Role of Caspase-8 and Fas in Cell Death After Spinal Cord Injury.

abstract：:Synaptic vesicle proteins 2 (SV2) were discovered in the early 80s, but the clear demonstration that SV2A is the target of efficacious anti-epileptic drugs from the racetam family stimulated efforts to improve understanding of its role in the brain. Many functions have been suggested for SV2 proteins including ions or...

journal_title：Frontiers in molecular neuroscience

authors： Bartholome O,Van den Ackerveken P,Sánchez Gil J,de la Brassinne Bonardeaux O,Leprince P,Franzen R,Rogister B

更新日期：2017-05-22 00:00:00

abstract：:The ubiquitous metabolic intermediary and nucleoside adenosine is a "master regulator" in all living systems. Under baseline conditions adenosine kinase (ADK) is the primary enzyme for the metabolic clearance of adenosine. By regulating the availability of adenosine, ADK is a critical upstream regulator of complex hom...

journal_title：Frontiers in molecular neuroscience

authors： Kiese K,Jablonski J,Boison D,Kobow K

更新日期：2016-10-20 00:00:00

abstract：:Previous reports have shown that running wheel activity or voluntary exercise prevents hyperphagia and obesity in various animal models of obesity, but such effects seem only minimal in obese animals lacking leptin or leptin receptors. The mechanisms underlying this ineffectiveness remain unclear. Here, we identified ...

journal_title：Frontiers in molecular neuroscience

authors： Zhang N,Yang L,Guo L,Bi S

更新日期：2018-05-29 00:00:00

abstract：:Ion channels are expressed throughout nervous system development. The type and diversity of conductances and gating mechanisms vary at different developmental stages and with the progressive maturational status of neural cells. The variety of ion channels allows for distinct signaling mechanisms in developing neural c...

journal_title：Frontiers in molecular neuroscience

authors： Goyal R,Spencer KA,Borodinsky LN

更新日期：2020-04-24 00:00:00

abstract：:Medical marijuana is increasingly prescribed as an analgesic for a growing number of indications, amongst which terminal cancer and multiple sclerosis. However, the mechanistic aspects and properties of cannabis remain remarkably poorly characterized. In this study we aimed to investigate the immune-cell modulatory pr...

journal_title：Frontiers in molecular neuroscience

authors： Utomo WK,de Vries M,Braat H,Bruno MJ,Parikh K,Comalada M,Peppelenbosch MP,van Goor H,Fuhler GM

更新日期：2017-01-24 00:00:00

abstract：:Ligand-binding of Cys-loop receptors results in rearrangements of extracellular loop structures which are further translated into the tilting of membrane spanning helices, and finally opening of the ion channels. The cryo-EM structure of the homopentameric α1 glycine receptor (GlyR) demonstrated an involvement of the ...

journal_title：Frontiers in molecular neuroscience

authors： Janzen D,Schaefer N,Delto C,Schindelin H,Villmann C

更新日期：2017-10-09 00:00:00

abstract：:Lipid metabolism is drastically dysregulated in amyotrophic lateral sclerosis and impacts prognosis of patients. Animal models recapitulate alterations in the energy metabolism, including hypermetabolism and severe loss of adipose tissue. To gain insight into the molecular mechanisms underlying disease progression in ...

journal_title：Frontiers in molecular neuroscience

authors： Henriques A,Croixmarie V,Bouscary A,Mosbach A,Keime C,Boursier-Neyret C,Walter B,Spedding M,Loeffler JP

更新日期：2018-01-04 00:00:00

abstract：:ADP-ribosylation of the P2X7k splice variant on mouse T cells by Ecto-ADP-ribosyltransferase ARTC2.2 in response to its substrate extracellular nicotinamide adenine dinucleotide (NAD+) triggers cell death. Since NAD+ is released as a danger signal during tissue damage, this NAD+-induced cell death (NICD) may impact th...

journal_title：Frontiers in molecular neuroscience

authors： Rissiek B,Stabernack J,Cordes M,Duan Y,Behr S,Menzel S,Magnus T,Koch-Nolte F

更新日期：2020-01-14 00:00:00

abstract：:Glutamate transporter-1 (GLT-1) is a Na+-dependent transporter that plays a key role in glutamate homeostasis by removing excess glutamate in the central nervous system (CNS). GLT-1 dysregulation occurs in various neurological diseases including Huntington's disease (HD), Alzheimer's disease (AD), Parkinson's disease ...

journal_title：Frontiers in molecular neuroscience

authors： Peterson AR,Binder DK

更新日期：2019-07-09 00:00:00

abstract：:The application of super-resolution optical microscopy to investigating synaptic structures has revealed a highly heterogeneous and variable intra-synaptic organization. Dense subsynaptic protein assemblies named subsynaptic domains or SSDs have been proposed as structural units that regulate the efficacy of neuronal ...

journal_title：Frontiers in molecular neuroscience

authors： Yang X,Specht CG

更新日期：2019-07-02 00:00:00

abstract：:In the brain, de novo gene expression driven by learning-associated neuronal activities is critical for the formation of long-term memories. However, the signaling machinery mediating neuronal activity-induced gene expression, especially the rapid transcription of immediate-early genes (IEGs) remains unclear. Cyclin-d...

journal_title：Frontiers in molecular neuroscience

authors： He G,Yang X,Wang G,Qi J,Mao R,Wu Z,Zhou Z

更新日期：2017-11-07 00:00:00

abstract：:[This corrects the article DOI: 10.3389/fnmol.2019.00099.]. ...

journal_title：Frontiers in molecular neuroscience

authors： Yadav SC,Tetenborg S,Dedek K

更新日期：2019-06-12 00:00:00

abstract：:Unlike a number of amyloid-forming proteins, stefins, and in particular stefin B (cystatin B) form amyloids under conditions where the native state predominates. In order to trigger oligomerization processes, the stability of the protein needs to be compromised, favoring structural re-arrangement however, accelerating...

journal_title：Frontiers in molecular neuroscience

authors： Paramore R,Morgan GJ,Davis PJ,Sharma CA,Hounslow A,Taler-Verčič A,Zerovnik E,Waltho JP,Cliff MJ,Staniforth RA

更新日期：2012-10-12 00:00:00

abstract：:Intracerebral hemorrhage (ICH) is a subtype of stroke with highest mortality and morbidity. We have previously demonstrated that dipotassium bisperoxo (picolinato) oxovanadate (V), (bpV[pic]) inhibits phosphatase and tensin homolog (PTEN) and activates extracellular signal-regulated kinase (ERK)1/2. In this study, we ...

journal_title：Frontiers in molecular neuroscience

authors： Zhao D,Qin XP,Chen SF,Liao XY,Cheng J,Liu R,Lei Y,Zhang ZF,Wan Q

更新日期：2019-12-05 00:00:00

abstract：:Atypical Parkinson syndromes (APSs) often have symptoms that overlap with those of Parkinson's disease (PD), especially early in the disease, making these disorders difficult to diagnose. Previous studies have demonstrated an association of oligomeric α-synuclein (α-Syn), a key element in the pathogenesis of PD, with ...

journal_title：Frontiers in molecular neuroscience

authors： Singh AP,Ramana G,Bajaj T,Singh V,Dwivedi S,Behari M,Dey AB,Dey S

更新日期：2019-06-12 00:00:00

abstract：:Using a high resolution in situ hybridization technique we have measured PIEZO1, PIEZO2, and TRPV1 transcripts in mouse dorsal root ganglion (DRG) neurons. Consistent with previous studies, PIEZO2 transcripts were highly expressed in DRG neurons of all sizes, including most notably the largest diameter neurons implica...

journal_title：Frontiers in molecular neuroscience

authors： Wang J,La JH,Hamill OP

更新日期：2019-07-19 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) and spinal and bulbar muscular atrophy (SBMA) are two motoneuron diseases (MNDs) characterized by aberrant protein behavior in affected cells. In familial ALS (fALS) and in SBMA specific gene mutations lead to the production of neurotoxic proteins or peptides prone to misfold, which...

journal_title：Frontiers in molecular neuroscience

authors： Rusmini P,Cristofani R,Galbiati M,Cicardi ME,Meroni M,Ferrari V,Vezzoli G,Tedesco B,Messi E,Piccolella M,Carra S,Crippa V,Poletti A

更新日期：2017-06-21 00:00:00

abstract：:The degeneration of dopaminergic neurons during Parkinson's disease (PD) is intimately linked to malfunction of α-synuclein (αSyn), the main component of the proteinaceous intracellular inclusions characteristic for this pathology. The cytotoxicity of αSyn has been attributed to disturbances in several biological proc...

journal_title：Frontiers in molecular neuroscience

authors： Aufschnaiter A,Habernig L,Kohler V,Diessl J,Carmona-Gutierrez D,Eisenberg T,Keller W,Büttner S

更新日期：2017-06-30 00:00:00

abstract：:Membrane bound guanylate cyclases are expressed in rod and cone cells of the vertebrate retina and mutations in several domains of rod outer segment guanylate cyclase 1 (ROS-GC1 encoded by the gene GUCY2D) correlate with different forms of retinal degenerations. In the present work we investigated the biochemical cons...

journal_title：Frontiers in molecular neuroscience

authors： Zägel P,Koch KW

更新日期：2014-02-26 00:00:00

abstract：:Increasing evidence highlighted the role of cancer stem cells (CSCs) in the development of tumor resistance to therapy, particularly in glioblastoma (GBM). Therefore, the development of new therapies, specifically directed against GBM CSCs, constitutes an important research avenue. Considering the extended range of ca...

journal_title：Frontiers in molecular neuroscience

authors： Angeletti F,Fossati G,Pattarozzi A,Würth R,Solari A,Daga A,Masiello I,Barbieri F,Florio T,Comincini S

更新日期：2016-10-27 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder that results from the loss of upper and lower motor neurons. One of the key pathological hallmarks in diseased neurons is the mislocalization of disease-associated proteins and the formation of cytoplasmic aggregates of these proteins and their intera...

journal_title：Frontiers in molecular neuroscience

authors： Ramesh N,Pandey UB

更新日期：2017-08-22 00:00:00

abstract：:Neurodegenerative diseases such as Parkinson's disease (PD), Alzheimer's disease (AD), amyotrophic lateral sclerosis (ALS), and spinal muscular atrophy (SMA) are chronic, progressive, and age-associated neurological disorders characterized by neuronal deterioration in specific brain regions. Although the specific path...

journal_title：Frontiers in molecular neuroscience

authors： Chang X,Wang J,Jiang H,Shi L,Xie J

更新日期：2019-06-05 00:00:00

abstract：:Aging cognitive decline has been associated to impairment of the Hypothalamus Pituitary Adrenals (HPA) axis activity and a higher level of the systemic inflammation. However, little is known about the molecules driving this process at peripheral level. In addition, the cognitive function is to some extent modifiable w...

journal_title：Frontiers in molecular neuroscience

authors： Pesce M,Tatangelo R,La Fratta I,Rizzuto A,Campagna G,Turli C,Ferrone A,Franceschelli S,Speranza L,Verrocchio MC,De Lutiis MA,Felaco M,Grilli A

更新日期：2017-07-24 00:00:00

abstract：:Although several agents have been identified to provide therapeutic benefits in Huntington disease (HD), the number of conventionally used treatments remains limited and only symptomatic. Thus, it is plausible that the need to identify new therapeutic targets for the development of alternative and more effective treat...

journal_title：Frontiers in molecular neuroscience

authors： Di Pardo A,Pepe G,Castaldo S,Marracino F,Capocci L,Amico E,Madonna M,Giova S,Jeong SK,Park BM,Park BD,Maglione V

更新日期：2019-04-24 00:00:00

abstract：:Connexin channels play numerous essential roles in virtually every organ by mediating solute exchange between adjacent cells, or between cytoplasm and extracellular milieu. Our understanding of the structure-function relationship of connexin channels relies on X-ray crystallographic data for human connexin 26 (hCx26) ...

journal_title：Frontiers in molecular neuroscience

authors： Zonta F,Buratto D,Crispino G,Carrer A,Bruno F,Yang G,Mammano F,Pantano S

更新日期：2018-05-31 00:00:00

abstract：:Peroxisome proliferator activated receptors (PPARs) are nuclear hormone receptors that act as transcription factors in response to endogenous lipid messengers. The fibrates and thiazolidinediones are synthetic PPAR agonists used clinically to treat dyslipidemia and Type 2 Diabetes Mellitus, respectively, but also impr...

journal_title：Frontiers in molecular neuroscience

authors： Ferguson LB,Zhang L,Wang S,Bridges C,Harris RA,Ponomarev I

更新日期：2018-09-19 00:00:00

abstract：:In this review we provide an overview of key in vivo experiments undertaken in the cat spinal cord in the 1950s and 1960s, and point out their contributions to our present understanding of glycine receptor (GlyR) function. Importantly, some of these discoveries were made well before an inhibitory receptor, or its agon...

journal_title：Frontiers in molecular neuroscience

authors： Callister RJ,Graham BA

更新日期：2010-05-21 00:00:00

abstract：:Microglial activation and the inflammatory response in the central nervous system (CNS) play important roles in secondary damage after traumatic brain injury (TBI). Transcriptional activation of genes that limit secondary damage to the CNS are mediated by a cis-acting element called the antioxidant responsive element ...

journal_title：Frontiers in molecular neuroscience

authors： Chen X,Wang H,Zhou M,Li X,Fang Z,Gao H,Li Y,Hu W

更新日期：2018-04-17 00:00:00

abstract：:Thiol groups can undergo numerous modifications, making cysteine a unique molecular switch. Cysteine plays structural and regulatory roles as part of proteins or glutathione, contributing to maintain redox homeostasis and regulate signaling within and amongst cells. Not surprisingly therefore, cysteines are associated...

journal_title：Frontiers in molecular neuroscience

authors： Fra A,Yoboue ED,Sitia R

更新日期：2017-06-06 00:00:00

abstract：:Many human neurodegenerative diseases are associated with amyloid fibril formation. Inhibition of amyloid formation is of importance for therapeutics of the related diseases. However, the development of selective potent amyloid inhibitors remains challenging. Here based on the structures of amyloid β (Aβ) fibrils and ...

journal_title：Frontiers in molecular neuroscience

authors： Lu J,Cao Q,Wang C,Zheng J,Luo F,Xie J,Li Y,Ma X,He L,Eisenberg D,Nowick J,Jiang L,Li D

更新日期：2019-03-04 00:00:00