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The pathology of small airways disease in COPD: historical aspects and future directions.

Abstract：

:Small airways disease (SAD) is a cardinal feature of chronic obstructive pulmonary disease (COPD) first recognized in the nineteenth century. The diverse histopathological features associated with SAD underpin the heterogeneous nature of COPD. Our understanding of the key molecular mechanisms which drive the pathological changes are not complete. In this article we will provide a historical overview of key histopathological studies which have helped shape our understanding of SAD and discuss the hallmark features of airway remodelling, mucous plugging and inflammation. We focus on the relationship between SAD and emphysema, SAD in the early stages of COPD, and the mechanisms which cause SAD progression, including bacterial colonization and exacerbations. We discuss the need to specifically target SAD to attenuate the progression of COPD.

journal_name

Respir Res

journal_title

Respiratory research

authors

Higham A,Quinn AM,Cançado JED,Singh D

doi

10.1186/s12931-019-1017-y

subject

Has Abstract

pub_date

2019-03-04 00:00:00

pages

49

issue

1

eissn

1465-9921

issn

1465-993X

pii

10.1186/s12931-019-1017-y

journal_volume

20

pub_type

杂志文章,评审

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