Consequences of CYP2D6 Copy-Number Variation for Pharmacogenomics in Psychiatry.

abstract：:The high rate of comorbidity between insomnia and anxiety disorders have been confirmed by previous studies. However, the underlying neurobiological correlates of the relationship between insomnia and anxiety disorders are largely unknown. The aim of the present study was to investigate the effect of insomnia on corti...

journal_title：Frontiers in psychiatry

authors： Huang Z,Zhan S,Chen C,Li N,Ding Y,Hou Y,Wang L,Wang Y

更新日期：2019-01-10 00:00:00

abstract：:Inflammatory processes associated with persistent (chronic) infection have long been discussed as etiological factors in psychiatric disorders. Studies have found that people with major depression have higher levels of pro-inflammatory cytokines, for example, IL-1, IL-6, and tumor necrosis factor-alpha, and C-reactive...

journal_title：Frontiers in psychiatry

authors： Müller N

更新日期：2019-05-31 00:00:00

abstract：:Background: The personality trait neuroticism has been implicated in a poor response to stress, may relate to increased concentrations of cytokines and the development of depression. Inflammatory mechanisms may also be associated with the onset, severity and symptoms of depression. Both are related to poor antidepress...

journal_title：Frontiers in psychiatry

authors： Schmidt FM,Sander C,Minkwitz J,Mergl R,Dalton B,Holdt LM,Teupser D,Hegerl U,Himmerich H

更新日期：2018-11-20 00:00:00

abstract：:Background: Voxel-based morphometry studies have repeatedly highlighted the presence of distributed gray matter changes in schizophrenia, but to date, it is not clear if clinically useful prognostic information can be gleaned from structural imaging. The suspected association between gray matter volume (GMV) and durat...

journal_title：Frontiers in psychiatry

authors： Li M,Li X,Das TK,Deng W,Li Y,Zhao L,Ma X,Wang Y,Yu H,Meng Y,Wang Q,Palaniyappan L,Li T

更新日期：2019-04-15 00:00:00

abstract：:Neuroimaging holds the promise that it may one day aid the clinical assessment of individual psychiatric patients. However, the vast majority of studies published so far have been based on average differences between groups, which do not permit accurate inferences at the level of the individual. We examined the potent...

journal_title：Frontiers in psychiatry

authors： Tognin S,Pettersson-Yeo W,Valli I,Hutton C,Woolley J,Allen P,McGuire P,Mechelli A

更新日期：2014-01-29 00:00:00

abstract：:Background: Young adults regularly using cannabis represent a uniquely vulnerable yet heterogeneous cohort. Few studies have examined user profiles using cannabis use motives and expectations. The association between user profiles and psychosocial functioning among only regular users remains unexplored. This explorati...

journal_title：Frontiers in psychiatry

authors： Amiet D,Youssef GJ,Hagg LJ,Lorenzetti V,Parkes L,Solowij N,Yücel M

更新日期：2020-12-15 00:00:00

abstract：:Proton exchange provides a powerful contrast mechanism for magnetic resonance imaging (MRI). MRI techniques sensitive to proton exchange provide new opportunities to map, with high spatial and temporal resolution, compounds important for brain metabolism and function. Two such techniques, chemical exchange saturation ...

journal_title：Frontiers in psychiatry

authors： Shaffer JJ Jr,Mani M,Schmitz SL,Xu J,Owusu N,Wu D,Magnotta VA,Wemmie JA

更新日期：2020-09-24 00:00:00

abstract：:Alcohol Use Disorder (AUD) is a chronic and relapsing condition characterized by harmful alcohol intake and behavioral-cognitive changes. AUD is the most common cause of liver disease in the Western world. Alcohol abstinence is the cornerstone of therapy in alcoholic patients affected with liver disease. Medical recom...

journal_title：Frontiers in psychiatry

authors： Mosoni C,Dionisi T,Vassallo GA,Mirijello A,Tarli C,Antonelli M,Sestito L,Rando MM,Tosoni A,De Cosmo S,Gasbarrini A,Addolorato G

更新日期：2018-10-01 00:00:00

abstract：Background:Gastric necrosis following acute gastric dilatation is rare but more common in females with eating disorders, such as anorexia nervosa or bulimia, during which patients often alternate restriction and binge eating behaviors. Case Presentation:A 37-year old female patient with a history of 15 years of bulimi...

journal_title：Frontiers in psychiatry

authors： Achamrah N,Grigioni S,Coëffier M,Ainseba N,Déchelotte P

更新日期：2020-07-31 00:00:00

abstract：:Background: Left-behind children (LBC) are becoming a widespread phenomenon and face higher risks of psychological and educational problems. Our study aimed to explore school bullying in LBC and examine the effectiveness of art therapy intervention for reducing bullying victimization affecting LBC in rural areas. Meth...

journal_title：Frontiers in psychiatry

authors： Yan H,Chen J,Huang J

更新日期：2019-02-07 00:00:00

abstract：:The progress of developing effective interventions against psychiatric disorders has been limited due to a lack of understanding of the underlying cellular and functional mechanisms. Recent research findings focused on exploring novel causes of psychiatric disorders have highlighted the importance of the axonal initia...

journal_title：Frontiers in psychiatry

authors： Hsu WC,Nilsson CL,Laezza F

更新日期：2014-08-21 00:00:00

abstract：:The extraordinary health emergency of the COVID-19 pandemic represents a new challenge for mental health researchers and clinical practitioners. The related containment measures may be a risk factor for psychological distress and mood disorders, especially in at-risk populations. This study aims to explore the impact ...

journal_title：Frontiers in psychiatry

authors： Spinola O,Liotti M,Speranza AM,Tambelli R

更新日期：2020-11-17 00:00:00

abstract：Background:Loss aversion is a central and well operationalized trait behavior that describes the tendency for humans to strongly prefer avoiding losses to making equivalent gains. Human decision-making is thus biased toward safer choices. Aim:The aim of this study was to explore the relationship between loss aversion ...

journal_title：Frontiers in psychiatry

authors： Hadlaczky G,Hökby S,Mkrtchian A,Wasserman D,Balazs J,Machín N,Sarchiapone M,Sisask M,Carli V

更新日期：2018-04-05 00:00:00

abstract：:The rapidly increasing number of patients with Alzheimer's disease (AD) worldwide has become a major public concern. Mild cognitive impairment (MCI), characterized with accelerated memory decline than normal aging, is a stage between cognitively unimpaired and dementia. Identification of MCI in the Alzheimer's continu...

journal_title：Frontiers in psychiatry

authors： Lin L,Xing G,Han Y

更新日期：2018-12-06 00:00:00

abstract：BACKGROUND:Attention deficit hyperactivity disorder (ADHD) is a prevalent neurodevelopmental disorder affecting children, adolescents, and adults. Its etiology is not well understood, but it is increasingly believed to result from diverse pathophysiologies that affect the structure and function of specific brain circui...

journal_title：Frontiers in psychiatry

authors： Khadka S,Pearlson GD,Calhoun VD,Liu J,Gelernter J,Bessette KL,Stevens MC

更新日期：2016-07-25 00:00:00

abstract：Background:Depression is a leading cause of disability worldwide and is a major contributor to the overall global burden of disease, but its etiology is poorly understood. It has been reported that a disrupted biological rhythm, in terms of a shortened light duration and total darkness, can cause depression-like behavi...

journal_title：Frontiers in psychiatry

authors： Hu H,Kang C,Hou X,Zhang Q,Meng Q,Jiang J,Hao W

更新日期：2020-04-08 00:00:00

abstract：Objective:Schizophrenia poses a tremendous health, social, and economic burden upon patients and society, indicating current treatment options remain inadequate. Recent findings from several lines of evidence have pointed to the importance of immune system involvement in not only premorbid neurodevelopmental but also s...

journal_title：Frontiers in psychiatry

authors： De Picker LJ,Morrens M,Chance SA,Boche D

更新日期：2017-11-16 00:00:00

abstract：:Social cognition refers to the mental operations underlying social interactions. Given the major role of social cognitive deficits in the disability associated with severe psychiatric disorders, they therefore constitute a crucial therapeutic target. However, no easily understandable and transnosographic self-assessme...

journal_title：Frontiers in psychiatry

authors： Graux J,Thillay A,Morlec V,Sarron PY,Roux S,Gaudelus B,Prost Z,Brénugat-Herné L,Amado I,Morel-Kohlmeyer S,Houy-Durand E,Franck N,Carteau-Martin I,Danset-Alexandre C,Peyroux E

更新日期：2019-11-21 00:00:00

abstract：Objective:To explore the attitudes and factors in seeking professional psychological help among a Chinese community-dwelling population in order to promote positive help-seeking behaviors and better utilization of mental health services. Methods:Using system and simple random sampling with Kish selection table methods...

journal_title：Frontiers in psychiatry

authors： Chen P,Liu XJ,Wang XQ,Yang BX,Ruan J,Liu Z

更新日期：2020-05-14 00:00:00

abstract：:Alcohol use disorder (AUD) is a devastating public health problem in which both genetic and environmental factors play a role. Growing evidence supports that epigenetic regulation is one major mechanism in neuroadaptation that contributes to development of AUD. Meanwhile, epigenetic patterns can be modified by various...

journal_title：Frontiers in psychiatry

authors： Chen J,Hutchison KE,Bryan AD,Filbey FM,Calhoun VD,Claus ED,Lin D,Sui J,Du Y,Liu J

更新日期：2018-11-15 00:00:00

abstract：BACKGROUND:Evidence indicates that early life stress (ELS) can induce persistent changes in the hypothalamic-pituitary-adrenal (HPA) axis to respond to stress in the adult life that leads to depression. These appear to be related to the impairment of HPA hormones through binding to glucocorticoid (GR) and mineralocorti...

journal_title：Frontiers in psychiatry

authors： Baes Cv,Martins CM,Tofoli SM,Juruena MF

更新日期：2014-01-24 00:00:00

abstract：Background:Discharge from acute mental health services has long been associated with mortality, risk, and related adverse outcomes for patients. Many of the interventions that currently aim to reduce adverse outcomes focus on a single group of healthcare professionals within a single healthcare setting. A recent system...

journal_title：Frontiers in psychiatry

authors： Tyler N,Wright N,Grundy A,Gregoriou K,Campbell S,Waring J

更新日期：2020-04-21 00:00:00

abstract：:Major depressive disorder (MDD) is a serious mental disease with negative effects on both mental and physical health of the patient. Currently, antidepressants are among the major ways to ease or treat MDD. However, the existing antidepressants have limited efficacy in treating MDD, with a large fraction of patients e...

journal_title：Frontiers in psychiatry

authors： Xin J,Yuan M,Peng Y,Wang J

更新日期：2020-03-18 00:00:00

abstract：:Background: Unlike other episodic sleep disorders in childhood, there are no agreed severity indices for rhythmic movement disorder. While movements can be characterized in detail by polysomnography, in our experience most children inhibit rhythmic movement during polysomnography. Actigraphy and home video allow asses...

journal_title：Frontiers in psychiatry

authors： Gall M,Kohn B,Wiesmeyr C,van Sluijs RM,Wilhelm E,Rondei Q,Jäger L,Achermann P,Landolt HP,Jenni OG,Riener R,Garn H,Hill CM

更新日期：2019-10-16 00:00:00

abstract：:There is accruing evidence of cerebellar abnormalities in schizophrenia. The theory of cognitive dysmetria considers cerebellar dysfunction a key component of schizophrenia. Delay eyeblink conditioning (EBC), a cerebellar-dependent translational probe, is a behavioral index of cerebellar integrity. The circuitry under...

journal_title：Frontiers in psychiatry

authors： Kent JS,Bolbecker AR,O'Donnell BF,Hetrick WP

更新日期：2015-12-18 00:00:00

abstract：Objective:There is a growing interest in evaluating the effectiveness of compassion interventions for treating psychological disorders. The present study evaluated the effectiveness of "attachment-based compassion therapy" (ABCT) in the treatment of fibromyalgia (FM), and the role of psychological flexibility as a medi...

journal_title：Frontiers in psychiatry

authors： Montero-Marín J,Navarro-Gil M,Puebla-Guedea M,Luciano JV,Van Gordon W,Shonin E,García-Campayo J

更新日期：2018-01-16 00:00:00

abstract：:A feature of human culture is that we can learn to consume chemical compounds, derived from natural plants or synthetic fabrication, for their psychoactive effects. These drugs change the mental state and/or the behavioral performance of an individual and can be instrumentalized for various purposes. After the emergen...

journal_title：Frontiers in psychiatry

authors： Hassan Z,Bosch OG,Singh D,Narayanan S,Kasinather BV,Seifritz E,Kornhuber J,Quednow BB,Müller CP

更新日期：2017-08-18 00:00:00

abstract：:Criminal responsibility assessment is undertaken by psychologists or psychiatrists to assess offenders' legal capacities, which vary among countries or regional legislations. There are two psychometric tools (i.e., checklists) validated for criminal responsibility assessment: the Roger Criminal Responsibility Scale, a...

journal_title：Frontiers in psychiatry

authors： Meyer LF,Leal CCS,Omena AAS,Mecler K,Valença AM

更新日期：2020-11-27 00:00:00

abstract：:Renewing interest in immune aspects of schizophrenia and new findings about the brain-fat axis encourage us to discuss the possible role of interleukin-6 (IL-6) in schizophrenia. Previously, it was suggested that a primary alteration of the innate immune system may be relevant in schizophrenia. Functional dichotomy of...

journal_title：Frontiers in psychiatry

authors： Borovcanin MM,Jovanovic I,Radosavljevic G,Pantic J,Minic Janicijevic S,Arsenijevic N,Lukic ML

更新日期：2017-11-06 00:00:00

abstract：:Patients with cancer are more likely to develop depression than the general population, which negatively impacts their quality of life and prognosis. In order to identify effective antidepressants catered toward cancer patients, the biology of depression in the context of cancer must be well-understood. Many theories ...

journal_title：Frontiers in psychiatry

authors： Young K,Singh G

更新日期：2018-07-10 00:00:00