当前位置： SCI文献检索 > RESPIRATORY RESEARCH期刊下所有文献 > Anxiety is associated with diminished exercise performance and quality of life in severe emphysema: a cross-sectional study.

Anxiety is associated with diminished exercise performance and quality of life in severe emphysema: a cross-sectional study.

Abstract：

BACKGROUND:Anxiety in patients with chronic obstructive pulmonary disease (COPD) is associated with self-reported disability. The purpose of this study is to determine whether there is an association between anxiety and functional measures, quality of life and dyspnea. METHODS:Data from 1828 patients with moderate to severe emphysema enrolled in the National Emphysema Treatment Trial (NETT), collected prior to rehabilitation and randomization, were used in linear regression models to test the association between anxiety symptoms, measured by the Spielberger State Trait Anxiety Inventory (STAI) and: (a) six-minute walk distance test (6 MWD), (b) cycle ergometry peak workload, (c) St. Georges Respiratory Questionnaire (SRGQ), and (d) UCSD Shortness of Breath Questionnaire (SOBQ), after controlling for potential confounders including age, gender, FEV1 (% predicted), DLCO (% predicted), and the Beck Depression Inventory (BDI). RESULTS:Anxiety was significantly associated with worse functional capacity [6 MWD (B = -0.944, p < .001), ergometry peak workload (B = -.087, p = .04)], quality of life (B = .172, p < .001) and shortness of breath (B = .180, p < .001). Regression coefficients show that a 10 point increase in anxiety score is associated with a mean decrease in 6 MWD of 9 meters, a 1 Watt decrease in peak exercise workload, and an increase of almost 2 points on both the SGRQ and SOBQ. CONCLUSION:In clinically stable patients with moderate to severe emphysema, anxiety is associated with worse exercise performance, quality of life and shortness of breath, after accounting for the influence of demographic and physiologic factors known to affect these outcomes. TRIAL REGISTRATION:ClinicalTrials.gov NCT00000606.

journal_name

Respir Res

journal_title

Respiratory research

authors

Giardino ND,Curtis JL,Andrei AC,Fan VS,Benditt JO,Lyubkin M,Naunheim K,Criner G,Make B,Wise RA,Murray SK,Fishman AP,Sciurba FC,Liberzon I,Martinez FJ,NETT Research Group.

doi

10.1186/1465-9921-11-29

subject

Has Abstract

pub_date

2010-03-09 00:00:00

pages

eissn

1465-9921

issn

1465-993X

pii

1465-9921-11-29

journal_volume

pub_type

杂志文章,随机对照试验

在线工具

Anxiety is associated with diminished exercise performance and quality of life in severe emphysema: a cross-sectional study.