Streptococcal Enzymes as Precision Tools Against Pathogenic IgG Autoantibodies in Small Vessel Vasculitis.

abstract：:Granulocytes, the most abundant types of leukocytes, are the first line of defense against pathogen invasion. However, the plasticity and diversity of granulocytes have been increasingly revealed, especially with regard to their versatile functions in orchestrating adaptive immune responses. A substantial body of rece...

journal_title：Frontiers in immunology

authors： Lin A,Loré K

更新日期：2017-12-11 00:00:00

abstract：:Lyme disease (Borrelia burgdorferi infection) is increasingly recognized as a significant source of morbidity worldwide. Here, we show that blood plasmablasts and CD27- memory B cells are elevated in untreated Lyme disease, with higher plasmablast levels associated with more rapid resolution of clinical symptoms. Stro...

journal_title：Frontiers in immunology

authors： Blum LK,Adamska JZ,Martin DS,Rebman AW,Elliott SE,Cao RRL,Embers ME,Aucott JN,Soloski MJ,Robinson WH

更新日期：2018-07-18 00:00:00

abstract：:A hallmark of cystic fibrosis (CF) chronic respiratory disease is an extensive neutrophil infiltrate in the mucosa filling the bronchial lumen, starting early in life for CF infants. The genetic defect of the CF Transmembrane conductance Regulator (CFTR) ion channel promotes dehydration of the airway surface liquid, a...

journal_title：Frontiers in immunology

authors： Cabrini G,Rimessi A,Borgatti M,Lampronti I,Finotti A,Pinton P,Gambari R

更新日期：2020-08-04 00:00:00

abstract：:Natural killer (NK) cells are a promising tool for the use in adoptive immunotherapy, since they efficiently recognize and kill tumor cells. In this context, ex vivo cultivation is an attractive option to increase NK cells in numbers and to improve their antitumor potential prior to clinical applications. Consequently...

journal_title：Frontiers in immunology

authors： Granzin M,Wagner J,Köhl U,Cerwenka A,Huppert V,Ullrich E

更新日期：2017-04-26 00:00:00

abstract：:Mucosal epithelia encounter both physicochemical and biological stress during their life and have evolved several mechanisms to deal with them, including regulation of immune cell functions. Stressed and damaged cells need to be cleared to control local inflammation and trigger tissue healing. Engagement of the activa...

journal_title：Frontiers in immunology

authors： Antonangeli F,Soriani A,Cerboni C,Sciumè G,Santoni A

更新日期：2017-11-20 00:00:00

abstract：:Background: Variants in recombination-activating genes (RAG) are common genetic causes of autosomal recessive forms of combined immunodeficiencies (CID) ranging from severe combined immunodeficiency (SCID), Omenn syndrome (OS), leaky SCID, and CID with granulomas and/or autoimmunity (CID-G/AI), and even milder present...

journal_title：Frontiers in immunology

authors： Sharapova SO,Skomska-Pawliszak M,Rodina YA,Wolska-Kuśnierz B,Dabrowska-Leonik N,Mikołuć B,Pashchenko OE,Pasic S,Freiberger T,Milota T,Formánková R,Szaflarska A,Siedlar M,Avčin T,Markelj G,Ciznar P,Kalwak K,Kołtan S,Ja

更新日期：2020-06-10 00:00:00

abstract：:Type I interferon is widely used for antiviral therapy, yet has yielded disappointing results toward chronic HBV infection. Here we identify that PEG-IFNα-2b therapy toward persistent infection in humans is a double-edged sword of both immunostimulation and immunomodulation. Our studies of this randomised trial showed...

journal_title：Frontiers in immunology

authors： Fu B,Wang D,Shen X,Guo C,Liu Y,Ye Y,Sun R,Li J,Tian Z,Wei H

更新日期：2020-12-23 00:00:00

abstract：:Antibodies can rapidly evolve in specific response to antigens. Affinity maturation drives this evolution through cycles of mutation and selection leading to enhanced antibody specificity and affinity. Elucidating the biophysical mechanisms that underlie affinity maturation is fundamental to understanding B-cell immun...

journal_title：Frontiers in immunology

authors： Jeliazkov JR,Sljoka A,Kuroda D,Tsuchimura N,Katoh N,Tsumoto K,Gray JJ

更新日期：2018-03-02 00:00:00

abstract：:Intestinal dysbiosis associated with immunological deregulation, leaky gut, bacterial translocation, and systemic inflammation has been associated with autoimmune diseases, such as type 1 diabetes (T1D). The aim of this study was to investigate the intestinal dysbiosis in T1D patients and correlate these results with ...

journal_title：Frontiers in immunology

authors： Higuchi BS,Rodrigues N,Gonzaga MI,Paiolo JCC,Stefanutto N,Omori WP,Pinheiro DG,Brisotti JL,Matheucci E Jr,Mariano VS,de Oliveira GLV

更新日期：2018-07-25 00:00:00

abstract：:The large family of chemoattractant cytokines (chemokines) embraces multiple, in part unrelated functions that go well beyond chemotaxis. Undoubtedly, the control of immune cell migration (chemotaxis) is the single, unifying response mediated by all chemokines, which involves the sequential engagement of chemokine rec...

journal_title：Frontiers in immunology

authors： Wolf M,Moser B

更新日期：2012-07-23 00:00:00

abstract：:The discovery of innate lymphoid cells (ILCs) with selective production of cytokines typically attributed to subsets of T helper cells forces immunologists to reassess the mechanisms by which selective effector functions arise. The parallelism between ILCs and T cells extends beyond these two cell types and comprises ...

journal_title：Frontiers in immunology

authors： Sciumè G,Shih HY,Mikami Y,O'Shea JJ

更新日期：2017-11-13 00:00:00

abstract：:Background: Each year, over 5 million red blood cell (RBC) transfusions are administered to patients in the USA. Despite the therapeutic benefits of RBC transfusions, there are associated risks. RBC-specific alloantibodies may form in response to antigenic differences between RBC donors and recipients; these alloantib...

journal_title：Frontiers in immunology

authors： Richards AL,Sheldon K,Wu X,Gruber DR,Hudson KE

更新日期：2018-10-05 00:00:00

abstract：:Mycobacteria display pro- and anti-inflammatory effects in human and experimental pathology. We show here that both effects are mediated by Toll-like receptor 2 (Tlr2), by exploiting a previously characterized Tlr2 variant (Met82Ile). Tlr2 82ile promoted self-specific proinflammatory polarization as well as expansion ...

journal_title：Frontiers in immunology

authors： Piermattei A,Migliara G,Di Sante G,Foti M,Hayrabedyan SB,Papagna A,Geloso MC,Corbi M,Valentini M,Sgambato A,Delogu G,Constantin G,Ria F

更新日期：2016-05-24 00:00:00

abstract：:The size and composition of the T lymphocyte compartment is subject to strict homeostatic regulation and is remarkably stable throughout life in spite of variable dynamics in cell production and death during T cell development and immune responses. Homeostasis is achieved by careful orchestration of lymphocyte surviva...

journal_title：Frontiers in immunology

authors： Hapuarachchi T,Lewis J,Callard RE

更新日期：2013-11-11 00:00:00

abstract：:TILRR (Toll-like interleukin-1 receptor regulator), a transcript variant of FREM1, is a novel regulatory component, which stimulates innate immune responses through binding to IL-1R1 (Interleukin-1 receptor, type 1) and TLR (Toll-like receptor) complex. However, it is not known whether TILRR expression influences othe...

journal_title：Frontiers in immunology

authors： Kashem MA,Li H,Toledo NP,Omange RW,Liang B,Liu LR,Li L,Yang X,Yuan XY,Kindrachuk J,Plummer FA,Luo M

更新日期：2019-02-28 00:00:00

abstract：:Multiple sclerosis is a chronic auto-inflammatory disease of the central nervous system affecting patients worldwide. Neuroinflammation in multiple sclerosis is mainly driven by peripheral immune cells which invade the central nervous system and cause neurodegenerative inflammation. To enter the target tissue, immune ...

journal_title：Frontiers in immunology

authors： Zondler L,Herich S,Kotte P,Körner K,Schneider-Hohendorf T,Wiendl H,Schwab N,Zarbock A

更新日期：2020-12-14 00:00:00

abstract：:Immune checkpoint blockade therapy has prevailed for several types of cancer; however, its effectiveness as a single therapy is still limited. In principle, dendritic cells (DCs) should be able to control the post-therapy immune response, in particular since they can link the two major arms of the immune system: innat...

journal_title：Frontiers in immunology

authors： Fujii SI,Shimizu K

更新日期：2017-07-31 00:00:00

abstract：:Adipose depots are heterogeneous tissues that store and sense fuel levels. Through the secretion of lipids, cytokines, and protein hormones (adipokines), they communicate with other organ systems, informing them of the organism's nutritional status. The adipose tissues include diverse types of adipocytes (white, beige...

journal_title：Frontiers in immunology

authors： Chaurasia B,Talbot CL,Summers SA

更新日期：2020-09-23 00:00:00

abstract：:Inflammation is a complex process which is highly conserved among species. Inflammation occurs in response to injury, infection, and cancer, as an allostatic mechanism to return the tissue and to return the organism back to health and homeostasis. Excessive, or chronic inflammation is associated with numerous diseases...

journal_title：Frontiers in immunology

authors： Desgeorges T,Caratti G,Mounier R,Tuckermann J,Chazaud B

更新日期：2019-07-09 00:00:00

abstract：:Controversy over the frequency of human B1 cells in normal individuals has arisen as different labs have begun to employ non-uniform techniques to study this population. The phenotypic profile and relative paucity of circulating human B1 cells place constraints on methodology to identify and isolate this population. M...

journal_title：Frontiers in immunology

authors： Griffin DO,Rothstein TL

更新日期：2012-05-25 00:00:00

abstract：:Diet composition may affect the onset and progression of chronic degenerative diseases, including cancer, whose pathogenesis relies on inflammatory processes. Growing evidence indicates that diet and its components critically contribute to human health, affecting the immune system, secretion of adipokines, and metabol...

journal_title：Frontiers in immunology

authors： Miccadei S,Masella R,Mileo AM,Gessani S

更新日期：2016-11-15 00:00:00

abstract：:C-reactive protein (CRP) binds to several species of bacterial pathogens including Streptococcus pneumoniae. Experiments in mice have revealed that one of the functions of CRP is to protect against pneumococcal infection by binding to pneumococci and activating the complement system. For protection, however, CRP must ...

journal_title：Frontiers in immunology

authors： Ngwa DN,Singh SK,Gang TB,Agrawal A

更新日期：2020-10-07 00:00:00

abstract：:Delivery of high doses of radiation to thoracic region, particularly with non-small cell lung cancer patients, becomes difficult due to subsequent complications arising in the lungs of the patient. Radiation-induced pneumonitis is an early event evident in most radiation exposed patients observed within 2-4 months of ...

journal_title：Frontiers in immunology

authors： Kainthola A,Haritwal T,Tiwari M,Gupta N,Parvez S,Tiwari M,Prakash H,Agrawala PK

更新日期：2017-05-02 00:00:00

abstract：:NKG2D is a potent activating immunoreceptor expressed on nearly all cytotoxic lymphocytes promoting their cytotoxicity against self-cells expressing NKG2D ligands (NKG2DLs). NKG2DLs are MHC class I-like glycoproteins that usually are not expressed on "healthy" cells. Rather, their surface expression is induced by vari...

journal_title：Frontiers in immunology

authors： Kim Y,Born C,Bléry M,Steinle A

更新日期：2020-06-04 00:00:00

abstract：:Heat-shock protein 70 (Hsp70) is frequently found on the plasma membrane of a large number of malignant tumors including non-small cell lung cancer (NSCLC) and gets released into the blood circulation in lipid vesicles. On the one hand, a membrane (m)Hsp70-positive phenotype correlates with a high aggressiveness of th...

journal_title：Frontiers in immunology

authors： Gunther S,Ostheimer C,Stangl S,Specht HM,Mozes P,Jesinghaus M,Vordermark D,Combs SE,Peltz F,Jung MP,Multhoff G

更新日期：2015-11-02 00:00:00

abstract：:Distinctive molecular characteristics of functionally diverse lymphocyte populations may represent novel pharmacological targets for immunotherapy. The intrinsic apoptosis pathway is differently regulated among conventional and regulatory T cells (Tregs). Targeted pharmacological modulation of this pathway with a smal...

journal_title：Frontiers in immunology

authors： Gabriel SS,Bon N,Chen J,Wekerle T,Bushell A,Fehr T,Cippà PE

更新日期：2016-03-01 00:00:00

abstract：:Neurological disorders caused by neuroviral infections are an obvious pathogenic manifestation. However, non-neurotropic viruses or peripheral viral infections pose a considerable challenge as their neuropathological manifestations do not emerge because of primary infection. Their secondary or bystander pathologies de...

journal_title：Frontiers in immunology

authors： Mishra R,Banerjea AC

更新日期：2020-09-10 00:00:00

abstract：:Interleukin-33 (IL-33) is a well-recognized immunomodulatory cytokine which plays critical roles in tissue function and immune-mediated diseases. The abundant expression of IL-33 in brain and spinal cord prompted many scientists to explore its unique role in the central nervous system (CNS) under physiological and pat...

journal_title：Frontiers in immunology

authors： Fairlie-Clarke K,Barbour M,Wilson C,Hridi SU,Allan D,Jiang HR

更新日期：2018-11-20 00:00:00

abstract：:Paneth cells contribute to intestinal innate immunity by sensing bacteria and secreting α-defensin. In Institute of Cancer Research (ICR) mice, α-defensin termed cryptdin (Crp) in Paneth cells consists of six major isoforms, Crp1 to 6. Despite accumulating evidences that α-defensin functions in controlling the intesti...

journal_title：Frontiers in immunology

authors： Nakamura K,Yokoi Y,Fukaya R,Ohira S,Shinozaki R,Nishida T,Kikuchi M,Ayabe T

更新日期：2020-10-13 00:00:00

abstract：:Increased concentrations of extracellular chromatin are observed in cancer, sepsis, and inflammatory autoimmune diseases like systemic lupus erythematosus (SLE) or rheumatoid arthritis (RA). In SLE and RA, extracellular chromatin may behave as a danger-associated molecular pattern (DAMP). Polymorphonuclear neutrophils...

journal_title：Frontiers in immunology

authors： Ribon M,Mussard J,Semerano L,Singer BB,Decker P

更新日期：2019-06-14 00:00:00