Childhood infections and asthma: at the crossroads of the hygiene and Barker hypotheses.

Abstract:

:The hygiene hypothesis states that childhood asthma develops as a result of decreased exposure to infectious agents during infancy and early childhood. This results in the persistence of the neonatal T helper lymphocyte 2 immunophenotype, thereby predisposing the child to atopic disease. While multiple studies support the hygiene hypothesis in asthma ontogeny, the evidence remains inconclusive; multiple other environmental exposures in early childhood also alter predisposition to asthma. Moreover, the current paradigm for asthma development extends far beyond simple childhood environmental exposures to include fetal development, genetic predisposition, and interactions of the developmental state and genetics with the environment.

journal_name

Respir Res

journal_title

Respiratory research

authors

Tantisira KG,Weiss ST

doi

10.1186/rr81

keywords:

subject

Has Abstract

pub_date

2001-01-01 00:00:00

pages

324-7

issue

6

eissn

1465-9921

issn

1465-993X

journal_volume

2

pub_type

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