The Role of the Heat Shock Protein B8 (HSPB8) in Motoneuron Diseases.

abstract：:Mitochondrial dysfunction is a prominent trait of cellular decline during aging and intimately linked to neuronal degeneration during Parkinson's disease (PD). Various proteins associated with PD have been shown to differentially impact mitochondrial dynamics, quality control and function, including the leucine-rich r...

journal_title：Frontiers in molecular neuroscience

authors： Aufschnaiter A,Kohler V,Walter C,Tosal-Castano S,Habernig L,Wolinski H,Keller W,Vögtle FN,Büttner S

更新日期：2018-06-21 00:00:00

abstract：:Fragile X syndrome (FXS) is the most common form of inherited intellectual disability. It is caused by the overexpansion of cytosine-guanine-guanine (CGG) trinucleotide in Fmr1 gene, resulting in complete loss of the fragile X mental retardation protein (FMRP). Previous studies using Fmr1 knockout (Fmr1 KO) mice have ...

journal_title：Frontiers in molecular neuroscience

authors： Yau SY,Bettio L,Chiu J,Chiu C,Christie BR

更新日期：2019-01-17 00:00:00

abstract：:Stromal interaction molecules (STIMs), including STIM1 and STIM2, are single-pass transmembrane proteins that are located predominantly in the endoplasmic reticulum (ER). They serve as calcium ion (Ca2+) sensors within the ER. In the central nervous system (CNS), they are involved mainly in Orai-mediated store-operate...

journal_title：Frontiers in molecular neuroscience

authors： Serwach K,Gruszczynska-Biegala J

更新日期：2020-12-23 00:00:00

abstract：:GABAergic inhibitory neurotransmission contributes to diverse aspects of brain development and adult plasticity, including the expression of complex cognitive processes. This is afforded for in part by the dynamic adaptations occurring at inhibitory synapses, which show great heterogeneity both in terms of upstream si...

journal_title：Frontiers in molecular neuroscience

authors： Campbell BFN,Tyagarajan SK

更新日期：2019-08-13 00:00:00

abstract：:Cell-to-cell communication is essential for the organization, coordination, and development of cellular networks and multi-cellular systems. Intercellular communication is mediated by soluble factors (including growth factors, neurotransmitters, and cytokines/chemokines), gap junctions, exosomes and recently described...

journal_title：Frontiers in molecular neuroscience

authors： Ariazi J,Benowitz A,De Biasi V,Den Boer ML,Cherqui S,Cui H,Douillet N,Eugenin EA,Favre D,Goodman S,Gousset K,Hanein D,Israel DI,Kimura S,Kirkpatrick RB,Kuhn N,Jeong C,Lou E,Mailliard R,Maio S,Okafo G,Osswald M,

更新日期：2017-10-17 00:00:00

abstract：:Neurodevelopmental disorders (NDDs) are characterized by a wide range of symptoms including delayed speech, intellectual disability, motor dysfunction, social deficits, breathing problems, structural abnormalities, and epilepsy. Unfortunately, current treatment strategies are limited and innovative new approaches are ...

journal_title：Frontiers in molecular neuroscience

authors： Fisher NM,Seto M,Lindsley CW,Niswender CM

更新日期：2018-10-23 00:00:00

abstract：:The ubiquitous metabolic intermediary and nucleoside adenosine is a "master regulator" in all living systems. Under baseline conditions adenosine kinase (ADK) is the primary enzyme for the metabolic clearance of adenosine. By regulating the availability of adenosine, ADK is a critical upstream regulator of complex hom...

journal_title：Frontiers in molecular neuroscience

authors： Kiese K,Jablonski J,Boison D,Kobow K

更新日期：2016-10-20 00:00:00

abstract：:Cell signaling in response to an array of diverse stress stimuli converges on the phosphorylation of eukaryotic initiation factor-2α (eIF2α). Evidence is accumulating that persistent eIF2α phosphorylation at Ser51 through prolonged overactivation of regulatory kinases occurs in neurodegenerative diseases such as Alzhe...

journal_title：Frontiers in molecular neuroscience

authors： Ohno M

更新日期：2014-04-16 00:00:00

abstract：:Mitochondria are key organelles in regulating the metabolic state of a cell. In the brain, mitochondrial oxidative metabolism is the prevailing mechanism for neurons to generate ATP. While it is firmly established that neuronal function is highly dependent on mitochondrial metabolism, it is less well-understood how as...

journal_title：Frontiers in molecular neuroscience

authors： Fiebig C,Keiner S,Ebert B,Schäffner I,Jagasia R,Lie DC,Beckervordersandforth R

更新日期：2019-02-22 00:00:00

abstract：:The low-density lipoprotein receptor-related protein 1, LRP1, interacts with APP and affects its processing. This is assumed to be mostly caused by the impact of LRP1 on APP endocytosis. More recently, also an interaction of APP and LRP1 early in the secretory pathway was reported whereat retention of LRP1 in the ER l...

journal_title：Frontiers in molecular neuroscience

authors： Herr UM,Strecker P,Storck SE,Thomas C,Rabiej V,Junker A,Schilling S,Schmidt N,Dowds CM,Eggert S,Pietrzik CU,Kins S

更新日期：2017-04-27 00:00:00

abstract：:Many human neurodegenerative diseases are associated with amyloid fibril formation. Inhibition of amyloid formation is of importance for therapeutics of the related diseases. However, the development of selective potent amyloid inhibitors remains challenging. Here based on the structures of amyloid β (Aβ) fibrils and ...

journal_title：Frontiers in molecular neuroscience

authors： Lu J,Cao Q,Wang C,Zheng J,Luo F,Xie J,Li Y,Ma X,He L,Eisenberg D,Nowick J,Jiang L,Li D

更新日期：2019-03-04 00:00:00

abstract：:Spinal cord injury (SCI) causes the death of neurons and glial cells due to the initial mechanical forces (i.e., primary injury) and through a cascade of secondary molecular events (e.g., inflammation or excitotoxicity) that exacerbate cell death. The loss of neurons and glial cells that are not replaced after the inj...

journal_title：Frontiers in molecular neuroscience

authors： Sobrido-Cameán D,Barreiro-Iglesias A

更新日期：2018-04-03 00:00:00

abstract：:Inflammation contributes to cognitive impairment in patients with hepatic encephalopathy (HE). However, the process by which peripheral inflammation results in cognitive impairment remains unclear. In animal models, neuroinflammation and altered neurotransmission mediate cognitive impairment. Taking into account these...

journal_title：Frontiers in molecular neuroscience

authors： Dadsetan S,Balzano T,Forteza J,Cabrera-Pastor A,Taoro-Gonzalez L,Hernandez-Rabaza V,Gil-Perotín S,Cubas-Núñez L,García-Verdugo JM,Agusti A,Llansola M,Felipo V

更新日期：2016-11-02 00:00:00

abstract：:The molecular mechanisms underlying plastic changes in the strength and connectivity of excitatory synapses have been studied extensively for the past few decades and remain the most attractive cellular models of learning and memory. One of the major mechanisms that regulate synaptic plasticity is the dynamic adjustme...

journal_title：Frontiers in molecular neuroscience

authors： Widagdo J,Guntupalli S,Jang SE,Anggono V

更新日期：2017-10-26 00:00:00

abstract：:Parkinson's disease (PD) is a debilitating neurodegenerative disease characterized primarily by the selective death of dopaminergic (DA) neurons in the substantia nigra pars compacta of the midbrain. Although several genetic forms of PD have been identified, the precise molecular mechanisms underlying DA neuron loss i...

journal_title：Frontiers in molecular neuroscience

authors： Heman-Ackah SM,Hallegger M,Rao MS,Wood MJ

更新日期：2013-11-20 00:00:00

abstract：:Ion channels are expressed throughout nervous system development. The type and diversity of conductances and gating mechanisms vary at different developmental stages and with the progressive maturational status of neural cells. The variety of ion channels allows for distinct signaling mechanisms in developing neural c...

journal_title：Frontiers in molecular neuroscience

authors： Goyal R,Spencer KA,Borodinsky LN

更新日期：2020-04-24 00:00:00

abstract：:The application of super-resolution optical microscopy to investigating synaptic structures has revealed a highly heterogeneous and variable intra-synaptic organization. Dense subsynaptic protein assemblies named subsynaptic domains or SSDs have been proposed as structural units that regulate the efficacy of neuronal ...

journal_title：Frontiers in molecular neuroscience

authors： Yang X,Specht CG

更新日期：2019-07-02 00:00:00

abstract：:Itch, a sensation eliciting a desire to scratch, is distinct from but not completely independent of pain. Inspiring achievements have been made in the characterization of itch-related receptors and neurotransmitters, but the molecular mechanisms controlling the development of pruriceptors remain poorly understood. Her...

journal_title：Frontiers in molecular neuroscience

authors： Huang C,Lu F,Li P,Cao C,Liu Z

更新日期：2017-06-28 00:00:00

abstract：:Electroacupuncture (EA) could improve the hyperactivity of the hypothalamus pituitary adrenal (HPA) axis induced by hepatectomy. However, its underlying mechanism still remains largely unclear. Here, we found that hypothalamic corticotrophin releasing hormone (CRH) modulates the function of the HPA axis, while hepatec...

journal_title：Frontiers in molecular neuroscience

authors： Zhu J,Chen Z,Meng Z,Ju M,Zhang M,Wu G,Guo H,Tian Z

更新日期：2017-09-27 00:00:00

abstract：:Eukaryotic cells release different types of extracellular vesicles (EVs) including exosomes, ectosomes, and microvesicles. Exosomes are nanovesicles, 30-200 nm in diameter, that carry cell- and cell-state-specific cargo of proteins, lipids, and nucleic acids, including mRNA and miRNA. Recent studies have shown that ce...

journal_title：Frontiers in molecular neuroscience

authors： Hornung S,Dutta S,Bitan G

更新日期：2020-03-19 00:00:00

abstract：:Collateral sprouting of surviving axons contributes to the synaptic reorganization after brain injury. To study this clinically relevant phenomenon, we used complex organotypic tissue cultures of mouse entorhinal cortex (EC) and hippocampus (H). Single EC-H cultures were generated to analyze associational sprouting, a...

journal_title：Frontiers in molecular neuroscience

authors： Del Turco D,Paul MH,Beeg Moreno VJ,Hildebrandt-Einfeldt L,Deller T

更新日期：2019-11-12 00:00:00

abstract：:Cytoplasmic FMR1-interacting protein 2 (CYFIP2) is a key component of the WAVE regulatory complex (WRC) which regulates actin polymerization and branching in diverse cellular compartments. Recent whole exome sequencing studies identified de novo hotspot variants in CYFIP2 from patients with early-onset epileptic encep...

journal_title：Frontiers in molecular neuroscience

authors： Zhang Y,Kang H,Lee Y,Kim Y,Lee B,Kim JY,Jin C,Kim S,Kim H,Han K

更新日期：2019-01-04 00:00:00

abstract：:Glaucoma is a progressive optic neuropathy characterized by visual field defects that ultimately lead to irreversible blindness (Alward, 2000; Anderson et al., 2006). By the year 2020, an estimated 80 million people will have glaucoma, 11 million of which will be bilaterally blind. Primary open-angle glaucoma (POAG) i...

journal_title：Frontiers in molecular neuroscience

authors： Buys ES,Potter LR,Pasquale LR,Ksander BR

更新日期：2014-05-19 00:00:00

abstract：:The constitutively active protein glycogen synthase kinase 3 (GSK3), a serine/threonine kinase, acts paradoxically as a tumor suppressor in some cancers while potentiates growth in others. Deciphering what governs its actions is vital for understanding many pathological conditions, including brain cancer. What are see...

journal_title：Frontiers in molecular neuroscience

authors： Mills CN,Nowsheen S,Bonner JA,Yang ES

更新日期：2011-11-25 00:00:00

abstract：:It is widely accepted that glutamate is the most important excitatory neurotransmitter in the central nervous system (CNS). However, there is also a large amount of glutamate in the blood. Generally, the concentration gradient of glutamate between intraparenchymal and blood environments is stable. However, this gradie...

journal_title：Frontiers in molecular neuroscience

authors： Bai W,Zhou YG

更新日期：2017-12-05 00:00:00

abstract：:The α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptors (AMPARs) are major excitatory receptors that mediate fast neurotransmission in the mammalian brain. The surface expression of functional AMPARs is crucial for synaptic transmission and plasticity. AMPAR auxiliary subunits control ...

journal_title：Frontiers in molecular neuroscience

authors： Wei M,Jia M,Zhang J,Yu L,Zhao Y,Chen Y,Ma Y,Zhang W,Shi YS,Zhang C

更新日期：2017-03-02 00:00:00

abstract：:In both excitable and non-excitable cells, calcium (Ca2+) signals are maintained by a highly integrated process involving store-operated Ca2+ entry (SOCE), namely the opening of plasma membrane (PM) Ca2+ channels following the release of Ca2+ from intracellular stores. Upon depletion of Ca2+ store, the stromal interac...

journal_title：Frontiers in molecular neuroscience

authors： Secondo A,Bagetta G,Amantea D

更新日期：2018-03-22 00:00:00

abstract：:Alzheimer's disease (AD) is the most common cause of dementia and is characterized by the buildup of β-amyloid plaques and neurofibrillary Tau tangles. This leads to decreased synaptic efficacy, cell death, and, consequently, brain atrophy in patients. Behaviorally, this manifests as memory loss and confusion. Using a...

journal_title：Frontiers in molecular neuroscience

authors： Greene AN,Parks LG,Solomon MB,Privette Vinnedge LM

更新日期：2020-11-16 00:00:00

abstract：:The tyrosine kinase Fyn plays an important role in synaptic plasticity, learning, and memory. Here we report that Fyn is activated in response to 15 min D1 receptor (D1R) but not D2 receptor (D2R) stimulation specifically in the dorsomedial striatum (DMS) of mice but not in the other substriatal regions, the dorsolate...

journal_title：Frontiers in molecular neuroscience

authors： Phamluong K,Darcq E,Wu S,Sakhai SA,Ron D

更新日期：2017-08-31 00:00:00

abstract：:It has been 200 years since Parkinson's disease (PD) was first described, yet many aspects of its etiopathogenesis remain unclear. PD is a progressive and complex neurodegenerative disorder caused by genetic and environmental factors including aging, nutrition, pesticides and exposure to heavy metals. DNA methylation ...

journal_title：Frontiers in molecular neuroscience

authors： Miranda-Morales E,Meier K,Sandoval-Carrillo A,Salas-Pacheco J,Vázquez-Cárdenas P,Arias-Carrión O

更新日期：2017-07-18 00:00:00