Epigenetic regulation of AXL and risk of childhood asthma symptoms.

abstract：:Researchers have begun to examine epigenetic alterations in the placenta, making key advances in understanding the epigenetic regulatory mechanisms of the placenta that define underlying processes of human development and disease. Examining changes in microRNA (miRNA) expression associated with environmental exposures...

journal_title：Clinical epigenetics

authors： Maccani MA,Marsit CJ

更新日期：2011-08-01 00:00:00

abstract：BACKGROUND:Characteristic DNA methylation differences have been identified between primary and metastatic melanomas at EBF3 and/or TBC1D16 gene loci. To further evaluate whether these epigenetic changes may act more generally as drivers of tumour onset and metastasis, we have investigated DNA methylation changes involv...

journal_title：Clinical epigenetics

authors： Rodger EJ,Chatterjee A,Stockwell PA,Eccles MR

更新日期：2019-08-05 00:00:00

abstract：:After publication of the original article [1], authors have requested to add a 'J' as middle name for Richard Gilbertson. Hence, full name should be Richard J Gilbertson. ...

journal_title：Clinical epigenetics

authors： Pienkowska M,Choufani S,Turinsky AL,Guha T,Merino DM,Novokmet A,Brudno M,Weksberg R,Shlien A,Hawkins C,Bouffet E,Tabori U,Gilbertson RJ,Finlay JL,Jabado N,Thomas C,Sill M,Capper D,Hasselblatt M,Malkin D

更新日期：2019-10-21 00:00:00

abstract：:Lymphocytes from the peripheral blood of patients with prostate cancer-the most frequent (noncutaneous) tumor in men-display epigenetic aberrations (altered modes of allelic replication) characteristic of the malignant phenotype. The present study aims to determine whether replication aberrations add certainty to the ...

journal_title：Clinical epigenetics

authors： Cytron S,Stepnov E,Bounkin I,Mashevich M,Dotan A,Avivi L

更新日期：2011-08-01 00:00:00

abstract：BACKGROUND:Most research into myocardial infarctions (MIs) have focused on preventative efforts. For survivors, the occurrence of an MI represents a major clinical event that can have long-lasting consequences. There has been little to no research into the molecular changes that can occur as a result of an incident MI....

journal_title：Clinical epigenetics

authors： Ward-Caviness CK,Agha G,Chen BH,Pfeiffer L,Wilson R,Wolf P,Gieger C,Schwartz J,Vokonas PS,Hou L,Just AC,Bandinelli S,Hernandez DG,Singleton AB,Prokisch H,Meitinger T,Kastenmüller G,Ferrucci L,Baccarelli AA,Waldenber

更新日期：2018-12-27 00:00:00

abstract：BACKGROUND:The recent discovery of cancer/tissue specificity of miRNA has indicated its great potential as a therapeutic target. In Epstein-Barr virus-associated gastric cancer (EBVaGC), host genes are affected by extensive DNA methylation, including miRNAs. However, the role of methylated miRNA in the development of E...

journal_title：Clinical epigenetics

authors： Zhu M,Liang Q,Chen T,Kong Q,Ye G,Yu S,Li X,He Q,Liu H,Hu Y,Yu J,Li G

更新日期：2021-01-29 00:00:00

abstract：BACKGROUND:The transcription factor Snail2 is a repressor of E-cadherin expression during carcinogenesis; however, the specific mechanisms involved in this process in human colorectal cancer (CRC) remain largely unknown. METHOD:We checked the expression of Snail2 in several clinical CRC specimens. Then, we established...

journal_title：Clinical epigenetics

authors： Hu Y,Dai M,Zheng Y,Wu J,Yu B,Zhang H,Kong W,Wu H,Yu X

更新日期：2018-12-12 00:00:00

abstract：BACKGROUND:Preterm birth (PTB), defined as child birth before completion of 37 weeks of gestation, is a major challenge in perinatal health care and can bear long-term medical and financial burden. Over a million children die each year due to PTB complications, and those who survive can face developmental delays. Unfor...

journal_title：Clinical epigenetics

authors： Wu Y,Lin X,Lim IY,Chen L,Teh AL,MacIsaac JL,Tan KH,Kobor MS,Chong YS,Gluckman PD,Karnani N

更新日期：2019-02-11 00:00:00

abstract：BACKGROUND:Colorectal cancer (CRC) is the third most commonly diagnosed human malignancy worldwide. Upregulation of inhibitory immune checkpoints by tumor-infiltrating immune cells (TIICs) or their ligands by tumor cells leads to tumor evasion from host immunosurveillance. Changes in DNA methylation pattern and enrichm...

journal_title：Clinical epigenetics

authors： Sasidharan Nair V,Toor SM,Taha RZ,Shaath H,Elkord E

更新日期：2018-08-06 00:00:00

abstract：BACKGROUND:Multiple sclerosis (MS) is thought to be a T cell-mediated autoimmune disorder. MS pathogenesis is likely due to a genetic predisposition triggered by a variety of environmental factors. Epigenetics, particularly DNA methylation, provide a logical interface for environmental factors to influence the genome. ...

journal_title：Clinical epigenetics

authors： Maltby VE,Graves MC,Lea RA,Benton MC,Sanders KA,Tajouri L,Scott RJ,Lechner-Scott J

更新日期：2015-11-05 00:00:00

abstract：BACKGROUND:Type 2 diabetes mellitus (T2D) is highly prevalent in Middle-Eastern and North African Arab populations, but the molecular basis for this susceptibility is unknown. Altered DNA methylation levels were reported in insulin-secreting and responding tissues, but whether methylation in accessible tissues such as ...

journal_title：Clinical epigenetics

authors： Toperoff G,Kark JD,Aran D,Nassar H,Ahmad WA,Sinnreich R,Azaiza D,Glaser B,Hellman A

更新日期：2015-03-28 00:00:00

abstract：BACKGROUND:Male obesity has profound effects on morbidity and mortality, but relatively little is known about the impact of obesity on gametes and the potential for adverse effects of male obesity to be passed to the next generation. DNA methylation contributes to gene regulation and is erased and re-established during...

journal_title：Clinical epigenetics

authors： Keyhan S,Burke E,Schrott R,Huang Z,Grenier C,Price T,Raburn D,Corcoran DL,Soubry A,Hoyo C,Murphy SK

更新日期：2021-01-25 00:00:00

abstract：BACKGROUND:Numerous pulmonary diseases manifest with upper lobe predominance including cystic fibrosis, smoking-related chronic obstructive pulmonary disease, and tuberculosis. Zonal hypoxia, characteristic of these pulmonary maladies, and oxygen stress in general is known to exert profound effects on various important...

journal_title：Clinical epigenetics

authors： Armstrong DA,Nymon AB,Ringelberg CS,Lesseur C,Hazlett HF,Howard L,Marsit CJ,Ashare A

更新日期：2017-05-30 00:00:00

abstract：Background:Maternal social environmental stressors during pregnancy are associated with adverse birth and child developmental outcomes, and epigenetics has been proposed as a possible mechanism for such relationships. Methods:In a Mexican-American birth cohort of 241 maternal-infant pairs, cord blood samples were meas...

journal_title：Clinical epigenetics

authors： Coker ES,Gunier R,Huen K,Holland N,Eskenazi B

更新日期：2018-05-08 00:00:00

abstract：Background:New efficient therapies for urothelial carcinoma (UC) are urgently required. Small-molecule drugs targeting chromatin regulators are reasonable candidates because these regulators are frequently mutated or deregulated in UC. Indeed, in previous work, Romidepsin, which targets class I histone deacetylases (HD...

journal_title：Clinical epigenetics

authors： Hölscher AS,Schulz WA,Pinkerneil M,Niegisch G,Hoffmann MJ

更新日期：2018-01-04 00:00:00

abstract：Background:Reduced expression of retinoic acid-induced 2 (RAI2) was found in breast cancer. The regulation and function of RAI2 in human colorectal cancer (CRC) remain unclear. Methods:Eight CRC cell lines and 237 cases of primary CRC were analyzed. Methylation-specific PCR (MSP), flow cytometry, xenograft mouse model...

journal_title：Clinical epigenetics

authors： Yan W,Wu K,Herman JG,Xu X,Yang Y,Dai G,Guo M

更新日期：2018-05-23 00:00:00

abstract：: Friedreich ataxia (FRDA) is a debilitating and frequently fatal neurological disorder that is recessively inherited. It belongs to the group of genetic disorders known as the Repeat Expansion Diseases, in which pathology arises from the deleterious consequences of the inheritance of a tandem repeat array whose repeat...

journal_title：Clinical epigenetics

authors： Kumari D,Usdin K

更新日期：2012-01-30 00:00:00

abstract：BACKGROUND:Canine mammary tumor (CMT) has long been considered as a good animal model for human breast cancer (HBC) due to their pathological and biological similarities. However, only a few aspects of the epigenome have been explored in both HBC and CMT. Moreover, DNA methylation studies have mainly been limited to th...

journal_title：Clinical epigenetics

authors： Nam AR,Lee KH,Hwang HJ,Schabort JJ,An JH,Won SH,Cho JY

更新日期：2020-07-21 00:00:00

abstract：:Epigenetic mechanisms are thought to play a major role in the pathogenesis of the major psychoses (schizophrenia and bipolar disorder), and they may be the link between the environment and the genome in the pathogenesis of these disorders. This paper discusses the role of epigenetics in the management of major psychos...

journal_title：Clinical epigenetics

authors： Peedicayil J

更新日期：2011-08-01 00:00:00

abstract：BACKGROUND:Compared to healthy individuals, those with stably repressed HIV experience a higher risk of developing insulin resistance, a hallmark of pre-diabetes and a major determinant for cardiometabolic diseases. Although epigenetic processes, including in particular DNA methylation, appear to be dysregulated in ind...

journal_title：Clinical epigenetics

authors： Dye CK,Corley MJ,Li D,Khadka VS,Mitchell BI,Sultana R,Lum-Jones A,Shikuma CM,Ndhlovu LC,Maunakea AK

更新日期：2019-06-28 00:00:00

abstract：Background:Staging and pathological grading systems are convenient but imperfect predictors of recurrence in head and neck squamous cell carcinoma (HNSCC). Identifying biomarkers for HNSCC that will progress and cause death is a critical research area, particularly if the biomarker can be linked to selection of patient...

journal_title：Clinical epigenetics

authors： Misawa K,Mima M,Imai A,Mochizuki D,Misawa Y,Endo S,Ishikawa R,Kanazawa T,Mineta H

更新日期：2018-04-11 00:00:00

abstract：BACKGROUND:Abnormal DNA methylation is a hallmark of human cancers and may be a promising biomarker for early diagnosis of human cancers. However, the majority of DNA methylation biomarkers that have been identified are based on the hypothesis that early differential methylation regions (DMRs) are maintained throughout...

journal_title：Clinical epigenetics

authors： Fan J,Li J,Guo S,Tao C,Zhang H,Wang W,Zhang Y,Zhang D,Ding S,Zeng C

更新日期：2020-04-21 00:00:00

abstract：BACKGROUND:Human 15q11-13 is responsible for Prader-Willi syndrome (PWS) and Angelman syndrome (AS) and includes several imprinted genes together with bipartite elements named AS-IC (imprinting center) and PWS-IC. These concertedly confer allele specificity on 15q11-13. Here, we report DNA methylation status of 15q11-1...

journal_title：Clinical epigenetics

authors： Matsubara K,Itoh M,Shimizu K,Saito S,Enomoto K,Nakabayashi K,Hata K,Kurosawa K,Ogata T,Fukami M,Kagami M

更新日期：2019-02-28 00:00:00

abstract：:Duchenne muscular dystrophy (DMD) is a multisystemic disorder that affects 1:5000 boys. The severity of the phenotype varies dependent on the mutation site in the DMD gene and the resultant dystrophin expression profile. In skeletal muscle, dystrophin loss is associated with the disintegration of myofibers and their i...

journal_title：Clinical epigenetics

authors： Rugowska A,Starosta A,Konieczny P

更新日期：2021-01-19 00:00:00

abstract：BACKGROUND:Kawasaki disease (KD) is a prevalent pediatric disease worldwide and can cause coronary artery aneurysm as a severe complication. Typically, DNA methylation is thought to repress the expression of nearby genes. However, the cases in which DNA methylation promotes gene expression have been reported. In additi...

journal_title：Clinical epigenetics

authors： Huang LH,Kuo HC,Pan CT,Lin YS,Huang YH,Li SC

更新日期：2018-11-01 00:00:00

abstract：BACKGROUND:Prostate cancer (PCa), a highly incident and heterogeneous malignancy, mostly affects men from developed countries. Increased knowledge of the biological mechanisms underlying PCa onset and progression are critical for improved clinical management. MicroRNAs (miRNAs) deregulation is common in human cancers, ...

journal_title：Clinical epigenetics

authors： Costa-Pinheiro P,Ramalho-Carvalho J,Vieira FQ,Torres-Ferreira J,Oliveira J,Gonçalves CS,Costa BM,Henrique R,Jerónimo C

更新日期：2015-04-10 00:00:00

abstract：BACKGROUND:Frozen-thawed embryo transfer (FET) is increasingly available for the improvement of the success rate of assisted reproductive technologies other than fresh embryo transfer (ET). There have been numerous findings that FET provides better obstetric and perinatal outcomes. However, the birth weight of infants ...

journal_title：Clinical epigenetics

authors： Hiura H,Hattori H,Kobayashi N,Okae H,Chiba H,Miyauchi N,Kitamura A,Kikuchi H,Yoshida H,Arima T

更新日期：2017-08-03 00:00:00

abstract：BACKGROUND:The pathogenesis of systemic lupus erythematosus (SLE) has not yet been completely elucidated. One of the hallmarks of SLE is the production of autoantibodies by uncontrolled over-activated B cells. Early B cell factor 1 (EBF1) contributes to the development, activation, and proliferation of B cells through ...

journal_title：Clinical epigenetics

authors： Luo S,Liu Y,Liang G,Zhao M,Wu H,Liang Y,Qiu X,Tan Y,Dai Y,Yung S,Chan TM,Lu Q

更新日期：2015-03-14 00:00:00

abstract：BACKGROUND:Zinc-finger protein 471 (ZNF471) is a member of the Krüppel-associated box domain zinc finger protein (KRAB-ZFP) family. ZNF471 is methylated in squamous cell carcinomas of tongue, stomach and esophageal. However, its role in breast carcinogenesis remains elusive. Here, we studied its expression, functions, ...

journal_title：Clinical epigenetics

authors： Tao C,Luo J,Tang J,Zhou D,Feng S,Qiu Z,Putti TC,Xiang T,Tao Q,Li L,Ren G

更新日期：2020-11-17 00:00:00

abstract：BACKGROUND:Aging is a complex phenomenon and characterized by a progressive decline in physiology and function of adult tissues. However, it hasn't been well established of the correlation between aging and global DNA methylation and hydroxymethylation that regulate the growth and development of higher organisms. RESU...

journal_title：Clinical epigenetics

authors： Xiong J,Jiang HP,Peng CY,Deng QY,Lan MD,Zeng H,Zheng F,Feng YQ,Yuan BF

更新日期：2015-07-23 00:00:00