Oxygen-regulated transcription factors and their role in pulmonary disease.


:The transcription factors nuclear factor interleukin-6 (NF-IL6), early growth response-1 (EGR-1) and hypoxia-inducible factor-1 (HIF-1) have important roles in the molecular pathophysiology of hypoxia-associated pulmonary disease. NF-IL6 controls the production of interleukin (IL)-6 in vascular endothelial cells, which may have anti-inflammatory activity by counteracting effects of IL-1 and IL-8. EGR-1 controls the production of tissue factor by macrophages, which triggers fibrin deposition in the pulmonary vasculature. HIF-1 activates the expression of the vasoconstrictor endothelin-1 in vascular endothelial cells. Angiotensin II induces HIF-1 expression and hypertrophy of pulmonary arterial smooth muscle cells. HIF-1 might therefore have multiple roles in the pathogenesis of pulmonary vascular remodeling.


Respir Res


Respiratory research


Semenza GL





Has Abstract


2000-01-01 00:00:00












  • Role of ATP-sensitive potassium channels on hypoxic pulmonary vasoconstriction in endotoxemia.

    abstract:BACKGROUND:ATP-regulated potassium channels (KATP) regulate pulmonary vascular tone and are involved in hypoxic pulmonary vasoconstriction (HPV). In patients with inflammation like sepsis or ARDS, HPV is impaired, resulting in a ventilation-perfusion mismatch and hypoxia. Since increase of vascular KATP channel Kir6.1 ...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Turzo M,Vaith J,Lasitschka F,Weigand MA,Busch CJ

    更新日期:2018-02-13 00:00:00

  • Oxidative stress mediates the apoptosis and epigenetic modification of the Bcl-2 promoter via DNMT1 in a cigarette smoke-induced emphysema model.

    abstract:BACKGROUND:Emphysema is a crucial pathological characteristic of chronic obstructive pulmonary disease (COPD). Oxidative stress, apoptosis and epigenetic mechanisms contribute to the pathogenesis of emphysema. However, an attempt to accurately identify whether these mechanisms interact with each other and how they are ...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Zeng H,Li T,He X,Cai S,Luo H,Chen P,Chen Y

    更新日期:2020-09-03 00:00:00

  • Therapeutic effect of budesonide/formoterol, montelukast and N-acetylcysteine for bronchiolitis obliterans syndrome after hematopoietic stem cell transplantation.

    abstract:BACKGROUND:Bronchiolitis obliterans syndrome (BOS) after allogeneic hematopoietic stem cell transplantation (HSCT) is currently treated with systemic corticosteroids despite poor efficacy and side effects. This study investigated the therapeutic effect of budesonide/formoterol, montelukast and n-acetylcysteine, which a...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Kim SW,Rhee CK,Kim YJ,Lee S,Kim HJ,Lee JW

    更新日期:2016-05-26 00:00:00

  • Cigarette smoke increases TLR4 and TLR9 expression and induces cytokine production from CD8(+) T cells in chronic obstructive pulmonary disease.

    abstract:BACKGROUND:Cigarette smoke is a major risk factor for chronic obstructive pulmonary disease (COPD), an inflammatory lung disorder. COPD is characterized by an increase in CD8(+) T cells within the central and peripheral airways. We hypothesized that the CD8(+) T cells in COPD patients have increased Toll-like receptor ...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Nadigel J,Préfontaine D,Baglole CJ,Maltais F,Bourbeau J,Eidelman DH,Hamid Q

    更新日期:2011-11-09 00:00:00

  • Impaired survival of regulatory T cells in pulmonary sarcoidosis.

    abstract:BACKGROUND:Impaired regulatory T cell (Treg) function is thought to contribute to ongoing inflammatory responses in sarcoidosis, but underlying mechanisms remain unclear. Moreover, it is not known if increased apoptotic susceptibility of Tregs may contribute to an impaired immunosuppressive function in sarcoidosis. The...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Broos CE,van Nimwegen M,Kleinjan A,ten Berge B,Muskens F,in 't Veen JC,Annema JT,Lambrecht BN,Hoogsteden HC,Hendriks RW,Kool M,van den Blink B

    更新日期:2015-09-16 00:00:00

  • Serum surfactant protein D as a predictive biomarker for the efficacy of pirfenidone in patients with idiopathic pulmonary fibrosis: a post-hoc analysis of the phase 3 trial in Japan.

    abstract:BACKGROUND:Idiopathic pulmonary fibrosis (IPF) is a progressive, fatal disorder with a variable disease course. The recent advancement of antifibrotic therapy has increased the need for reliable and specific biomarkers. This study aimed to assess alveolar epithelial biomarkers as predictors for the efficacy of the anti...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Ikeda K,Chiba H,Nishikiori H,Azuma A,Kondoh Y,Ogura T,Taguchi Y,Ebina M,Sakaguchi H,Miyazawa S,Suga M,Sugiyama Y,Nukiwa T,Kudoh S,Takahashi H,Pirfenidone Clinical Study Group in Japan.

    更新日期:2020-11-30 00:00:00

  • Prevalence and incidence of sarcoidosis in Korea: a nationwide population-based study.

    abstract:BACKGROUND:The prevalence and incidence of sarcoidosis varies worldwide. We estimated the prevalence and incidence of sarcoidosis in Korea using nationwide claims data from the Korean Health Insurance Review and Assessment Service. METHODS:Cases of sarcoidosis were identified for any visit between 2007 to 2016 that li...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Yoon HY,Kim HM,Kim YJ,Song JW

    更新日期:2018-08-28 00:00:00

  • Dibutyryl-cAMP attenuates pulmonary fibrosis by blocking myofibroblast differentiation via PKA/CREB/CBP signaling in rats with silicosis.

    abstract:BACKGROUND:Myofibroblasts play a major role in the synthesis of extracellular matrix (ECM) and the stimulation of these cells is thought to play an important role in the development of silicosis. The present study was undertaken to investigate the anti-fibrotic effects of dibutyryl-cAMP (db-cAMP) on rats induced by sil...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Liu Y,Xu H,Geng Y,Xu D,Zhang L,Yang Y,Wei Z,Zhang B,Li S,Gao X,Wang R,Zhang X,Brann D,Yang F

    更新日期:2017-02-21 00:00:00

  • HIF-1 expression is associated with CCL2 chemokine expression in airway inflammatory cells: implications in allergic airway inflammation.

    abstract:BACKGROUND:The pathogenesis of allergic airway inflammation in asthmatic patients is complex and characterized by cellular infiltrates and activity of many cytokines and chemokines. Both the transcription factor hypoxia inducible factor-1 (HIF-1) and chemokine CCL2 have been shown to play pivotal roles in allergic airw...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Baay-Guzman GJ,Bebenek IG,Zeidler M,Hernandez-Pando R,Vega MI,Garcia-Zepeda EA,Antonio-Andres G,Bonavida B,Riedl M,Kleerup E,Tashkin DP,Hankinson O,Huerta-Yepez S

    更新日期:2012-07-23 00:00:00

  • Clinical outcomes stratified by baseline functional class after initial combination therapy for pulmonary arterial hypertension.

    abstract:BACKGROUND:Initial combination therapy with ambrisentan and tadalafil reduced the risk of clinical failure events for treatment-naïve participants with pulmonary arterial hypertension (PAH) as compared to monotherapy. Previous studies in PAH have demonstrated greater treatment benefits in more symptomatic participants....

    journal_title:Respiratory research

    pub_type: 杂志文章,随机对照试验


    authors: White RJ,Vonk-Noordegraaf A,Rosenkranz S,Oudiz RJ,McLaughlin VV,Hoeper MM,Grünig E,Ghofrani HA,Chakinala MM,Barberà JA,Blair C,Langley J,Frost AE

    更新日期:2019-09-12 00:00:00

  • Perforin, granzyme B, and FasL expression by peripheral blood T lymphocytes in emphysema.

    abstract:BACKGROUND:It is generally accepted that emphysematous lungs are characterized by an increase in the numbers of neutrophils, macrophages, and CD8+ T lymphocytes, the lasts having increased cytotoxic activity. Because systemic inflammation is also a component of emphysema, we hypothesize that peripheral CD8+ T lymphocyt...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Morissette MC,Parent J,Milot J

    更新日期:2007-09-06 00:00:00

  • CASCADE: a phase 2, randomized, double-blind, placebo-controlled, parallel-group trial to evaluate the effect of tezepelumab on airway inflammation in patients with uncontrolled asthma.

    abstract:BACKGROUND:Patients with severe, uncontrolled asthma, particularly those with a non-eosinophilic phenotype, have a great unmet need for new treatments that act on a broad range of inflammatory pathways in the airway. Tezepelumab is a human monoclonal antibody that blocks the activity of thymic stromal lymphopoietin, an...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Emson C,Diver S,Chachi L,Megally A,Small C,Downie J,Parnes JR,Bowen K,Colice G,Brightling CE

    更新日期:2020-10-13 00:00:00

  • Polymorphisms in signal transducer and activator of transcription 3 and lung function in asthma.

    abstract:BACKGROUND:Identifying genetic determinants for lung function is important in providing insight into the pathophysiology of asthma. Signal transducer and activator of transcription 3 is a transcription factor latent in the cytoplasm; the gene (STAT3) is activated by a wide range of cytokines, and may play a role in lun...

    journal_title:Respiratory research

    pub_type: 杂志文章,随机对照试验


    authors: Litonjua AA,Tantisira KG,Lake S,Lazarus R,Richter BG,Gabriel S,Silverman ES,Weiss ST

    更新日期:2005-06-03 00:00:00

  • Inhibition of TNFalpha in vivo prevents hyperoxia-mediated activation of caspase 3 in type II cells.

    abstract:BACKGROUND:The mechanisms during the initial phase of oxygen toxicity leading to pulmonary tissue damage are incompletely known. Increase of tumour necrosis factor alpha (TNFalpha) represents one of the first pulmonary responses to hyperoxia. We hypothesised that, in the initial phase of hyperoxia, TNFalpha activates t...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Guthmann F,Wissel H,Schachtrup C,Tölle A,Rüdiger M,Spener F,Rüstow B

    更新日期:2005-01-21 00:00:00

  • Recent advances in our understanding of human host responses to tuberculosis.

    abstract::Tuberculosis remains one of the world's greatest public health challenges: 2 billion persons have latent infection, 8 million people develop active tuberculosis annually, and 2-3 million die. Recently, significant advances in our understanding of the human immune response against tuberculosis have occurred. The presen...

    journal_title:Respiratory research

    pub_type: 杂志文章,评审


    authors: Schluger NW

    更新日期:2001-01-01 00:00:00

  • Maintained inspiratory activity during proportional assist ventilation in surfactant-depleted cats early after surfactant instillation: phrenic nerve and pulmonary stretch receptor activity.

    abstract:BACKGROUND:Inspiratory activity is a prerequisite for successful application of patient triggered ventilation such as proportional assist ventilation (PAV). It has recently been reported that surfactant instillation increases the activity of slowly adapting pulmonary stretch receptors (PSRs) followed by a shorter inspi...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Sindelar R,Rieger-Fackeldey E,Jonzon A,Schaller P,Schulze A,Sedin G

    更新日期:2006-03-10 00:00:00

  • Incidence of asthma and mortality in a cohort of young adults: a 7-year prospective study.

    abstract:BACKGROUND:Few longitudinal data exist on the incidence of asthma in young adults and on the overall mortality risk due to asthma. A 7-year follow-up prospective study was performed to assess the incidence of asthma and mortality from all causes in a cohort of young adults. METHODS:The life status of a cohort of 6031 ...

    journal_title:Respiratory research

    pub_type: 临床试验,杂志文章


    authors: de Marco R,Locatelli F,Cazzoletti L,Bugianio M,Carosso A,Marinoni A

    更新日期:2005-08-16 00:00:00

  • Increase in markers of airway inflammation after ozone exposure can be observed also in stable treated asthmatics with minimal functional response to ozone.

    abstract:BACKGROUND:The discrepancy between functional and inflammatory airway response to ozone has been reported in normal subjects, but few data are available for stable asthmatics regularly treated with inhaled corticosteroids. METHODS:Twenty-three well controlled, regularly treated, mild-to-moderate asthmatic patients und...

    journal_title:Respiratory research

    pub_type: 杂志文章,随机对照试验


    authors: Vagaggini B,Bartoli ML,Cianchetti S,Costa F,Bacci E,Dente FL,Di Franco A,Malagrinò L,Paggiaro P

    更新日期:2010-01-19 00:00:00

  • SN50 attenuates alveolar hypercoagulation and fibrinolysis inhibition in acute respiratory distress syndrome mice through inhibiting NF-κB p65 translocation.

    abstract:BACKGROUND:It has been confirmed that NF-κB p65 signaling pathway is involved in the regulation of alveolar hypercoagulation and fibrinolysis inhibition in acute respiratory distress syndrome (ARDS). Whether SN50, a NF-κB cell permeable inhibitor, could attenuate alveolar hypercoagulation and fibrinolysis inhibition in...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Wu Y,Wang Y,Liu B,Cheng Y,Qian H,Yang H,Li X,Yang G,Zheng X,Shen F

    更新日期:2020-05-27 00:00:00

  • A systematic review of the role of vitamin insufficiencies and supplementation in COPD.

    abstract:BACKGROUND:Pulmonary inflammation, oxidants-antioxidants imbalance, as well as innate and adaptive immunity have been proposed as playing a key role in the development of COPD. The role of vitamins, as assessed either by food frequency questionnaires or measured in serum levels, have been reported to improve pulmonary ...

    journal_title:Respiratory research

    pub_type: 杂志文章,meta分析,评审


    authors: Tsiligianni IG,van der Molen T

    更新日期:2010-12-06 00:00:00

  • Estimating the U.S. prevalence of chronic obstructive pulmonary disease using pre- and post-bronchodilator spirometry: the National Health and Nutrition Examination Survey (NHANES) 2007-2010.

    abstract:BACKGROUND:During 2007-2010, the National Health and Nutrition Examination Survey (NHANES) conducted a spirometry component which obtained pre-bronchodilator pulmonary lung function data on a nationally representative sample of US adults aged 6-79 years and post-bronchodilator pulmonary lung function data for the subse...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Tilert T,Dillon C,Paulose-Ram R,Hnizdo E,Doney B

    更新日期:2013-10-09 00:00:00

  • Primary data, claims data, and linked data in observational research: the case of COPD in Germany.

    abstract:BACKGROUND:Real-world evidence (RWE) can inform patient management decisions, but RWE studies are associated with limitations. Linkage of different RWE data types could address such limitations by enriching data and improving scientific quality. Using the example of chronic obstructive pulmonary disease (COPD) in Germa...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Mueller S,Gottschalk F,Groth A,Meeraus W,Driessen M,Kohlmann T,Wilke T

    更新日期:2018-08-30 00:00:00

  • The value of ischemia-modified albumin compared with d-dimer in the diagnosis of pulmonary embolism.

    abstract:STUDY OBJECTIVE:The primary aim of this study was to investigate whether IMA levels are helpful in the diagnosis of pulmonary embolism (PE). The secondary aim was to determine whether IMA was more effective alone or in combination with clinical probability scores in the diagnosis of PE. Thirdly, the sensitivity and spe...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Turedi S,Gunduz A,Mentese A,Topbas M,Karahan SC,Yeniocak S,Turan I,Eroglu O,Ucar U,Karaca Y,Turkmen S,Russell RM

    更新日期:2008-05-30 00:00:00

  • Pharmacology of airways and vessels in lung slices in situ: role of endogenous dilator hormones.

    abstract::Small airway and vessels play a critical role in chronic airway and pulmonary vascular diseases, but their pharmacology has not been well characterised. We have studied airway and vascular responses in rat lung slices and separately in vitro using myography. In lung slices, under basal conditions, acetylcholine contra...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Moreno L,Perez-Vizcaino F,Harrington L,Faro R,Sturton G,Barnes PJ,Mitchell JA

    更新日期:2006-08-21 00:00:00

  • Electronic cigarette vapour increases virulence and inflammatory potential of respiratory pathogens.

    abstract:INTRODUCTION:Bacteria have been extensively implicated in the development of smoking related diseases, such as COPD, by either direct infection or bacteria-mediated inflammation. In response to the health risks associated with tobacco exposure, the use of electronic cigarettes (e-cigs) has increased. This study compare...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Gilpin DF,McGown KA,Gallagher K,Bengoechea J,Dumigan A,Einarsson G,Elborn JS,Tunney MM

    更新日期:2019-12-18 00:00:00

  • Prevention of bronchial hyperreactivity in a rat model of precapillary pulmonary hypertension.

    abstract:BACKGROUND:The development of bronchial hyperreactivity (BHR) subsequent to precapillary pulmonary hypertension (PHT) was prevented by acting on the major signalling pathways (endothelin, nitric oxide, vasoactive intestine peptide (VIP) and prostacyclin) involved in the control of the pulmonary vascular and bronchial t...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Habre W,Albu G,Janosi TZ,Fontao F,von Ungern-Sternberg BS,Beghetti M,Petak F

    更新日期:2011-04-27 00:00:00

  • Epilysin (matrix metalloproteinase-28) contributes to airway epithelial cell survival.

    abstract::MMP28 is constitutively expressed by epithelial cells in many tissues, including the respiratory epithelium in the lung and keratinocytes in the skin. This constitutive expression suggests that MMP28 may serve a role in epithelial cell homeostasis. In an effort to determine its function in epithelial cell biology, we ...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Manicone AM,Harju-Baker S,Johnston LK,Chen AJ,Parks WC

    更新日期:2011-10-31 00:00:00

  • Sialic acid receptor detection in the human respiratory tract: evidence for widespread distribution of potential binding sites for human and avian influenza viruses.

    abstract:BACKGROUND:Influenza virus binds to cell receptors via sialic acid (SA) linked glycoproteins. They recognize SA on host cells through their haemagglutinins (H). The distribution of SA on cell surfaces is one determinant of host tropism and understanding its expression on human cells and tissues is important for underst...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Nicholls JM,Bourne AJ,Chen H,Guan Y,Peiris JS

    更新日期:2007-10-25 00:00:00

  • Auxiliary diagnostic value of tumor biomarkers in pleural fluid for lung cancer-associated malignant pleural effusion.

    abstract:BACKGROUND:Pleural effusion (PE) can be divided into benign pleural effusion (BPE) and malignant pleural effusion (MPE). There is no consensus on the identification of lung cancer-associated MPE using the optimal cut-off levels from five common tumor biomarkers (CEA, CYFRA 21-1, CA125, SCC-Ag, and NSE). Therefore, we a...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Zhang H,Li C,Hu F,Zhang X,Shen Y,Chen Y,Li F

    更新日期:2020-10-29 00:00:00

  • CCR2 and CXCR3 agonistic chemokines are differently expressed and regulated in human alveolar epithelial cells type II.

    abstract::The attraction of leukocytes from circulation to inflamed lungs depends on the activation of both the leukocytes and the resident cells within the lung. In this study we determined gene expression and secretion patterns for monocyte chemoattractant protein-1 (MCP-1/CCL2) and T-cell specific CXCR3 agonistic chemokines ...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Pechkovsky DV,Goldmann T,Ludwig C,Prasse A,Vollmer E,Müller-Quernheim J,Zissel G

    更新日期:2005-07-20 00:00:00