Two independent epigenetic biomarkers predict survival in neuroblastoma.

abstract：BACKGROUNDS:Colorectal cancer (CRC) results from the accumulation of epigenetic and genetic changes in colon cells during neoplasic transformation, which the activation of Wingless (Wnt) signaling pathway is a common mechanism for CRC initiation. The Wnt pathway is mainly regulated by Wnt antagonists, as secreted frizz...

journal_title：Clinical epigenetics

authors： Boughanem H,Cabrera-Mulero A,Hernández-Alonso P,Clemente-Postigo M,Casanueva FF,Tinahones FJ,Morcillo S,Crujeiras AB,Macias-Gonzalez M

更新日期：2020-06-09 00:00:00

abstract：BACKGROUND:Adiponectin critically contributes to metabolic homeostasis, especially by insulin-sensitizing action. Gestational diabetes mellitus (GDM) is characterized by insulin resistance leading to materno-fetal hyperglycemia and detrimental birth outcomes. By investigating paired subcutaneous (SAT) and visceral adip...

journal_title：Clinical epigenetics

authors： Ott R,Stupin JH,Melchior K,Schellong K,Ziska T,Dudenhausen JW,Henrich W,Rancourt RC,Plagemann A

更新日期：2018-10-24 00:00:00

abstract：:Esophageal cancer is one of the most common malignancies in the world. Squamous cell carcinoma accounts for approximately 90 % of esophageal cancer cases. Genetic and epigenetic changes have been found to accumulate during the development of various cancers, including esophageal squamous carcinoma (ESCC). Tobacco smok...

journal_title：Clinical epigenetics

authors： Ma K,Cao B,Guo M

更新日期：2016-04-22 00:00:00

abstract：BACKGROUND:Toll-like receptor 4 (TLR4) expression is increased in activated monocytes, which play a critical role in the pathogenesis of coronary artery disease (CAD). However, the mechanism remains unclear. Regulatory factor X1 (RFX1) is a critical transcription factor regulating epigenetic modifications. In this stud...

journal_title：Clinical epigenetics

authors： Du P,Gao K,Cao Y,Yang S,Wang Y,Guo R,Zhao M,Jia S

更新日期：2019-03-11 00:00:00

abstract：BACKGROUND:The neuropeptide oxytocin regulates mammalian social behavior. Disruptions in oxytocin signaling are a feature of many psychopathologies. One commonly studied biomarker for oxytocin involvement in psychiatric diseases is DNA methylation at the oxytocin receptor gene (OXTR). Such studies focus on DNA methylat...

journal_title：Clinical epigenetics

authors： Danoff JS,Wroblewski KL,Graves AJ,Quinn GC,Perkeybile AM,Kenkel WM,Lillard TS,Parikh HI,Golino HF,Gregory SG,Carter CS,Bales KL,Connelly JJ

更新日期：2021-01-30 00:00:00

abstract：BACKGROUND:The prevalence of type 2 diabetes (T2D) and obesity has dramatically increased within a few generations, reaching epidemic levels. In addition to genetic risk factors, epigenetic mechanisms triggered by changing environment are investigated for their role in the pathogenesis of these complex diseases. Epigen...

journal_title：Clinical epigenetics

authors： Al Muftah WA,Al-Shafai M,Zaghlool SB,Visconti A,Tsai PC,Kumar P,Spector T,Bell J,Falchi M,Suhre K

更新日期：2016-01-28 00:00:00

abstract：BACKGROUND:Emerging evidence has shown that MUC1 and TFF2 play crucial roles in the H. pylori-infected pathogenesis of gastric cancer (GC). A recent study revealed that H. pylori infection induced obviously increased Tff2 methylation levels in Muc1-/- mice compared with controls. However, little is known of the molecul...

journal_title：Clinical epigenetics

authors： Ge Y,Ma G,Liu H,Lin Y,Zhang G,Du M,Wang M,Chu H,Zhang H,Zhang Z

更新日期：2020-03-02 00:00:00

abstract：BACKGROUND:Obesity and diabetes mellitus are directly implicated in many adverse health consequences in adults as well as in the offspring of obese and diabetic mothers. Hispanic Americans are particularly at risk for obesity, diabetes, and end-stage renal disease. Maternal obesity and/or diabetes through prenatal prog...

journal_title：Clinical epigenetics

authors： Rizzo HE,Escaname EN,Alana NB,Lavender E,Gelfond J,Fernandez R,Hibbs MA,King JM,Carr NR,Blanco CL

更新日期：2020-02-19 00:00:00

abstract：BACKGROUND:Male obesity has profound effects on morbidity and mortality, but relatively little is known about the impact of obesity on gametes and the potential for adverse effects of male obesity to be passed to the next generation. DNA methylation contributes to gene regulation and is erased and re-established during...

journal_title：Clinical epigenetics

authors： Keyhan S,Burke E,Schrott R,Huang Z,Grenier C,Price T,Raburn D,Corcoran DL,Soubry A,Hoyo C,Murphy SK

更新日期：2021-01-25 00:00:00

abstract：INTRODUCTION:DNA methylation of CpG islands within the promoter region of genes is an epigenetic modification with an important role in the development of cancer and it is typically mediated by DNA methyltransferases (DNMTs). In cancer cells, global hypomethylation of the genome as a whole and regional hypermethylation...

journal_title：Clinical epigenetics

authors： Kullmann K,Deryal M,Ong MF,Schmidt W,Mahlknecht U

更新日期：2013-05-02 00:00:00

abstract：BACKGROUND:Apabetalone (RVX-208) is a bromodomain and extraterminal protein inhibitor (BETi) that in phase II trials reduced the relative risk (RR) of major adverse cardiac events (MACE) in patients with cardiovascular disease (CVD) by 44% and in diabetic CVD patients by 57% on top of statins. A phase III trial, BETonM...

journal_title：Clinical epigenetics

authors： Tsujikawa LM,Fu L,Das S,Halliday C,Rakai BD,Stotz SC,Sarsons CD,Gilham D,Daze E,Wasiak S,Studer D,Rinker KD,Sweeney M,Johansson JO,Wong NCW,Kulikowski E

更新日期：2019-07-12 00:00:00

abstract：BACKGROUND:Human immunodeficiency virus type 1 (HIV-1) latency represents the major barrier to virus eradication in infected individuals because cells harboring latent HIV-1 provirus are not affected by current antiretroviral therapy (ART). We previously demonstrated that DNA methylation of HIV-1 long terminal repeat (...

journal_title：Clinical epigenetics

authors： Trejbalová K,Kovářová D,Blažková J,Machala L,Jilich D,Weber J,Kučerová D,Vencálek O,Hirsch I,Hejnar J

更新日期：2016-02-19 00:00:00

abstract：BACKGROUND:B vitamins in the one-carbon metabolism pathway (folate, vitamin B6, and vitamin B12) have been implicated in DNA methylation, and their deficiency may contribute to cognitive decline through increased homocysteine (Hcy) levels and subsequent oxidative damage. The aim of this study was to investigate whether...

journal_title：Clinical epigenetics

authors： An Y,Feng L,Zhang X,Wang Y,Wang Y,Tao L,Qin Z,Xiao R

更新日期：2019-10-11 00:00:00

abstract：:Remodeling of the sperm epigenome by lifestyle factors before conception could account for altered metabolism in the next generation offspring. Here, we hypothesized that endurance training changes the epigenome of human spermatozoa. Using small RNA (sRNA) sequencing and reduced representation bisulfite sequencing (RR...

journal_title：Clinical epigenetics

authors： Ingerslev LR,Donkin I,Fabre O,Versteyhe S,Mechta M,Pattamaprapanont P,Mortensen B,Krarup NT,Barrès R

更新日期：2018-01-25 00:00:00

abstract：BACKGROUND:Epigenetic mechanisms have been suggested to play a role in the development of post-traumatic stress disorder (PTSD). Here, blood-derived DNA methylation data (HumanMethylation450 BeadChip) collected prior to and following combat exposure in three cohorts of male military members were analyzed to assess whet...

journal_title：Clinical epigenetics

authors： Snijders C,Maihofer AX,Ratanatharathorn A,Baker DG,Boks MP,Geuze E,Jain S,Kessler RC,Pishva E,Risbrough VB,Stein MB,Ursano RJ,Vermetten E,Vinkers CH,PGC PTSD EWAS Consortium.,Smith AK,Uddin M,Rutten BPF,Nievergelt CM

更新日期：2020-01-13 00:00:00

abstract：BACKGROUND:Epigenetic mechanisms may partly explain the persistent effects of adverse childhood experiences (ACEs) on health outcomes in later life. DNA methylation can predict chronological age, and advanced methylation-predicted age beyond chronological age (DNA methylation age acceleration) is associated with ACEs, ...

journal_title：Clinical epigenetics

authors： Tang R,Howe LD,Suderman M,Relton CL,Crawford AA,Houtepen LC

更新日期：2020-04-07 00:00:00

abstract：BACKGROUND:Tobacco smoking is a risk factor for multiple diseases, including cardiovascular disease and diabetes. Many smoking-associated signals have been detected in the blood methylome, but the extent to which these changes are widespread to metabolically relevant tissues, and impact gene expression or metabolic hea...

journal_title：Clinical epigenetics

authors： Tsai PC,Glastonbury CA,Eliot MN,Bollepalli S,Yet I,Castillo-Fernandez JE,Carnero-Montoro E,Hardiman T,Martin TC,Vickers A,Mangino M,Ward K,Pietiläinen KH,Deloukas P,Spector TD,Viñuela A,Loucks EB,Ollikainen M,Kelsey K

更新日期：2018-10-20 00:00:00

abstract：BACKGROUND:The current epidemic of obesity and associated diseases calls for swift actions to better understand the mechanisms by which genetics and environmental factors affect metabolic health in humans. Monozygotic (MZ) twin pairs showing discordance for obesity suggest that epigenetic influences represent one such ...

journal_title：Clinical epigenetics

authors： Ollikainen M,Ismail K,Gervin K,Kyllönen A,Hakkarainen A,Lundbom J,Järvinen EA,Harris JR,Lundbom N,Rissanen A,Lyle R,Pietiläinen KH,Kaprio J

更新日期：2015-04-02 00:00:00

abstract：BACKGROUND:Inadequate maternal nutrition during early fetal development can create permanent alterations in the offspring, leading to poor health outcomes. While nutrients involved in one-carbon cycle metabolism are important to fetal growth, associations with specific nutrients remain inconsistent. This study estimate...

journal_title：Clinical epigenetics

authors： McCullough LE,Miller EE,Mendez MA,Murtha AP,Murphy SK,Hoyo C

更新日期：2016-01-22 00:00:00

abstract：BACKGROUND:ADNP syndrome is a rare Mendelian disorder characterized by global developmental delay, intellectual disability, and autism. It is caused by truncating mutations in ADNP, which is involved in chromatin regulation. We hypothesized that the disruption of chromatin regulation might result in specific DNA methyl...

journal_title：Clinical epigenetics

authors： Bend EG,Aref-Eshghi E,Everman DB,Rogers RC,Cathey SS,Prijoles EJ,Lyons MJ,Davis H,Clarkson K,Gripp KW,Li D,Bhoj E,Zackai E,Mark P,Hakonarson H,Demmer LA,Levy MA,Kerkhof J,Stuart A,Rodenhiser D,Friez MJ,Stevenson

更新日期：2019-04-27 00:00:00

abstract：BACKGROUND:The DNA modification 5-hydroxymethylcytosine (5hmC) is now referred to as the sixth base of DNA with evidence of tissue-specific patterns and correlation with gene regulation and expression. This epigenetic mark was recently reported as a potential biomarker for multiple types of cancer, but its application ...

journal_title：Clinical epigenetics

authors： Gilat N,Tabachnik T,Shwartz A,Shahal T,Torchinsky D,Michaeli Y,Nifker G,Zirkin S,Ebenstein Y

更新日期：2017-07-14 00:00:00

abstract：BACKGROUND:Both forms of facioscapulohumeral muscular dystrophy (FSHD) are associated with aberrant epigenetic regulation of the chromosome 4q35 D4Z4 macrosatellite. Chromatin changes due to large deletions of heterochromatin (FSHD1) or mutations in chromatin regulatory proteins (FSHD2) lead to relaxation of epigenetic...

journal_title：Clinical epigenetics

authors： Jones TI,King OD,Himeda CL,Homma S,Chen JC,Beermann ML,Yan C,Emerson CP Jr,Miller JB,Wagner KR,Jones PL

更新日期：2015-03-29 00:00:00

abstract：BACKGROUND:Goblet cell metaplasia, a common feature of chronic obstructive pulmonary disease (COPD), is associated with mucus hypersecretion which contributes to the morbidity and mortality among patients. Transcription factors SAM-pointed domain-containing Ets-like factor (SPDEF) and forkhead box protein A2 (FOXA2) re...

journal_title：Clinical epigenetics

authors： Song J,Heijink IH,Kistemaker LEM,Reinders-Luinge M,Kooistra W,Noordhoek JA,Gosens R,Brandsma CA,Timens W,Hiemstra PS,Rots MG,Hylkema MN

更新日期：2017-04-24 00:00:00

abstract：BACKGROUND:Although HPV testing and cytology detection are successful for cervical screening in China, additional procedures are urgently required to avoid misdiagnosis and overtreatment. In this multicenter study, we collected cervical samples during screening in clinics. A total of 588 women with HPV16/18+ and/or cyt...

journal_title：Clinical epigenetics

authors： Gu YY,Zhou GN,Wang Q,Ding JX,Hua KQ

更新日期：2020-04-21 00:00:00

abstract：Background:This study was aimed at understanding whether bronchial biopsy specimen can be used as a surrogate for DNA methylation analysis in surgically resected lung cancer. Methods:A genome-wide methylation was analyzed in 42 surgically resected tumor tissues, 136 bronchial washing, 12 sputum, and 8 bronchial biopsy...

journal_title：Clinical epigenetics

authors： Um SW,Kim HK,Kim Y,Lee BB,Kim D,Han J,Kim H,Shim YM,Kim DH

更新日期：2017-12-20 00:00:00

abstract：BACKGROUND:Preeclampsia, a pregnancy complication of placental origin is associated with altered expression of angiogenic factors and their receptors. Recently, there is considerable interest in understanding the role of adverse intrauterine conditions in placental dysfunction and adverse pregnancy outcomes. Since we h...

journal_title：Clinical epigenetics

authors： Sundrani DP,Reddy US,Joshi AA,Mehendale SS,Chavan-Gautam PM,Hardikar AA,Chandak GR,Joshi SR

更新日期：2013-04-26 00:00:00

abstract：:Altered DNA methylation events contribute to the pathogenesis and progression of metabolic disorders, including nonalcoholic fatty liver disease (NAFLD). Investigations of global DNA methylation patterns in liver biopsies representing severe NAFLD fibrosis have been limited. We used the HumanMethylation 450K BeadChip ...

journal_title：Clinical epigenetics

authors： Gerhard GS,Malenica I,Llaci L,Chu X,Petrick AT,Still CD,DiStefano JK

更新日期：2018-07-13 00:00:00

abstract：:Heterozygous mutation of the transcription factor HNF1B is the most common cause of monogenetic developmental renal disease. Disease-associated mutations fall into two categories: HNF1B intragenic mutations and a 1.3 Mb deletion at chromosome 17q12. An increase in neurodevelopmental disorders has been observed in indi...

journal_title：Clinical epigenetics

authors： Clissold RL,Ashfield B,Burrage J,Hannon E,Bingham C,Mill J,Hattersley A,Dempster EL

更新日期：2018-07-18 00:00:00

abstract：BACKGROUND:Pancreatic cancer has a 5-year survival rate of only 5-7%. Difficulties in detecting pancreatic cancer at early stages results in the high mortality and substantiates the need for additional diagnostic tools. Surgery is the only curative treatment and unfortunately only possible in localized tumours. A diagn...

journal_title：Clinical epigenetics

authors： Henriksen SD,Madsen PH,Larsen AC,Johansen MB,Drewes AM,Pedersen IS,Krarup H,Thorlacius-Ussing O

更新日期：2016-11-16 00:00:00

abstract：BACKGROUND:Characteristic DNA methylation differences have been identified between primary and metastatic melanomas at EBF3 and/or TBC1D16 gene loci. To further evaluate whether these epigenetic changes may act more generally as drivers of tumour onset and metastasis, we have investigated DNA methylation changes involv...

journal_title：Clinical epigenetics

authors： Rodger EJ,Chatterjee A,Stockwell PA,Eccles MR

更新日期：2019-08-05 00:00:00