Abstract:
:Delivery of high doses of radiation to thoracic region, particularly with non-small cell lung cancer patients, becomes difficult due to subsequent complications arising in the lungs of the patient. Radiation-induced pneumonitis is an early event evident in most radiation exposed patients observed within 2-4 months of treatment and leading to fibrosis later. Several cytokines and inflammatory molecules interplay in the vicinity of the tissue developing radiation injury leading to pneumonitis and fibrosis. While certain cytokines may be exploited as biomarkers, they also appear to be a potent target of intervention at transcriptional level. Initiation and progression of pneumonitis and fibrosis thus are dynamic processes arising after few months to year after irradiation of the lung tissue. Currently, available treatment strategies are challenged by the major dose limiting complications that curtails success of the treatment as well as well being of the patient's future life. Several approaches have been in practice while many other are still being explored to overcome such complications. The current review gives a brief account of the immunological aspects, existing management practices, and suggests possible futuristic approaches.
journal_name
Front Immunoljournal_title
Frontiers in immunologyauthors
Kainthola A,Haritwal T,Tiwari M,Gupta N,Parvez S,Tiwari M,Prakash H,Agrawala PKdoi
10.3389/fimmu.2017.00506subject
Has Abstractpub_date
2017-05-02 00:00:00pages
506issn
1664-3224journal_volume
8pub_type
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