Intravenous Immunoglobulin and Immunomodulation of B-Cell - in vitro and in vivo Effects.

abstract：:Adoptive cell transfer therapy is currently one of the most promising approaches for cancer treatment. This therapy has some limitations, however, such as the dispersion of in vivo-administered cells, causing only a small proportion to reach the tumor. Nanotechnological approaches could offer a solution for this drawb...

journal_title：Frontiers in immunology

authors： Sanz-Ortega L,Rojas JM,Portilla Y,Pérez-Yagüe S,Barber DF

更新日期：2019-08-30 00:00:00

abstract：:Intravenous IgG (IVIg) contains polyclonal immunoglobulin G (IgG) from thousands of donors. It is administered at a low dose at regular intervals as antibody replacement therapy and at a higher dose as immunomodulatory treatment in various auto-immune or auto-inflammatory diseases. The working mechanism of immunomodul...

journal_title：Frontiers in immunology

authors： Nagelkerke SQ,Kuijpers TW

更新日期：2015-01-21 00:00:00

abstract：:Vaccines aiming to promote T-cell-mediated immune responses have so far showed limited efficacy, and there is a need for novel strategies. Studies indicate that autophagy plays an inherent role in antigen processing and presentation for CD4(+) and CD8(+) T cells. Here, we report a novel vaccine strategy based on fusio...

journal_title：Frontiers in immunology

authors： Andersen AN,Landsverk OJ,Simonsen A,Bogen B,Corthay A,Øynebråten I

更新日期：2016-05-10 00:00:00

abstract：:The impact of the highly polymorphic Killer-cell immunoglobulin-like receptor (KIR) gene cluster on the outcome of hematopoietic stem cell transplantation (HCST) is subject of current research. To further understand the involvement of this gene family into Natural Killer (NK) cell-mediated graft-versus-leukemia reacti...

journal_title：Frontiers in immunology

authors： Solloch UV,Schefzyk D,Schäfer G,Massalski C,Kohler M,Pruschke J,Heidl A,Schetelig J,Schmidt AH,Lange V,Sauter J

更新日期：2020-03-12 00:00:00

abstract：:Vaccination against Salmonella Typhi using the Vi capsular polysaccharide, a T-cell independent antigen, can protect from the development of typhoid fever. This implies that antibodies to Vi alone can protect in the absence of a T cell-mediated immune response; however, protective Vi antibodies have not been well-char...

journal_title：Frontiers in immunology

authors： Dahora LC,Jin C,Spreng RL,Feely F,Mathura R,Seaton KE,Zhang L,Hill J,Jones E,Alam SM,Dennison SM,Pollard AJ,Tomaras GD

更新日期：2019-11-01 00:00:00

abstract：:Systemic Lupus Erythematosus (SLE) is a common and devastating autoimmune disease, characterized by a dysregulated adaptive immune response against intracellular antigens, which involves both autoreactive T and B cells. In SLE, mainly intracellular autoantigens generate autoantibodies and these assemble into immune co...

journal_title：Frontiers in immunology

authors： Ugarte-Berzal E,Boon L,Martens E,Rybakin V,Blockmans D,Vandooren J,Proost P,Opdenakker G

更新日期：2019-03-22 00:00:00

abstract：:Diseases due to mycobacteria, including tuberculosis, leprosy, and Buruli ulcer, rank among the top causes of death and disability worldwide. Animal studies have revealed the importance of T cells in controlling these infections. However, the specific antigens recognized by T cells that confer protective immunity and ...

journal_title：Frontiers in immunology

authors： James CA,Seshadri C

更新日期：2020-02-11 00:00:00

abstract：:Acute graft-vs.-host disease (aGvHD) is one of the most frequent causes of transplant-related mortality (TRM) after allogeneic hematopoietic cell transplantation (alloHCT). Its treatment is complex and costly. The aim of this study was to retrospectively analyze the impact of country-specific socioeconomic factors on ...

journal_title：Frontiers in immunology

authors： Frankiewicz A,Peczynski C,Giebel S,Harrington A,Socié G,Niederwieser D,Scheid C,Bornhäuser M,Kröger N,Elmaagacli A,Afanasyev B,Dreger P,Rössig C,Blaise D,Kratz C,Yakoub-Agha I,Kremens B,Niemeyer CM,Wulf G,Blau I,P

更新日期：2020-07-23 00:00:00

abstract：:The complement anaphylatoxin, C5a, through binding to its receptors (C5aR or C5L2), has important biological properties for recruitment and activation of phagocytes. C5a has been identified as a powerful modulator of Toll-like receptor-induced cytokine and chemokine production by macrophages. Both the complement syste...

journal_title：Frontiers in immunology

authors： Grailer JJ,Bosmann M,Ward PA

更新日期：2013-01-09 00:00:00

abstract：:The innate immune system plays a critical early role in host defense against viruses, bacteria, and tumor cells. Until recently, natural killer (NK) cells and lymphoid tissue inducer (LTi) cells were the primary members of the innate lymphocyte family: NK cells form the front-line interface between the external enviro...

journal_title：Frontiers in immunology

authors： Rankin L,Groom J,Mielke LA,Seillet C,Belz GT

更新日期：2013-03-04 00:00:00

abstract：:Cell signaling is an essential requirement for mammalian cell invasion by Trypanosoma cruzi. Depending on the parasite strain and the parasite developmental form, distinct signaling pathways may be induced. In this short review, we focus on the data coming from studies with metacyclic trypomastigotes (MT) generated in...

journal_title：Frontiers in immunology

authors： Maeda FY,Cortez C,Yoshida N

更新日期：2012-11-28 00:00:00

abstract：:While it is now acknowledged that CD4+ T cells expressing CD25 and Foxp3 (Treg cells) regulate immune responses and, consequently, influence the pathogenesis of infectious diseases, the regulatory response mediated by Treg cells upon infection by Trypanosoma cruzi was still poorly characterized. In order to understand...

journal_title：Frontiers in immunology

authors： Araujo Furlan CL,Tosello Boari J,Rodriguez C,Canale FP,Fiocca Vernengo F,Boccardo S,Beccaria CG,Adoue V,Joffre O,Gruppi A,Montes CL,Acosta Rodriguez EV

更新日期：2018-11-05 00:00:00

abstract：:Immunomodulation and chronic inflammation are important mechanisms utilized by cancer cells to evade the immune defense and promote tumor progression. Therefore, various efforts were focused on the development of approaches to reprogram the immune response to increase the immune detection of cancer cells and enhance p...

journal_title：Frontiers in immunology

authors： Hammoudeh SM,Venkatachalam T,Ansari AW,Bendardaf R,Hamid Q,Rahmani M,Hamoudi R

更新日期：2020-12-14 00:00:00

abstract：:Therapy with Tyrosine Kinase Inhibitors (TKI) aiming stable deep molecular response is the gold standard to treat Chronic Myeloid Leukemia (CML). NKT-like cells (CD3+CD56+) combine characteristics of T and NK cells. The physiopathological role of these cells remains unknown although the literature refers their associa...

journal_title：Frontiers in immunology

authors： Almeida JS,Couceiro P,López-Sejas N,Alves V,Růžičková L,Tarazona R,Solana R,Freitas-Tavares P,Santos-Rosa M,Rodrigues-Santos P

更新日期：2019-10-22 00:00:00

abstract：:Increased concentrations of extracellular chromatin are observed in cancer, sepsis, and inflammatory autoimmune diseases like systemic lupus erythematosus (SLE) or rheumatoid arthritis (RA). In SLE and RA, extracellular chromatin may behave as a danger-associated molecular pattern (DAMP). Polymorphonuclear neutrophils...

journal_title：Frontiers in immunology

authors： Ribon M,Mussard J,Semerano L,Singer BB,Decker P

更新日期：2019-06-14 00:00:00

abstract：:Tuberculosis (TB) remains a leading global health problem that is aggravated by emergence of drug-resistant strains, which account for increasing number of treatment-refractory cases. Thus, eradication of this disease will strongly require better therapeutic strategies. Identification of host factors promoting disease...

journal_title：Frontiers in immunology

authors： Ndlovu H,Marakalala MJ

更新日期：2016-10-24 00:00:00

abstract：:microRNAs (miRNAs) are conserved non-coding small nucleotide molecules found in nearly all species and breastmilk. miRNAs present in breastmilk are very stable to freeze-thaw, RNase treatment, and low pH as they are protected inside exosomes. They are involved in regulating several physiologic and pathologic processes...

journal_title：Frontiers in immunology

authors： Carr LE,Bowlin AK,Elolimy AA,Byrum SD,Washam CL,Randolph CE,MacLeod SL,Yeruva L

更新日期：2020-06-23 00:00:00

abstract：:Inflammatory bowel disease (IBD) is a chronic and multifactorial disease of the gastrointestinal tract. The exact etiology of IBD remains complex and unclear involving an inadequately defined relationship between microbial insult, genetic predisposition, altered intestinal barrier permeability, oxidative stress compon...

journal_title：Frontiers in immunology

authors： Senhaji N,Kojok K,Darif Y,Fadainia C,Zaid Y

更新日期：2015-10-16 00:00:00

abstract：:Recent years have seen an unprecedented rise in the incidence of multidrug-resistant (MDR) Gram-negative bacteria (GNBs) such as Acinetobacter and Klebsiella species. In view of the shortage of novel drugs in the pipeline, alternative strategies to prevent, and treat infections by GNBs are urgently needed. Previously,...

journal_title：Frontiers in immunology

authors： Youssef EG,Zhang L,Alkhazraji S,Gebremariam T,Singh S,Yount NY,Yeaman MR,Uppuluri P,Ibrahim AS

更新日期：2020-02-18 00:00:00

abstract：:Protein 4.1R, a member of the 4.1 family, functions as a bridge between cytoskeletal and plasma membrane proteins. It is expressed in T cells, where it binds to a linker for activation of T cell (LAT) family member 1 and inhibits its phosphorylation and downstream signaling events after T cell receptor triggering. The...

journal_title：Frontiers in immunology

authors： Draberova L,Draberova H,Potuckova L,Halova I,Bambouskova M,Mohandas N,Draber P

更新日期：2020-01-14 00:00:00

abstract：:Preclinical and early human clinical studies of broadly neutralizing antibodies (bNAbs) to prevent and treat HIV infection support the clinical utility and potential of bNAbs for prevention, postexposure prophylaxis, and treatment of acute and chronic infection. Observed and potential limitations of bNAbs from these r...

journal_title：Frontiers in immunology

authors： Hua CK,Ackerman ME

更新日期：2017-11-28 00:00:00

abstract：:The study of molecular host-parasite interactions is essential to understand parasitic infection and adaptation within the host system. As well, prevention and treatment of infectious diseases require a clear understanding of the molecular crosstalk between parasites and their hosts. Yet, large-scale experimental iden...

journal_title：Frontiers in immunology

authors： Cuesta-Astroz Y,Santos A,Oliveira G,Jensen LJ

更新日期：2019-02-13 00:00:00

abstract：Objective:To examine the utility of the peripheral blood neutrophil-to-lymphocyte ratio (NLR) and monocyte-to-lymphocyte ratio (MLR) as biomarkers of prognosis in seropositive autoimmune encephalitis (AE). Methods:In this multicenter study, we retrospectively analyzed 57 cases of seropositive AE with hospital admissio...

journal_title：Frontiers in immunology

authors： Broadley J,Wesselingh R,Seneviratne U,Kyndt C,Beech P,Buzzard K,Nesbitt C,D'Souza W,Brodtmann A,Kalincik T,Butzkueven H,O'Brien TJ,Monif M,Australian Autoimmune Encephalitis Consortium.

更新日期：2021-01-14 00:00:00

abstract：:Toll-like receptors (TLR) triggering of B cells are known to promote B cell expansion, differentiation of B cells into antibody-producing and memory cells, but the TLR responses of porcine B cells is poorly characterized. Therefore, this study investigated the response pattern of porcine B cell subsets to a large coll...

journal_title：Frontiers in immunology

authors： Braun RO,Python S,Summerfield A

更新日期：2017-08-25 00:00:00

abstract：:The aberrant expression of human endogenous retrovirus (HERV) elements of the HERV-W family has been associated with different diseases, including multiple sclerosis (MS). In particular, the expression of the envelope protein (Env) from the multiple sclerosis-associated retrovirus (MSRV), a member of HERV-W family and...

journal_title：Frontiers in immunology

authors： Charvet B,Reynaud JM,Gourru-Lesimple G,Perron H,Marche PN,Horvat B

更新日期：2018-12-06 00:00:00

abstract：:Red blood cell (RBC) alloimmunization can make it difficult to procure compatible RBCs for future transfusion, directly leading to increased morbidity and mortality in transfusion-dependent patients. However, the factors that regulate RBC alloimmunization remain incompletely understood. As complement has been shown to...

journal_title：Frontiers in immunology

authors： Mener A,Arthur CM,Patel SR,Liu J,Hendrickson JE,Stowell SR

更新日期：2018-06-11 00:00:00

abstract：:Intrarenal robust inflammatory response following ischemia-reperfusion injury (IRI) is a major factor in the pathogenesis of renal injury in ischemic acute kidney injury (AKI). Although numerous studies have investigated various agents of immune modulation or suppression for ischemic AKI, few showed reproducible effec...

journal_title：Frontiers in immunology

authors： Jang HR,Lee K,Jeon J,Kim JR,Lee JE,Kwon GY,Kim YG,Kim DJ,Ko JW,Huh W

更新日期：2020-10-14 00:00:00

abstract：:Infiltration of immune cells into the tumor microenvironment (TME) can regulate growth and survival of neoplastic cells, impacting tumorigenesis and tumor progression. Correlations between the number of effector immune cells present in a tumor and clinical outcomes in many human tumors, including breast, have been wid...

journal_title：Frontiers in immunology

authors： Pachynski RK,Wang P,Salazar N,Zheng Y,Nease L,Rosalez J,Leong WI,Virdi G,Rennier K,Shin WJ,Nguyen V,Butcher EC,Zabel BA

更新日期：2019-05-08 00:00:00

abstract：:Natural killer (NK) cells are large granular lymphocytes involved in our defense against certain virus-infected and malignant cells. In contrast to T cells, NK cells elicit rapid anti-tumor responses based on signals from activating and inhibitory cell surface receptors. They also lyse target cells via antibody-depend...

journal_title：Frontiers in immunology

authors： Carlsten M,Järås M

更新日期：2019-10-11 00:00:00

abstract：:Red blood cells (RBCs) have a well-defined lifespan, indicating a mechanism by which senescent cells of a certain age are removed from circulation. However, the specifics by which senescent cells are recognized and removed are poorly understood. There are multiple competing hypotheses for this process, perhaps the mos...

journal_title：Frontiers in immunology

authors： Hudson KE,de Wolski K,Kapp LM,Richards AL,Schniederjan MJ,Zimring JC

更新日期：2017-10-30 00:00:00