Predictors of Remission of Early-Onset Poststroke Depression and the Interaction Between Depression and Cognition During Follow-Up.


:Objectives: This study aimed to examine the rate of remission in individuals experiencing early-onset poststroke depression (PSD) in China and to identify predictors of remission during a 3-month follow-up. This study also explored the interaction between cognitive impairment and depression. Methods: A total of 820 patients with PSD from a massive multicenter prospective cohort project in China (PRIOD) were included in the present study. Depressive symptoms were measured with the Hamilton Depression Rating Scale (17 Items, HDRS-17) at 2 weeks and the endpoint of the 3-month follow-up. The cut-off score of HDRS-17 (< 8) was used to define remission of depression at the endpoint. The Mini-Mental State Exam (MMSE) was used to evaluate the cognitive impairment of the patients (at the 2-week follow-up and 3-month endpoint). The National Institutes of Health Stroke Scale (NIHSS) was used to measure the severity of stroke. Results: (1) Six hundred and forty-two patients completed the 3-month follow-up, and 332 (51.7%) patients remitted by the end of the study. Univariate analyses indicated that there was a higher proportion of patients who had hypertension, frontal lobe lesion, basal ganglia lesion, poor outcome at 2 weeks, high scores on the NIHSS at 2 weeks, major life events within 3 months, and major medical diseases within 3 months in the nonremission group. In stepwise multiple logistic regression analyses, remission was significantly predicted by lower NIHSS scores at 2 weeks (p = 0.001, OR = 1.086, 95% CI 1.035-1.139), fewer major life events (p = 0.036, OR = 5.195, 95% CI 1.111-27.283), fewer major medical comorbidities (p = 0.015, OR = 2.434, 95% CI 1.190-4.979), and fewer frontal lobe lesions (p = 0.042, OR = 1.717, 95% CI 1.019-2.891). (2) After controlling for confounding variables, repeated measures analysis of variance revealed a significant interaction between time (2 weeks vs. 3 months) and group (remitters vs. nonremitters) on MMSE scores [F(1, 532) = 20.2, p < 0.001]. Conclusions: Early-onset PSD patients with milder neurological impairment, fewer major life events, fewer major medical comorbidities and no frontal lobe lesion at baseline were more likely to achieve remission 3 months after stroke. Only remitters of PSD improved significantly in cognitive impairment after stroke. The PRIOD trial is registered at, number ISRCTN62169508.


Front Psychiatry


Frontiers in psychiatry


Huang J,Zhou FC,Guan B,Zhang N,Wang A,Yu P,Zhou L,Wang CY,Wang C




Has Abstract


2019-01-08 00:00:00








  • Anti-Suicide Function of Nonsuicidal Self-Injury in Female Inpatient Adolescents.

    abstract:Background:There have been numerous studies investigating the relationship between nonsuicidal self-injury (NSSI) and suicidality. On the one side, NSSI is an important risk factor for suicidality, including suicidal thoughts and behaviors. On the other side, it has been suggested that one function of NSSI might be as ...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章


    authors: Kraus L,Schmid M,In-Albon T

    更新日期:2020-06-03 00:00:00

  • Self-Reported Visual Perceptual Abnormalities Are Strongly Associated with Core Clinical Features in Psychotic Disorders.

    abstract:Background:Past studies using the Bonn Scale for the Assessment of Basic Symptoms (hereafter, Bonn Scale) have shown that self-reported perceptual/cognitive disturbances reveal which persons have or will soon develop schizophrenia. Here, we focused specifically on the clinical value of self-reported visual perceptual a...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章


    authors: Keane BP,Cruz LN,Paterno D,Silverstein SM

    更新日期:2018-03-12 00:00:00

  • Outpatient Psychotherapy Reduces Health-Care Costs: A Study of 22,294 Insurants over 5 Years.

    abstract:BACKGROUND:The project "Quality Assurance in Ambulatory Psychotherapy in Bavaria" (QS-PSY-BAY) focuses on the quality assurance of outpatient psychotherapy (OPT) in Germany in terms of symptom reduction and cost reduction under naturalistic conditions. In this study, we examined the effectiveness of psychotherapy in te...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章


    authors: Altmann U,Zimmermann A,Kirchmann HA,Kramer D,Fembacher A,Bruckmayer E,Pfaffinger I,von Heymann F,Auch E,Steyer R,Strauss BM

    更新日期:2016-06-13 00:00:00

  • Mothering, Substance Use Disorders and Intergenerational Trauma Transmission: An Attachment-Based Perspective.

    abstract::Background: A growing body of research underlines that interpersonal trauma in childhood leads to heightened susceptibility for substance use disorders (SUDs) in later life. Little research has been conducted on parenting experiences of mothers in recovery from substance use, taking into account their own upbringing a...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章


    authors: Meulewaeter F,De Pauw SSW,Vanderplasschen W

    更新日期:2019-10-18 00:00:00

  • Neurobiology of cognitive remediation therapy for schizophrenia: a systematic review.

    abstract::Cognitive impairment is an important aspect of schizophrenia, where cognitive remediation therapy (CRT) is a promising treatment for improving cognitive functioning. While neurobiological dysfunction in schizophrenia has been the target of much research, the neural substrate of cognitive remediation and recovery has n...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章,评审


    authors: Thorsen AL,Johansson K,Løberg EM

    更新日期:2014-08-15 00:00:00

  • Mental Health Symptoms and Work-Related Stressors in Hospital Midwives and NICU Nurses: A Mixed Methods Study.

    abstract::Hospital midwives and neonatal intensive care (NICU) nurses frequently encounter work-related stressors and are therefore vulnerable to developing mental health problems, such as secondary traumatic stress, burnout, anxiety, and depression. However, so far, the exact nature of these work-related stressors (traumatic v...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章


    authors: Favrod C,Jan du Chêne L,Martin Soelch C,Garthus-Niegel S,Tolsa JF,Legault F,Briet V,Horsch A

    更新日期:2018-08-20 00:00:00

  • Ward Atmosphere and Patient Satisfaction in Psychiatric Hospitals With Different Ward Settings and Door Policies. Results From a Mixed Methods Study.

    abstract::Background: Open-door policies in psychiatry are discussed as a means to improve the treatment of involuntarily committed patients in various aspects. Current research on open-door policies focuses mainly on objective effects, such as the number of coercive interventions or serious incidents. The aim of the present st...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章


    authors: Efkemann SA,Bernard J,Kalagi J,Otte I,Ueberberg B,Assion HJ,Zeiß S,Nyhuis PW,Vollmann J,Juckel G,Gather J

    更新日期:2019-08-30 00:00:00

  • Dare to delay? The impacts of adolescent alcohol and marijuana use onset on cognition, brain structure, and function.

    abstract::Throughout the world, drug and alcohol use has a clear adolescent onset (Degenhardt et al., 2008). Alcohol continues to be the most popular drug among teens and emerging adults, with almost a third of 12th graders and 40% of college students reporting recent binge drinking (Johnston et al., 2009, 2010), and marijuana ...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章


    authors: Lisdahl KM,Gilbart ER,Wright NE,Shollenbarger S

    更新日期:2013-07-01 00:00:00

  • Fatigue in Multiple Sclerosis Is Associated With Childhood Adversities.

    abstract::Fatigue is a common and disabling symptom in patients with Multiple Sclerosis (PwMS). Its pathogenesis, however, is still not fully understood. Potential psychological roots, in particular, have received little attention to date. The present study examined the association of childhood adversities, specific trait chara...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章


    authors: Pust GEA,Dettmers C,Randerath J,Rahn AC,Heesen C,Schmidt R,Gold SM

    更新日期:2020-08-28 00:00:00

  • Exploration of Major Cognitive Deficits in Medication-Free Patients With Major Depressive Disorder.

    abstract::Background: Major depressive disorder (MDD) is associated with a wide range of cognitive deficits. However, it remains unclear whether there will be a major cognitive deficit independently caused by depression at acute episodes of MDD. Method: A comprehensive neurocognitive test battery was used to assess the executiv...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章


    authors: Liu J,Dong Q,Lu X,Sun J,Zhang L,Wang M,Wan P,Guo H,Zhao F,Ju Y,Yan D,Li H,Fang H,Guo W,Liao M,Zhang X,Zhang Y,Liu B,Li L

    更新日期:2019-11-12 00:00:00

  • Association of frontal gray matter volume and cerebral perfusion in heroin addiction: a multimodal neuroimaging study.

    abstract::Structure and function are closely related in the healthy human brain. In patients with chronic heroin exposure, brain imaging studies have identified long-lasting changes in gray matter (GM) volume. More recently, we showed that acute application of heroin in dependent patients results in hypoperfusion of fronto-temp...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章


    authors: Denier N,Schmidt A,Gerber H,Schmid O,Riecher-Rössler A,Wiesbeck GA,Huber CG,Lang UE,Radue EW,Walter M,Borgwardt S

    更新日期:2013-10-21 00:00:00

  • Enhanced dopamine D1 and BDNF signaling in the adult dorsal striatum but not nucleus accumbens of prenatal cocaine treated mice.

    abstract::Previous work from our group and others utilizing animal models have demonstrated long-lasting structural and functional alterations in the meso-cortico-striatal dopamine pathway following prenatal cocaine (PCOC) treatment. We have shown that PCOC treatment results in augmented D1-induced cyclic AMP (cAMP) and cocaine...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章


    authors: Tropea TF,Kabir ZD,Kaur G,Rajadhyaksha AM,Kosofsky BE

    更新日期:2011-12-07 00:00:00

  • The Effects of Individual Psychotherapy in BDNF Levels of Patients With Mental Disorders: A Systematic Review.

    abstract:Background:Brain-derived Neurotrophic Factor (BDNF) is considered the main cerebral neurotrophin and is produced in the central neural system and peripherals. Its levels are reduced in patients with several psychiatric disorders, but it is unclear if the response to psychotherapy can alter its concentration. Objective...

    journal_title:Frontiers in psychiatry



    authors: Claudino FCA,Gonçalves L,Schuch FB,Martins HRS,da Rocha NS

    更新日期:2020-05-19 00:00:00

  • Changes of Altruistic Behavior and Kynurenine Pathway in Late-Life Depression.

    abstract:Background:Depressive patients show less altruistic behavior. While, older adults present higher tendencies for altruism than younger adults. Depression and age are two of the influencing factors of altruism, kynurenine (KYN), and its metabolites. However, the characteristics of altruism in late-life depression (LLD) a...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章


    authors: Wu Y,Mai N,Weng X,Liang J,Ning Y

    更新日期:2020-04-30 00:00:00

  • N-Methyl-D-Aspartate(NMDA) Receptor and Voltage-Gated Potassium Channel (VGKC) Antibody-Associated Encephalitides Presenting as First Episode Acute Psychosis.

    abstract::Aim: Acute psychosis is not an uncommon presenting feature in immune-mediated encephalitides. Most patients improve if properly diagnosed and treated expediently with immunotherapy. Our study aimed to describe the frequency, clinical spectrum, and long-term outcomes in patients presenting with acute psychosis who have...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章


    authors: Tang C,Tan K,Lim G,Tan L,Tay KY,Kandiah N,Abdin E,Verma SK

    更新日期:2019-12-13 00:00:00

  • Reliving, Replaying Lived Experiences Through Auditory Verbal Hallucinations: Implications on Theories and Management.

    abstract::Objective: This study aims to understand the impact of negative life experience (NLE) in auditory hallucinations (AHs) and explain the heterogeneity in phenomenology of auditory verbal hallucinations (AVHs). Method: In depth interviews were conducted with 21 individuals (7 males and 14 females) experiencing AHs and ac...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章


    authors: Vallath S,Luhrmann T,Bunders J,Ravikant L,Gopikumar V

    更新日期:2018-10-30 00:00:00

  • The Obesity-Impulsivity Axis: Potential Metabolic Interventions in Chronic Psychiatric Patients.

    abstract::Pathological impulsivity is encountered in a broad range of psychiatric conditions and is thought to be a risk factor for aggression directed against oneself or others. Recently, a strong association was found between impulsivity and obesity which may explain the high prevalence of metabolic disorders in individuals w...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章,评审


    authors: Sfera A,Osorio C,Inderias LA,Parker V,Price AI,Cummings M

    更新日期:2017-02-13 00:00:00

  • The HDAC Inhibitor Phenylbutyrate Reverses Effects of Neonatal Ventral Hippocampal Lesion in Rats.

    abstract::Recent evidence suggests that epigenetic mechanisms play a role in psychiatric diseases. In this study, we considered rats with neonatal ventral hippocampal lesions (NVHL) that are currently used for modeling neurodevelopmental aspects of schizophrenia. Contribution of epigenetic regulation to the effects of the lesio...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章


    authors: Sandner G,Host L,Angst MJ,Guiberteau T,Guignard B,Zwiller J

    更新日期:2011-01-07 00:00:00

  • Efficacy of the Whole-Body Cryotherapy as Add-on Therapy to Pharmacological Treatment of Depression-A Randomized Controlled Trial.

    abstract:Introduction:Accumulating evidence indicates the effectiveness of cryogenic temperature interventions in rheumatoid arthritis, ankylosing spondylitis, fibromyalgia, multiple sclerosis, and chronic low back pain. The application of whole-body cryotherapy (WBC) in psychiatric aspects of medicine was also noted. Neverthel...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章


    authors: Rymaszewska J,Lion KM,Pawlik-Sobecka L,Pawłowski T,Szcześniak D,Trypka E,Rymaszewska JE,Zabłocka A,Stanczykiewicz B

    更新日期:2020-06-09 00:00:00

  • Pilot Testing of Peak Alpha Frequency Stability During Repetitive Transcranial Magnetic Stimulation.

    abstract::Over half of those diagnosed with post-traumatic stress disorder (PTSD) have comorbid major depressive disorder (MDD), and rates are even higher among military veterans. Transcranial magnetic stimulation (TMS) may be a safe and efficacious treatment for PTSD, both with and without comorbid MDD. Still, the mechanism of...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章


    authors: Petrosino NJ,Zandvakili A,Carpenter LL,Philip NS

    更新日期:2018-11-20 00:00:00

  • Altered Global Brain Functional Connectivity in Drug-Naive Patients With Obsessive-Compulsive Disorder.

    abstract::Abnormal functional connectivity (FC) within discrete brain networks is involved in the pathophysiology of obsessive-compulsive disorder (OCD) with inconsistent results. In the present study, we investigated the FC patterns of 40 drug-naive patients with OCD and 38 healthy controls (HCs) through an unbiased voxel-wise...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章


    authors: Cui G,Ou Y,Chen Y,Lv D,Jia C,Zhong Z,Yang R,Wang Y,Meng X,Cui H,Li C,Sun Z,Wang X,Guo W,Li P

    更新日期:2020-03-03 00:00:00

  • Opposite Epigenetic Associations With Alcohol Use and Exercise Intervention.

    abstract::Alcohol use disorder (AUD) is a devastating public health problem in which both genetic and environmental factors play a role. Growing evidence supports that epigenetic regulation is one major mechanism in neuroadaptation that contributes to development of AUD. Meanwhile, epigenetic patterns can be modified by various...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章


    authors: Chen J,Hutchison KE,Bryan AD,Filbey FM,Calhoun VD,Claus ED,Lin D,Sui J,Du Y,Liu J

    更新日期:2018-11-15 00:00:00

  • The Autonomic Progress Bar Motivates Treatment Completion for Patients of Stimulant Use Disorder and Cannabis Use Disorder.

    abstract::Background: The intrinsic motivation behind the "need to complete" is more influential than external incentives. We introduced a novel progress-bar tool to motivate the completion of programs designed to treat stimulant and cannabis use disorders. We further examined the effectiveness of the progress bar's scoring app...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章


    authors: Chen IC,Teng G,Chen CJ,Lan TH,Liu HJ

    更新日期:2020-01-13 00:00:00

  • Microglia and Brain Plasticity in Acute Psychosis and Schizophrenia Illness Course: A Meta-Review.

    abstract:Objective:Schizophrenia poses a tremendous health, social, and economic burden upon patients and society, indicating current treatment options remain inadequate. Recent findings from several lines of evidence have pointed to the importance of immune system involvement in not only premorbid neurodevelopmental but also s...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章,评审


    authors: De Picker LJ,Morrens M,Chance SA,Boche D

    更新日期:2017-11-16 00:00:00

  • An Intervention to Increase Situational Awareness and the Culture of Mutual Care (Foco) and Its Effects During COVID-19 Pandemic: A Randomized Controlled Trial and Qualitative Analysis.

    abstract::Situational awareness is especially important to decision-making in health care. Comprehending the situation is crucial for anticipating any change in the environment and delivering optimal care. The objective of this study was to evaluate the effects of a training to increase situational awareness and mutual care des...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章


    authors: Kozasa EH,Lacerda SS,Polissici MA,Coelho RDS,Farias GDS,Chaves P,Leão ER

    更新日期:2020-11-26 00:00:00

  • Glutamatergic Dysfunction and Glutamatergic Compounds for Major Psychiatric Disorders: Evidence From Clinical Neuroimaging Studies.

    abstract::Excessive glutamate release has been linked to stress and many neurodegenerative diseases. Evidence indicates abnormalities of glutamatergic neurotransmission or glutamatergic dysfunction as playing an important role in the development of many major psychiatric disorders (e.g., schizophrenia, bipolar disorder, and maj...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章,评审


    authors: Li CT,Yang KC,Lin WC

    更新日期:2019-01-24 00:00:00

  • Sex Hormones Regulate Cytoskeletal Proteins Involved in Brain Plasticity.

    abstract::In the brain of female mammals, including humans, a number of physiological and behavioral changes occur as a result of sex hormone exposure. Estradiol and progesterone regulate several brain functions, including learning and memory. Sex hormones contribute to shape the central nervous system by modulating the formati...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章,评审


    authors: Hansberg-Pastor V,González-Arenas A,Piña-Medina AG,Camacho-Arroyo I

    更新日期:2015-11-20 00:00:00

  • Gastric Necrosis After Binge Eating in Bulimia: Recovery From Eating Disorder After Total Gastrectomy.

    abstract:Background:Gastric necrosis following acute gastric dilatation is rare but more common in females with eating disorders, such as anorexia nervosa or bulimia, during which patients often alternate restriction and binge eating behaviors. Case Presentation:A 37-year old female patient with a history of 15 years of bulimi...

    journal_title:Frontiers in psychiatry



    authors: Achamrah N,Grigioni S,Coëffier M,Ainseba N,Déchelotte P

    更新日期:2020-07-31 00:00:00

  • Effect of the Nature of Subsequent Environment on Oxytocin and Cortisol Secretion in Maltreated Children.

    abstract::Childhood maltreatment (CM), including abuse and neglect, is a crucial factor that distorts child development. CM is associated with alterations in numerous brain regions, and may be associated with hormonal dysregulation. This study aimed to investigate differences in secretion patterns of cortisol (CT) and oxytocin ...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章


    authors: Mizushima SG,Fujisawa TX,Takiguchi S,Kumazaki H,Tanaka S,Tomoda A

    更新日期:2015-12-11 00:00:00

  • Primary and Secondary Diagnoses of Gambling Disorder and Psychiatric Comorbidity in the Swedish Health Care System-A Nationwide Register Study.

    abstract::Background: Psychiatric comorbidity is common in gambling disorder, a condition with low rates of treatment seeking. There is a paucity of documented nationwide data on gambling disorder and its co-occurring psychiatric comorbidities in the health care system. Methods: This is a nationwide register-based study of all ...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章


    authors: Håkansson A,Karlsson A,Widinghoff C

    更新日期:2018-09-07 00:00:00