Decline of COPD exacerbations in clinical trials over two decades - a systematic review and meta-regression.

Abstract:

BACKGROUND:An important goal of chronic obstructive pulmonary disease (COPD) treatment is to reduce the frequency of exacerbations. Some observations suggest a decline in exacerbation rates in clinical trials over time. A more systematic understanding would help to improve the design and interpretation of COPD trials. METHODS:We performed a systematic review and meta-regression of the placebo groups in published randomized controlled trials reporting exacerbations as an outcome. A Bayesian negative binomial model was developed to accommodate results that are reported in different formats; results are reported with credible intervals (CI) and posterior tail probabilities (pB). RESULTS:Of 1114 studies identified by our search, 55 were ultimately included. Exacerbation rates decreased by 6.7% (95% CI (4.4, 9.0); pB <  0.001) per year, or 50% (95% CI (36, 61)) per decade. Adjusting for available study and baseline characteristics such as forced expiratory volume in 1 s (FEV1) did not alter the observed trend considerably. Two subsets of studies, one using a true placebo group and the other allowing inhaled corticosteroids in the "placebo" group, also yielded consistent results. CONCLUSIONS:In conclusion, this meta-regression indicates that the rate of COPD exacerbations decreased over the past two decades to a clinically relevant extent independent of important prognostic factors. This suggests that care is needed in the design of new trials or when comparing results from older trials with more recent ones. Also a considerable effect of adjunct therapy on COPD exacerbations can be assumed. REGISTRATION:PROSPERO 2018 CRD4218118823.

journal_name

Respir Res

journal_title

Respiratory research

authors

Andreas S,Röver C,Heinz J,Straube S,Watz H,Friede T

doi

10.1186/s12931-019-1163-2

subject

Has Abstract

pub_date

2019-08-16 00:00:00

pages

186

issue

1

eissn

1465-9921

issn

1465-993X

pii

10.1186/s12931-019-1163-2

journal_volume

20

pub_type

杂志文章,meta分析
  • Rituximab therapy in pulmonary alveolar proteinosis improves alveolar macrophage lipid homeostasis.

    abstract:RATIONALE:Pulmonary Alveolar Proteinosis (PAP) patients exhibit an acquired deficiency of biologically active granulocyte-macrophage colony stimulating factor (GM-CSF) attributable to GM-CSF specific autoantibodies. PAP alveolar macrophages are foamy, lipid-filled cells with impaired surfactant clearance and markedly r...

    journal_title:Respiratory research

    pub_type: 临床试验,杂志文章

    doi:10.1186/1465-9921-13-46

    authors: Malur A,Kavuru MS,Marshall I,Barna BP,Huizar I,Karnekar R,Thomassen MJ

    更新日期:2012-06-14 00:00:00

  • A 3D epithelial-mesenchymal co-culture model of human bronchial tissue recapitulates multiple features of airway tissue remodeling by TGF-β1 treatment.

    abstract:BACKGROUND:The collagen gel contraction assay measures gel size to assess the contraction of cells embedded in collagen gel matrices. Using the assay with lung fibroblasts is useful in studying the lung tissue remodeling process in wound healing and disease development. However, the involvement of bronchial epithelial ...

    journal_title:Respiratory research

    pub_type: 杂志文章

    doi:10.1186/s12931-017-0680-0

    authors: Ishikawa S,Ishimori K,Ito S

    更新日期:2017-11-22 00:00:00

  • Induction and regulation of matrix metalloproteinase-12 in human airway smooth muscle cells.

    abstract:BACKGROUND:The elastolytic enzyme matrix metalloproteinase (MMP)-12 has been implicated in the development of airway inflammation and remodeling. We investigated whether human airway smooth muscle cells could express and secrete MMP-12, thereby participating in the pathogenesis of airway inflammatory diseases. METHODS...

    journal_title:Respiratory research

    pub_type: 杂志文章

    doi:10.1186/1465-9921-6-148

    authors: Xie S,Issa R,Sukkar MB,Oltmanns U,Bhavsar PK,Papi A,Caramori G,Adcock I,Chung KF

    更新日期:2005-12-16 00:00:00

  • Association of mast cells with lung function in chronic obstructive pulmonary disease.

    abstract:BACKGROUND:In asthma, higher chymase positive mast cell (MC-C) numbers are associated with less airway obstruction. In COPD, the distribution of MC-C and tryptase positive mast cells (MC-T) in central and peripheral airways, and their relation with lung function, is unknown. We compared MC-T and MC-C distributions in C...

    journal_title:Respiratory research

    pub_type: 杂志文章

    doi:10.1186/1465-9921-9-64

    authors: Gosman MM,Postma DS,Vonk JM,Rutgers B,Lodewijk M,Smith M,Luinge MA,Ten Hacken NH,Timens W

    更新日期:2008-09-10 00:00:00

  • Exchange protein directly activated by cAMP (Epac) protects against airway inflammation and airway remodeling in asthmatic mice.

    abstract:BACKGROUND:β2 receptor agonists induce airway smooth muscle relaxation by increasing intracellular cAMP production. PKA is the traditional downstream signaling pathway of cAMP. Exchange protein directly activated by cAMP (Epac) was identified as another important signaling molecule of cAMP recently. The role of Epac in...

    journal_title:Respiratory research

    pub_type: 杂志文章

    doi:10.1186/s12931-019-1260-2

    authors: Chen YF,Huang G,Wang YM,Cheng M,Zhu FF,Zhong JN,Gao YD

    更新日期:2019-12-18 00:00:00

  • Effect of chemokine receptor CXCR4 on hypoxia-induced pulmonary hypertension and vascular remodeling in rats.

    abstract:BACKGROUND:CXCR4 is the receptor for chemokine CXCL12 and reportedly plays an important role in systemic vascular repair and remodeling, but the role of CXCR4 in development of pulmonary hypertension and vascular remodeling has not been fully understood. METHODS:In this study we investigated the role of CXCR4 in the d...

    journal_title:Respiratory research

    pub_type: 杂志文章

    doi:10.1186/1465-9921-12-21

    authors: Yu L,Hales CA

    更新日期:2011-02-04 00:00:00

  • Transformation of adrenal medullary chromaffin cells increases asthmatic susceptibility in pups from allergen-sensitized rats.

    abstract:BACKGROUND:Studies have shown that epinephrine release is impaired in patients with asthma. The pregnancy of female rats (dams) with asthma promotes in their pups the differentiation of adrenal medulla chromaffin cells (AMCCs) into sympathetic neurons, mediated by nerve growth factor, which leads to a reduction in epin...

    journal_title:Respiratory research

    pub_type: 杂志文章

    doi:10.1186/1465-9921-13-99

    authors: Feng JT,Wu XM,Li XZ,Zou YQ,Qin L,Hu CP

    更新日期:2012-11-08 00:00:00

  • Legionella pneumophila induces cathepsin B-dependent necrotic cell death with releasing high mobility group box1 in macrophages.

    abstract:BACKGROUND:Legionella pneumophila (LPN) can cause a lethal infectious disease with a marked inflammatory response in humans. However, the mechanism of this severe inflammation remains poorly understood. Since necrosis is known to induce inflammation, we investigated whether LPN induces necrosis in macrophages. We also ...

    journal_title:Respiratory research

    pub_type: 杂志文章

    doi:10.1186/1465-9921-11-158

    authors: Morinaga Y,Yanagihara K,Nakamura S,Hasegawa H,Seki M,Izumikawa K,Kakeya H,Yamamoto Y,Yamada Y,Kohno S,Kamihira S

    更新日期:2010-11-22 00:00:00

  • A confocal microscopic study of solitary pulmonary neuroendocrine cells in human airway epithelium.

    abstract:BACKGROUND:Pulmonary neuroendocrine cells (PNEC) are specialized epithelial cells that are thought to play important roles in lung development and airway function. PNEC occur either singly or in clusters called neuroepithelial bodies. Our aim was to characterize the three dimensional morphology of PNEC, their distribut...

    journal_title:Respiratory research

    pub_type: 杂志文章

    doi:10.1186/1465-9921-6-115

    authors: Weichselbaum M,Sparrow MP,Hamilton EJ,Thompson PJ,Knight DA

    更新日期:2005-10-10 00:00:00

  • Identification of vitamin D sensitive pathways during lung development.

    abstract:BACKGROUND:We have previously shown that vitamin D deficiency has a detrimental impact on lung development. In this study, we aimed to identify the mechanisms linking vitamin D with lung development using a mouse model of dietary manipulation. METHODS:Female offspring were euthanized at different time-points; embryoni...

    journal_title:Respiratory research

    pub_type: 杂志文章

    doi:10.1186/s12931-016-0362-3

    authors: Chen L,Wilson R,Bennett E,Zosky GR

    更新日期:2016-04-27 00:00:00

  • Protein tyrosine phosphatase PTP-RR regulates corticosteroid sensitivity.

    abstract:BACKGROUND:We have recently reported that protein phosphate 2A (PP2A) inactivation resulted in increased phosphorylation of the mitogen-activated protein kinase (MAPK) c-Jun N-terminal kinase 1 (JNK1) and glucocorticoid receptors (GR) at Ser(226), thereby reducing GR nuclear translocation and causing corticosteroid ins...

    journal_title:Respiratory research

    pub_type: 杂志文章

    doi:10.1186/s12931-016-0349-0

    authors: Kobayashi Y,Ito K,Kanda A,Tomoda K,Miller-Larsson A,Barnes PJ,Mercado N

    更新日期:2016-03-24 00:00:00

  • Serum biomarkers in interstitial lung diseases.

    abstract::The use of biomarkers in medicine lies in their ability to detect disease and support diagnostic and therapeutic decisions. New research and novel understanding of the molecular basis of the disease reveals an abundance of exciting new biomarkers who present a promise for use in the everyday clinical practice. The pas...

    journal_title:Respiratory research

    pub_type: 杂志文章,评审

    doi:10.1186/1465-9921-6-78

    authors: Tzouvelekis A,Kouliatsis G,Anevlavis S,Bouros D

    更新日期:2005-07-21 00:00:00

  • Diagnostic value of plasma and bronchoalveolar lavage samples in acute lung allograft rejection: differential cytology.

    abstract::Diagnosis of acute lung allograft rejection is currently based on transbronchial lung biopsies. Additional methods to detect acute allograft dysfunction derived from plasma and bronchoalveolar lavage samples might facilitate diagnosis and ultimately improve allograft survival. This review article gives an overview of ...

    journal_title:Respiratory research

    pub_type: 杂志文章,评审

    doi:10.1186/s12931-016-0391-y

    authors: Speck NE,Schuurmans MM,Murer C,Benden C,Huber LC

    更新日期:2016-06-21 00:00:00

  • Inhaled fluticasone propionate impairs pulmonary clearance of Klebsiella pneumoniae in mice.

    abstract:BACKGROUND:Recent trials demonstrate increased pneumonia risk in chronic obstructive pulmonary disease patients treated with the inhaled corticosteroid (ICS) fluticasone propionate (FP). There is limited work describing FP effects on host defenses against bacterial pneumonia. METHODS:C57BL/6 mice received daily, nose-...

    journal_title:Respiratory research

    pub_type: 杂志文章

    doi:10.1186/1465-9921-13-40

    authors: Patterson CM,Morrison RL,D'Souza A,Teng XS,Happel KI

    更新日期:2012-05-31 00:00:00

  • PDGF-Ralpha gene expression predicts proliferation, but PDGF-A suppresses transdifferentiation of neonatal mouse lung myofibroblasts.

    abstract:BACKGROUND:Platelet-derived growth factor A (PDGF-A) signals solely through PDGF-Ralpha, and is required for fibroblast proliferation and transdifferentiation (fibroblast to myofibroblast conversion) during alveolar development, because pdgfa-null mice lack both myofibroblasts and alveoli. However, these PDGF-A-mediate...

    journal_title:Respiratory research

    pub_type: 杂志文章

    doi:10.1186/1465-9921-10-119

    authors: Kimani PW,Holmes AJ,Grossmann RE,McGowan SE

    更新日期:2009-11-25 00:00:00

  • Pectoralis muscle area and mortality in smokers without airflow obstruction.

    abstract:BACKGROUND:Low muscle mass is associated with increased mortality in the general population but its prognostic value in at-risk smokers, those without expiratory airflow obstruction, is unknown. We aimed to test the hypothesis that reduced muscle mass is associated with increased mortality in at-risk smokers. METHODS:...

    journal_title:Respiratory research

    pub_type: 杂志文章

    doi:10.1186/s12931-018-0771-6

    authors: Diaz AA,Martinez CH,Harmouche R,Young TP,McDonald ML,Ross JC,Han ML,Bowler R,Make B,Regan EA,Silverman EK,Crapo J,Boriek AM,Kinney GL,Hokanson JE,Estepar RSJ,Washko GR

    更新日期:2018-04-10 00:00:00

  • Impact of gastroesophageal reflux on longitudinal lung function and quantitative computed tomography in the COPDGene cohort.

    abstract:RATIONALE:Gastroesophageal reflux disease (GERD) is a common comorbidity in chronic obstructive pulmonary disease (COPD) and has been associated with increased risk of acute exacerbations, hospitalization, emergency room visits, costs, and quality-of-life impairment. However, it remains unclear whether GERD contributes...

    journal_title:Respiratory research

    pub_type: 杂志文章

    doi:10.1186/s12931-020-01469-y

    authors: Baldomero AK,Wendt CH,Petersen A,Gaeckle NT,Han MK,Kunisaki KM,COPDGene Investigators.

    更新日期:2020-08-03 00:00:00

  • Metformin attenuates lung fibrosis development via NOX4 suppression.

    abstract:BACKGROUND:Accumulation of profibrotic myofibroblasts in fibroblastic foci (FF) is a crucial process for development of fibrosis during idiopathic pulmonary fibrosis (IPF) pathogenesis, and transforming growth factor (TGF)-β plays a key regulatory role in myofibroblast differentiation. Reactive oxygen species (ROS) has...

    journal_title:Respiratory research

    pub_type: 杂志文章

    doi:10.1186/s12931-016-0420-x

    authors: Sato N,Takasaka N,Yoshida M,Tsubouchi K,Minagawa S,Araya J,Saito N,Fujita Y,Kurita Y,Kobayashi K,Ito S,Hara H,Kadota T,Yanagisawa H,Hashimoto M,Utsumi H,Wakui H,Kojima J,Numata T,Kaneko Y,Odaka M,Morikawa T,Na

    更新日期:2016-08-30 00:00:00

  • The Tiotropium Safety and Performance in Respimat Trial (TIOSPIR), a large scale, randomized, controlled, parallel-group trial-design and rationale.

    abstract:BACKGROUND:Tiotropium bromide is an effective therapy for COPD patients. Comparing across programs tiotropium Respimat Soft Mist inhaler was at least as efficacious as tiotropium HandiHaler, however, concerns have been raised about tiotropium's safety when given via Respimat. METHODS:The TIOSPIR trial (NCT01126437) co...

    journal_title:Respiratory research

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1186/1465-9921-14-40

    authors: Wise RA,Anzueto A,Calverley P,Dahl R,Dusser D,Pledger G,Koenen-Bergmann M,Joseph E,Cotton D,Disse B

    更新日期:2013-04-02 00:00:00

  • Responses of FEV6, FVC, and FET to inhaled bronchodilator in the adult general population.

    abstract:BACKGROUND:The assessment of bronchodilator-induced change in forced vital capacity (FVC) is dependent on forced expiratory time (FET) in subjects with airflow limitation. Limited information is available on the concurrent responses of FVC, forced expiratory volume in six seconds (FEV6), and FET in the bronchodilation ...

    journal_title:Respiratory research

    pub_type: 杂志文章

    doi:10.1186/1465-9921-10-71

    authors: Kainu A,Lindqvist A,Sarna S,Lundbäck B,Sovijärvi A

    更新日期:2009-07-28 00:00:00

  • Hospitalisation and mortality in patients with comorbid COPD and heart failure: a systematic review and meta-analysis.

    abstract:BACKGROUND:Discrepancy exists amongst studies investigating the effect of comorbid heart failure (HF) on the morbidity and mortality of chronic obstructive pulmonary disease (COPD) patients. METHODS:MEDLINE and Embase were searched using a pre-specified search strategy for studies comparing hospitalisation, rehospital...

    journal_title:Respiratory research

    pub_type: 杂志文章,meta分析

    doi:10.1186/s12931-020-1312-7

    authors: Axson EL,Ragutheeswaran K,Sundaram V,Bloom CI,Bottle A,Cowie MR,Quint JK

    更新日期:2020-02-14 00:00:00

  • Increase in markers of airway inflammation after ozone exposure can be observed also in stable treated asthmatics with minimal functional response to ozone.

    abstract:BACKGROUND:The discrepancy between functional and inflammatory airway response to ozone has been reported in normal subjects, but few data are available for stable asthmatics regularly treated with inhaled corticosteroids. METHODS:Twenty-three well controlled, regularly treated, mild-to-moderate asthmatic patients und...

    journal_title:Respiratory research

    pub_type: 杂志文章,随机对照试验

    doi:10.1186/1465-9921-11-5

    authors: Vagaggini B,Bartoli ML,Cianchetti S,Costa F,Bacci E,Dente FL,Di Franco A,Malagrinò L,Paggiaro P

    更新日期:2010-01-19 00:00:00

  • Pathophysiological classification of chronic rhinosinusitis.

    abstract:BACKGROUND:Recent consensus statements demonstrate the breadth of the chronic rhinosinusitis (CRS) differential diagnosis. However, the classification and mechanisms of different CRS phenotypes remains problematic. METHOD:Statistical patterns of subjective and objective findings were assessed by retrospective chart re...

    journal_title:Respiratory research

    pub_type: 杂志文章

    doi:10.1186/1465-9921-6-149

    authors: Baraniuk JN,Maibach H

    更新日期:2005-12-19 00:00:00

  • Impact of gender on COPD expression in a real-life cohort.

    abstract::Reports regarding gender-related differences in COPD expression have provided conflicting results. In the French Initiatives BPCO real-world cohort, which contained 688 patients (146 women) when data were extracted, women were matched with men (1:3 ratio: n = 107:275) on age (5-year intervals) and FEV1 (5% predicted i...

    journal_title:Respiratory research

    pub_type: 杂志文章

    doi:10.1186/1465-9921-15-20

    authors: Roche N,Deslée G,Caillaud D,Brinchault G,Court-Fortune I,Nesme-Meyer P,Surpas P,Escamilla R,Perez T,Chanez P,Pinet C,Jebrak G,Paillasseur JL,Burgel PR,INITIATIVES BPCO Scientific Committee.

    更新日期:2014-02-17 00:00:00

  • Whole blood RNA sequencing reveals a unique transcriptomic profile in patients with ARDS following hematopoietic stem cell transplantation.

    abstract:BACKGROUND:The acute respiratory distress syndrome (ARDS) is characterized by the acute onset of hypoxemia and bilateral lung infiltrates in response to an inciting event, and is associated with high morbidity and mortality. Patients undergoing allogeneic hematopoietic stem cell transplantation (HSCT) are at increased ...

    journal_title:Respiratory research

    pub_type: 杂志文章

    doi:10.1186/s12931-019-0981-6

    authors: Englert JA,Cho MH,Lamb AE,Shumyatcher M,Barragan-Bradford D,Basil MC,Higuera A,Isabelle C,Vera MP,Dieffenbach PB,Fredenburgh LE,Kang JB,Bhatt AS,Antin JH,Ho VT,Soiffer RJ,Howrylak JA,Himes BE,Baron RM

    更新日期:2019-01-21 00:00:00

  • COVID-19 multidisciplinary high dependency unit: the Milan model.

    abstract::COVID-19 is a complex and heterogeneous disease. The pathogenesis and the complications of the disease are not fully elucidated, and increasing evidence shows that SARS-CoV-2 causes a systemic inflammatory disease rather than a pulmonary disease. The management of hospitalized patients in COVID-19 dedicated units is a...

    journal_title:Respiratory research

    pub_type: 杂志文章,评审

    doi:10.1186/s12931-020-01516-8

    authors: Aliberti S,Amati F,Pappalettera M,Di Pasquale M,D'Adda A,Mantero M,Gramegna A,Simonetta E,Oneta AM,Privitera E,Gori A,Bozzi G,Peyvandi F,Minoia F,Filocamo G,Abbruzzese C,Vicenzi M,Tagliabue P,Alongi S,Blasi F

    更新日期:2020-10-09 00:00:00

  • Estimating the U.S. prevalence of chronic obstructive pulmonary disease using pre- and post-bronchodilator spirometry: the National Health and Nutrition Examination Survey (NHANES) 2007-2010.

    abstract:BACKGROUND:During 2007-2010, the National Health and Nutrition Examination Survey (NHANES) conducted a spirometry component which obtained pre-bronchodilator pulmonary lung function data on a nationally representative sample of US adults aged 6-79 years and post-bronchodilator pulmonary lung function data for the subse...

    journal_title:Respiratory research

    pub_type: 杂志文章

    doi:10.1186/1465-9921-14-103

    authors: Tilert T,Dillon C,Paulose-Ram R,Hnizdo E,Doney B

    更新日期:2013-10-09 00:00:00

  • Airway protease/antiprotease imbalance in atopic asthmatics contributes to increased influenza A virus cleavage and replication.

    abstract::Asthmatics are more susceptible to influenza infections, yet mechanisms mediating this enhanced susceptibility are unknown. Influenza virus hemagglutinin (HA) protein binds to sialic acid residues on the host cells. HA requires cleavage to allow fusion of the viral HA with host cell membrane, which is mediated by host...

    journal_title:Respiratory research

    pub_type: 信件

    doi:10.1186/1465-9921-13-82

    authors: Kesic MJ,Hernandez M,Jaspers I

    更新日期:2012-09-19 00:00:00

  • Understanding alveolarization to induce lung regeneration.

    abstract:BACKGROUND:Gas exchange represents the key physiological function of the lung, and is dependent upon proper formation of the delicate alveolar structure. Malformation or destruction of the alveolar gas-exchange regions are key histopathological hallmarks of diseases such as bronchopulmonary dysplasia (BPD), chronic obs...

    journal_title:Respiratory research

    pub_type: 杂志文章,评审

    doi:10.1186/s12931-018-0837-5

    authors: Rodríguez-Castillo JA,Pérez DB,Ntokou A,Seeger W,Morty RE,Ahlbrecht K

    更新日期:2018-08-06 00:00:00

  • Predictive factors of severe coronavirus disease 2019 in previously healthy young adults: a single-center, retrospective study.

    abstract:BACKGROUND:Several previously healthy young adults have developed Coronavirus Disease 2019 (COVID-19), and a few of them progressed to the severe stage. However, the factors are not yet determined. METHOD:We retrospectively analyzed 123 previously healthy young adults diagnosed with COVID-19 from January to March 2020...

    journal_title:Respiratory research

    pub_type: 杂志文章

    doi:10.1186/s12931-020-01412-1

    authors: Zhou C,Huang Z,Tan W,Li X,Yin W,Xiao Y,Tao Z,Geng S,Hu Y

    更新日期:2020-06-22 00:00:00