Oxygen-regulated transcription factors and their role in pulmonary disease.

Abstract:

:The transcription factors nuclear factor interleukin-6 (NF-IL6), early growth response-1 (EGR-1) and hypoxia-inducible factor-1 (HIF-1) have important roles in the molecular pathophysiology of hypoxia-associated pulmonary disease. NF-IL6 controls the production of interleukin (IL)-6 in vascular endothelial cells, which may have anti-inflammatory activity by counteracting effects of IL-1 and IL-8. EGR-1 controls the production of tissue factor by macrophages, which triggers fibrin deposition in the pulmonary vasculature. HIF-1 activates the expression of the vasoconstrictor endothelin-1 in vascular endothelial cells. Angiotensin II induces HIF-1 expression and hypertrophy of pulmonary arterial smooth muscle cells. HIF-1 might therefore have multiple roles in the pathogenesis of pulmonary vascular remodeling.

journal_name

Respir Res

journal_title

Respiratory research

authors

Semenza GL

doi

10.1186/rr27

keywords:

subject

Has Abstract

pub_date

2000-01-01 00:00:00

pages

159-62

issue

3

eissn

1465-9921

issn

1465-993X

journal_volume

1

pub_type

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