The Electrophysiological Determinants of Corticospinal Motor Neuron Vulnerability in ALS.

abstract：:Mitochondria are key organelles in regulating the metabolic state of a cell. In the brain, mitochondrial oxidative metabolism is the prevailing mechanism for neurons to generate ATP. While it is firmly established that neuronal function is highly dependent on mitochondrial metabolism, it is less well-understood how as...

journal_title：Frontiers in molecular neuroscience

authors： Fiebig C,Keiner S,Ebert B,Schäffner I,Jagasia R,Lie DC,Beckervordersandforth R

更新日期：2019-02-22 00:00:00

abstract：:The ubiquitin proteasome system (UPS) is crucial for intracellular protein homeostasis and for degradation of aberrant and damaged proteins. The accumulation of ubiquitinated proteins is a hallmark of many neurodegenerative diseases, including amyotrophic lateral sclerosis, Alzheimer's, Parkinson's, and Huntington's d...

journal_title：Frontiers in molecular neuroscience

authors： Jansen AH,Reits EA,Hol EM

更新日期：2014-08-08 00:00:00

abstract：:Stroke results in high morbidity and high mortality worldwide, with ischemic stroke accounting for 80% to 85%. As effective treatments for ischemic stroke remain limited because of the narrow therapeutic time window, a better understanding of the pathologic mechanism and new therapeutic intervention targets are needed...

journal_title：Frontiers in molecular neuroscience

authors： Chen R,Xu X,Huang L,Zhong W,Cui L

更新日期：2019-03-22 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) and spinal and bulbar muscular atrophy (SBMA) are two motoneuron diseases (MNDs) characterized by aberrant protein behavior in affected cells. In familial ALS (fALS) and in SBMA specific gene mutations lead to the production of neurotoxic proteins or peptides prone to misfold, which...

journal_title：Frontiers in molecular neuroscience

authors： Rusmini P,Cristofani R,Galbiati M,Cicardi ME,Meroni M,Ferrari V,Vezzoli G,Tedesco B,Messi E,Piccolella M,Carra S,Crippa V,Poletti A

更新日期：2017-06-21 00:00:00

abstract：:Collateral sprouting of surviving axons contributes to the synaptic reorganization after brain injury. To study this clinically relevant phenomenon, we used complex organotypic tissue cultures of mouse entorhinal cortex (EC) and hippocampus (H). Single EC-H cultures were generated to analyze associational sprouting, a...

journal_title：Frontiers in molecular neuroscience

authors： Del Turco D,Paul MH,Beeg Moreno VJ,Hildebrandt-Einfeldt L,Deller T

更新日期：2019-11-12 00:00:00

abstract：:Alzheimer's disease (AD) is a widely distributed neurodegenerative disease characterized clinically by cognitive deficits and pathologically by formation of amyloid-β (Aβ) plaque and neurofibrillary tangles (NFTs) in the brain. Vanadium is a biological trace element that has a function to mimic insulin for diabetes. B...

journal_title：Frontiers in molecular neuroscience

authors： He Z,Han S,Zhu H,Hu X,Li X,Hou C,Wu C,Xie Q,Li N,Du X,Ni J,Liu Q

更新日期：2020-03-10 00:00:00

abstract：:Ischemic stroke is one of the most common causes of death and disability worldwide. Neuroinflammation is a major pathological event involved in the process of ischemic injury and repair. In particular, microglia play a dual role in neuroinflammation. During the acute phase of stroke onset, M2 microglia are the dominan...

journal_title：Frontiers in molecular neuroscience

authors： Lian L,Zhang Y,Liu L,Yang L,Cai Y,Zhang J,Xu S

更新日期：2021-01-07 00:00:00

abstract：:The bioactive lipid sphingosine-1-phosphate (S1P) is an important regulator in the nervous system. Here, we explored the role of S1P and its receptors in vitro and in preclinical models of peripheral nerve regeneration. Adult sensory neurons and motor neuron-like cells were exposed to S1P in an in vitro assay, and vir...

journal_title：Frontiers in molecular neuroscience

authors： Quarta S,Camprubí-Robles M,Schweigreiter R,Matusica D,Haberberger RV,Proia RL,Bandtlow CE,Ferrer-Montiel A,Kress M

更新日期：2017-10-10 00:00:00

abstract：:The tetrameric capsaicin receptor transient receptor potential vanilloid 1 (TRPV1) in mammals has evolved the capability to integrate pain signal arising from harmful temperature and chemical irritants. The four repetitions of TRPV1 subunits result in an ion channel with excellent pain sensitivity, allowing this ionot...

journal_title：Frontiers in molecular neuroscience

authors： Liu TY,Chu Y,Mei HR,Chang D,Chuang HH

更新日期：2020-01-09 00:00:00

abstract：:Caenorhabditis elegans somatic protein homeostasis (proteostasis) is actively remodeled at the onset of reproduction. This proteostatic collapse is regulated cell-nonautonomously by signals from the reproductive system that transmit the commitment to reproduction to somatic cells. Here, we asked whether the link betwe...

journal_title：Frontiers in molecular neuroscience

authors： Shemesh N,Shai N,Meshnik L,Katalan R,Ben-Zvi A

更新日期：2017-04-20 00:00:00

abstract：:The ubiquitous metabolic intermediary and nucleoside adenosine is a "master regulator" in all living systems. Under baseline conditions adenosine kinase (ADK) is the primary enzyme for the metabolic clearance of adenosine. By regulating the availability of adenosine, ADK is a critical upstream regulator of complex hom...

journal_title：Frontiers in molecular neuroscience

authors： Kiese K,Jablonski J,Boison D,Kobow K

更新日期：2016-10-20 00:00:00

abstract：:Neurosensory responses of hearing and balance are mediated by receptors in specialized neuroepithelial sensory cells. Any disruption of the biochemical and molecular pathways that facilitate these responses can result in severe deficits, including hearing loss and vestibular dysfunction. Hearing is affected by both en...

journal_title：Frontiers in molecular neuroscience

authors： Mittal R,Nguyen D,Patel AP,Debs LH,Mittal J,Yan D,Eshraghi AA,Van De Water TR,Liu XZ

更新日期：2017-07-31 00:00:00

abstract：:Increasing evidence highlighted the role of cancer stem cells (CSCs) in the development of tumor resistance to therapy, particularly in glioblastoma (GBM). Therefore, the development of new therapies, specifically directed against GBM CSCs, constitutes an important research avenue. Considering the extended range of ca...

journal_title：Frontiers in molecular neuroscience

authors： Angeletti F,Fossati G,Pattarozzi A,Würth R,Solari A,Daga A,Masiello I,Barbieri F,Florio T,Comincini S

更新日期：2016-10-27 00:00:00

abstract：:Microglia are the innate sentinels of the central nervous system (CNS) and are responsible for the homeostasis and immune defense of the CNS. Under the influence of the local environment and cell-cell interaction, microglia exhibit a multidimensional and context-dependent phenotypes that can be cytotoxic and neuroprot...

journal_title：Frontiers in molecular neuroscience

authors： Siew JJ,Chern Y

更新日期：2018-05-14 00:00:00

abstract：:Growth of postmitotic neurons occurs during different stages of development, including metamorphosis, and may also be part of neuronal plasticity and regeneration. Recently we showed that growth of post-mitotic neuroendocrine cells expressing the basic helix loop helix (bHLH) transcription factor Dimmed (Dimm) in Dros...

journal_title：Frontiers in molecular neuroscience

authors： Liu Y,Luo J,Nässel DR

更新日期：2016-10-13 00:00:00

abstract：:The basic helix-loop-helix (bHLH) protein family has previously been shown to be involved in the development of mesodiencephalic dopaminergic (mdDA) neurons in the murine midbrain. Specifically, Ngn2 and Mash1 are known to have a role in the specification of neural progenitors in the ventricular zone (VZ) of the midbr...

journal_title：Frontiers in molecular neuroscience

authors： Mesman S,Smidt MP

更新日期：2017-11-01 00:00:00

abstract：:Phosphatase and tensin homolog (PTEN)-induced putative kinase 1 (PINK1) is a gatekeeper of mitochondrial quality control. The present study was aimed to examine whether PINK1 possesses a protective function against gentamicin (GM)-induced sensory hair cell (HC) damage in vitro. The formation of parkin particles (a mar...

journal_title：Frontiers in molecular neuroscience

authors： Yang Q,Zhou Y,Yin H,Li H,Zhou M,Sun G,Cao Z,Man R,Wang H,Li J

更新日期：2018-11-12 00:00:00

abstract：:[This corrects the article on p. 116 in vol. 9, PMID: 27867348.]. ...

journal_title：Frontiers in molecular neuroscience

authors： Jackson KL,Dayton RD,Deverman BE,Klein RL

更新日期：2016-12-22 00:00:00

abstract：:Kainate (KA) is a potent neurotoxin that has been widely used experimentally to induce acute brain seizures and, after repetitive treatments, as a chronic model of temporal lobe epilepsy (TLE), with similar features to those observed in human patients with TLE. However, whether KA activates KA receptors (KARs) as an a...

journal_title：Frontiers in molecular neuroscience

authors： Falcón-Moya R,Sihra TS,Rodríguez-Moreno A

更新日期：2018-06-22 00:00:00

abstract：:Control of proper protein synthesis, function, and turnover is essential for the health of all cells. In neurons these demands take on the additional importance of supporting and regulating the highly dynamic connections between neurons that are necessary for cognitive function, learning, and memory. Regulating multip...

journal_title：Frontiers in molecular neuroscience

authors： Atkin G,Paulson H

更新日期：2014-07-08 00:00:00

abstract：:The dorsal root ganglion (DRG) contains heterogeneous populations of sensory neurons including primary nociceptive neurons and C-fibers implicated in pain signaling. Recent studies have demonstrated DRG hyperexcitability associated with downregulation of A-type K(+) channels; however, the molecular correlate of the co...

journal_title：Frontiers in molecular neuroscience

authors： Phuket TR,Covarrubias M

更新日期：2009-07-07 00:00:00

abstract：:Blast induced neurotrauma (BINT) is a prevalent injury within military and civilian populations. The injury is characterized by persistent inflammation at the cellular level which manifests as a multitude of cognitive and functional impairments. Epigenetic regulation of transcription offers an important control mechan...

journal_title：Frontiers in molecular neuroscience

authors： Bailey ZS,Grinter MB,VandeVord PJ

更新日期：2016-08-08 00:00:00

abstract：:It is widely accepted that glutamate is the most important excitatory neurotransmitter in the central nervous system (CNS). However, there is also a large amount of glutamate in the blood. Generally, the concentration gradient of glutamate between intraparenchymal and blood environments is stable. However, this gradie...

journal_title：Frontiers in molecular neuroscience

authors： Bai W,Zhou YG

更新日期：2017-12-05 00:00:00

abstract：:The neuromuscular junction (NMJ) is the chemical synapse connecting motor neurons and skeletal muscle fibers. NMJs allow all voluntary movements, and ensure vital functions like breathing. Changes in the structure and function of NMJs are hallmarks of numerous pathological conditions that affect muscle function includ...

journal_title：Frontiers in molecular neuroscience

authors： Castets P,Ham DJ,Rüegg MA

更新日期：2020-08-28 00:00:00

abstract：:Neuroblastoma, the major cause of infant cancer deaths, results from fast proliferation of undifferentiated neuroblasts. Treatment of high-risk neuroblastoma includes differentiation with retinoic acid (RA); however, the resistance of many of these tumors to RA-induced differentiation poses a considerable challenge. H...

journal_title：Frontiers in molecular neuroscience

authors： Kasim M,Heß V,Scholz H,Persson PB,Fähling M

更新日期：2016-12-21 00:00:00

abstract：:Inflammation contributes to cognitive impairment in patients with hepatic encephalopathy (HE). However, the process by which peripheral inflammation results in cognitive impairment remains unclear. In animal models, neuroinflammation and altered neurotransmission mediate cognitive impairment. Taking into account these...

journal_title：Frontiers in molecular neuroscience

authors： Dadsetan S,Balzano T,Forteza J,Cabrera-Pastor A,Taoro-Gonzalez L,Hernandez-Rabaza V,Gil-Perotín S,Cubas-Núñez L,García-Verdugo JM,Agusti A,Llansola M,Felipo V

更新日期：2016-11-02 00:00:00

abstract：:N-methyl-D-aspartate receptors (NMDARs) play critical roles in both excitatory neurotransmission and synaptic plasticity. NMDARs containing the nonconventional GluN3A subunit have different functional properties compared to receptors comprised of GluN1/GluN2 subunits. Previous studies showed that GluN1/GluN2 receptors...

journal_title：Frontiers in molecular neuroscience

authors： Skrenkova K,Lee S,Lichnerova K,Kaniakova M,Hansikova H,Zapotocky M,Suh YH,Horak M

更新日期：2018-06-04 00:00:00

abstract：:Emerging studies have demonstrated that interleukin (IL)-33 and its receptor ST2 act as key factors in inflammatory diseases. Moreover, accumulating evidence has suggested that cytokines, including tumor necrosis factor (TNF)-α and IL-1β, trigger an inflammatory cascade. SIRT1 has been shown to suppress the expression...

journal_title：Frontiers in molecular neuroscience

authors： Zeng Y,Shi Y,Zhan H,Liu W,Cai G,Zhong H,Wang Y,Chen S,Huang S,Wu W

更新日期：2020-02-12 00:00:00

abstract：:Long non-coding RNAs (lncRNAs) have emerged as an important regulatory control in biological systems. Though the field of lncRNA has been progressing rapidly, a complete understanding of the role of lncRNAs in neuroblastoma pathogenesis is still lacking. To identify the abrogated lncRNAs in primary neuroblastoma and i...

journal_title：Frontiers in molecular neuroscience

authors： Prajapati B,Fatma M,Fatima M,Khan MT,Sinha S,Seth PK

更新日期：2019-12-12 00:00:00

abstract：:γ-Aminobutyric acid type A receptors (GABAARs) mediate the majority of fast synaptic inhibition in the central nervous system (CNS). GABAARs belong to the Cys-loop superfamily of pentameric ligand-gated ion channels (pLGIC) and are assembled from 19 different subunits. As dysfunctional GABAergic neurotransmission mani...

journal_title：Frontiers in molecular neuroscience

authors： Kasaragod VB,Schindelin H

更新日期：2019-08-07 00:00:00