IL13 gene polymorphisms modify the effect of exposure to tobacco smoke on persistent wheeze and asthma in childhood, a longitudinal study.


BACKGROUND:Tobacco smoke and genetic susceptibility are risk factors for asthma and wheezing. The aim of this study was to investigate whether there is a combined effect of interleukin-13 gene (IL13) polymorphisms and tobacco smoke on persistent childhood wheezing and asthma. METHODS:In the Isle of Wight birth cohort (UK, 1989-1999), five IL13 single nucleotide polymorphisms (SNPs): rs1800925 (-1112C/T), rs2066960, rs1295686, rs20541 (R130Q) and rs1295685 were genotyped. Parents were asked whether their children had wheezed in the last 12 months at ages 1, 2, 4 and 10 years. Children who reported wheeze in the first 4 years of life and also had wheezing at age 10 were classified as early-onset persistent wheeze phenotype; non-wheezers never wheezed up to age 10. Persistent asthma was defined as having a diagnosis of asthma both during the first four years of life and at age 10. Logistic regression methods were used to analyze data on 791 children with complete information. Potential confounders were gender, birth weight, duration of breast feeding, and household cat or dog present during pregnancy. RESULTS:Maternal smoking during pregnancy was associated with early-onset persistent wheeze (OR 2.93, p < 0.0001); polymorphisms in IL13 were not (OR 1.15, p = 0.60 for the common haplotype pair). However, the effect of maternal smoking during pregnancy was stronger in children with the common IL13 haplotype pair compared to those without it (OR 5.58 and OR 1.29, respectively; p for interaction = 0.014). Single SNP analysis revealed a similar statistical significance for rs20541 (p for interaction = 0.02). Comparable results were observed for persistent childhood asthma (p for interaction = 0.03). CONCLUSION:This is the first report that shows a combined effect of in utero exposure to smoking and IL13 on asthma phenotypes in childhood. The results emphasize that genetic studies need to take environmental exposures into account, since they may explain contradictory findings.


Respir Res


Respiratory research


Sadeghnejad A,Karmaus W,Arshad SH,Kurukulaaratchy R,Huebner M,Ewart S




Has Abstract


2008-01-10 00:00:00












  • The influence of chlorine in indoor swimming pools on the composition of breathing phase of professional swimmers.

    abstract:OBJECTIVES:Swimming is one of the most popular forms of physical activity. Pool water is cleaned with chlorine, which - in combination with compounds contained in water - could form chloramines and trichloromethane in the swimmer's lungs. The aim of the present study was to examine the effect of swimming training in an...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Swinarew AS,Stanula AJ,Gabor J,Raif P,Paluch J,Karpiński J,Kubik K,Okła H,Ostrowski A,Tkacz E,Skoczyński S,Waśkiewicz Z,Rosemann T,Nikolaidis PT,Knechtle B

    更新日期:2020-04-15 00:00:00

  • Critical combination of initial markers for predicting refractory Mycoplasma pneumoniae pneumonia in children: a case control study.

    abstract:BACKGROUND:It is unclear whether the responses of refractory and common Mycoplasma pneumoniae (MP) pneumonia to macrolides differ. Hence, this study aimed to identify biomarkers that may be used to distinguish refractory and common pneumonias caused by MP in children at hospital admission. METHODS:The study included 1...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Choi YJ,Jeon JH,Oh JW

    更新日期:2019-08-23 00:00:00

  • Exogenous interleukin-6, interleukin-13, and interferon-γ provoke pulmonary abnormality with mild edema in enterovirus 71-infected mice.

    abstract:BACKGROUND:Neonatal mice developed neurological disease and pulmonary dysfunction after an infection with a mouse-adapted human Enterovirus 71 (EV71) strain MP4. However, the hallmark of severe human EV71 infection, pulmonary edema (PE), was not evident. METHODS:To test whether EV71-induced PE required a proinflammato...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Huang SW,Lee YP,Hung YT,Lin CH,Chuang JI,Lei HY,Su IJ,Yu CK

    更新日期:2011-11-06 00:00:00

  • The importance of balanced pro-inflammatory and anti-inflammatory mechanisms in diffuse lung disease.

    abstract::The lung responds to a variety of insults in a remarkably consistent fashion but with inconsistent outcomes that vary from complete resolution and return to normal to the destruction of normal architecture and progressive fibrosis. Increasing evidence indicates that diffuse lung disease results from an imbalance betwe...

    journal_title:Respiratory research

    pub_type: 杂志文章,评审


    authors: Keane MP,Strieter RM

    更新日期:2002-01-01 00:00:00

  • Nebulization of the acidified sodium nitrite formulation attenuates acute hypoxic pulmonary vasoconstriction.

    abstract:BACKGROUND:Generalized hypoxic pulmonary vasoconstriction (HPV) occurring during exposure to hypoxia is a detrimental process resulting in an increase in lung vascular resistance. Nebulization of sodium nitrite has been shown to inhibit HPV. The aim of this project was to investigate and compare the effects of nebuliza...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Egemnazarov B,Schermuly RT,Dahal BK,Elliott GT,Hoglen NC,Surber MW,Weissmann N,Grimminger F,Seeger W,Ghofrani HA

    更新日期:2010-06-21 00:00:00

  • Impact of interleukin-6 on hypoxia-induced pulmonary hypertension and lung inflammation in mice.

    abstract:BACKGROUND:Inflammation may contribute to the pathogenesis of various forms of pulmonary hypertension (PH). Recent studies in patients with idiopathic PH or PH associated with underlying diseases suggest a role for interleukin-6 (IL-6). METHODS:To determine whether endogenous IL-6 contributes to mediate hypoxic PH and...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Savale L,Tu L,Rideau D,Izziki M,Maitre B,Adnot S,Eddahibi S

    更新日期:2009-01-27 00:00:00

  • Weighted Epworth sleepiness scale predicted the apnea-hypopnea index better.

    abstract:BACKGROUND:The relationship between the Epworth sleepiness scale (ESS) and the apnea-hypopnea index (AHI) is uncertain and even poor. The major problem associated with the ESS might be a lack of consideration of weight in prediction in clinical practice. Would awarding different item-scores to the four scales of ESS it...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Guo Q,Song WD,Li W,Zeng C,Li YH,Mo JM,Lü ZD,Jiang M

    更新日期:2020-06-12 00:00:00

  • Use of Berlin questionnaire in comparison to polysomnography and home sleep study in patients with obstructive sleep apnea.

    abstract:BACKGROUND:Obstructive sleep apnea syndrome (OSAS) is a common disorder with significant morbidity and mortality. We aimed to evaluate the predictive accuracy of the Berlin questionnaire in patients with suspected OSAS undergoing PSG in the sleep laboratory setting against those going through the Embletta™ portable dia...

    journal_title:Respiratory research

    pub_type: 杂志文章,随机对照试验


    authors: Ng SS,Tam W,Chan TO,To KW,Ngai J,Chan KKP,Yip WH,Lo RL,Yiu K,Ko FW,Hui DS

    更新日期:2019-02-22 00:00:00

  • Lymphocyte senescence in COPD is associated with loss of glucocorticoid receptor expression by pro-inflammatory/cytotoxic lymphocytes.

    abstract:BACKGROUND:Glucocorticoid (GC) resistance is a major barrier in COPD treatment. We have shown increased expression of the drug efflux pump, Pgp1 in cytotoxic/pro-inflammatory lymphocytes in COPD. Loss of lymphocyte co-stimulatory molecule CD28 (lymphocyte senescence) was associated with a further increase in their pro-...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Hodge G,Jersmann H,Tran HB,Holmes M,Reynolds PN,Hodge S

    更新日期:2015-01-09 00:00:00

  • Epidemiology, genetics, and subtyping of preserved ratio impaired spirometry (PRISm) in COPDGene.

    abstract:BACKGROUND:Preserved Ratio Impaired Spirometry (PRISm), defined as a reduced FEV1 in the setting of a preserved FEV1/FVC ratio, is highly prevalent and is associated with increased respiratory symptoms, systemic inflammation, and mortality. Studies investigating quantitative chest tomographic features, genetic associat...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Wan ES,Castaldi PJ,Cho MH,Hokanson JE,Regan EA,Make BJ,Beaty TH,Han MK,Curtis JL,Curran-Everett D,Lynch DA,DeMeo DL,Crapo JD,Silverman EK,COPDGene Investigators.

    更新日期:2014-08-06 00:00:00

  • Transposable elements and their potential role in complex lung disorder.

    abstract::Transposable elements (TEs) are a class of mobile genetic elements (MGEs) that were long regarded as junk DNA, which make up approximately 45% of the genome. Although most of these elements are rendered inactive by mutations and other gene silencing mechanisms, TEs such as long interspersed nuclear elements (LINEs) ar...

    journal_title:Respiratory research

    pub_type: 杂志文章,评审


    authors: Sargurupremraj M,Wjst M

    更新日期:2013-10-05 00:00:00

  • Perforin, granzyme B, and FasL expression by peripheral blood T lymphocytes in emphysema.

    abstract:BACKGROUND:It is generally accepted that emphysematous lungs are characterized by an increase in the numbers of neutrophils, macrophages, and CD8+ T lymphocytes, the lasts having increased cytotoxic activity. Because systemic inflammation is also a component of emphysema, we hypothesize that peripheral CD8+ T lymphocyt...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Morissette MC,Parent J,Milot J

    更新日期:2007-09-06 00:00:00

  • Acquired defects in CFTR-dependent β-adrenergic sweat secretion in chronic obstructive pulmonary disease.

    abstract:RATIONALE:Smoking-induced chronic obstructive pulmonary disease (COPD) is associated with acquired systemic cystic fibrosis transmembrane conductance regulator (CFTR) dysfunction. Recently, sweat evaporimetry has been shown to efficiently measure β-adrenergic sweat rate and specifically quantify CFTR function in the se...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Courville CA,Tidwell S,Liu B,Accurso FJ,Dransfield MT,Rowe SM

    更新日期:2014-02-25 00:00:00

  • COPD diagnosis related to different guidelines and spirometry techniques.

    abstract::The aim was to compare the diagnosis of COPD among smokers according to different international guidelines and to compare the outcome when using slow (SVC) and forced vital capacity (FVC). In order to find current smokers a questionnaire was sent to persons who had been on sick leave for more than two weeks. Those who...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Nathell L,Nathell M,Malmberg P,Larsson K

    更新日期:2007-12-04 00:00:00

  • Therapeutic efficacy of α-1 antitrypsin augmentation therapy on the loss of lung tissue: an integrated analysis of 2 randomised clinical trials using computed tomography densitometry.

    abstract:BACKGROUND:Two randomised, double-blind, placebo-controlled trials have investigated the efficacy of IV alpha-1 antitrypsin (AAT) augmentation therapy on emphysema progression using CT densitometry. METHODS:Data from these similar trials, a 2-center Danish-Dutch study (n = 54) and the 3-center EXAcerbations and CT sca...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Stockley RA,Parr DG,Piitulainen E,Stolk J,Stoel BC,Dirksen A

    更新日期:2010-10-05 00:00:00

  • Interleukin-17 regulation: an attractive therapeutic approach for asthma.

    abstract::Interleukin (IL)-17 is recognized to play a critical role in numerous immune and inflammatory responses by regulating the expression of various inflammatory mediators, which include cytokines, chemokines, and adhesion molecules. There is growing evidence that IL-17 is involved in the pathogenesis of asthma. IL-17 orch...

    journal_title:Respiratory research

    pub_type: 杂志文章,评审


    authors: Park SJ,Lee YC

    更新日期:2010-06-16 00:00:00

  • Superoxide dismutase A antigens derived from molecular analysis of sarcoidosis granulomas elicit systemic Th-1 immune responses.

    abstract:BACKGROUND:Sarcoidosis is an idiopathic granulomatous disease with pathologic and immunologic features similar to tuberculosis. Routine histologic staining and culture fail to identify infectious agents. An alternative means for investigating a role of infectious agents in human pathogenesis involves molecular analysis...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Allen SS,Evans W,Carlisle J,Hajizadeh R,Nadaf M,Shepherd BE,Pride DT,Johnson JE,Drake WP

    更新日期:2008-04-25 00:00:00

  • Blood and sputum eosinophils in COPD; relationship with bacterial load.

    abstract:BACKGROUND:Sputum and blood eosinophil counts predict corticosteroid effects in COPD patients. Bacterial infection causes increased airway neutrophilic inflammation. The relationship of eosinophil counts with airway bacterial load in COPD patients is uncertain. We tested the hypothesis that bacterial load and eosinophi...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Kolsum U,Donaldson GC,Singh R,Barker BL,Gupta V,George L,Webb AJ,Thurston S,Brookes AJ,McHugh TD,Wedzicha JA,Brightling CE,Singh D

    更新日期:2017-05-08 00:00:00

  • Approach to diagnosis and pathological examination in bronchial Dieulafoy disease: a case series.

    abstract:BACKGROUND:There are limited series concerning Dieulafoy disease of the bronchus. We describe the clinical presentation of a series of 7 patients diagnosed with Dieulafoy disease of the bronchus and provide information about the pathological diagnosis approach. PATIENTS AND METHODS:A retrospective review of patients w...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Parrot A,Antoine M,Khalil A,Théodore J,Mangiapan G,Bazelly B,Fartoukh M

    更新日期:2008-08-05 00:00:00

  • A comparison of four different models of acute respiratory distress syndrome in sheep.

    abstract:BACKGROUND:Acute respiratory distress syndrome (ARDS) can have various causes. The study objective was to investigate whether different pathophysiologic models of ARDS would show different respiratory, cardiovascular and inflammatory outcomes. METHODS:We performed a prospective, randomized study in 27 ventilated ewes ...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Engel M,Nowacki RME,Jonker EM,Ophelders D,Nikiforou M,Kloosterboer N,Zimmermann LJI,van Waardenburg DA,Kramer BW

    更新日期:2020-08-08 00:00:00

  • Increase in markers of airway inflammation after ozone exposure can be observed also in stable treated asthmatics with minimal functional response to ozone.

    abstract:BACKGROUND:The discrepancy between functional and inflammatory airway response to ozone has been reported in normal subjects, but few data are available for stable asthmatics regularly treated with inhaled corticosteroids. METHODS:Twenty-three well controlled, regularly treated, mild-to-moderate asthmatic patients und...

    journal_title:Respiratory research

    pub_type: 杂志文章,随机对照试验


    authors: Vagaggini B,Bartoli ML,Cianchetti S,Costa F,Bacci E,Dente FL,Di Franco A,Malagrinò L,Paggiaro P

    更新日期:2010-01-19 00:00:00

  • Maintained inspiratory activity during proportional assist ventilation in surfactant-depleted cats early after surfactant instillation: phrenic nerve and pulmonary stretch receptor activity.

    abstract:BACKGROUND:Inspiratory activity is a prerequisite for successful application of patient triggered ventilation such as proportional assist ventilation (PAV). It has recently been reported that surfactant instillation increases the activity of slowly adapting pulmonary stretch receptors (PSRs) followed by a shorter inspi...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Sindelar R,Rieger-Fackeldey E,Jonzon A,Schaller P,Schulze A,Sedin G

    更新日期:2006-03-10 00:00:00

  • Gender differences in pulmonary arterial hypertension patients with BMPR2 mutation: a meta-analysis.

    abstract:OBJECTIVE:To investigate the differences in the proportions of BMPR2 mutations in familial hereditary pulmonary arterial hypertension (HPAH) and idiopathic pulmonary arterial hypertension (IPAH) between males and females and the relationship between BMPR2 mutation and PAH severity. METHODS:A computer was used to searc...

    journal_title:Respiratory research

    pub_type: 杂志文章,meta分析


    authors: Ge X,Zhu T,Zhang X,Liu Y,Wang Y,Zhang W

    更新日期:2020-02-06 00:00:00

  • Different effects of deep inspirations on central and peripheral airways in healthy and allergen-challenged mice.

    abstract:BACKGROUND:Deep inspirations (DI) have bronchodilatory and bronchoprotective effects in healthy human subjects, but these effects appear to be absent in asthmatic lungs. We have characterized the effects of DI on lung mechanics during mechanical ventilation in healthy mice and in a murine model of acute and chronic air...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Jonasson S,Swedin L,Lundqvist M,Hedenstierna G,Dahlén SE,Hjoberg J

    更新日期:2008-02-28 00:00:00

  • The need for fast-track, high-quality and low-cost studies about the role of the BCG vaccine in the fight against COVID-19.

    abstract::Bacillus Calmette-Guérin (BCG) vaccination is routine and near-universal in many low- and middle-income countries (LMIC). It has been suggested that BCG can have a protective effect on COVID-19 morbidity and mortality. This commentary discusses the limitations of the evidence around BCG and COVID-19. We argue that hig...

    journal_title:Respiratory research

    pub_type: 信件,评审


    authors: Pereira M,Paixão E,Trajman A,de Souza RA,da Natividade MS,Pescarini JM,Pereira SM,Barreto FR,Ximenes R,Dalcomo M,Ichihara MY,Nunes C,Barral-Netto M,Barreto ML

    更新日期:2020-07-11 00:00:00

  • Pathophysiological classification of chronic rhinosinusitis.

    abstract:BACKGROUND:Recent consensus statements demonstrate the breadth of the chronic rhinosinusitis (CRS) differential diagnosis. However, the classification and mechanisms of different CRS phenotypes remains problematic. METHOD:Statistical patterns of subjective and objective findings were assessed by retrospective chart re...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Baraniuk JN,Maibach H

    更新日期:2005-12-19 00:00:00

  • Corticosteroid suppression of lipoxin A4 and leukotriene B4 from alveolar macrophages in severe asthma.

    abstract:BACKGROUND:An imbalance in the generation of pro-inflammatory leukotrienes, and counter-regulatory lipoxins is present in severe asthma. We measured leukotriene B4 (LTB4), and lipoxin A4 (LXA4) production by alveolar macrophages (AMs) and studied the impact of corticosteroids. METHODS:AMs obtained by fiberoptic bronch...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Bhavsar PK,Levy BD,Hew MJ,Pfeffer MA,Kazani S,Israel E,Chung KF

    更新日期:2010-06-07 00:00:00

  • Identifying tuberculous pleural effusion using artificial intelligence machine learning algorithms.

    abstract:BACKGROUND:The differential diagnosis of tuberculous pleural effusion (TPE) is challenging. In recent years, artificial intelligence (AI) machine learning algorithms have started being used to an increasing extent in disease diagnosis due to the high level of efficiency, objectivity, and accuracy that they offer. METH...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Ren Z,Hu Y,Xu L

    更新日期:2019-10-16 00:00:00

  • Sequential broncho-alveolar lavages reflect distinct pulmonary compartments: clinical and research implications in lung transplantation.

    abstract:BACKGROUND:Bronchoalveolar lavage (BAL) has proven to be very useful to monitor the lung allograft after transplantation. In addition to allowing detection of infections, multiple BAL analytes have been proposed as potential biomarkers of lung allograft rejection or dysfunction. However, BAL collection is not well stan...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Levy L,Juvet SC,Boonstra K,Singer LG,Azad S,Joe B,Cypel M,Keshavjee S,Martinu T

    更新日期:2018-05-25 00:00:00

  • AIDS patients have increased surfactant protein D but normal mannose binding lectin levels in lung fluid.

    abstract:BACKGROUND:Surfactant protein D (SP-D) and Mannose Binding Lectin (MBL) are collectins that have opsonic and immunoregulatory functions, are found in lung fluid and interact with the human immunodeficiency virus (HIV). We compared collectin levels in lung fluid and serum from HIV infected and normal subjects to determi...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Jambo KC,French N,Zijlstra E,Gordon SB

    更新日期:2007-06-13 00:00:00