Abstract:
BACKGROUND:Evidence suggests that dendritic cells accumulate in the lungs of COPD patients and correlate with disease severity. We investigated the importance of IL-1R1 and its ligands IL-1α and β to dendritic cell accumulation and maturation in response to cigarette smoke exposure. METHODS:Mice were exposed to cigarette smoke using a whole body smoke exposure system. IL-1R1-, TLR4-, and IL-1α-deficient mice, as well as anti-IL-1α and anti-IL-1β blocking antibodies were used to study the importance of IL-1R1 and TLR4 to dendritic cell accumulation and activation. RESULTS:Acute and chronic cigarette smoke exposure led to increased frequency of lung dendritic cells. Accumulation and activation of dendritic cells was IL-1R1/IL-1α dependent, but TLR4- and IL-1β-independent. Corroborating the cellular data, expression of CCL20, a potent dendritic cells chemoattractant, was IL-1R1/IL-1α-dependent. Studies using IL-1R1 bone marrow-chimeric mice revealed the importance of IL-1R1 signaling on lung structural cells for CCL20 expression. Consistent with the importance of dendritic cells in T cell activation, we observed decreased CD4+ and CD8+ T cell activation in cigarette smoke-exposed IL-1R1-deficient mice. CONCLUSION:Our findings convey the importance of IL-1R1/IL-1α to the recruitment and activation of dendritic cells in response to cigarette smoke exposure.
journal_name
Respir Resjournal_title
Respiratory researchauthors
Botelho FM,Nikota JK,Bauer CM,Morissette MC,Iwakura Y,Kolbeck R,Finch D,Humbles AA,Stämpfli MRdoi
10.1186/1465-9921-13-81subject
Has Abstractpub_date
2012-09-19 00:00:00pages
81eissn
1465-9921issn
1465-993Xpii
1465-9921-13-81journal_volume
13pub_type
杂志文章abstract:BACKGROUND:The role of the microbiota in the pathogenesis of chronic obstructive pulmonary disease (COPD) following exposure to ambient particulate matter (PM) is largely unknown. METHODS:Fifty-four male Sprague-Dawley rats were exposed to clean air, biomass fuel (BMF), or motor vehicle exhaust (MVE) for 4, 12, and 24...
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pub_type: 杂志文章
doi:10.1186/s12931-020-01529-3
更新日期:2020-10-19 00:00:00
abstract:BACKGROUND:Little is known about the factors associated with CT-quantified emphysema progression in heavy smokers. The objective of this study was to investigate the effect of length of smoking cessation and clinical / demographical factors on the rate of emphysema progression and FEV1-decline in male heavy smokers. M...
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pub_type: 杂志文章,随机对照试验
doi:10.1186/1465-9921-14-55
更新日期:2013-05-20 00:00:00
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pub_type: 杂志文章
doi:10.1186/1465-9921-11-136
更新日期:2010-10-05 00:00:00
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doi:10.1186/1465-9921-8-75
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doi:10.1186/s12931-019-1149-0
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pub_type: 社论
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pub_type: 杂志文章
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更新日期:2011-07-05 00:00:00
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journal_title:Respiratory research
pub_type: 杂志文章,多中心研究,随机对照试验
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pub_type: 杂志文章
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abstract:: ...
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pub_type: 社论
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更新日期:2018-11-26 00:00:00
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pub_type: 临床试验,杂志文章
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更新日期:2019-03-01 00:00:00
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doi:10.1186/s12931-017-0591-0
更新日期:2017-06-27 00:00:00
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pub_type: 杂志文章
doi:10.1186/s12931-020-01442-9
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pub_type: 杂志文章
doi:10.1186/1465-9921-6-128
更新日期:2005-11-01 00:00:00
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journal_title:Respiratory research
pub_type: 杂志文章
doi:10.1186/1465-9921-13-99
更新日期:2012-11-08 00:00:00
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pub_type: 杂志文章
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更新日期:2016-11-16 00:00:00
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pub_type: 杂志文章
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更新日期:2018-04-07 00:00:00
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journal_title:Respiratory research
pub_type: 杂志文章,多中心研究
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更新日期:2018-11-20 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2019-07-08 00:00:00
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journal_title:Respiratory research
pub_type: 杂志文章,随机对照试验
doi:10.1186/1465-9921-14-125
更新日期:2013-11-14 00:00:00
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journal_title:Respiratory research
pub_type: 杂志文章,随机对照试验
doi:10.1186/1465-9921-5-19
更新日期:2004-11-04 00:00:00
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pub_type: 杂志文章,评审
doi:10.1186/s12931-019-1210-z
更新日期:2019-10-30 00:00:00
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journal_title:Respiratory research
pub_type: 杂志文章,评审
doi:10.1186/rr177
更新日期:2002-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:2015-11-16 00:00:00