Exploiting Antitumor Immunotherapeutic Novel Strategies by Deciphering the Cross Talk between Invariant NKT Cells and Dendritic Cells.

abstract：:Idiopathic pulmonary fibrosis (IPF) is a disease with a poor prognosis and very few available treatment options. The involvement of the purinergic receptor subtypes P2Y2 and P2X7 in fibrotic lung disease has been demonstrated recently. In this study, we investigated the role of P2Y6 receptors in the pathogenesis of IP...

journal_title：Frontiers in immunology

authors： Müller T,Fay S,Vieira RP,Karmouty-Quintana H,Cicko S,Ayata CK,Zissel G,Goldmann T,Lungarella G,Ferrari D,Di Virgilio F,Robaye B,Boeynaems JM,Lazarowski ER,Blackburn MR,Idzko M

更新日期：2017-08-22 00:00:00

abstract：:Autoimmune diseases involve a complex dysregulation of immunity. Autoimmune diseases include many members [e.g., rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE)], and most of them are classified according to what organs and tissues are targeted by the damaging immune response. Many studies have focuse...

journal_title：Frontiers in immunology

authors： Jin F,Hu H,Xu M,Zhan S,Wang Y,Zhang H,Chen X

更新日期：2018-10-16 00:00:00

abstract：:Programmed cell death-1 (PD-1) receptor signaling dampens the functionality of T cells faced with repetitive antigenic stimulation from chronic infections or tumors. Using intracerebral (i.c.) inoculation with mouse polyomavirus (MuPyV), we have shown that CD8 T cells establish a PD-1hi, tissue-resident memory populat...

journal_title：Frontiers in immunology

authors： Shwetank,Frost EL,Mockus TE,Ren HM,Toprak M,Lauver MD,Netherby-Winslow CS,Jin G,Cosby JM,Evavold BD,Lukacher AE

更新日期：2019-04-17 00:00:00

abstract：:Enhanced susceptibility to bacterial infection in the days following an acute virus infection such as flu is a major clinical problem. Mouse models have provided major advances in understanding viral-bacterial superinfections, yet interactions of the anti-viral and anti-bacterial responses remain elusive. Here, we hav...

journal_title：Frontiers in immunology

authors： Boucontet L,Passoni G,Thiry V,Maggi L,Herbomel P,Levraud JP,Colucci-Guyon E

更新日期：2018-05-24 00:00:00

abstract：:The dual potential to promote tolerance or inflammation to self-antigens makes dendritic cells (DCs) fundamental players in autoimmunity. Previous results have shown that stimulation of dopamine receptor D5 (DRD5) in DCs potentiates their inflammatory behaviour, favouring the development of experimental autoimmune enc...

journal_title：Frontiers in immunology

authors： Prado C,Gaiazzi M,González H,Ugalde V,Figueroa A,Osorio-Barrios FJ,López E,Lladser A,Rasini E,Marino F,Zaffaroni M,Cosentino M,Pacheco R

更新日期：2018-03-21 00:00:00

abstract：:Chlamydia trachomatis (CT) is the most prevalent bacterial sexually transmitted infection in the world, with more than 100 million cases reported annually. While there have been extensive studies into the adverse effects that CT infection has on the female genital tract, and on the subsequent ability of these women to...

journal_title：Frontiers in immunology

authors： Redgrove KA,McLaughlin EA

更新日期：2014-10-27 00:00:00

abstract：:Natural killer (NK) cells are large granular lymphocytes involved in our defense against certain virus-infected and malignant cells. In contrast to T cells, NK cells elicit rapid anti-tumor responses based on signals from activating and inhibitory cell surface receptors. They also lyse target cells via antibody-depend...

journal_title：Frontiers in immunology

authors： Carlsten M,Järås M

更新日期：2019-10-11 00:00:00

abstract：:Indoleamine 2,3-dioxygenase 2 (IDO2) is an analog of the tryptophan degrading and immunomodulating enzyme indoleamine 2,3-dioxygenase 1 (IDO1). Although the role of IDO1 is largely understood, the function of IDO2 is not yet well-elucidated. IDO2 overexpression was documented in some human tumors, but the linkage betw...

journal_title：Frontiers in immunology

authors： Mandarano M,Bellezza G,Belladonna ML,Vannucci J,Gili A,Ferri I,Lupi C,Ludovini V,Falabella G,Metro G,Mondanelli G,Chiari R,Cagini L,Stracci F,Roila F,Puma F,Volpi C,Sidoni A

更新日期：2020-05-27 00:00:00

abstract：:Abundant clinical, epidemiological, imaging, genetic, molecular, and pathophysiological data together indicate that there occur an unusual inflammatory reaction and a disruption of the innate-immune signaling system in Alzheimer's disease (AD) brain. Despite many years of intense study, the origin and molecular mechan...

journal_title：Frontiers in immunology

authors： Zhao Y,Cong L,Jaber V,Lukiw WJ

更新日期：2017-09-04 00:00:00

abstract：:Allergic asthma is a chronic Th2 inflammatory disease of the lower airways affecting a growing number of people worldwide. The impact of infections and microbiota composition on allergic asthma has been investigated frequently. Until now, however, there have been few attempts to investigate the impact of asthma on the...

journal_title：Frontiers in immunology

authors： Machelart A,Potemberg G,Van Maele L,Demars A,Lagneaux M,De Trez C,Sabatel C,Bureau F,De Prins S,Percier P,Denis O,Jurion F,Romano M,Vanderwinden JM,Letesson JJ,Muraille E

更新日期：2018-08-10 00:00:00

abstract：:Intravenous immunoglobulin (IVIG) is used as replacement therapy in patients with antibody deficiencies and at higher dosages in immune-mediated disorders. Although different mechanisms have been described in vitro, the in vivo immunomodulatory effects of IVIG are poorly understood. Different studies have suggested th...

journal_title：Frontiers in immunology

authors： Mitrevski M,Marrapodi R,Camponeschi A,Cavaliere FM,Lazzeri C,Todi L,Visentini M

更新日期：2015-01-22 00:00:00

abstract：:Cholera toxin (CT) is one of most strong mucosal adjuvants, but it cannot be clinically used owing to its toxicity. The cytosolic A1 subunit of CT (CTA1) is the molecule responsible for its immunostimulatory activity, which increases the concentration of cyclic AMP and causes the induction of pro-inflammatory cytokine...

journal_title：Frontiers in immunology

authors： Kim MS,Yi EJ,Kim YI,Kim SH,Jung YS,Kim SR,Iwawaki T,Ko HJ,Chang SY

更新日期：2019-06-04 00:00:00

abstract：:PU.1 is an ETS-family transcription factor that plays a broad range of roles in hematopoiesis. A direct regulator of myeloid, dendritic-cell, and B cell functional programs, and a well-known antagonist of terminal erythroid cell differentiation, it is also expressed in the earliest stages of T-cell development of each...

journal_title：Frontiers in immunology

authors： Rothenberg EV,Hosokawa H,Ungerbäck J

更新日期：2019-02-20 00:00:00

abstract：:Tolerogenic dendritic cells and T-regulatory cells are two immune cell populations with the potential to prevent the onset of clinical stage type 1 diabetes, and manage the beginning of underlying autoimmunity, at the time-at-onset and onwards. Initial phase I trials demonstrated that the administration of a number of...

journal_title：Frontiers in immunology

authors： Phillips BE,Garciafigueroa Y,Engman C,Trucco M,Giannoukakis N

更新日期：2019-02-06 00:00:00

abstract：:Immunoglobulin (Ig) replacement therapy dramatically changed the clinical course of primary hypogammaglobulinemias, significantly reducing the incidence of infectious events. Over the last two decades its use has been extended to secondary antibody deficiencies, particularly those related to hematological disorders as...

journal_title：Frontiers in immunology

authors： Compagno N,Malipiero G,Cinetto F,Agostini C

更新日期：2014-12-08 00:00:00

abstract：:Natural killer cells (NK) represent a population of lymphocytes involved in innate immune response. In addition to their role in anti-viral and anti-tumor defense, they also regulate several aspects of the allo-immune response in kidney transplant recipients. Growing evidence suggests a key role of NK cells in the pat...

journal_title：Frontiers in immunology

authors： Pontrelli P,Rascio F,Castellano G,Grandaliano G,Gesualdo L,Stallone G

更新日期：2020-07-23 00:00:00

abstract：:Impaired immune reconstitution after allogeneic hematopoietic stem cell transplantation (HSCT) contributes to increased risk of cancer relapse and infection resulting in significant morbidity and mortality. Unfortunately, effective strategies to functionally assess the quality of immune reconstitution are still missin...

journal_title：Frontiers in immunology

authors： Pradier A,Masouridi-Levrat S,Bosshard C,Dantin C,Vu DL,Zanella MC,Boely E,Tapparel C,Kaiser L,Chalandon Y,Simonetta F,Roosnek E

更新日期：2020-05-27 00:00:00

abstract：:MicroRNAs (miRNAs), the small non-coding RNAs, play a pivotal role in post-transcriptional gene regulation in various cellular processes. However, the miRNA function in shrimp antiviral response is not clearly understood. This research aims to uncover the function of pmo-miR-315, a white spot syndrome virus (WSSV)-res...

journal_title：Frontiers in immunology

authors： Jaree P,Wongdontri C,Somboonwiwat K

更新日期：2018-09-25 00:00:00

abstract：:Immunoglobulin superfamily member (IgSF) proteins play a significant role in regulating immune responses with surface expression on all immune cell subsets, making the IgSF an attractive family of proteins for therapeutic targeting in human diseases. We have developed a directed evolution platform capable of engineeri...

journal_title：Frontiers in immunology

authors： Levin SD,Evans LS,Bort S,Rickel E,Lewis KE,Wu RP,Hoover J,MacNeil S,La D,Wolfson MF,Rixon MW,Dillon SR,Kornacker MG,Swanson R,Peng SL

更新日期：2020-01-21 00:00:00

abstract：:Background: Sex differences in immune responses to influenza vaccine may impact efficacy across populations. Methods: In a cohort of 138 older adults (50-74 years old), we measured influenza A/H1N1 antibody titers, B-cell ELISPOT response, PBMC transcriptomics, and PBMC cell compositions at 0, 3, and 28 days post-immu...

journal_title：Frontiers in immunology

authors： Voigt EA,Ovsyannikova IG,Kennedy RB,Grill DE,Goergen KM,Schaid DJ,Poland GA

更新日期：2019-02-27 00:00:00

abstract：:Dendritic cell (DC) vaccination has been investigated as a potential strategy to target hematologic malignancies, while generating sustained immunological responses to control potential future relapse. Nonetheless, few clinical trials have shown robust long-term efficacy. It has been suggested that a combination of su...

journal_title：Frontiers in immunology

authors： Cornel AM,van Til NP,Boelens JJ,Nierkens S

更新日期：2018-05-18 00:00:00

abstract：:Background: Haploinsufficiency A20 (HA20) is a newly described monogenic disease characterized by a wide spectrum of manifestations and caused by heterozygous mutations in TNFAIP3 which encodes A20 protein. TNFAIP3 mutation leads to disruption of the A20 ovarian tumor (OTU) domain and/or the zinc finger (ZnF) domain. ...

journal_title：Frontiers in immunology

authors： Chen Y,Ye Z,Chen L,Qin T,Seidler U,Tian D,Xiao F

更新日期：2020-09-23 00:00:00

abstract：:Background: Although myelin is composed of mostly lipids, the pathological role of myelin lipids in demyelinating diseases remains elusive. The principal lipid of the myelin sheath is β-galactosylceramide (β-Galcer). Its α-anomer (α-Galcer) has been demonstrated to be antigenically presented by macrophages via CD1d, a...

journal_title：Frontiers in immunology

authors： Ban Y,Dong W,Zhang L,Zhou T,Altiti AS,Ali K,Mootoo DR,Blaho VA,Hla T,Ren Y,Ma X

更新日期：2019-03-19 00:00:00

abstract：:Immunological aging remodels the immune system at several levels. This has been documented in particular for the T-cell receptor (TCR)αβ+ T-cell compartment, showing reduced naive T-cell outputs and an accumulation of terminally differentiated clonally expanding effector T-cells, leading to increased proneness to auto...

journal_title：Frontiers in immunology

authors： Kallemeijn MJ,Kavelaars FG,van der Klift MY,Wolvers-Tettero ILM,Valk PJM,van Dongen JJM,Langerak AW

更新日期：2018-03-06 00:00:00

abstract：:New vaccine design approaches would be greatly facilitated by a better understanding of the early systemic changes, and those that occur at the site of injection, responsible for the installation of a durable and oriented protective response. We performed a detailed characterization of very early infection and host re...

journal_title：Frontiers in immunology

authors： Rosenbaum P,Tchitchek N,Joly C,Stimmer L,Hocini H,Dereuddre-Bosquet N,Beignon AS,Chapon C,Levy Y,Le Grand R,Martinon F

更新日期：2018-04-25 00:00:00

abstract：:In primary infection with Salmonella, it has been reported-without consideration of Salmonella's functions-that humoral immunity plays no role in the clearance of bacteria. In fact, Salmonella targets and suppresses several aspects of humoral immunity, including B cell lymphopoiesis, B cell activation, and IgG product...

journal_title：Frontiers in immunology

authors： Takaya A,Yamamoto T,Tokoyoda K

更新日期：2020-01-21 00:00:00

abstract：:Neutrophils are known to extrude decondensed chromatin, thus forming NETs (neutrophil extracellular traps). These structures immobilize pathogens, thereby preventing their spreading, and are also adorned with antimicrobial molecules. NETs can also influence pathogenesis in chronic inflammation, autoimmunity, and cance...

journal_title：Frontiers in immunology

authors： Tatsiy O,McDonald PP

更新日期：2018-09-18 00:00:00

abstract：:The ability of the host to clear hepatitis B virus (HBV) is closely correlated to the establishment of commensal microbiota. However, how microbiota affects anti-HBV immunity is still unclear. Using a well-known hydrodynamical HBV transfection mouse model and treatment with antibiotics (Atb), we explored the change in...

journal_title：Frontiers in immunology

authors： Wu T,Li F,Chen Y,Wei H,Tian Z,Sun C,Sun R

更新日期：2019-04-30 00:00:00

abstract：:Volcanic ash is a heterogeneous mineral dust that is typically composed of a mixture of amorphous (glass) and crystalline (mineral) fragments. It commonly contains an abundance of the crystalline silica (SiO2) polymorph cristobalite. Inhalation of crystalline silica can induce inflammation by stimulating the NLRP3 inf...

journal_title：Frontiers in immunology

authors： Damby DE,Horwell CJ,Baxter PJ,Kueppers U,Schnurr M,Dingwell DB,Duewell P

更新日期：2018-01-22 00:00:00

abstract：:Short-chain fatty acids (SCFAs) are mainly produced by microbiota through the fermentation of carbohydrates in the intestine. Acetate, propionate, and butyrate are the most abundant SCFA metabolites and have been shown to be important in the maintenance of host health. In this study, head kidney macrophages (HKMs) wer...

journal_title：Frontiers in immunology

authors： Zhang J,Zhang H,Liu M,Lan Y,Sun H,Mai K,Wan M

更新日期：2020-12-23 00:00:00