Abstract:
:We use auditory verbal hallucinations (AVH) to illustrate the challenges in defining and assessing target engagement in the context of transcranial direct current stimulation (tDCS) for psychiatric disorders. We defined the target network as the cluster of regions of interest (ROIs) that are consistently implicated in AVH based on the conjunction of multimodal meta-analytic neuroimaging data. These were prescribed in the New York Head (a population derived model) and head models of four single individuals. We appraised two potential measures of target engagement, tDCS-induced peak electric field strength and tDCS-modulated volume defined as the percentage of the volume of the AVH network exposed to electric field magnitude stronger than the postulated threshold for neuronal excitability. We examined a left unilateral (LUL) montage targeting the prefrontal cortex (PFC) and temporoparietal junction (TPJ), a bilateral (BL) prefrontal montage, and a 2 × 1 montage targeting the left PFC and the TPJ bilaterally. Using computational modeling, we estimated the peak electric field strength and modulated volume induced by each montage for current amplitudes ranging 1-4 mA. We found that the LUL montage was inferior to both other montages in terms of peak electric field strength in right-sided AVH-ROIs. The BL montage was inferior to both other montages in terms of modulated volume of the left-sided AVH-ROIs. As the modulated volume is non-linear, its variability between montages reduced for current amplitudes above 3 mA. These findings illustrate how computational target engagement for tDCS can be tailored to specific networks and provide a principled approach for future study design.
journal_name
Front Psychiatryjournal_title
Frontiers in psychiatryauthors
Lee WH,Kennedy NI,Bikson M,Frangou Sdoi
10.3389/fpsyt.2018.00048subject
Has Abstractpub_date
2018-02-22 00:00:00pages
48issn
1664-0640journal_volume
9pub_type
杂志文章abstract::Objective: The purpose of this study was to investigate the influence of parenting style on children's behavior problems after the Great East Japan Earthquake in 2011. Methods: Participants were children exposed to the 2011 disaster at preschool age (n = 163). Data were collected from August 2012 to March 2013, and fr...
journal_title:Frontiers in psychiatry
pub_type: 杂志文章
doi:10.3389/fpsyt.2019.00045
更新日期:2019-02-19 00:00:00
abstract::Background: Australia is a high-income country with increasing income inequality. It is unclear whether Australia's well-developed mental healthcare system is making a difference to population mental health and the Federal Government has targeted outcomes accountability in service funding strategies. In high-income co...
journal_title:Frontiers in psychiatry
pub_type: 杂志文章
doi:10.3389/fpsyt.2018.00536
更新日期:2018-10-26 00:00:00
abstract::Objective: To determine the risks of suicide attempt (SA) and suicidal drug overdose (SDO) after head trauma in patients with sleep-disordered breathing (SDB) by using the National Health Insurance Research Database of Taiwan. Methods: We analyzed the data of patients aged ≥20 years who were diagnosed with SDB between...
journal_title:Frontiers in psychiatry
pub_type: 杂志文章
doi:10.3389/fpsyt.2020.533784
更新日期:2020-12-09 00:00:00
abstract::Depression is one of the most prevalent and serious mental disorders with a worldwide significant health burden. Metabolic abnormalities and disorders in patients with depression have attracted great research attention. Thirty-six metabolic biomarkers of clinical plasma metabolomics were detected by platform technolog...
journal_title:Frontiers in psychiatry
pub_type: 杂志文章
doi:10.3389/fpsyt.2020.00667
更新日期:2020-07-15 00:00:00
abstract::Computational methods are increasingly being applied to the study of psychiatric disorders. Often, this involves fitting models to the behavior of individuals with subclinical character traits that are known vulnerability factors for the development of psychiatric conditions. Anxiety disorders can be examined with ref...
journal_title:Frontiers in psychiatry
pub_type: 杂志文章,评审
doi:10.3389/fpsyt.2017.00001
更新日期:2017-01-23 00:00:00
abstract::Attention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) often co-occur and share neurocognitive deficits. One such shared impairment is in duration discrimination. However, no studies using functional magnetic resonance imaging (fMRI) have investigated whether these duration discrimination d...
journal_title:Frontiers in psychiatry
pub_type: 杂志文章
doi:10.3389/fpsyt.2018.00569
更新日期:2018-11-14 00:00:00
abstract::Motivated behaviors are often initiated in response to perturbations of homeostasis. Indeed, animals and humans have fundamental drives to procure (appetitive behaviors) and eventually ingest (consummatory behaviors) substances based on deficits in body fluid (e.g., thirst) and energy balance (e.g., hunger). Consumpti...
journal_title:Frontiers in psychiatry
pub_type: 杂志文章,评审
doi:10.3389/fpsyt.2018.00410
更新日期:2018-09-03 00:00:00
abstract::A small number of severely and persistently mentally ill in-patients awaiting residential or long-stay facilities represent an obstacle to the efficient utilization of acute care beds. These facilities are costly and currently reputed to be contrary to recovery principles. In 2013, all acute psychiatric care wards in ...
journal_title:Frontiers in psychiatry
pub_type: 杂志文章
doi:10.3389/fpsyt.2020.00231
更新日期:2020-04-07 00:00:00
abstract::Childhood maltreatment (CM), including abuse and neglect, is a crucial factor that distorts child development. CM is associated with alterations in numerous brain regions, and may be associated with hormonal dysregulation. This study aimed to investigate differences in secretion patterns of cortisol (CT) and oxytocin ...
journal_title:Frontiers in psychiatry
pub_type: 杂志文章
doi:10.3389/fpsyt.2015.00173
更新日期:2015-12-11 00:00:00
abstract::Background: Insufficient sleep is common in daily life and can lead to cognitive impairment. Sleep disturbance also exists in neuropsychiatric diseases. However, whether and how acute and chronic sleep loss affect brain morphology remain largely unknown. Methods: We used voxel-based morphology method to study the brai...
journal_title:Frontiers in psychiatry
pub_type: 杂志文章
doi:10.3389/fpsyt.2018.00266
更新日期:2018-06-27 00:00:00
abstract::Background: Cognitive impairments in bipolar disorder (BD) such as memory deficits are associated with poor functional outcomes and it has been suggested that the brain-derived neurotrophic factor (BDNF) Val66Met polymorphism contributes to individual variability in memory function in BD. The current study investigate...
journal_title:Frontiers in psychiatry
pub_type: 杂志文章
doi:10.3389/fpsyt.2019.00845
更新日期:2019-12-06 00:00:00
abstract::The COVID-19 epidemic has caused increasing public panic and mental health stress. In this study, we explore the prevalence and factors linked to anxiety and depression in hospitalized patients with COVID-19. A total of 144 patients diagnosed with COVID-19 underwent depression and anxiety assessment by using the Hospi...
journal_title:Frontiers in psychiatry
pub_type: 杂志文章
doi:10.3389/fpsyt.2020.586355
更新日期:2020-11-20 00:00:00
abstract::Cocaine addiction is a widespread psychiatric condition still waiting for approved efficacious medications. Previous studies suggested that simultaneous activation of nociceptin opioid (NOP) and mu opioid (MOP) receptors could be a successful strategy to treat cocaine addiction, but the paucity of molecules co-activat...
journal_title:Frontiers in psychiatry
pub_type: 杂志文章
doi:10.3389/fpsyt.2017.00234
更新日期:2017-11-13 00:00:00
abstract:Introduction:Visual impairment (VI) is associated with a variety of comorbidities including physical and mental health in industrial countries. Our aim is to examine associations between self-reported impairment and depressive symptoms in the German population. Methods:The point prevalence of self-reported VI in Germa...
journal_title:Frontiers in psychiatry
pub_type: 杂志文章
doi:10.3389/fpsyt.2018.00114
更新日期:2018-04-09 00:00:00
abstract:Background:The quality of life (QOL) of patients with methamphetamine use disorder (MAUD) is increasingly recognized as an important outcome. Previous studies have found that impulsivity is negatively associated with QOL in mental disorders, but this relationship is rarely confirmed in patients with MAUD. We hypothesiz...
journal_title:Frontiers in psychiatry
pub_type: 杂志文章
doi:10.3389/fpsyt.2020.579302
更新日期:2020-09-30 00:00:00
abstract::Converging lines of evidence indicates that smoking and internet gaming disorder (IGD) affect spontaneous brain activity, respectively. However, little is known about whether these two factors work together on the human brain. In this study, we investigated the interaction between smoking and IGD on local spontaneous ...
journal_title:Frontiers in psychiatry
pub_type: 杂志文章
doi:10.3389/fpsyt.2020.586114
更新日期:2020-12-03 00:00:00
abstract::Mental imagery, seeing with the mind's eyes, can induce stronger positive as well as negative affect compared to verbal processing. Given this emotion-amplifying effect, it appears likely that mental images play an important role in affective disorders. According to the subcomponents model of depression, depressed moo...
journal_title:Frontiers in psychiatry
pub_type: 杂志文章
doi:10.3389/fpsyt.2015.00094
更新日期:2015-07-07 00:00:00
abstract::The extraordinary health emergency of the COVID-19 pandemic represents a new challenge for mental health researchers and clinical practitioners. The related containment measures may be a risk factor for psychological distress and mood disorders, especially in at-risk populations. This study aims to explore the impact ...
journal_title:Frontiers in psychiatry
pub_type: 杂志文章
doi:10.3389/fpsyt.2020.589916
更新日期:2020-11-17 00:00:00
abstract::As the population ages and the number of people living with dementia or mild cognitive impairment (MCI) continues to increase, it is critical to identify creative and innovative ways to support and improve their quality of life. Motion-based technology has shown significant potential for people living with dementia or...
journal_title:Frontiers in psychiatry
pub_type: 杂志文章,评审
doi:10.3389/fpsyt.2018.00189
更新日期:2018-05-11 00:00:00
abstract::Excessive glutamate release has been linked to stress and many neurodegenerative diseases. Evidence indicates abnormalities of glutamatergic neurotransmission or glutamatergic dysfunction as playing an important role in the development of many major psychiatric disorders (e.g., schizophrenia, bipolar disorder, and maj...
journal_title:Frontiers in psychiatry
pub_type: 杂志文章,评审
doi:10.3389/fpsyt.2018.00767
更新日期:2019-01-24 00:00:00
abstract:UNLABELLED:Collecting information about the prevalence of cannabis use is necessary but not sufficient for understanding the size, dynamics, and outcomes associated with cannabis markets. This paper uses two data sets describing cannabis consumption in the United States and Europe to highlight (1) differences in infere...
journal_title:Frontiers in psychiatry
pub_type: 杂志文章
doi:10.3389/fpsyt.2013.00138
更新日期:2013-11-06 00:00:00
abstract::Disrupted white matter (WM) integrity in the anterior thalamic radiation (ATR) has been identified in individuals with bipolar disorder (BD). We explored whether structural WM aberration in the ATR could be visually evaluated by diffusion tensor tractography (DTT). The study comprised 114 participants, including 57 pa...
journal_title:Frontiers in psychiatry
pub_type: 杂志文章
doi:10.3389/fpsyt.2018.00522
更新日期:2018-10-24 00:00:00
abstract::Previous work from our group and others utilizing animal models have demonstrated long-lasting structural and functional alterations in the meso-cortico-striatal dopamine pathway following prenatal cocaine (PCOC) treatment. We have shown that PCOC treatment results in augmented D1-induced cyclic AMP (cAMP) and cocaine...
journal_title:Frontiers in psychiatry
pub_type: 杂志文章
doi:10.3389/fpsyt.2011.00067
更新日期:2011-12-07 00:00:00
abstract::Mental illnesses, among which depression and anxiety are most common, are the leading cause for permanent disability. It is of interest to know what case characteristics determine if a person returns to the work force in spite of mental illness to tailor specific interventions. So far, there has been little research i...
journal_title:Frontiers in psychiatry
pub_type: 杂志文章
doi:10.3389/fpsyt.2020.00740
更新日期:2020-07-31 00:00:00
abstract:INTRODUCTION:Despite the importance of dopamine neurotransmission in schizophrenia, very few studies have addressed anomalies in the mesencephalic dopaminergic neurons of the substantia nigra/ventral tegmental area (SN/VTA). Tyrosine hydroxylase (TH) is the rate-limiting enzyme for the production of dopamine, and a pos...
journal_title:Frontiers in psychiatry
pub_type: 杂志文章
doi:10.3389/fpsyt.2012.00031
更新日期:2012-04-09 00:00:00
abstract:AIM:In efforts to develop reliable methods to detect the likelihood of impending suicidal behaviors, we have proposed the following. OBJECTIVE:To gain a deeper understanding of the state of suicide risk by determining the combination of variables that distinguishes between groups with and without suicide risk. METHOD...
journal_title:Frontiers in psychiatry
pub_type: 杂志文章
doi:10.3389/fpsyt.2017.00007
更新日期:2017-02-02 00:00:00
abstract::Therapies for Tourette syndrome (TS) are insufficient, and novel therapies are needed. Fecal microbiota transplantation (FMT) has been a potential therapy for several neurological diseases. Here, we report a preliminary study to investigate the effects of FMT on patients with TS. Five patients with TS received a singl...
journal_title:Frontiers in psychiatry
pub_type:
doi:10.3389/fpsyt.2020.554441
更新日期:2020-12-23 00:00:00
abstract::Background: Recently, many case-control studies have reported the association between 5-HTTLPR polymorphism and autism risk. However, the results are inconclusive and conflicting. To investigate the genetic association of 5-HTTLPR polymorphism and autism risk, we conducted a comprehensive meta-analysis based on previo...
journal_title:Frontiers in psychiatry
pub_type: 杂志文章
doi:10.3389/fpsyt.2019.00051
更新日期:2019-02-13 00:00:00
abstract::Following the severe attacks by the so-called "Islamic State of Iraq and Syria" on the Yazidi population, which started in summer 2014, the state government of Baden-Württemberg, Germany, funded a Special-Quota Project to bring 1,000 very ill or left-behind women and children who were being held hostage to 22 cities a...
journal_title:Frontiers in psychiatry
pub_type:
doi:10.3389/fpsyt.2017.00282
更新日期:2017-12-13 00:00:00
abstract:BACKGROUND:Several lines of evidence implicate dysfunctional neuronal plasticity in the pathophysiology of schizophrenia (SCZ). Aberrant glutamatergic and gamma amino--butyric acid neurotransmission are thought to underlie core cognitive deficits and negative symptoms of SCZ. Non-invasive brain stimulation (NIBS) allow...
journal_title:Frontiers in psychiatry
pub_type: 杂志文章,评审
doi:10.3389/fpsyt.2016.00045
更新日期:2016-03-29 00:00:00