Abstract:
BACKGROUND:Pentraxin 3 (PTX3) regulates multiple aspects of innate immunity and tissue inflammation. Recently, it has been reported that PTX3 deficiency enhances interleukin (IL)-17A-dominant pulmonary inflammation in an ovalbumin (OVA)-induced mouse asthma model. However, whether PTX3 treatment would provide protection against allergic airway inflammation has not been clearly elucidated. The goal of this study was to further investigate the effect of recombinant PTX3 administration on the phenotype of asthma. METHODS:C57BL/6 J mice were sensitized and challenged with OVA to induce eosinophilic asthma model, as well as sensitized with OVA plus LPS and challenged with OVA to induce neutrophilic asthma model. We evaluated effect of recombinant PTX3 on asthma phenotype through both asthma models. The bronchoalveolar lavage fluid (BALF) inflammatory cells and cytokines, airway hyperresponsiveness, and pathological alterations of the lung tissues were assessed. RESULTS:In both eosinophilic and neutrophilic asthma models, PTX3 treatment provoked airway hyperresponsiveness, concomitant with increased inflammatory cytokines IL-4, IL-17, eotaxin, and transforming growth factor (TGF)-β1 and aggravated airway accumulation of inflammatory cells, especially eosinophils and neutrophils. In histological analysis of the lung tissue, administration of PTX3 promoted inflammatory cells infiltration, mucus production, and collagen deposition. In addition, PTX3 also significantly enhanced STAT3 phosphorylation in lung tissue. CONCLUSION:Our results show that exogenous PTX3 can exacerbate multiple asthmatic features by promoting both eosinophils and neutrophils lung infiltration and provide new evidence to better understand the complex role of PTX3 in allergic airway inflammation.
journal_name
Respir Resjournal_title
Respiratory researchauthors
Gao P,Tang K,Lu Y,Huang Z,Wang S,Wang M,Wang J,Zhao J,Xie Jdoi
10.1186/s12931-020-01499-6subject
Has Abstractpub_date
2020-09-16 00:00:00pages
237issue
1eissn
1465-9921issn
1465-993Xpii
10.1186/s12931-020-01499-6journal_volume
21pub_type
杂志文章abstract:BACKGROUND:We have previously shown that vitamin D deficiency has a detrimental impact on lung development. In this study, we aimed to identify the mechanisms linking vitamin D with lung development using a mouse model of dietary manipulation. METHODS:Female offspring were euthanized at different time-points; embryoni...
journal_title:Respiratory research
pub_type: 杂志文章
doi:10.1186/s12931-016-0362-3
更新日期:2016-04-27 00:00:00
abstract:BACKGROUND:Alpha-1-Antitrypsin (AAT) deficiency (AATD) is a hereditary disorder that manifests primarily as pulmonary emphysema and liver cirrhosis. The clinically most relevant mutation causing AATD is a single nucleotide polymorphism Glu342Lys (Z-mutation). Despite the recommendation to test every COPD patient, the c...
journal_title:Respiratory research
pub_type: 杂志文章,多中心研究
doi:10.1186/s12931-018-0826-8
更新日期:2018-08-13 00:00:00
abstract:BACKGROUND:Inflammation may contribute to the pathogenesis of various forms of pulmonary hypertension (PH). Recent studies in patients with idiopathic PH or PH associated with underlying diseases suggest a role for interleukin-6 (IL-6). METHODS:To determine whether endogenous IL-6 contributes to mediate hypoxic PH and...
journal_title:Respiratory research
pub_type: 杂志文章
doi:10.1186/1465-9921-10-6
更新日期:2009-01-27 00:00:00
abstract::Extracellular vesicles (EVs) are cell-derived membranous vesicles secreted by cells into the extracellular space, which play a role in cell to cell communication. EVs are categorized into 3 groups depending on their size, surface marker, and method of release from the host cell. Recently, EVs have become of interest i...
journal_title:Respiratory research
pub_type: 杂志文章,评审
doi:10.1186/s12931-019-1210-z
更新日期:2019-10-30 00:00:00
abstract:RATIONALE:We had shown that COPD women expressed more dyspnea than men for the same degree of airway obstruction. OBJECTIVES:Evaluate gender differences in respiratory factors associated with dyspnea in COPD patients. METHODS:In a FEV1 % matched population of 100 men and women with COPD we measured: age, MMRC, FEV1, ...
journal_title:Respiratory research
pub_type: 杂志文章
doi:10.1186/1465-9921-8-18
更新日期:2007-03-06 00:00:00
abstract:BACKGROUND:Resident stem and progenitor cells have been identified in the lung over the last decade, but isolation and culture of these cells remains a challenge. Thus, although these lung stem and progenitor cells provide an ideal source for stem-cell based therapy, mesenchymal stem cells (MSCs) remain the most popula...
journal_title:Respiratory research
pub_type: 杂志文章
doi:10.1186/s12931-017-0611-0
更新日期:2017-06-30 00:00:00
abstract:BACKGROUND:Possible variation in bronchodilator response (BDR) according to age at the diagnosis of adult-onset asthma is unknown. Our aim was to assess if BDR in FEV1 is related to age at diagnosis of adult-onset asthma and how many subjects fulfill the 400 mL criterion of BDR, the suggested cut-off for asthma-like re...
journal_title:Respiratory research
pub_type: 杂志文章
doi:10.1186/s12931-020-01441-w
更新日期:2020-07-13 00:00:00
abstract:BACKGROUND:Myofibroblasts, proposed as being derived from circulating fibrocytes, are considered to be important cells in thickening of the basement membrane in patients with asthma. We have studied the correlation of tissue fibrocyte levels to basement membrane thickness and the presence of fibrocytes in bronchoalveol...
journal_title:Respiratory research
pub_type: 杂志文章
doi:10.1186/1465-9921-7-50
更新日期:2006-03-29 00:00:00
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journal_title:Respiratory research
pub_type: 杂志文章
doi:10.1186/s12931-017-0551-8
更新日期:2017-04-20 00:00:00
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journal_title:Respiratory research
pub_type: 杂志文章,meta分析
doi:10.1186/s12931-019-1209-5
更新日期:2019-10-29 00:00:00
abstract:BACKGROUND:The relative contributions of the cytotoxic phenotype of P. aeruginosa expressing type III secretory toxins and an immunocompromised condition lacking normal Toll-like receptor 4 (TLR4) signaling in the pathogenesis of acute lung injury and sepsis were evaluated in a mouse model for Pseudomonas aeruginosa pn...
journal_title:Respiratory research
pub_type: 杂志文章
doi:10.1186/1465-9921-5-1
更新日期:2004-02-12 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2018-08-06 00:00:00
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journal_title:Respiratory research
pub_type: 杂志文章,评审
doi:10.1186/s12931-019-0980-7
更新日期:2019-01-18 00:00:00
abstract:BACKGROUND:The differential diagnosis of tuberculous pleural effusion (TPE) is challenging. In recent years, artificial intelligence (AI) machine learning algorithms have started being used to an increasing extent in disease diagnosis due to the high level of efficiency, objectivity, and accuracy that they offer. METH...
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pub_type: 杂志文章
doi:10.1186/s12931-019-1197-5
更新日期:2019-10-16 00:00:00
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journal_title:Respiratory research
pub_type: 杂志文章,评审
doi:10.1186/rr33
更新日期:2001-01-01 00:00:00
abstract::The attraction of leukocytes from circulation to inflamed lungs depends on the activation of both the leukocytes and the resident cells within the lung. In this study we determined gene expression and secretion patterns for monocyte chemoattractant protein-1 (MCP-1/CCL2) and T-cell specific CXCR3 agonistic chemokines ...
journal_title:Respiratory research
pub_type: 杂志文章
doi:10.1186/1465-9921-6-75
更新日期:2005-07-20 00:00:00
abstract:BACKGROUND:Cognitive impairment has been found in chronic obstructive pulmonary disease (COPD) patients. However, the structural alteration of the brain and underlying mechanisms are poorly understood. METHODS:Thirty-seven mild-to-moderate COPD patients, forty-eight severe COPD patients, and thirty-one control subject...
journal_title:Respiratory research
pub_type: 杂志文章
doi:10.1186/1465-9921-14-140
更新日期:2013-12-21 00:00:00
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pub_type: 杂志文章
doi:10.1186/s12931-020-01588-6
更新日期:2020-12-10 00:00:00
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journal_title:Respiratory research
pub_type: 临床试验,杂志文章
doi:10.1186/1465-9921-6-95
更新日期:2005-08-16 00:00:00
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pub_type: 杂志文章
doi:10.1186/1465-9921-10-62
更新日期:2009-07-03 00:00:00
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doi:10.1186/1465-9921-14-3
更新日期:2013-01-09 00:00:00
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pub_type: 杂志文章
doi:10.1186/s12931-016-0462-0
更新日期:2016-11-16 00:00:00
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pub_type: 杂志文章
doi:10.1186/s12931-016-0408-6
更新日期:2016-07-26 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2010-11-23 00:00:00
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pub_type: 杂志文章
doi:10.1186/s12931-018-0774-3
更新日期:2018-04-27 00:00:00
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journal_title:Respiratory research
pub_type: 杂志文章
doi:10.1186/s12931-020-1297-2
更新日期:2020-01-28 00:00:00
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journal_title:Respiratory research
pub_type: 杂志文章
doi:10.1186/1465-9921-13-63
更新日期:2012-07-31 00:00:00
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journal_title:Respiratory research
pub_type: 杂志文章
doi:10.1186/s12931-014-0161-7
更新日期:2015-01-09 00:00:00
abstract:BACKGROUND:Several small molecule corrector and potentiator drugs have recently been licensed for Cystic Fibrosis (CF) therapy. However, other aspects of the disease, especially inflammation, are less effectively treated by these drugs. We hypothesized that small molecule drugs could function either alone or as an adju...
journal_title:Respiratory research
pub_type: 杂志文章
doi:10.1186/s12931-019-1214-8
更新日期:2019-12-21 00:00:00
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journal_title:Respiratory research
pub_type: 杂志文章
doi:10.1186/s12931-018-0798-8
更新日期:2018-05-10 00:00:00