The neuropeptide genes SST, TAC1, HCRT, NPY, and GAL are powerful epigenetic biomarkers in head and neck cancer: a site-specific analysis.

abstract：BACKGROUND:Numerous pulmonary diseases manifest with upper lobe predominance including cystic fibrosis, smoking-related chronic obstructive pulmonary disease, and tuberculosis. Zonal hypoxia, characteristic of these pulmonary maladies, and oxygen stress in general is known to exert profound effects on various important...

journal_title：Clinical epigenetics

authors： Armstrong DA,Nymon AB,Ringelberg CS,Lesseur C,Hazlett HF,Howard L,Marsit CJ,Ashare A

更新日期：2017-05-30 00:00:00

abstract：BACKGROUND:Neuroblastoma (NB) is the most common extracranial pediatric solid tumor with a highly variable clinical course, ranging from spontaneous regression to life-threatening disease. Survival rates for high-risk NB patients remain disappointingly low despite multimodal treatment. Thus, there is an urgent clinical...

journal_title：Clinical epigenetics

authors： Yáñez Y,Grau E,Rodríguez-Cortez VC,Hervás D,Vidal E,Noguera R,Hernández M,Segura V,Cañete A,Conesa A,Font de Mora J,Castel V

更新日期：2015-02-27 00:00:00

abstract：Background:Maternal social environmental stressors during pregnancy are associated with adverse birth and child developmental outcomes, and epigenetics has been proposed as a possible mechanism for such relationships. Methods:In a Mexican-American birth cohort of 241 maternal-infant pairs, cord blood samples were meas...

journal_title：Clinical epigenetics

authors： Coker ES,Gunier R,Huen K,Holland N,Eskenazi B

更新日期：2018-05-08 00:00:00

abstract：BACKGROUND:Characteristic DNA methylation differences have been identified between primary and metastatic melanomas at EBF3 and/or TBC1D16 gene loci. To further evaluate whether these epigenetic changes may act more generally as drivers of tumour onset and metastasis, we have investigated DNA methylation changes involv...

journal_title：Clinical epigenetics

authors： Rodger EJ,Chatterjee A,Stockwell PA,Eccles MR

更新日期：2019-08-05 00:00:00

abstract：BACKGROUND:Obesity and diabetes mellitus are directly implicated in many adverse health consequences in adults as well as in the offspring of obese and diabetic mothers. Hispanic Americans are particularly at risk for obesity, diabetes, and end-stage renal disease. Maternal obesity and/or diabetes through prenatal prog...

journal_title：Clinical epigenetics

authors： Rizzo HE,Escaname EN,Alana NB,Lavender E,Gelfond J,Fernandez R,Hibbs MA,King JM,Carr NR,Blanco CL

更新日期：2020-02-19 00:00:00

abstract：:Duchenne muscular dystrophy (DMD) is a multisystemic disorder that affects 1:5000 boys. The severity of the phenotype varies dependent on the mutation site in the DMD gene and the resultant dystrophin expression profile. In skeletal muscle, dystrophin loss is associated with the disintegration of myofibers and their i...

journal_title：Clinical epigenetics

authors： Rugowska A,Starosta A,Konieczny P

更新日期：2021-01-19 00:00:00

abstract：BACKGROUND:Colorectal cancer (CRC) screening can effectively reduce disease-related mortality by detecting CRC at earlier stages. We have previously demonstrated that the presence of SDC2 methylation in stool DNA is significantly associated with the occurrence of CRC regardless of clinical stage. The aim of this study ...

journal_title：Clinical epigenetics

authors： Han YD,Oh TJ,Chung TH,Jang HW,Kim YN,An S,Kim NK

更新日期：2019-03-15 00:00:00

abstract：BACKGROUND:Goblet cell metaplasia, a common feature of chronic obstructive pulmonary disease (COPD), is associated with mucus hypersecretion which contributes to the morbidity and mortality among patients. Transcription factors SAM-pointed domain-containing Ets-like factor (SPDEF) and forkhead box protein A2 (FOXA2) re...

journal_title：Clinical epigenetics

authors： Song J,Heijink IH,Kistemaker LEM,Reinders-Luinge M,Kooistra W,Noordhoek JA,Gosens R,Brandsma CA,Timens W,Hiemstra PS,Rots MG,Hylkema MN

更新日期：2017-04-24 00:00:00

abstract：BACKGROUND:The DNA modification 5-hydroxymethylcytosine (5hmC) is now referred to as the sixth base of DNA with evidence of tissue-specific patterns and correlation with gene regulation and expression. This epigenetic mark was recently reported as a potential biomarker for multiple types of cancer, but its application ...

journal_title：Clinical epigenetics

authors： Gilat N,Tabachnik T,Shwartz A,Shahal T,Torchinsky D,Michaeli Y,Nifker G,Zirkin S,Ebenstein Y

更新日期：2017-07-14 00:00:00

abstract：BACKGROUND:Age is one of the most important risk factors for developing breast cancer. However, age-related changes in normal breast tissue that potentially lead to breast cancer are incompletely understood. Quantifying tissue-level DNA methylation can contribute to understanding these processes. We hypothesized that o...

journal_title：Clinical epigenetics

authors： Hofstatter EW,Horvath S,Dalela D,Gupta P,Chagpar AB,Wali VB,Bossuyt V,Storniolo AM,Hatzis C,Patwardhan G,Von Wahlde MK,Butler M,Epstein L,Stavris K,Sturrock T,Au A,Kwei S,Pusztai L

更新日期：2018-08-29 00:00:00

abstract：BACKGROUND:Human 15q11-13 is responsible for Prader-Willi syndrome (PWS) and Angelman syndrome (AS) and includes several imprinted genes together with bipartite elements named AS-IC (imprinting center) and PWS-IC. These concertedly confer allele specificity on 15q11-13. Here, we report DNA methylation status of 15q11-1...

journal_title：Clinical epigenetics

authors： Matsubara K,Itoh M,Shimizu K,Saito S,Enomoto K,Nakabayashi K,Hata K,Kurosawa K,Ogata T,Fukami M,Kagami M

更新日期：2019-02-28 00:00:00

abstract：BACKGROUND:In vitro follicle culture (IFC), as applied in the mouse system, allows the growth and maturation of a large number of immature preantral follicles to become mature and competent oocytes. In the human oncofertility clinic, there is increasing interest in developing this technique as an alternative to ovarian...

journal_title：Clinical epigenetics

authors： Saenz-de-Juano MD,Ivanova E,Billooye K,Herta AC,Smitz J,Kelsey G,Anckaert E

更新日期：2019-12-19 00:00:00

abstract：BACKGROUND:Tobacco smoking is a risk factor for multiple diseases, including cardiovascular disease and diabetes. Many smoking-associated signals have been detected in the blood methylome, but the extent to which these changes are widespread to metabolically relevant tissues, and impact gene expression or metabolic hea...

journal_title：Clinical epigenetics

authors： Tsai PC,Glastonbury CA,Eliot MN,Bollepalli S,Yet I,Castillo-Fernandez JE,Carnero-Montoro E,Hardiman T,Martin TC,Vickers A,Mangino M,Ward K,Pietiläinen KH,Deloukas P,Spector TD,Viñuela A,Loucks EB,Ollikainen M,Kelsey K

更新日期：2018-10-20 00:00:00

abstract：BACKGROUND:Normal-weight polycystic ovary syndrome (PCOS) women exhibit adipose resistance in vivo accompanied by enhanced subcutaneous (SC) abdominal adipose stem cell (ASC) development to adipocytes with accelerated lipid accumulation per cell in vitro. The present study examines chromatin accessibility, RNA expressi...

journal_title：Clinical epigenetics

authors： Leung KL,Sanchita S,Pham CT,Davis BA,Okhovat M,Ding X,Dumesic P,Grogan TR,Williams KJ,Morselli M,Ma F,Carbone L,Li X,Pellegrini M,Dumesic DA,Chazenbalk GD

更新日期：2020-11-23 00:00:00

abstract：BACKGROUND:The introduction of pathology tissue-chromatin immunoprecipitation (PAT-ChIP), a technique allowing chromatin immunoprecipitation (ChIP) from formalin-fixed paraffin-embedded (FFPE) tissues, has extended the application of chromatin studies to clinical patient samples. However, extensive crosslinking introdu...

journal_title：Clinical epigenetics

authors： Amatori S,Persico G,Paolicelli C,Hillje R,Sahnane N,Corini F,Furlan D,Luzi L,Minucci S,Giorgio M,Pelicci PG,Fanelli M

更新日期：2018-11-16 00:00:00

abstract：BACKGROUND:Prostate cancer (PC) is a commonly diagnosed malignancy in males, especially in the western hemisphere. The extensive use of multiple biomarkers plays an important role in the diagnosis and prognosis of PC. However, the accuracy of biomarkers for PC prognosis needs to be urgently improved. This study aimed t...

journal_title：Clinical epigenetics

authors： Li X,Zhang W,Song J,Zhang X,Ran L,He Y

更新日期：2019-07-09 00:00:00

abstract：BACKGROUND:Adiponectin critically contributes to metabolic homeostasis, especially by insulin-sensitizing action. Gestational diabetes mellitus (GDM) is characterized by insulin resistance leading to materno-fetal hyperglycemia and detrimental birth outcomes. By investigating paired subcutaneous (SAT) and visceral adip...

journal_title：Clinical epigenetics

authors： Ott R,Stupin JH,Melchior K,Schellong K,Ziska T,Dudenhausen JW,Henrich W,Rancourt RC,Plagemann A

更新日期：2018-10-24 00:00:00

abstract：BACKGROUND:Inadequate maternal nutrition during early fetal development can create permanent alterations in the offspring, leading to poor health outcomes. While nutrients involved in one-carbon cycle metabolism are important to fetal growth, associations with specific nutrients remain inconsistent. This study estimate...

journal_title：Clinical epigenetics

authors： McCullough LE,Miller EE,Mendez MA,Murtha AP,Murphy SK,Hoyo C

更新日期：2016-01-22 00:00:00

abstract：BACKGROUNDS:Colorectal cancer (CRC) results from the accumulation of epigenetic and genetic changes in colon cells during neoplasic transformation, which the activation of Wingless (Wnt) signaling pathway is a common mechanism for CRC initiation. The Wnt pathway is mainly regulated by Wnt antagonists, as secreted frizz...

journal_title：Clinical epigenetics

authors： Boughanem H,Cabrera-Mulero A,Hernández-Alonso P,Clemente-Postigo M,Casanueva FF,Tinahones FJ,Morcillo S,Crujeiras AB,Macias-Gonzalez M

更新日期：2020-06-09 00:00:00

abstract：BACKGROUND:Zinc-finger protein 471 (ZNF471) is a member of the Krüppel-associated box domain zinc finger protein (KRAB-ZFP) family. ZNF471 is methylated in squamous cell carcinomas of tongue, stomach and esophageal. However, its role in breast carcinogenesis remains elusive. Here, we studied its expression, functions, ...

journal_title：Clinical epigenetics

authors： Tao C,Luo J,Tang J,Zhou D,Feng S,Qiu Z,Putti TC,Xiang T,Tao Q,Li L,Ren G

更新日期：2020-11-17 00:00:00

abstract：BACKGROUND:Prostate cancer (PCa), a highly incident and heterogeneous malignancy, mostly affects men from developed countries. Increased knowledge of the biological mechanisms underlying PCa onset and progression are critical for improved clinical management. MicroRNAs (miRNAs) deregulation is common in human cancers, ...

journal_title：Clinical epigenetics

authors： Costa-Pinheiro P,Ramalho-Carvalho J,Vieira FQ,Torres-Ferreira J,Oliveira J,Gonçalves CS,Costa BM,Henrique R,Jerónimo C

更新日期：2015-04-10 00:00:00

abstract：BACKGROUND:Canine mammary tumor (CMT) has long been considered as a good animal model for human breast cancer (HBC) due to their pathological and biological similarities. However, only a few aspects of the epigenome have been explored in both HBC and CMT. Moreover, DNA methylation studies have mainly been limited to th...

journal_title：Clinical epigenetics

authors： Nam AR,Lee KH,Hwang HJ,Schabort JJ,An JH,Won SH,Cho JY

更新日期：2020-07-21 00:00:00

abstract：BACKGROUND:Human immunodeficiency virus type 1 (HIV-1) latency represents the major barrier to virus eradication in infected individuals because cells harboring latent HIV-1 provirus are not affected by current antiretroviral therapy (ART). We previously demonstrated that DNA methylation of HIV-1 long terminal repeat (...

journal_title：Clinical epigenetics

authors： Trejbalová K,Kovářová D,Blažková J,Machala L,Jilich D,Weber J,Kučerová D,Vencálek O,Hirsch I,Hejnar J

更新日期：2016-02-19 00:00:00

abstract：BACKGROUND:The autoimmune disease systemic lupus erythematosus (SLE) has a modified epigenome with modified tri-methylation of histone H3 lysine 4 (H3K4me3) at specific loci across the genome. H3K4me3 is a canonical chromatin mark of active transcription. Recent studies have suggested that H3K4me3 breadth has an import...

journal_title：Clinical epigenetics

authors： Zhang Z,Shi L,Dawany N,Kelsen J,Petri MA,Sullivan KE

更新日期：2016-02-02 00:00:00

abstract：BACKGROUND:Preeclampsia, a pregnancy complication of placental origin is associated with altered expression of angiogenic factors and their receptors. Recently, there is considerable interest in understanding the role of adverse intrauterine conditions in placental dysfunction and adverse pregnancy outcomes. Since we h...

journal_title：Clinical epigenetics

authors： Sundrani DP,Reddy US,Joshi AA,Mehendale SS,Chavan-Gautam PM,Hardikar AA,Chandak GR,Joshi SR

更新日期：2013-04-26 00:00:00

abstract：BACKGROUND:Pancreatic cancer has a 5-year survival rate of only 5-7%. Difficulties in detecting pancreatic cancer at early stages results in the high mortality and substantiates the need for additional diagnostic tools. Surgery is the only curative treatment and unfortunately only possible in localized tumours. A diagn...

journal_title：Clinical epigenetics

authors： Henriksen SD,Madsen PH,Larsen AC,Johansen MB,Drewes AM,Pedersen IS,Krarup H,Thorlacius-Ussing O

更新日期：2016-11-16 00:00:00

abstract：BACKGROUND:Compared to healthy individuals, those with stably repressed HIV experience a higher risk of developing insulin resistance, a hallmark of pre-diabetes and a major determinant for cardiometabolic diseases. Although epigenetic processes, including in particular DNA methylation, appear to be dysregulated in ind...

journal_title：Clinical epigenetics

authors： Dye CK,Corley MJ,Li D,Khadka VS,Mitchell BI,Sultana R,Lum-Jones A,Shikuma CM,Ndhlovu LC,Maunakea AK

更新日期：2019-06-28 00:00:00

abstract：BACKGROUND:Modification of DNA by methylation of cytosines at CpG dinucleotides is a widespread phenomenon that leads to changes in gene expression, thereby influencing and regulating many biological processes. Recent technical advances in the genome-wide determination of single-base DNA-methylation enabled epigenome-w...

journal_title：Clinical epigenetics

authors： Zaghlool SB,Al-Shafai M,Al Muftah WA,Kumar P,Falchi M,Suhre K

更新日期：2015-01-22 00:00:00

abstract：BACKGROUND:Kawasaki disease (KD) is a prevalent pediatric disease worldwide and can cause coronary artery aneurysm as a severe complication. Typically, DNA methylation is thought to repress the expression of nearby genes. However, the cases in which DNA methylation promotes gene expression have been reported. In additi...

journal_title：Clinical epigenetics

authors： Huang LH,Kuo HC,Pan CT,Lin YS,Huang YH,Li SC

更新日期：2018-11-01 00:00:00

abstract：BACKGROUND:Epigenetic mechanisms have been suggested to play a role in the development of post-traumatic stress disorder (PTSD). Here, blood-derived DNA methylation data (HumanMethylation450 BeadChip) collected prior to and following combat exposure in three cohorts of male military members were analyzed to assess whet...

journal_title：Clinical epigenetics

authors： Snijders C,Maihofer AX,Ratanatharathorn A,Baker DG,Boks MP,Geuze E,Jain S,Kessler RC,Pishva E,Risbrough VB,Stein MB,Ursano RJ,Vermetten E,Vinkers CH,PGC PTSD EWAS Consortium.,Smith AK,Uddin M,Rutten BPF,Nievergelt CM

更新日期：2020-01-13 00:00:00