Using EEG-Guided Basket and Umbrella Trials in Psychiatry: A Precision Medicine Approach for Cognitive Impairment in Schizophrenia.

Abstract:

:Due to advances over the last several decades, many fields of medicine are moving toward a precision medicine approach where treatments are tailored to nuanced patient factors. While in some disciplines these innovations are commonplace leading to unique biomarker-guided experimental medicine trials, there are no such analogs in psychiatry. In this brief review, we will overview two unique biomarker-guided trial designs for future use in psychiatry: basket and umbrella trials. We will illustrate how such trials could be useful in psychiatry using schizophrenia as a candidate illness, the EEG measure mismatch negativity as the candidate biomarker, and cognitive impairment as the target disease dimension.

journal_name

Front Psychiatry

journal_title

Frontiers in psychiatry

authors

Joshi YB,Light GA

doi

10.3389/fpsyt.2018.00554

subject

Has Abstract

pub_date

2018-11-19 00:00:00

pages

554

issn

1664-0640

journal_volume

9

pub_type

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