Cerebellar Contributions to Major Depression.

abstract：:Pharmacogenomics represents a potentially powerful enhancement to the current standard of care for psychiatric patients. However, a variety of biological and technical challenges must be addressed in order to provide adequate clinical decision support for personalized prescribing and dosing based on genomic data. This...

journal_title：Frontiers in psychiatry

authors： Jarvis JP,Peter AP,Shaman JA

更新日期：2019-06-20 00:00:00

abstract：:It has been proposed that compulsive drug seeking reflects an underlying dysregulation in adaptive behavior that favors habitual (automatic and inflexible) over goal-directed (deliberative and highly flexible) action selection. Rodent studies have established that repeated exposure to cocaine or amphetamine facilitate...

journal_title：Frontiers in psychiatry

authors： Halbout B,Liu AT,Ostlund SB

更新日期：2016-03-21 00:00:00

abstract：:Adenosine-to-inosine (A-to-I) RNA editing is a co-/posttranscriptional modification of double-stranded RNA, catalyzed by the adenosine deaminase acting on RNA (ADAR) family of enzymes, which results in recognition of inosine as guanosine by translational and splicing machinery causing potential recoding events in amin...

journal_title：Frontiers in psychiatry

authors： Dick ALW,Khermesh K,Paul E,Stamp F,Levanon EY,Chen A

更新日期：2019-04-26 00:00:00

abstract：:Acute growth in negative affect is thought to play a major role in triggering relapse in opiate-dependent individuals. Consistent with this view, three lab studies have demonstrated that negative mood induction increases opiate craving in opiate-dependent individuals. The current study sought to confirm these effects ...

journal_title：Frontiers in psychiatry

authors： Hogarth L,Hardy L,Bakou A,Mahlberg J,Weidemann G,Cashel S,Moustafa AA

更新日期：2019-05-15 00:00:00

abstract：:Background: Open-door policies in psychiatry are discussed as a means to improve the treatment of involuntarily committed patients in various aspects. Current research on open-door policies focuses mainly on objective effects, such as the number of coercive interventions or serious incidents. The aim of the present st...

journal_title：Frontiers in psychiatry

authors： Efkemann SA,Bernard J,Kalagi J,Otte I,Ueberberg B,Assion HJ,Zeiß S,Nyhuis PW,Vollmann J,Juckel G,Gather J

更新日期：2019-08-30 00:00:00

abstract：:Background: Bipolar disorder (BD) has been associated with distributed network disruption, but little is known on how different clinical subtypes, particularly those with an earlier and later onset of disease, are related to connectivity changes in white matter (WM) tracts. Methods: Diffusion tensor imaging (DTI) and ...

journal_title：Frontiers in psychiatry

authors： Alves GS,Knöchel C,Paulitsch MA,Reinke B,Carvalho AF,Feddern R,Prvulovic D,Sudo FK,Pantel J,Reif A,Oertel V

更新日期：2018-10-09 00:00:00

abstract：:Objectives: This study aimed to examine the rate of remission in individuals experiencing early-onset poststroke depression (PSD) in China and to identify predictors of remission during a 3-month follow-up. This study also explored the interaction between cognitive impairment and depression. Methods: A total of 820 pa...

journal_title：Frontiers in psychiatry

authors： Huang J,Zhou FC,Guan B,Zhang N,Wang A,Yu P,Zhou L,Wang CY,Wang C

更新日期：2019-01-08 00:00:00

abstract：:Patients with cancer are more likely to develop depression than the general population, which negatively impacts their quality of life and prognosis. In order to identify effective antidepressants catered toward cancer patients, the biology of depression in the context of cancer must be well-understood. Many theories ...

journal_title：Frontiers in psychiatry

authors： Young K,Singh G

更新日期：2018-07-10 00:00:00

abstract：:Background: While preliminary evidence suggests that sensors may be employed to detect presence of low mood it is still unclear whether they can be leveraged for measuring depression symptom severity. This study evaluates the feasibility and performance of assessing depressive symptom severity by using behavioral and ...

journal_title：Frontiers in psychiatry

authors： Pedrelli P,Fedor S,Ghandeharioun A,Howe E,Ionescu DF,Bhathena D,Fisher LB,Cusin C,Nyer M,Yeung A,Sangermano L,Mischoulon D,Alpert JE,Picard RW

更新日期：2020-12-18 00:00:00

abstract：:Aim: Acute psychosis is not an uncommon presenting feature in immune-mediated encephalitides. Most patients improve if properly diagnosed and treated expediently with immunotherapy. Our study aimed to describe the frequency, clinical spectrum, and long-term outcomes in patients presenting with acute psychosis who have...

journal_title：Frontiers in psychiatry

authors： Tang C,Tan K,Lim G,Tan L,Tay KY,Kandiah N,Abdin E,Verma SK

更新日期：2019-12-13 00:00:00

abstract：:Introduction: Although binge eating disorder (BED) is an eating disorder and obesity is a clinical disease, it is known that both conditions present overlapped symptoms related to, at least partially, the disruption of homeostatic and hedonistic eating behavior pathways. Therefore, the understanding of neural substrat...

journal_title：Frontiers in psychiatry

authors： Antunes LC,Elkfury JL,Parizotti CS,Brietzke AP,Bandeira JS,Torres ILDS,Fregni F,Caumo W

更新日期：2020-10-14 00:00:00

abstract：:Current diagnoses of schizophrenia and related psychiatric disorders are classified by phenomenological principles and clinical descriptions while ruling out other symptoms and conditions. Specific biomarkers are needed to assist the current diagnostic system. However, complicated gene and environment interactions ind...

journal_title：Frontiers in psychiatry

authors： Jiang W,King TZ,Turner JA

更新日期：2019-07-12 00:00:00

abstract：:We use auditory verbal hallucinations (AVH) to illustrate the challenges in defining and assessing target engagement in the context of transcranial direct current stimulation (tDCS) for psychiatric disorders. We defined the target network as the cluster of regions of interest (ROIs) that are consistently implicated in...

journal_title：Frontiers in psychiatry

authors： Lee WH,Kennedy NI,Bikson M,Frangou S

更新日期：2018-02-22 00:00:00

abstract：:Introduction: Evidence from developed countries shows the efficacy of computer-assisted cognitive-behavioral therapy (cCBT) in addressing adolescent depression in home and/or school settings. This paper presents the results of a randomized controlled trial (RCT) of a brief therapist-guided cCBT intervention for adoles...

journal_title：Frontiers in psychiatry

authors： Martínez V,Rojas G,Martínez P,Gaete J,Zitko P,Vöhringer PA,Araya R

更新日期：2019-07-30 00:00:00

abstract：:The nucleus accumbens (NAc) plays an important role in the reward circuit, and abnormal regional activities of the reward circuit have been reported in various psychiatric disorders including somatization disorder (SD). However, few researches are designed to analyze the NAc connectivity in SD. This study was designed...

journal_title：Frontiers in psychiatry

authors： Ou Y,Su Q,Liu F,Ding Y,Chen J,Zhang Z,Zhao J,Guo W

更新日期：2019-08-16 00:00:00

abstract：:Bipolar disorder (BD) is a leading cause of worldwide disability among mood disorders. Pathological mechanisms are still vastly unclear, and current treatments with conventional medications are often unsatisfactory in maintaining symptoms control and an adequate quality of life. Consequently, current research is focus...

journal_title：Frontiers in psychiatry

authors： Benedetti F,Aggio V,Pratesi ML,Greco G,Furlan R

更新日期：2020-02-26 00:00:00

abstract：:A small number of severely and persistently mentally ill in-patients awaiting residential or long-stay facilities represent an obstacle to the efficient utilization of acute care beds. These facilities are costly and currently reputed to be contrary to recovery principles. In 2013, all acute psychiatric care wards in ...

journal_title：Frontiers in psychiatry

authors： Rapisarda F,Felx A,Gagnon S,De Benedictis L,Luyet A,Boutin M,Corbière M,Lesage A

更新日期：2020-04-07 00:00:00

abstract：Introduction:Visual impairment (VI) is associated with a variety of comorbidities including physical and mental health in industrial countries. Our aim is to examine associations between self-reported impairment and depressive symptoms in the German population. Methods:The point prevalence of self-reported VI in Germa...

journal_title：Frontiers in psychiatry

authors： Schuster AK,Tesarz J,Rezapour J,Beutel ME,Bertram B,Pfeiffer N

更新日期：2018-04-09 00:00:00

abstract：:Cognitive neuroscience enables us now to decompose major depressive disorder into dysfunctional component processes and relate these processes to specific neural substrates. This approach can be used to illuminate the biological basis of altered psychological processes in depression, including abnormal decision-making...

journal_title：Frontiers in psychiatry

authors： Howlett JR,Paulus MP

更新日期：2013-11-08 00:00:00

abstract：:Background: The intrinsic motivation behind the "need to complete" is more influential than external incentives. We introduced a novel progress-bar tool to motivate the completion of programs designed to treat stimulant and cannabis use disorders. We further examined the effectiveness of the progress bar's scoring app...

journal_title：Frontiers in psychiatry

authors： Chen IC,Teng G,Chen CJ,Lan TH,Liu HJ

更新日期：2020-01-13 00:00:00

abstract：:Autism spectrum disorder (ASD) is a behaviorally defined disorder that is now thought to affect approximately 1 in 69 children in the United States. In most cases, the etiology is unknown, but several studies point to the interaction of genetic predisposition with environmental factors. The immune system is thought to...

journal_title：Frontiers in psychiatry

authors： Harville T,Rhodes-Clark B,Bennuri SC,Delhey L,Slattery J,Tippett M,Wynne R,Rose S,Kahler S,Frye RE

更新日期：2019-09-11 00:00:00

abstract：:Previous work from our group and others utilizing animal models have demonstrated long-lasting structural and functional alterations in the meso-cortico-striatal dopamine pathway following prenatal cocaine (PCOC) treatment. We have shown that PCOC treatment results in augmented D1-induced cyclic AMP (cAMP) and cocaine...

journal_title：Frontiers in psychiatry

authors： Tropea TF,Kabir ZD,Kaur G,Rajadhyaksha AM,Kosofsky BE

更新日期：2011-12-07 00:00:00

abstract：:Background: Individual placement and support (IPS) has proven to be effective for vocational outcomes in people with mental illness. The original concept of IPS requires temporally unlimited provision of support. Using limited placement budgets and investigating factors that predict their effectiveness may inform deci...

journal_title：Frontiers in psychiatry

authors： Rössler W,Ujeyl M,Kawohl W,Nordt C,Lasalvia A,Haker H,Hengartner MP

更新日期：2019-07-19 00:00:00

abstract：:Social cognition is a fundamental ability in human everyday lives. Deficits in social functioning also represent a core aspect of many psychiatric disorders. Yet, despite its significance, deficits in social cognition skills are insufficiently targeted by current treatments. Hallucinogens and entactogens have been sho...

journal_title：Frontiers in psychiatry

authors： Preller KH,Vollenweider FX

更新日期：2019-12-03 00:00:00

abstract：Background:Epidemiological studies have shown that total scores in depression screening scales change with age, but the mechanism underlying these age-related changes remains unclear. Previous research has indicated that item responses in depression screening scales exhibit characteristic distributions in the general p...

journal_title：Frontiers in psychiatry

authors： Tomitaka S,Kawasaki Y,Ide K,Akutagawa M,Ono Y,Furukawa TA

更新日期：2020-07-22 00:00:00

abstract：:Previous work has demonstrated that goal-directed control of alcohol-seeking and other drug-related behaviors is reduced following extended self-administration and drug exposure. Here, we examined how the magnitude of stimulus influences on responding changes across similar training and drug exposure. Rats self-admini...

journal_title：Frontiers in psychiatry

authors： Corbit LH,Janak PH

更新日期：2016-10-10 00:00:00

abstract：:Background: Young adults regularly using cannabis represent a uniquely vulnerable yet heterogeneous cohort. Few studies have examined user profiles using cannabis use motives and expectations. The association between user profiles and psychosocial functioning among only regular users remains unexplored. This explorati...

journal_title：Frontiers in psychiatry

authors： Amiet D,Youssef GJ,Hagg LJ,Lorenzetti V,Parkes L,Solowij N,Yücel M

更新日期：2020-12-15 00:00:00

abstract：:Due to advances over the last several decades, many fields of medicine are moving toward a precision medicine approach where treatments are tailored to nuanced patient factors. While in some disciplines these innovations are commonplace leading to unique biomarker-guided experimental medicine trials, there are no such...

journal_title：Frontiers in psychiatry

authors： Joshi YB,Light GA

更新日期：2018-11-19 00:00:00

abstract：:Objectives: While evidence that episodes of mania in bipolar I are associated with changes in bioenergetic and regional cerebral blood flow (rCBF) and cerebral blood flow velocity (rCBFV), both the regions and the extent of these changes have not yet been defined. Therefore, we determined the pattern of regional cereb...

journal_title：Frontiers in psychiatry

authors： Wang Y,Liu X,Li P,Zhou H,Yang L,Zheng L,Xie P,Li L,Liao DJ,Liu Q,Fang D

更新日期：2018-07-04 00:00:00

abstract：:This protocol describes a study that will test the effectiveness of a 7-week non-clinical digital coaching intervention to promote self-control. The goal of the coaching is to support and guide people who are willing and motivated to improve their self-control with the help of the smartphone application MindHike. The ...

journal_title：Frontiers in psychiatry

authors： Allemand M,Keller L,Gmür B,Gehriger V,Oberholzer T,Stieger M

更新日期：2020-10-09 00:00:00