortality in at-risk smokers. METHODS:...

journal_title：Respiratory research

authors： Diaz AA,Martinez CH,Harmouche R,Young TP,McDonald ML,Ross JC,Han ML,Bowler R,Make B,Regan EA,Silverman EK,Crapo J,Boriek AM,Kinney GL,Hokanson JE,Estepar RSJ,Washko GR

更新日期：2018-04-10 00:00:00

abstract：BACKGROUND:Apoptosis has recently been proposed to contribute to the pathogenesis of emphysema. METHODS:In order to establish if cell fate plays a role even in end-stage disease we studied 16 lungs (9 smoking-associated and 7 alpha1antitrypsin (AAT)-deficiency emphysema) from patients who had undergone lung transplant...

journal_title：Respiratory research

authors： Calabrese F,Giacometti C,Beghe B,Rea F,Loy M,Zuin R,Marulli G,Baraldo S,Saetta M,Valente M

更新日期：2005-02-10 00:00:00

abstract：:There is an increasing interest in the potential of exhaled biomarkers, such as volatile organic compounds (VOCs), to improve accurate diagnoses and management decisions in pulmonary diseases. The objective of this manuscript is to systematically review the current knowledge on exhaled VOCs with respect to their poten...

journal_title：Respiratory research

authors： van de Kant KD,van der Sande LJ,Jöbsis Q,van Schayck OC,Dompeling E

更新日期：2012-12-21 00:00:00

abstract：:Monitoring of pulmonary physiology is fundamental to the clinical management of patients with Cystic Fibrosis. The current standard clinical practise uses spirometry to assess lung function which delivers a clinically relevant functional readout of total lung function, however does not supply any visible or localised ...

journal_title：Respiratory research

authors： Kołodziej M,de Veer MJ,Cholewa M,Egan GF,Thompson BR

更新日期：2017-05-17 00:00:00

abstract：BACKGROUND:In order to find novel noninvasive biomarkers with high accuracy for the screening of early-stage non-small cell lung cancer (NSCLC), we investigate the predictive power of 5 microRNAs (miR-20a, miR-145, miR-21, miR223 and miR-221) as potential biomarkers in early-stage NSCLC. METHODS:In training set, 25 ea...

journal_title：Respiratory research

authors： Geng Q,Fan T,Zhang B,Wang W,Xu Y,Hu H

更新日期：2014-11-25 00:00:00

abstract：BACKGROUND:Chronic obstructive pulmonary disease (COPD) is characterised by pulmonary and systemic inflammation which flare-up during episodes of acute exacerbation (AECOPD). Given the role of Toll-like receptors (TLRs) in the induction of inflammatory responses we investigated the involvement of TLRs in COPD pathogene...

journal_title：Respiratory research

authors： Pons J,Sauleda J,Regueiro V,Santos C,López M,Ferrer J,Agustí AG,Bengoechea JA

更新日期：2006-04-10 00:00:00

abstract：BACKGROUND:The investigation of mesenchymal stromal cell (MSC)-conditioned medium or extracellular vesicles (exosomes or microvesicles) as a remedy for acute lung injury (ALI) or acute respiratory distress syndrome (ARDS) has become a fast-growing field in recent years. Our purpose was to conduct a meta-analysis to inv...

journal_title：Respiratory research

authors： Wang F,Fang B,Qiang X,Shao J,Zhou L

更新日期：2020-11-20 00:00:00

abstract：BACKGROUND:Antigen desensitization through oral tolerance is becoming an increasingly attractive treatment option for allergic diseases. However, the mechanism(s) by which tolerization is achieved remain poorly defined. In this study we endeavored to induce oral tolerance to cockroach allergen (CRA: a complex mixture o...

journal_title：Respiratory research

authors： Vaickus LJ,Bouchard J,Kim J,Natarajan S,Remick DG

更新日期：2010-11-23 00:00:00

abstract：:A new international statement defines usual interstitial pneumonia (UIP) which is a histological and radiological form of idiopathic pulmonary fibrosis (IPF) more precisely than previously. In the diagnosis of IPF, either in high resolution computed tomography (HRCT) a UIP pattern must be present or alternatively spec...

journal_title：Respiratory research

authors： Kaarteenaho R

更新日期：2013-04-15 00:00:00

abstract：BACKGROUND:Pulmonary arterial hypertension (PAH) is associated with inflammatory response but it is unknown whether it is associated with alterations in NNMT activity and MNA plasma concentration. Here we examined changes in NNMT-MNA pathway in PAH in rats and humans. METHODS:PAH in rats was induced by a single subcut...

journal_title：Respiratory research

authors： Fedorowicz A,Mateuszuk Ł,Kopec G,Skórka T,Kutryb-Zając B,Zakrzewska A,Walczak M,Jakubowski A,Łomnicka M,Słomińska E,Chlopicki S

更新日期：2016-08-31 00:00:00

abstract：BACKGROUND:Recent consensus statements demonstrate the breadth of the chronic rhinosinusitis (CRS) differential diagnosis. However, the classification and mechanisms of different CRS phenotypes remains problematic. METHOD:Statistical patterns of subjective and objective findings were assessed by retrospective chart re...

journal_title：Respiratory research

authors： Baraniuk JN,Maibach H

更新日期：2005-12-19 00:00:00

abstract：BACKGROUND:It is unclear whether the responses of refractory and common Mycoplasma pneumoniae (MP) pneumonia to macrolides differ. Hence, this study aimed to identify biomarkers that may be used to distinguish refractory and common pneumonias caused by MP in children at hospital admission. METHODS:The study included 1...

journal_title：Respiratory research

authors： Choi YJ,Jeon JH,Oh JW

更新日期：2019-08-23 00:00:00

abstract：RATIONALE:We had shown that COPD women expressed more dyspnea than men for the same degree of airway obstruction. OBJECTIVES:Evaluate gender differences in respiratory factors associated with dyspnea in COPD patients. METHODS:In a FEV1 % matched population of 100 men and women with COPD we measured: age, MMRC, FEV1, ...

journal_title：Respiratory research

authors： de Torres JP,Casanova C,Montejo de Garcini A,Aguirre-Jaime A,Celli BR

更新日期：2007-03-06 00:00:00

abstract：BACKGROUND:Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease with poor prognosis. The kinase inhibitor nintedanib specific for vascular endothelial growth factor receptor (VEGFR), platelet-derived growth factor receptor (PDGFR) and fibroblast growth factor receptor (FGFR) significantly reduced the rate ...

journal_title：Respiratory research

authors： Hostettler KE,Zhong J,Papakonstantinou E,Karakiulakis G,Tamm M,Seidel P,Sun Q,Mandal J,Lardinois D,Lambers C,Roth M

更新日期：2014-12-12 00:00:00

abstract：BACKGROUND:Various signals are known to participate in the pathogenesis of lung fibrosis. Our aim was to determine which signal is predominantly mobilized in the early inflammatory phase and thereafter modulates the development of lung fibrosis. METHODS:Mice received a single dose of 3 mg/kg body weight of bleomycin (...

journal_title：Respiratory research

authors： Kobayashi T,Tanaka K,Fujita T,Umezawa H,Amano H,Yoshioka K,Naito Y,Hatano M,Kimura S,Tatsumi K,Kasuya Y

更新日期：2015-08-20 00:00:00

abstract：BACKGROUND:Discrepancy exists amongst studies investigating the effect of comorbid heart failure (HF) on the morbidity and mortality of chronic obstructive pulmonary disease (COPD) patients. METHODS:MEDLINE and Embase were searched using a pre-specified search strategy for studies comparing hospitalisation, rehospital...

journal_title：Respiratory research

authors： Axson EL,Ragutheeswaran K,Sundaram V,Bloom CI,Bottle A,Cowie MR,Quint JK

更新日期：2020-02-14 00:00:00

abstract：BACKGROUND:Although T cells, especially CD8+, have been implicated in chronic obstructive pulmonary disease (COPD) pathogenesis, their role during acute exacerbations (AE-COPD) is uncertain. METHODS:We recruited subjects with COPD and a history of previous AE-COPD and studied them quarterly to collect blood and sponta...

journal_title：Respiratory research

authors： Freeman CM,Martinez CH,Todt JC,Martinez FJ,Han MK,Thompson DL,McCloskey L,Curtis JL

更新日期：2015-08-05 00:00:00

abstract：:In many model systems, cystic fibrosis (CF) phenotype airway epithelial cells in culture respond to P. aeruginosa with greater interleukin (IL)-8 and IL-6 secretion than matched controls. In order to test whether this excess inflammatory response results from the reported increased adherence of P. aeruginosa to the CF...

journal_title：Respiratory research

authors： Kube DM,Fletcher D,Davis PB

更新日期：2005-07-11 00:00:00

abstract：BACKGROUND:Asthma is a heterogeneous chronic airway disease, which may be classified into different phenotypes. YKL-40 is a chitin-binding glycoprotein with unclear functions, but its expression is associated with inflammation and tissue remodeling. However, few studies have explored whether YKL-40 is associated with i...

journal_title：Respiratory research

authors： Liu L,Zhang X,Liu Y,Zhang L,Zheng J,Wang J,Hansbro PM,Wang L,Wang G,Hsu AC

更新日期：2019-05-22 00:00:00