Childhood infections and asthma: at the crossroads of the hygiene and Barker hypotheses.


:The hygiene hypothesis states that childhood asthma develops as a result of decreased exposure to infectious agents during infancy and early childhood. This results in the persistence of the neonatal T helper lymphocyte 2 immunophenotype, thereby predisposing the child to atopic disease. While multiple studies support the hygiene hypothesis in asthma ontogeny, the evidence remains inconclusive; multiple other environmental exposures in early childhood also alter predisposition to asthma. Moreover, the current paradigm for asthma development extends far beyond simple childhood environmental exposures to include fetal development, genetic predisposition, and interactions of the developmental state and genetics with the environment.


Respir Res


Respiratory research


Tantisira KG,Weiss ST





Has Abstract


2001-01-01 00:00:00












  • Intermittent hypoxia promotes melanoma lung metastasis via oxidative stress and inflammation responses in a mouse model of obstructive sleep apnea.

    abstract:BACKGROUND:Recently, increased tumor incidence and cancer-related mortality have been reported among patients with obstructive sleep apnea (OSA). Intermittent hypoxia (IH), the hallmark feature of OSA, contributes to the metastasis of tumors. However, the molecular mechanisms by which tumor metastasis is accelerated by...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Li L,Ren F,Qi C,Xu L,Fang Y,Liang M,Feng J,Chen B,Ning W,Cao J

    更新日期:2018-02-12 00:00:00

  • Differences in the risk of mood disorders in patients with asthma-COPD overlap and in patients with COPD alone: a nationwide population-based retrospective cohort study in Korea.

    abstract:BACKGROUND:Although feelings of anxiety and depression are common in patients with chronic obstructive pulmonary disease (COPD), little is known about the estimates of their incidence in patients with asthma-COPD overlap (ACO), which has been described and acknowledged as a distinct clinical entity. We aimed to estimat...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Kang HR,Hong SH,Ha SY,Kim TB,Lee EK

    更新日期:2019-04-30 00:00:00

  • The influence of chlorine in indoor swimming pools on the composition of breathing phase of professional swimmers.

    abstract:OBJECTIVES:Swimming is one of the most popular forms of physical activity. Pool water is cleaned with chlorine, which - in combination with compounds contained in water - could form chloramines and trichloromethane in the swimmer's lungs. The aim of the present study was to examine the effect of swimming training in an...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Swinarew AS,Stanula AJ,Gabor J,Raif P,Paluch J,Karpiński J,Kubik K,Okła H,Ostrowski A,Tkacz E,Skoczyński S,Waśkiewicz Z,Rosemann T,Nikolaidis PT,Knechtle B

    更新日期:2020-04-15 00:00:00

  • Legionella pneumophila induces cathepsin B-dependent necrotic cell death with releasing high mobility group box1 in macrophages.

    abstract:BACKGROUND:Legionella pneumophila (LPN) can cause a lethal infectious disease with a marked inflammatory response in humans. However, the mechanism of this severe inflammation remains poorly understood. Since necrosis is known to induce inflammation, we investigated whether LPN induces necrosis in macrophages. We also ...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Morinaga Y,Yanagihara K,Nakamura S,Hasegawa H,Seki M,Izumikawa K,Kakeya H,Yamamoto Y,Yamada Y,Kohno S,Kamihira S

    更新日期:2010-11-22 00:00:00

  • Dibutyryl-cAMP attenuates pulmonary fibrosis by blocking myofibroblast differentiation via PKA/CREB/CBP signaling in rats with silicosis.

    abstract:BACKGROUND:Myofibroblasts play a major role in the synthesis of extracellular matrix (ECM) and the stimulation of these cells is thought to play an important role in the development of silicosis. The present study was undertaken to investigate the anti-fibrotic effects of dibutyryl-cAMP (db-cAMP) on rats induced by sil...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Liu Y,Xu H,Geng Y,Xu D,Zhang L,Yang Y,Wei Z,Zhang B,Li S,Gao X,Wang R,Zhang X,Brann D,Yang F

    更新日期:2017-02-21 00:00:00

  • Lymphocyte senescence in COPD is associated with loss of glucocorticoid receptor expression by pro-inflammatory/cytotoxic lymphocytes.

    abstract:BACKGROUND:Glucocorticoid (GC) resistance is a major barrier in COPD treatment. We have shown increased expression of the drug efflux pump, Pgp1 in cytotoxic/pro-inflammatory lymphocytes in COPD. Loss of lymphocyte co-stimulatory molecule CD28 (lymphocyte senescence) was associated with a further increase in their pro-...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Hodge G,Jersmann H,Tran HB,Holmes M,Reynolds PN,Hodge S

    更新日期:2015-01-09 00:00:00

  • Gene expression analysis of a murine model with pulmonary vascular remodeling compared to end-stage IPAH lungs.

    abstract:BACKGROUND:Idiopathic pulmonary arterial hypertension (IPAH) continues to be one of the most serious intractable diseases that might start with activation of several triggers representing the genetic susceptibility of a patient. To elucidate what essentially contributes to the onset and progression of IPAH, we investig...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Shimodaira K,Okubo Y,Ochiai E,Nakayama H,Katano H,Wakayama M,Shinozaki M,Ishiwatari T,Sasai D,Tochigi N,Nemoto T,Saji T,Kamei K,Shibuya K

    更新日期:2012-11-17 00:00:00

  • Matrix metalloproteinases in lung biology.

    abstract::Despite much information on their catalytic properties and gene regulation, we actually know very little of what matrix metalloproteinases (MMPs) do in tissues. The catalytic activity of these enzymes has been implicated to function in normal lung biology by participating in branching morphogenesis, homeostasis, and r...

    journal_title:Respiratory research

    pub_type: 杂志文章,评审


    authors: Parks WC,Shapiro SD

    更新日期:2001-01-01 00:00:00

  • Inhaled furosemide for relief of air hunger versus sense of breathing effort: a randomized controlled trial.

    abstract:BACKGROUND:Inhaled furosemide offers a potentially novel treatment for dyspnoea, which may reflect modulation of pulmonary stretch receptor feedback to the brain. Specificity of relief is unclear because different neural pathways may account for different components of clinical dyspnoea. Our objective was to evaluate i...

    journal_title:Respiratory research

    pub_type: 杂志文章,随机对照试验


    authors: Grogono JC,Butler C,Izadi H,Moosavi SH

    更新日期:2018-09-20 00:00:00

  • Oxygen-regulated transcription factors and their role in pulmonary disease.

    abstract::The transcription factors nuclear factor interleukin-6 (NF-IL6), early growth response-1 (EGR-1) and hypoxia-inducible factor-1 (HIF-1) have important roles in the molecular pathophysiology of hypoxia-associated pulmonary disease. NF-IL6 controls the production of interleukin (IL)-6 in vascular endothelial cells, whic...

    journal_title:Respiratory research

    pub_type: 杂志文章,评审


    authors: Semenza GL

    更新日期:2000-01-01 00:00:00

  • Impact of gender on COPD expression in a real-life cohort.

    abstract::Reports regarding gender-related differences in COPD expression have provided conflicting results. In the French Initiatives BPCO real-world cohort, which contained 688 patients (146 women) when data were extracted, women were matched with men (1:3 ratio: n = 107:275) on age (5-year intervals) and FEV1 (5% predicted i...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Roche N,Deslée G,Caillaud D,Brinchault G,Court-Fortune I,Nesme-Meyer P,Surpas P,Escamilla R,Perez T,Chanez P,Pinet C,Jebrak G,Paillasseur JL,Burgel PR,INITIATIVES BPCO Scientific Committee.

    更新日期:2014-02-17 00:00:00

  • What have transgenic and knockout animals taught us about respiratory disease?

    abstract::Over the past decade there has been a significant shift to the use of murine models for investigations into the molecular basis of respiratory diseases, including asthma and chronic obstructive pulmonary disease. These models offer the exciting prospect of dissecting the complex interaction between cytokines, chemokin...

    journal_title:Respiratory research

    pub_type: 杂志文章,评审


    authors: Vasquez YR,Spina D

    更新日期:2000-01-01 00:00:00

  • The mode of lymphoblastoid cell death in response to gas phase cigarette smoke is dose-dependent.

    abstract:BACKGROUND:Cigarette smoke (CS) is the main cause in the development of chronic obstructive pulmonary disease (COPD), the pathogenesis of which is related to an extended inflammatory response. In this study, we investigated the effect of low and high doses of gas phase cigarette smoke (GPS) on cultured lymphocyte proge...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Sdralia ND,Patmanidi AL,Velentzas AD,Margaritis LH,Baltatzis GE,Hatzinikolaou DG,Stavridou A

    更新日期:2009-09-10 00:00:00

  • Indacaterol/glycopyrronium is cost-effective compared to salmeterol/fluticasone in COPD: FLAME-based modelling in a Swedish population.

    abstract:BACKGROUND:This study assessed the cost-effectiveness of indacaterol/glycopyrronium (IND/GLY) versus salmeterol/fluticasone (SFC) in chronic obstructive pulmonary disease (COPD) patients with moderate to very severe airflow limitation and ≥1 exacerbation in the preceding year. METHODS:A previously published and valida...

    journal_title:Respiratory research

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Bjermer L,van Boven JFM,Costa-Scharplatz M,Keininger DL,Gutzwiller FS,Lisspers K,Mahon R,Olsson P,Roche N

    更新日期:2017-12-11 00:00:00

  • IL-4 and IL-13 exposure during mucociliary differentiation of bronchial epithelial cells increases antimicrobial activity and expression of antimicrobial peptides.

    abstract::The airway epithelium forms a barrier against infection but also produces antimicrobial peptides (AMPs) and other inflammatory mediators to activate the immune system. It has been shown that in allergic disorders, Th2 cytokines may hamper the antimicrobial activity of the epithelium. However, the presence of Th2 cytok...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Zuyderduyn S,Ninaber DK,Schrumpf JA,van Sterkenburg MA,Verhoosel RM,Prins FA,van Wetering S,Rabe KF,Hiemstra PS

    更新日期:2011-05-02 00:00:00

  • Inhibition of TNFalpha in vivo prevents hyperoxia-mediated activation of caspase 3 in type II cells.

    abstract:BACKGROUND:The mechanisms during the initial phase of oxygen toxicity leading to pulmonary tissue damage are incompletely known. Increase of tumour necrosis factor alpha (TNFalpha) represents one of the first pulmonary responses to hyperoxia. We hypothesised that, in the initial phase of hyperoxia, TNFalpha activates t...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Guthmann F,Wissel H,Schachtrup C,Tölle A,Rüdiger M,Spener F,Rüstow B

    更新日期:2005-01-21 00:00:00

  • Estimating the U.S. prevalence of chronic obstructive pulmonary disease using pre- and post-bronchodilator spirometry: the National Health and Nutrition Examination Survey (NHANES) 2007-2010.

    abstract:BACKGROUND:During 2007-2010, the National Health and Nutrition Examination Survey (NHANES) conducted a spirometry component which obtained pre-bronchodilator pulmonary lung function data on a nationally representative sample of US adults aged 6-79 years and post-bronchodilator pulmonary lung function data for the subse...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Tilert T,Dillon C,Paulose-Ram R,Hnizdo E,Doney B

    更新日期:2013-10-09 00:00:00

  • Oxidative stress mediates the apoptosis and epigenetic modification of the Bcl-2 promoter via DNMT1 in a cigarette smoke-induced emphysema model.

    abstract:BACKGROUND:Emphysema is a crucial pathological characteristic of chronic obstructive pulmonary disease (COPD). Oxidative stress, apoptosis and epigenetic mechanisms contribute to the pathogenesis of emphysema. However, an attempt to accurately identify whether these mechanisms interact with each other and how they are ...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Zeng H,Li T,He X,Cai S,Luo H,Chen P,Chen Y

    更新日期:2020-09-03 00:00:00

  • The gene encoding interleukin-13: a susceptibility locus for asthma and related traits.

    abstract::Asthma is a complex inflammatory disorder controlled by both genetic and environmental influences. Multiple genetic analyses have identified the T helper type 2 (Th2) cytokine gene cluster on chromosome 5q as a susceptibility locus for asthma. Recently, the Th2 cytokine interleukin-13 has been shown to be a critical m...

    journal_title:Respiratory research

    pub_type: 杂志文章,评审


    authors: Wills-Karp M

    更新日期:2000-01-01 00:00:00

  • Artificial intelligence accuracy in detecting pathological breath sounds in children using digital stethoscopes.

    abstract:BACKGROUND:Manual auscultation to detect abnormal breath sounds has poor inter-observer reliability. Digital stethoscopes with artificial intelligence (AI) could improve reliable detection of these sounds. We aimed to independently test the abilities of AI developed for this purpose. METHODS:One hundred and ninety two...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Kevat A,Kalirajah A,Roseby R

    更新日期:2020-09-29 00:00:00

  • Factors associated with hospitalization in bronchiectasis exacerbations: a one-year follow-up study.

    abstract:BACKGROUND:Bronchiectasis (BE) is a chronic structural lung disease with frequent exacerbations, some of which require hospital admission though no clear associated factors have been identified. We aimed to evaluate factors associated with hospitalization due to exacerbations during a 1-year follow-up period. METHODS:...

    journal_title:Respiratory research

    pub_type: 杂志文章,多中心研究


    authors: Menéndez R,Méndez R,Polverino E,Rosales-Mayor E,Amara-Elori I,Reyes S,Posadas T,Fernández-Barat L,Torres A

    更新日期:2017-09-30 00:00:00

  • Primary data, claims data, and linked data in observational research: the case of COPD in Germany.

    abstract:BACKGROUND:Real-world evidence (RWE) can inform patient management decisions, but RWE studies are associated with limitations. Linkage of different RWE data types could address such limitations by enriching data and improving scientific quality. Using the example of chronic obstructive pulmonary disease (COPD) in Germa...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Mueller S,Gottschalk F,Groth A,Meeraus W,Driessen M,Kohlmann T,Wilke T

    更新日期:2018-08-30 00:00:00

  • Analysis of comorbid factors that increase the COPD assessment test scores.

    abstract:BACKGROUND:The chronic obstructive pulmonary disease (COPD) Assessment Test (CAT) is a concise health status measure for COPD. COPD patients have a variety of comorbidities, but little is known about their impact on quality of life. This study was designed to investigate comorbid factors that may contribute to high CAT...

    journal_title:Respiratory research

    pub_type: 临床试验,杂志文章


    authors: Miyazaki M,Nakamura H,Chubachi S,Sasaki M,Haraguchi M,Yoshida S,Tsuduki K,Shirahata T,Takahashi S,Minematsu N,Koh H,Nakamura M,Sakamaki F,Terashima T,Sayama K,Jones PW,Asano K,Betsuyaku T,Keio COPD Comorbidity Researc

    更新日期:2014-02-06 00:00:00

  • Neutrophil cannibalism--a back up when the macrophage clearance system is insufficient.

    abstract:BACKGROUND:During a lipopolysaccharide-induced lung inflammation, a massive accumulation of neutrophils occurs, which is normally cleared by macrophage phagocytosis following neutrophil apoptosis. However, in cases of extensive apoptosis the normal clearance system may fail, resulting in extensive neutrophil secondary ...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Rydell-Törmänen K,Uller L,Erjefält JS

    更新日期:2006-12-14 00:00:00

  • Influence of viral infection on the relationships between airway cytokines and lung function in asthmatic children.

    abstract:BACKGROUND:Few longitudinal studies examine inflammation and lung function in asthma. We sought to determine the cytokines that reduce airflow, and the influence of respiratory viral infections on these relationships. METHODS:Children underwent home collections of nasal lavage during scheduled surveillance periods and...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Lewis TC,Metitiri EE,Mentz GB,Ren X,Carpenter AR,Goldsmith AM,Wicklund KE,Eder BN,Comstock AT,Ricci JM,Brennan SR,Washington GL,Owens KB,Mukherjee B,Robins TG,Batterman SA,Hershenson MB,Community Action Against Asthma S

    更新日期:2018-11-21 00:00:00

  • Prenatal fine particulate exposure associated with reduced childhood lung function and nasal epithelia GSTP1 hypermethylation: Sex-specific effects.

    abstract:BACKGROUND:In utero exposure to particulate matter with an aerodynamic diameter of less than 2.5 μm (PM2.5) has been linked to child lung function. Overlapping evidence suggests that child sex and exposure timing may modify effects and associations may be mediated through glutathione S-transferase P1 (GSTP1) methylatio...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Lee AG,Le Grand B,Hsu HL,Chiu YM,Brennan KJ,Bose S,Rosa MJ,Brunst KJ,Kloog I,Wilson A,Schwartz J,Morgan W,Coull BA,Wright RO,Baccarelli AA,Wright RJ

    更新日期:2018-04-27 00:00:00

  • Genome-wide DNA methylation analysis in lung fibroblasts co-cultured with silica-exposed alveolar macrophages.

    abstract:BACKGROUND:Exposure to crystalline silica is considered to increase the risk of lung fibrosis. The primary effector cell, the myofibroblast, plays an important role in the deposition of extracellular matrix (ECM). DNA methylation change is considered to have a potential effect on myofibroblast differentiation. Therefor...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Li J,Yao W,Zhang L,Bao L,Chen H,Wang D,Yue Z,Li Y,Zhang M,Hao C

    更新日期:2017-05-12 00:00:00

  • EIF2AK4 mutation as "second hit" in hereditary pulmonary arterial hypertension.

    abstract:BACKGROUND:Mutations in the eukaryotic translation initiation factor 2α kinase 4 (EIF2AK4) gene have recently been identified in recessively inherited veno-occlusive disease. In this study we assessed if EIF2AK4 mutations occur also in a family with autosomal dominantly inherited pulmonary arterial hypertension (HPAH) ...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Eichstaedt CA,Song J,Benjamin N,Harutyunova S,Fischer C,Grünig E,Hinderhofer K

    更新日期:2016-11-04 00:00:00

  • Prevalence and distribution patterns of allergens among children with asthma and asthma-like symptoms in Shanghai, China.

    abstract:OBJECTIVE:We aimed to identify the prevalence and distribution patterns of allergens among Chinese children with asthma/asthma-like symptoms (ALS). METHODS:A total of 3479 children with asthma/ALS were enrolled. Skin prick test (SPT) was used to test the allergen-specific IgE. We analysed allergens prevalence and dist...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Mao S,Wu L,Shi W

    更新日期:2020-02-18 00:00:00

  • AIDS patients have increased surfactant protein D but normal mannose binding lectin levels in lung fluid.

    abstract:BACKGROUND:Surfactant protein D (SP-D) and Mannose Binding Lectin (MBL) are collectins that have opsonic and immunoregulatory functions, are found in lung fluid and interact with the human immunodeficiency virus (HIV). We compared collectin levels in lung fluid and serum from HIV infected and normal subjects to determi...

    journal_title:Respiratory research

    pub_type: 杂志文章


    authors: Jambo KC,French N,Zijlstra E,Gordon SB

    更新日期:2007-06-13 00:00:00