Collaborative interactions between neutrophil elastase and metalloproteinases in extracellular matrix degradation in three-dimensional collagen gels.

abstract：BACKGROUND:Fibrocytes are implicated in Idiopathic Pulmonary Fibrosis (IPF) pathogenesis and increased proportions in the circulation are associated with poor prognosis. Upon tissue injury, fibrocytes migrate to the affected organ. In IPF patients, circulating fibrocytes are increased especially during exacerbations, h...

journal_title：Respiratory research

authors： Heukels P,van Hulst JAC,van Nimwegen M,Boorsma CE,Melgert BN,van den Toorn LM,Boomars KAT,Wijsenbeek MS,Hoogsteden H,von der Thüsen JH,Hendriks RW,Kool M,van den Blink B

更新日期：2018-05-10 00:00:00

abstract：RATIONALE:We had shown that COPD women expressed more dyspnea than men for the same degree of airway obstruction. OBJECTIVES:Evaluate gender differences in respiratory factors associated with dyspnea in COPD patients. METHODS:In a FEV1 % matched population of 100 men and women with COPD we measured: age, MMRC, FEV1, ...

journal_title：Respiratory research

authors： de Torres JP,Casanova C,Montejo de Garcini A,Aguirre-Jaime A,Celli BR

更新日期：2007-03-06 00:00:00

abstract：BACKGROUND:Tobacco smoke and genetic susceptibility are risk factors for asthma and wheezing. The aim of this study was to investigate whether there is a combined effect of interleukin-13 gene (IL13) polymorphisms and tobacco smoke on persistent childhood wheezing and asthma. METHODS:In the Isle of Wight birth cohort ...

journal_title：Respiratory research

authors： Sadeghnejad A,Karmaus W,Arshad SH,Kurukulaaratchy R,Huebner M,Ewart S

更新日期：2008-01-10 00:00:00

abstract：BACKGROUND:Recent studies have indicated the presence of multipotent mesenchymal stromal cells (MSCs) in human lung diseases. Excess airway smooth muscle, myofibroblasts and activated fibroblasts have each been noted in asthma, suggesting that mesenchymal progenitor cells play a role in asthma pathogenesis. We therefor...

journal_title：Respiratory research

authors： Bentley JK,Popova AP,Bozyk PD,Linn MJ,Baek AE,Lei J,Goldsmith AM,Hershenson MB

更新日期：2010-09-21 00:00:00

abstract：BACKGROUND:IL-10 is a cytokine mainly produced by macrophages that plays key roles in tolerance to inhaled antigens and in lung homeostasis. Its regulation in alveolar macrophages (HAM), the resident lung phagocytes, remains however unknown. METHODS:The present study investigated the role of intracellular signalling a...

journal_title：Respiratory research

authors： Chanteux H,Guisset AC,Pilette C,Sibille Y

更新日期：2007-10-04 00:00:00

abstract：BACKGROUND:Retinoid X receptors (RXRs) are members of the nuclear receptor (NR) superfamily that mediate signalling by 9-cis retinoic acid, a vitamin A derivative. RXRs play key roles not only as homodimers but also as heterodimeric partners, e.g., for retinoic acid receptors, vitamin D receptors, and peroxisome prolif...

journal_title：Respiratory research

authors： Morichika D,Miyahara N,Fujii U,Taniguchi A,Oda N,Senoo S,Kataoka M,Tanimoto M,Kakuta H,Kiura K,Maeda Y,Kanehiro A

更新日期：2019-01-03 00:00:00

abstract：:The use of biomarkers in medicine lies in their ability to detect disease and support diagnostic and therapeutic decisions. New research and novel understanding of the molecular basis of the disease reveals an abundance of exciting new biomarkers who present a promise for use in the everyday clinical practice. The pas...

journal_title：Respiratory research

authors： Tzouvelekis A,Kouliatsis G,Anevlavis S,Bouros D

更新日期：2005-07-21 00:00:00

abstract：:The role of the ATP binding cassette transporter A1 (ABCA1) in maintaining cellular lipid homeostasis in cardiovascular disease is well established. More recently, the important beneficial role played by ABCA1 in modulating pathogenic disease mechanisms, such as inflammation, in a broad range of chronic conditions has...

journal_title：Respiratory research

authors： He P,Gelissen IC,Ammit AJ

更新日期：2020-09-25 00:00:00

abstract：BACKGROUND:Recent research has suggested that the Th1 and Th2 chemokine/cytokine axis contributes to the development of chronic hypersensitivity pneumonitis (HP). Acute exacerbations (AE) are significant factors in the prognosis of chronic HP. Little is known, however, about these biomarkers in association with AE in c...

journal_title：Respiratory research

authors： Miyazaki Y,Unoura K,Tateishi T,Akashi T,Takemura T,Tomita M,Inase N,Yoshizawa Y

更新日期：2013-05-25 00:00:00

abstract：BACKGROUND:Nintedanib is an approved therapy for idiopathic pulmonary fibrosis (IPF). Some patients treated with nintedanib experience weight loss. Exploratory data suggest that low body mass index or weight loss are associated with worse outcomes in patients with IPF. We investigated whether BMI at baseline or weight ...

journal_title：Respiratory research

authors： Jouneau S,Crestani B,Thibault R,Lederlin M,Vernhet L,Valenzuela C,Wijsenbeek M,Kreuter M,Stansen W,Quaresma M,Cottin V

更新日期：2020-11-25 00:00:00

abstract：BACKGROUND:The relationship between the Epworth sleepiness scale (ESS) and the apnea-hypopnea index (AHI) is uncertain and even poor. The major problem associated with the ESS might be a lack of consideration of weight in prediction in clinical practice. Would awarding different item-scores to the four scales of ESS it...

journal_title：Respiratory research

authors： Guo Q,Song WD,Li W,Zeng C,Li YH,Mo JM,Lü ZD,Jiang M

更新日期：2020-06-12 00:00:00

abstract：:In the present study, we used tumor necrosis factor-R1 knock out mice (TNF-alpha R1KO) to understand the roles of TNF-alpha on epithelial function in models of carrageenan-induced acute lung inflammation. In order to elucidate whether the observed anti-inflammatory status is related to the inhibition of TNF-alpha, we ...

journal_title：Respiratory research

authors： Mazzon E,Cuzzocrea S

更新日期：2007-10-30 00:00:00

abstract：BACKGROUND:Inspiratory activity is a prerequisite for successful application of patient triggered ventilation such as proportional assist ventilation (PAV). It has recently been reported that surfactant instillation increases the activity of slowly adapting pulmonary stretch receptors (PSRs) followed by a shorter inspi...

journal_title：Respiratory research

authors： Sindelar R,Rieger-Fackeldey E,Jonzon A,Schaller P,Schulze A,Sedin G

更新日期：2006-03-10 00:00:00

abstract：BACKGROUND:Advanced glycation end products (AGEs) have been proposed to be involved in pulmonary fibrosis, but its role in this process has not been fully understood. To investigate the role of AGE formation in pulmonary fibrosis, we used a bleomycin (BLM)-stimulated rat model treated with aminoguanidine (AG), a crossl...

journal_title：Respiratory research

authors： Chen L,Wang T,Wang X,Sun BB,Li JQ,Liu DS,Zhang SF,Liu L,Xu D,Chen YJ,Wen FQ

更新日期：2009-06-24 00:00:00

abstract：BACKGROUND:In utero exposure to particulate matter with an aerodynamic diameter of less than 2.5 μm (PM2.5) has been linked to child lung function. Overlapping evidence suggests that child sex and exposure timing may modify effects and associations may be mediated through glutathione S-transferase P1 (GSTP1) methylatio...

journal_title：Respiratory research

authors： Lee AG,Le Grand B,Hsu HL,Chiu YM,Brennan KJ,Bose S,Rosa MJ,Brunst KJ,Kloog I,Wilson A,Schwartz J,Morgan W,Coull BA,Wright RO,Baccarelli AA,Wright RJ

更新日期：2018-04-27 00:00:00

abstract：BACKGROUND:Systemic sclerosis (SSc) is a rare connective tissue disease with a heterogeneous clinical course. Interstitial lung disease (ILD) is a common manifestation of SSc and a leading cause of death. MAIN BODY:All patients newly diagnosed with SSc should receive a comprehensive clinical evaluation, including asse...

journal_title：Respiratory research

authors： Cottin V,Brown KK

更新日期：2019-01-18 00:00:00

abstract：BACKGROUND:During 2007-2010, the National Health and Nutrition Examination Survey (NHANES) conducted a spirometry component which obtained pre-bronchodilator pulmonary lung function data on a nationally representative sample of US adults aged 6-79 years and post-bronchodilator pulmonary lung function data for the subse...

journal_title：Respiratory research

authors： Tilert T,Dillon C,Paulose-Ram R,Hnizdo E,Doney B

更新日期：2013-10-09 00:00:00

abstract：BACKGROUND:Programming a mechanical ventilator with a biologically variable or fractal breathing pattern (an example of 1/f noise) improves gas exchange and respiratory mechanics. Here we show that fractal ventilation increases respiratory sinus arrhythmia (RSA) -- a mechanism known to improve ventilation/perfusion mat...

journal_title：Respiratory research

authors： Mutch WA,Graham MR,Girling LG,Brewster JF

更新日期：2005-05-09 00:00:00

abstract：:Pulmonary surfactant is a complex fluid that comprises phospholipids and four proteins (SP-A, SP-B, SP-C, and SP-D) with different biological functions. SP-B, SP-C, and SP-D are essential for the lungs' surface tension function and for the organization, stability and metabolism of lung parenchyma. SP-A and SP-D, which...

journal_title：Respiratory research

authors： Carreto-Binaghi LE,Aliouat el M,Taylor ML

更新日期：2016-06-01 00:00:00

abstract：BACKGROUND:In asthma, higher chymase positive mast cell (MC-C) numbers are associated with less airway obstruction. In COPD, the distribution of MC-C and tryptase positive mast cells (MC-T) in central and peripheral airways, and their relation with lung function, is unknown. We compared MC-T and MC-C distributions in C...

journal_title：Respiratory research

authors： Gosman MM,Postma DS,Vonk JM,Rutgers B,Lodewijk M,Smith M,Luinge MA,Ten Hacken NH,Timens W

更新日期：2008-09-10 00:00:00

abstract：BACKGROUND:There are limited series concerning Dieulafoy disease of the bronchus. We describe the clinical presentation of a series of 7 patients diagnosed with Dieulafoy disease of the bronchus and provide information about the pathological diagnosis approach. PATIENTS AND METHODS:A retrospective review of patients w...

journal_title：Respiratory research

authors： Parrot A,Antoine M,Khalil A,Théodore J,Mangiapan G,Bazelly B,Fartoukh M

更新日期：2008-08-05 00:00:00

abstract：BACKGROUND:The aim of the study is to examine the effect of limited and prolonged hyperoxia on neonatal rat lung. This is done by examining the morphologic changes of apoptosis, the expression of ceramide, an important mediator of apoptosis, the expression of inflammatory mediators represented by IL-1beta and the expre...

journal_title：Respiratory research

authors： Husari AW,Dbaibo GS,Bitar H,Khayat A,Panjarian S,Nasser M,Bitar FF,El-Sabban M,Zaatari G,Mroueh SM

更新日期：2006-07-26 00:00:00

abstract：BACKGROUND:Asthma is a disease of varying severity and differing disease mechanisms. To date, studies aimed at stratifying asthma into clinically useful phenotypes have produced a number of phenotypes that have yet to be assessed for stability and to be validated in independent cohorts. The aim of this study was to def...

journal_title：Respiratory research

authors： Loza MJ,Djukanovic R,Chung KF,Horowitz D,Ma K,Branigan P,Barnathan ES,Susulic VS,Silkoff PE,Sterk PJ,Baribaud F,ADEPT (Airways Disease Endotyping for Personalized Therapeutics) and U-BIOPRED (Unbiased Biomarkers for the Prediction

更新日期：2016-12-15 00:00:00

abstract：BACKGROUND:An important goal of chronic obstructive pulmonary disease (COPD) treatment is to reduce the frequency of exacerbations. Some observations suggest a decline in exacerbation rates in clinical trials over time. A more systematic understanding would help to improve the design and interpretation of COPD trials. ...

journal_title：Respiratory research

authors： Andreas S,Röver C,Heinz J,Straube S,Watz H,Friede T

更新日期：2019-08-16 00:00:00

abstract：:The airway epithelium forms a barrier against infection but also produces antimicrobial peptides (AMPs) and other inflammatory mediators to activate the immune system. It has been shown that in allergic disorders, Th2 cytokines may hamper the antimicrobial activity of the epithelium. However, the presence of Th2 cytok...

journal_title：Respiratory research

authors： Zuyderduyn S,Ninaber DK,Schrumpf JA,van Sterkenburg MA,Verhoosel RM,Prins FA,van Wetering S,Rabe KF,Hiemstra PS

更新日期：2011-05-02 00:00:00

abstract：BACKGROUND:Smoking cessation following lung cancer diagnosis has been found to improve several patient outcomes. Electronic cigarette (e-cigarette) use is now prevalent within Great Britain, however, use and practice among patients with lung cancer has not as yet been explored. The current study aims to explore e-cigar...

journal_title：Respiratory research

authors： Sherratt FC,Newson L,Field JK

更新日期：2016-05-17 00:00:00

abstract：BACKGROUND:The pathogenesis of allergic airway inflammation in asthmatic patients is complex and characterized by cellular infiltrates and activity of many cytokines and chemokines. Both the transcription factor hypoxia inducible factor-1 (HIF-1) and chemokine CCL2 have been shown to play pivotal roles in allergic airw...

journal_title：Respiratory research

authors： Baay-Guzman GJ,Bebenek IG,Zeidler M,Hernandez-Pando R,Vega MI,Garcia-Zepeda EA,Antonio-Andres G,Bonavida B,Riedl M,Kleerup E,Tashkin DP,Hankinson O,Huerta-Yepez S

更新日期：2012-07-23 00:00:00

abstract：BACKGROUND:Hepcidin serves as a major regulator of systemic iron metabolism and immune function. Airway epithelial cells have an extensive interface with the environment, and so must be able to respond locally to the presence of particulates, infection, and inflammation. Therefore, we hypothesized that hepcidin is expr...

journal_title：Respiratory research

authors： Frazier MD,Mamo LB,Ghio AJ,Turi JL

更新日期：2011-08-02 00:00:00

abstract：BACKGROUND:Functional deterioration in cystic fibrosis (CF) may be reflected by increasing bronchial obstruction and, as recently shown, by ventilation inhomogeneities. This study investigated which physiological factors (airway obstruction, ventilation inhomogeneities, pulmonary hyperinflation, development of trapped ...

journal_title：Respiratory research

authors： Kraemer R,Baldwin DN,Ammann RA,Frey U,Gallati S

更新日期：2006-11-30 00:00:00

abstract：BACKGROUND:Numerous studies have demonstrated associations between genetic markers and COPD, but results have been inconsistent. One reason may be heterogeneity in disease definition. Unsupervised learning approaches may assist in understanding disease heterogeneity. METHODS:We selected 31 phenotypic variables and 12 ...

journal_title：Respiratory research

authors： Cho MH,Washko GR,Hoffmann TJ,Criner GJ,Hoffman EA,Martinez FJ,Laird N,Reilly JJ,Silverman EK

更新日期：2010-03-16 00:00:00