Blockade of advanced glycation end product formation attenuates bleomycin-induced pulmonary fibrosis in rats.

abstract：BACKGROUND:Cigarette smoke induced oxidative stress has been shown to reduce silent information regulator 1 (Sirt1) levels in lung tissue from smokers and patients with COPD patients. Sirt1 is known to inhibit endothelial senescence and may play a protective role in vascular cells. Endothelial progenitor cells (EPCs) a...

journal_title：Respiratory research

authors： Kato R,Mizuno S,Kadowaki M,Shiozaki K,Akai M,Nakagawa K,Oikawa T,Iguchi M,Osanai K,Ishizaki T,Voelkel NF,Toga H

更新日期：2016-10-27 00:00:00

abstract：:Healthy individuals have few goblet cells in their airways, but in patients with hypersecretory diseases goblet-cell upregulation results in mucus hypersecretion, airway plugging, and death. Multiple stimuli produce hypersecretion via epidermal growth factor receptor (EGFR) expression and activation, causing goblet-ce...

journal_title：Respiratory research

authors： Nadel JA

更新日期：2001-01-01 00:00:00

abstract：BACKGROUND:Patients with severe, uncontrolled asthma, particularly those with a non-eosinophilic phenotype, have a great unmet need for new treatments that act on a broad range of inflammatory pathways in the airway. Tezepelumab is a human monoclonal antibody that blocks the activity of thymic stromal lymphopoietin, an...

journal_title：Respiratory research

authors： Emson C,Diver S,Chachi L,Megally A,Small C,Downie J,Parnes JR,Bowen K,Colice G,Brightling CE

更新日期：2020-10-13 00:00:00

abstract：BACKGROUND:Little is known about the association between cigarette smoking and asthma severity. We assessed smoking as a determinant of disease severity and control in a cohort of clinic-referred allergic subjects who developed new onset asthma. METHODS:Allergic rhinitis subjects with no asthma (n = 371) were followed...

journal_title：Respiratory research

authors： Polosa R,Russo C,Caponnetto P,Bertino G,Sarvà M,Antic T,Mancuso S,Al-Delaimy WK

更新日期：2011-01-24 00:00:00

abstract：BACKGROUND:Work-place exposure to silica dust may lead to progressive lung inflammation culminating in the development of silicosis, an irreversible condition that can be complicated by onset of pulmonary hypertension (PH). The molecular mechanisms leading to the development of PH and lung fibrosis in response to silic...

journal_title：Respiratory research

authors： Zelko IN,Zhu J,Roman J

更新日期：2018-11-20 00:00:00

abstract：BACKGROUND:Influenza virus binds to cell receptors via sialic acid (SA) linked glycoproteins. They recognize SA on host cells through their haemagglutinins (H). The distribution of SA on cell surfaces is one determinant of host tropism and understanding its expression on human cells and tissues is important for underst...

journal_title：Respiratory research

authors： Nicholls JM,Bourne AJ,Chen H,Guan Y,Peiris JS

更新日期：2007-10-25 00:00:00

abstract：BACKGROUND:Real-world evidence (RWE) can inform patient management decisions, but RWE studies are associated with limitations. Linkage of different RWE data types could address such limitations by enriching data and improving scientific quality. Using the example of chronic obstructive pulmonary disease (COPD) in Germa...

journal_title：Respiratory research

authors： Mueller S,Gottschalk F,Groth A,Meeraus W,Driessen M,Kohlmann T,Wilke T

更新日期：2018-08-30 00:00:00

abstract：BACKGROUND:Heat shock protein (HSP) 47 is a collagen-specific molecular chaperone that is required for molecular maturation of various types of collagens. We recently reported that HSP47 serum levels were markedly higher in patients with acute exacerbations of idiopathic pulmonary fibrosis (IPF) when compared with pati...

journal_title：Respiratory research

authors： Kakugawa T,Yokota S,Ishimatsu Y,Hayashi T,Nakashima S,Hara S,Sakamoto N,Matsuoka Y,Kubota H,Mine M,Mukae H,Nagata K,Kohno S

更新日期：2013-11-20 00:00:00

abstract：BACKGROUND:Glucocorticoid (GC) resistance is a major barrier in COPD treatment. We have shown increased expression of the drug efflux pump, Pgp1 in cytotoxic/pro-inflammatory lymphocytes in COPD. Loss of lymphocyte co-stimulatory molecule CD28 (lymphocyte senescence) was associated with a further increase in their pro-...

journal_title：Respiratory research

authors： Hodge G,Jersmann H,Tran HB,Holmes M,Reynolds PN,Hodge S

更新日期：2015-01-09 00:00:00

abstract：BACKGROUND:MIF is a critical mediator of the host defense, and is involved in both acute and chronic responses in the lung. Neutralization of MIF reduces neutrophil accumulation into the lung in animal models. We hypothesized that MIF, in the alveolar space, promotes neutrophil accumulation via activation of the CD74 r...

journal_title：Respiratory research

authors： Takahashi K,Koga K,Linge HM,Zhang Y,Lin X,Metz CN,Al-Abed Y,Ojamaa K,Miller EJ

更新日期：2009-05-04 00:00:00

abstract：BACKGROUND:The discrepancy between functional and inflammatory airway response to ozone has been reported in normal subjects, but few data are available for stable asthmatics regularly treated with inhaled corticosteroids. METHODS:Twenty-three well controlled, regularly treated, mild-to-moderate asthmatic patients und...

journal_title：Respiratory research

authors： Vagaggini B,Bartoli ML,Cianchetti S,Costa F,Bacci E,Dente FL,Di Franco A,Malagrinò L,Paggiaro P

更新日期：2010-01-19 00:00:00

abstract：BACKGROUND:Recently, increased tumor incidence and cancer-related mortality have been reported among patients with obstructive sleep apnea (OSA). Intermittent hypoxia (IH), the hallmark feature of OSA, contributes to the metastasis of tumors. However, the molecular mechanisms by which tumor metastasis is accelerated by...

journal_title：Respiratory research

authors： Li L,Ren F,Qi C,Xu L,Fang Y,Liang M,Feng J,Chen B,Ning W,Cao J

更新日期：2018-02-12 00:00:00

abstract：BACKGROUND:Idiopathic pulmonary arterial hypertension (IPAH) continues to be one of the most serious intractable diseases that might start with activation of several triggers representing the genetic susceptibility of a patient. To elucidate what essentially contributes to the onset and progression of IPAH, we investig...

journal_title：Respiratory research

authors： Shimodaira K,Okubo Y,Ochiai E,Nakayama H,Katano H,Wakayama M,Shinozaki M,Ishiwatari T,Sasai D,Tochigi N,Nemoto T,Saji T,Kamei K,Shibuya K

更新日期：2012-11-17 00:00:00

abstract：BACKGROUND:Current therapy for relieving bronchoconstriction may be ineffective in severe asthma, particularly in the small airways. The aim of this study was to further characterise responses to the recently identified novel bronchodilators rosiglitazone (RGZ) and chloroquine (CQ) under conditions where β-adrenoceptor...

journal_title：Respiratory research

authors： Donovan C,Simoons M,Esposito J,Ni Cheong J,Fitzpatrick M,Bourke JE

更新日期：2014-03-12 00:00:00

abstract：:Small airway and vessels play a critical role in chronic airway and pulmonary vascular diseases, but their pharmacology has not been well characterised. We have studied airway and vascular responses in rat lung slices and separately in vitro using myography. In lung slices, under basal conditions, acetylcholine contra...

journal_title：Respiratory research

authors： Moreno L,Perez-Vizcaino F,Harrington L,Faro R,Sturton G,Barnes PJ,Mitchell JA

更新日期：2006-08-21 00:00:00

abstract：BACKGROUND:Extended culture of monocytes and fibroblasts in three-dimensional collagen gels leads to degradation of the gels (see linked study in this issue, "Fibroblasts and monocytes contract and degrade three-dimensional collagen gels in extended co-culture"). The current study, therefore, was designed to evaluate p...

journal_title：Respiratory research

authors： Zhu Y,Liu X,Sköld CM,Wang H,Kohyama T,Wen FQ,Ertl RF,Rennard SI

更新日期：2001-01-01 00:00:00

abstract：:The role of the ATP binding cassette transporter A1 (ABCA1) in maintaining cellular lipid homeostasis in cardiovascular disease is well established. More recently, the important beneficial role played by ABCA1 in modulating pathogenic disease mechanisms, such as inflammation, in a broad range of chronic conditions has...

journal_title：Respiratory research

authors： He P,Gelissen IC,Ammit AJ

更新日期：2020-09-25 00:00:00

abstract：BACKGROUND:To assess the symptomatic and cost burden among patients initiating long-acting bronchodilator (LABD) therapy and impact of adherence on healthcare resource use and costs. METHODS:This retrospective cohort study identified patients with COPD who were newly prescribed a LABD (long-acting muscarinic antagonis...

journal_title：Respiratory research

authors： Punekar YS,Landis SH,Wurst K,Le H

更新日期：2015-11-16 00:00:00

abstract：BACKGROUND:Cigarette smoke (CS) is the main cause in the development of chronic obstructive pulmonary disease (COPD), the pathogenesis of which is related to an extended inflammatory response. In this study, we investigated the effect of low and high doses of gas phase cigarette smoke (GPS) on cultured lymphocyte proge...

journal_title：Respiratory research

authors： Sdralia ND,Patmanidi AL,Velentzas AD,Margaritis LH,Baltatzis GE,Hatzinikolaou DG,Stavridou A

更新日期：2009-09-10 00:00:00

abstract：:The use of biomarkers in medicine lies in their ability to detect disease and support diagnostic and therapeutic decisions. New research and novel understanding of the molecular basis of the disease reveals an abundance of exciting new biomarkers who present a promise for use in the everyday clinical practice. The pas...

journal_title：Respiratory research

authors： Tzouvelekis A,Kouliatsis G,Anevlavis S,Bouros D

更新日期：2005-07-21 00:00:00

abstract：OBJECTIVES:Swimming is one of the most popular forms of physical activity. Pool water is cleaned with chlorine, which - in combination with compounds contained in water - could form chloramines and trichloromethane in the swimmer's lungs. The aim of the present study was to examine the effect of swimming training in an...

journal_title：Respiratory research

authors： Swinarew AS,Stanula AJ,Gabor J,Raif P,Paluch J,Karpiński J,Kubik K,Okła H,Ostrowski A,Tkacz E,Skoczyński S,Waśkiewicz Z,Rosemann T,Nikolaidis PT,Knechtle B

更新日期：2020-04-15 00:00:00

abstract：BACKGROUND:Fibrocytes are implicated in Idiopathic Pulmonary Fibrosis (IPF) pathogenesis and increased proportions in the circulation are associated with poor prognosis. Upon tissue injury, fibrocytes migrate to the affected organ. In IPF patients, circulating fibrocytes are increased especially during exacerbations, h...

journal_title：Respiratory research

authors： Heukels P,van Hulst JAC,van Nimwegen M,Boorsma CE,Melgert BN,van den Toorn LM,Boomars KAT,Wijsenbeek MS,Hoogsteden H,von der Thüsen JH,Hendriks RW,Kool M,van den Blink B

更新日期：2018-05-10 00:00:00

abstract：BACKGROUND:Progestins as respiratory stimulants in chronic obstructive pulmonary disease (COPD) have been investigated in males and during wakefulness. However, sleep and gender may influence therapeutic responses. We investigated the effects of a 2-week medroxyprogesterone acetate (MPA) therapy on sleep and nocturnal ...

journal_title：Respiratory research

authors： Saaresranta T,Aittokallio T,Utriainen K,Polo O

更新日期：2005-04-04 00:00:00

abstract：BACKGROUND:In order to find novel noninvasive biomarkers with high accuracy for the screening of early-stage non-small cell lung cancer (NSCLC), we investigate the predictive power of 5 microRNAs (miR-20a, miR-145, miR-21, miR223 and miR-221) as potential biomarkers in early-stage NSCLC. METHODS:In training set, 25 ea...

journal_title：Respiratory research

authors： Geng Q,Fan T,Zhang B,Wang W,Xu Y,Hu H

更新日期：2014-11-25 00:00:00

abstract：BACKGROUND:An important goal of chronic obstructive pulmonary disease (COPD) treatment is to reduce the frequency of exacerbations. Some observations suggest a decline in exacerbation rates in clinical trials over time. A more systematic understanding would help to improve the design and interpretation of COPD trials. ...

journal_title：Respiratory research

authors： Andreas S,Röver C,Heinz J,Straube S,Watz H,Friede T

更新日期：2019-08-16 00:00:00

abstract：BACKGROUND:Chronic obstructive pulmonary disease (COPD) is characterized by expiratory flow limitation, causing air trapping and lung hyperinflation. Hyperinflation leads to reduced exercise tolerance and poor quality of life in COPD patients. Total lung capacity (TLC) is an indicator of hyperinflation particularly in ...

journal_title：Respiratory research

authors： Lee JH,McDonald ML,Cho MH,Wan ES,Castaldi PJ,Hunninghake GM,Marchetti N,Lynch DA,Crapo JD,Lomas DA,Coxson HO,Bakke PS,Silverman EK,Hersh CP,COPDGene and ECLIPSE Investigators.

更新日期：2014-08-20 00:00:00

abstract：BACKGROUND:Accumulation of profibrotic myofibroblasts in fibroblastic foci (FF) is a crucial process for development of fibrosis during idiopathic pulmonary fibrosis (IPF) pathogenesis, and transforming growth factor (TGF)-β plays a key regulatory role in myofibroblast differentiation. Reactive oxygen species (ROS) has...

journal_title：Respiratory research

authors： Sato N,Takasaka N,Yoshida M,Tsubouchi K,Minagawa S,Araya J,Saito N,Fujita Y,Kurita Y,Kobayashi K,Ito S,Hara H,Kadota T,Yanagisawa H,Hashimoto M,Utsumi H,Wakui H,Kojima J,Numata T,Kaneko Y,Odaka M,Morikawa T,Na

更新日期：2016-08-30 00:00:00

abstract：:Signaling through G protein-coupled receptors (GPCRs) mediates numerous airway smooth muscle (ASM) functions including contraction, growth, and "synthetic" functions that orchestrate airway inflammation and promote remodeling of airway architecture. In this review we provide a comprehensive overview of the GPCRs that ...

journal_title：Respiratory research

authors： Billington CK,Penn RB

更新日期：2003-01-01 00:00:00

abstract：BACKGROUND:The coexistence of COPD and asthma is widely recognized but has not been well described. This study characterizes clinical features, spirometry, and chest CT scans of smoking subjects with both COPD and asthma. METHODS:We performed a cross-sectional study comparing subjects with COPD and asthma to subjects ...

journal_title：Respiratory research

authors： Hardin M,Silverman EK,Barr RG,Hansel NN,Schroeder JD,Make BJ,Crapo JD,Hersh CP,COPDGene Investigators.

更新日期：2011-09-27 00:00:00

abstract：BACKGROUND:Asthma is a disease of varying severity and differing disease mechanisms. To date, studies aimed at stratifying asthma into clinically useful phenotypes have produced a number of phenotypes that have yet to be assessed for stability and to be validated in independent cohorts. The aim of this study was to def...

journal_title：Respiratory research

authors： Loza MJ,Djukanovic R,Chung KF,Horowitz D,Ma K,Branigan P,Barnathan ES,Susulic VS,Silkoff PE,Sterk PJ,Baribaud F,ADEPT (Airways Disease Endotyping for Personalized Therapeutics) and U-BIOPRED (Unbiased Biomarkers for the Prediction

更新日期：2016-12-15 00:00:00