White Spot Syndrome Virus-Induced Shrimp miR-315 Attenuates Prophenoloxidase Activation via PPAE3 Gene Suppression.


:MicroRNAs (miRNAs), the small non-coding RNAs, play a pivotal role in post-transcriptional gene regulation in various cellular processes. However, the miRNA function in shrimp antiviral response is not clearly understood. This research aims to uncover the function of pmo-miR-315, a white spot syndrome virus (WSSV)-responsive miRNAs identified from Penaeus monodon hemocytes during WSSV infection. The expression of the predicted pmo-miR-315 target mRNA, a novel PmPPAE gene called PmPPAE3, was negatively correlated with that of the pmo-miR-315. Furthermore, the luciferase assay indicated that the pmo-miR-315 directly interacted with the target site in PmPPAE3 suggesting the regulatory role of pmo-miR-315 on PmPPAE3 gene expression. Introducing the pmo-miR-315 into the WSSV-infected shrimp caused the reduction of the PmPPAE3 transcript level and, hence, the PO activity activated by the PmPPAE3 whereas the WSSV copy number in the shrimp hemocytes was increased. Taken together, our findings state a crucial role of pmo-miR-315 in attenuating proPO activation via PPAE3 gene suppression and facilitating the WSSV propagation in shrimp WSSV infection.


Front Immunol


Frontiers in immunology


Jaree P,Wongdontri C,Somboonwiwat K




Has Abstract


2018-09-25 00:00:00








  • Post-Aire maturation of thymic medullary epithelial cells involves selective expression of keratinocyte-specific autoantigens.

    abstract::The autoimmune regulator (Aire)-directed ectopic expression of tissue-specific antigens (TSAs) by mature medullary thymic epithelial cells (mTECs) has been viewed as an essential mechanism in the induction of central tolerance. Recent data suggest that the survival of mTECs extends beyond the Aire+ cell population to ...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Wang X,Laan M,Bichele R,Kisand K,Scott HS,Peterson P

    更新日期:2012-03-01 00:00:00

  • Alum Activates the Bovine NLRP3 Inflammasome.

    abstract::There has been a move away from vaccines composed of whole or inactivated antigens toward subunit-based vaccines, which although safe, provide less immunological protection. As a result, the use of adjuvants to enhance and direct adaptive immune responses has become the focus of much targeted bovine vaccine research. ...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Harte C,Gorman AL,McCluskey S,Carty M,Bowie AG,Scott CJ,Meade KG,Lavelle EC

    更新日期:2017-11-09 00:00:00

  • Multiple Variables at the Leukocyte Cell Surface Impact Fc γ Receptor-Dependent Mechanisms.

    abstract::Fc γ receptors (FcγR) expressed on the surface of human leukocytes bind clusters of immunoglobulin G (IgG) to induce a variety of responses. Many therapeutic antibodies and vaccine-elicited antibodies prevent or treat infectious diseases, cancers and autoimmune disorders by binding FcγRs, thus there is a need to fully...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审


    authors: Patel KR,Roberts JT,Barb AW

    更新日期:2019-02-14 00:00:00

  • Exploiting the Immunogenic Potential of Cancer Cells for Improved Dendritic Cell Vaccines.

    abstract::Cancer immunotherapy is currently the hottest topic in the oncology field, owing predominantly to the discovery of immune checkpoint blockers. These promising antibodies and their attractive combinatorial features have initiated the revival of other effective immunotherapies, such as dendritic cell (DC) vaccinations. ...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审


    authors: Vandenberk L,Belmans J,Van Woensel M,Riva M,Van Gool SW

    更新日期:2016-01-14 00:00:00

  • Culture-Expanded Human Invariant Natural Killer T Cells Suppress T-Cell Alloreactivity and Eradicate Leukemia.

    abstract::Graft-versus-host disease (GVHD) is a major cause of significant morbidity and mortality after allogeneic hematopoietic cell transplantation (HCT). Invariant natural killer T (iNKT) cells are potent regulators of immune responses, protect from lethal GVHD, and promote graft-versus-leukemia effects in murine studies. S...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Schmid H,Schneidawind C,Jahnke S,Kettemann F,Secker KA,Duerr-Stoerzer S,Keppeler H,Kanz L,Savage PB,Schneidawind D

    更新日期:2018-08-06 00:00:00

  • Triggers of Autoimmunity: The Role of Bacterial Infections in the Extracellular Exposure of Lupus Nuclear Autoantigens.

    abstract::Infections are considered important environmental triggers of autoimmunity and can contribute to autoimmune disease onset and severity. Nucleic acids and the complexes that they form with proteins-including chromatin and ribonucleoproteins-are the main autoantigens in the autoimmune disease systemic lupus erythematosu...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审


    authors: Qiu CC,Caricchio R,Gallucci S

    更新日期:2019-11-08 00:00:00

  • Pak1 Kinase Promotes Activated T Cell Trafficking by Regulating the Expression of L-Selectin and CCR7.

    abstract::Normal function of the adaptive immune system requires trafficking of T cells between the blood and lymphoid organs. Lymphocyte homing to lymph nodes requires that they cross endothelial barriers present in blood vessels and lymphatics. This multi-step process requires a remodeling of the lymphocyte plasma membrane, w...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Dios-Esponera A,Melis N,Subramanian BC,Weigert R,Samelson LE

    更新日期:2019-03-05 00:00:00

  • Critical Role of AdipoR1 in Regulating Th17 Cell Differentiation Through Modulation of HIF-1α-Dependent Glycolysis.

    abstract::We previously reported that adiponectin (AD) promotes naïve T cell differentiation into Th17 cells and participates in synovial inflammation and the bone erosion process in patients with rheumatoid arthritis. Here, we use a T cell lineage adiponectin receptor 1 (AdipoR1) conditional knockout model to investigate the r...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Zhang Q,Wang L,Jiang J,Lin S,Luo A,Zhao P,Tan W,Zhang M

    更新日期:2020-08-18 00:00:00

  • Immunoregulatory CD4(-)CD8(-) T cells as a potential therapeutic tool for transplantation, autoimmunity, and cancer.

    abstract::A central objective in organ transplantation and the treatment or prevention of autoimmune disease is the achievement of antigen-specific immune tolerance. An additional challenge in bone marrow transplantation for the treatment of hematological malignancies is the prevention of graft-vs-host disease (GVHD) while main...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Hillhouse EE,Delisle JS,Lesage S

    更新日期:2013-01-24 00:00:00

  • Novel Treatments in Lupus.

    abstract:PURPOSE OF REVIEW:The standard treatment options for systemic lupus erythematosus (SLE) are focused on non-specific immunosuppression. Over the past few years, scientific studies and ongoing clinical trials have shifted the paradigm with rapid advances in developing biologics and small molecules. A number of monoclonal...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审


    authors: Vukelic M,Li Y,Kyttaris VC

    更新日期:2018-11-16 00:00:00

  • Nanoparticle Interactions with the Immune System: Clinical Implications for Liposome-Based Cancer Chemotherapy.

    abstract::The development of stable and long-circulating liposomes provides protection of the drug cargo from degradation and increases tumor drug delivery, leading to the design of liposome formulations with great potential in cancer therapy. However, despite the sound pharmacologic basis, many liposomal as well as other nanop...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: La-Beck NM,Gabizon AA

    更新日期:2017-04-06 00:00:00

  • Adipocytes Directly Affect Coronary Artery Disease Pathogenesis via Induction of Adipokine and Cytokine Imbalances.

    abstract::This study aimed to investigate the adipokine and cytokine profiles of adipocytes from epicardial and subcutaneous adipose tissues in interconnection with the visceral adipose tissue area and the biochemical and clinical characteristics of patients with coronary artery disease. We assessed 84 patients with coronary ar...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Gruzdeva O,Uchasova E,Dyleva Y,Borodkina D,Akbasheva O,Antonova L,Matveeva V,Belik E,Ivanov S,Sotnikov A,Kozyrin K,Brel N,Sinitsky M,Karetnikova V,Kokov A,Bychkova E,Pecherina T,Barbarash O

    更新日期:2019-09-19 00:00:00

  • Genome-Wide Association Study on Immunoglobulin G Glycosylation Patterns.

    abstract::Immunoglobulin G (IgG), a glycoprotein secreted by plasma B-cells, plays a major role in the human adaptive immune response and are associated with a wide range of diseases. Glycosylation of the Fc binding region of IgGs, responsible for the antibody's effector function, is essential for prompting a proper immune resp...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Wahl A,van den Akker E,Klaric L,Štambuk J,Benedetti E,Plomp R,Razdorov G,Trbojević-Akmačić I,Deelen J,van Heemst D,Slagboom PE,Vučković F,Grallert H,Krumsiek J,Strauch K,Peters A,Meitinger T,Hayward C,Wuhrer M,Beekm

    更新日期:2018-02-26 00:00:00

  • Gene Expression Profiling of PDGFRA Mutant GIST Reveals Immune Signatures as a Specific Fingerprint of D842V Exon 18 Mutation.

    abstract::Platelet Derived Growth Factor Receptor Alpha (PDGFRA) mutations occur in only about 5-7% of gastrointestinal stromal tumors (GIST), notably with alterations on exons 12/14/18. The most frequent PDGFRA mutation is the exon 18 D842V, which is correlated to specific clinico-pathological features, such as primary imatini...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Indio V,Ravegnini G,Astolfi A,Urbini M,Saponara M,De Leo A,Gruppioni E,Tarantino G,Angelini S,Pession A,Pantaleo MA,Nannini M

    更新日期:2020-06-02 00:00:00

  • Targeting Complement Pathways in Polytrauma- and Sepsis-Induced Multiple-Organ Dysfunction.

    abstract::Exposure to traumatic or infectious insults results in a rapid activation of the complement cascade as major fluid defense system of innate immunity. The complement system acts as a master alarm system during the molecular danger response after trauma and significantly contributes to the clearance of DAMPs and PAMPs. ...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审


    authors: Karasu E,Nilsson B,Köhl J,Lambris JD,Huber-Lang M

    更新日期:2019-03-21 00:00:00

  • Oral Administration of Acrylamide Worsens the Inflammatory Responses in the Airways of Asthmatic Mice Through Agitation of Oxidative Stress in the Lungs.

    abstract::Acrylamide is a toxic chemical substance produced when starch-rich foods are fried at high temperatures. Asthma is a chronic and complicated respiratory disease, of which genetic and environmental factors are the main triggers. Orally-received components may have an effect on asthma pathophysiology. The aim of this st...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Hajimohammadi B,Athari SM,Abdollahi M,Vahedi G,Athari SS

    更新日期:2020-10-09 00:00:00

  • Metabolic Reprogramming in CD8+ T Cells During Acute Viral Infections.

    abstract::CD8+ T cells represent one of the most versatile immune cells critical for clearing away viral infections. Due to their important role, CD8+ T cell activation and memory formation during viral infection have been the focus of several studies recently. Although CD8+ T cell activation and memory formation have been asso...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审


    authors: Gupta SS,Wang J,Chen M

    更新日期:2020-05-22 00:00:00

  • Tannic Acid-Modified Silver and Gold Nanoparticles as Novel Stimulators of Dendritic Cells Activation.

    abstract::Silver nanoparticles (AgNPs) are promising new antimicrobial agents against a wide range of skin and mucosal pathogens. However, their interaction with the immune system is currently not fully understood. Dendritic cells (DCs) are crucial during development of T cell-specific responses against bacterial and viral path...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Orlowski P,Tomaszewska E,Ranoszek-Soliwoda K,Gniadek M,Labedz O,Malewski T,Nowakowska J,Chodaczek G,Celichowski G,Grobelny J,Krzyzowska M

    更新日期:2018-05-22 00:00:00

  • Altered Microbiota, Impaired Quality of Life, Malabsorption, Infection, and Inflammation in CVID Patients With Diarrhoea.

    abstract::Background: Diarrhoea is the commonest gastrointestinal symptom in patients with common variable immunodeficiency (CVID). Objective: The aim of this study was to describe the prevalence and clinical presentation of chronic and recurrent diarrhoea in the Royal-Free-Hospital (RFH) London CVID cohort, including symptoms,...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: van Schewick CM,Nöltner C,Abel S,Burns SO,Workman S,Symes A,Guzman D,Proietti M,Bulashevska A,Moreira F,Soetedjo V,Lowe DM,Grimbacher B

    更新日期:2020-07-31 00:00:00

  • Role of Dendritic Cells in Natural Immune Control of HIV-1 Infection.

    abstract::Dendritic cells (DCs) are professional antigen-presenting cells that link innate and adaptive immunity and are critical for the induction of protective immune responses against pathogens. Proportions of these cells are markedly decreased in the blood of untreated HIV-1-infected individuals, suggesting they might be in...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审


    authors: Martin-Gayo E,Yu XG

    更新日期:2019-06-06 00:00:00

  • T-cell immunity to infection with dengue virus in humans.

    abstract::Dengue virus (DENV) is the etiologic agent of dengue fever, the most significant mosquito-borne viral disease in humans. Up to 400 million DENV infections occur every year, and severity can range from asymptomatic to an acute self-limiting febrile illness. In a small proportion of patients, the disease can exacerbate ...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章,评审


    authors: Weiskopf D,Sette A

    更新日期:2014-03-07 00:00:00

  • Presence of Infected Gr-1intCD11bhiCD11cint Monocytic Myeloid Derived Suppressor Cells Subverts T Cell Response and Is Associated With Impaired Dendritic Cell Function in Mycobacterium avium-Infected Mice.

    abstract::Myeloid-derived suppressor cells (MDSC) are immature myeloid cells with immunomodulatory function. To study the mechanism by which MDSC affect antimicrobial immunity, we infected mice with two M. avium strains of differential virulence, highly virulent Mycobacterium avium subsp. avium strain 25291 (MAA) and low virule...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Abdissa K,Nerlich A,Beineke A,Ruangkiattikul N,Pawar V,Heise U,Janze N,Falk C,Bruder D,Schleicher U,Bogdan C,Weiss S,Goethe R

    更新日期:2018-10-16 00:00:00

  • Severe Heterotopic Ossification in the Skeletal Muscle and Endothelial Cells Recruitment to Chondrogenesis Are Enhanced by Monocyte/Macrophage Depletion.

    abstract::Altered macrophage infiltration upon tissue damage results in inadequate healing due to inappropriate remodeling and stem cell recruitment and differentiation. We investigated in vivo whether cells of endothelial origin phenotypically change upon heterotopic ossification induction and whether infiltration of innate im...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Tirone M,Giovenzana A,Vallone A,Zordan P,Sormani M,Nicolosi PA,Meneveri R,Gigliotti CR,Spinelli AE,Bocciardi R,Ravazzolo R,Cifola I,Brunelli S

    更新日期:2019-07-19 00:00:00

  • Adverse Husbandry of Maraena Whitefish Directs the Immune System to Increase Mobilization of Myeloid Cells and Proinflammatory Responses.

    abstract::Adverse life circumstances evoke a common "conserved transcriptional response to adversity" (CTRA) in mammalian leukocytes. To investigate whether this pattern is preserved in lower vertebrates, maraena whitefish (Coregonus maraena) were exposed for 9 days to different stocking densities: ~10 kg/m3 (low density), ~33 ...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Korytář T,Nipkow M,Altmann S,Goldammer T,Köllner B,Rebl A

    更新日期:2016-12-23 00:00:00

  • Alkaline pH Promotes NADPH Oxidase-Independent Neutrophil Extracellular Trap Formation: A Matter of Mitochondrial Reactive Oxygen Species Generation and Citrullination and Cleavage of Histone.

    abstract::pH is highly variable in different tissues and affects many enzymatic reactions in neutrophils. In response to calcium ionophores such as A23187 and ionomycin, neutrophils undergo nicotinamide adenine dinucleotide phosphate oxidase (NOX)-independent neutrophil extracellular trap (NET) formation (NETosis). However, how...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Naffah de Souza C,Breda LCD,Khan MA,de Almeida SR,Câmara NOS,Sweezey N,Palaniyar N

    更新日期:2018-01-09 00:00:00

  • Negative Effect of Age, but Not of Latent Cytomegalovirus Infection on the Antibody Response to a Novel Influenza Vaccine Strain in Healthy Adults.

    abstract::Older adults are more vulnerable to influenza virus infection and at higher risk for severe complications and influenza-related death compared to younger adults. Unfortunately, influenza vaccine responses tend to be impaired in older adults due to aging of the immune system (immunosenescence). Latent infection with cy...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: van den Berg SPH,Wong A,Hendriks M,Jacobi RHJ,van Baarle D,van Beek J

    更新日期:2018-01-29 00:00:00

  • Multiplexed Proteomic Analysis for Diagnosis and Screening of Five Primary Immunodeficiency Disorders From Dried Blood Spots.

    abstract::Early detection of Primary Immunodeficiencies Disorders (PIDDs) is of paramount importance for effective treatment and disease management. Many PIDDs would be strong candidates for newborn screening (NBS) if robust screening methods could identify patients from dried blood spots (DBS) during the neonatal period. As ma...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Collins CJ,Yi F,Dayuha R,Whiteaker JR,Ochs HD,Freeman A,Su HC,Paulovich AG,Segundo GRS,Torgerson T,Hahn SH

    更新日期:2020-04-01 00:00:00

  • Expression of Tumor Necrosis Factor Receptor 2 Characterizes TLR9-Driven Formation of Interleukin-10-Producing B Cells.

    abstract::B cell-derived interleukin-10 (IL-10) production has been described as a hallmark for regulatory function in B lymphocytes. However, there is an ongoing debate on the origin of IL-10-secreting B cells and lack of specific surface markers has turned into an important obstacle for studying human B regulatory cells. In t...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Ticha O,Moos L,Wajant H,Bekeredjian-Ding I

    更新日期:2018-01-19 00:00:00

  • Immune Tolerance Maintained by Cooperative Interactions between T Cells and Antigen Presenting Cells Shapes a Diverse TCR Repertoire.

    abstract::The T cell population in an individual needs to avoid harmful activation by self peptides while maintaining the ability to respond to an unknown set of foreign peptides. This property is acquired by a combination of thymic and extra-thymic mechanisms. We extend current models for the development of self/non-self discr...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Best K,Chain B,Watkins C

    更新日期:2015-08-07 00:00:00

  • Characterization of the Highly Prevalent Regulatory CD24hiCD38hi B-Cell Population in Human Cord Blood.

    abstract::The newborn's immune system must transition from a sterile haploidentical uterus to the world full of antigens. Regulatory B-cells (Breg; broadly defined as CD19+CD24hiCD38hi) are tolerance promoters in the adult immune system. They can inhibit IFN-γ and IL-17 production by T-cells and are essential in different condi...

    journal_title:Frontiers in immunology

    pub_type: 杂志文章


    authors: Esteve-Solé A,Teixidó I,Deyà-Martínez A,Yagüe J,Plaza-Martín AM,Juan M,Alsina L

    更新日期:2017-03-07 00:00:00