当前位置： SCI文献检索 > Clinical Epigenetics期刊下所有文献 > Aberrant DNA methylation and expression of SPDEF and FOXA2 in airway epithelium of patients with COPD.

Aberrant DNA methylation and expression of SPDEF and FOXA2 in airway epithelium of patients with COPD.

Abstract：

BACKGROUND:Goblet cell metaplasia, a common feature of chronic obstructive pulmonary disease (COPD), is associated with mucus hypersecretion which contributes to the morbidity and mortality among patients. Transcription factors SAM-pointed domain-containing Ets-like factor (SPDEF) and forkhead box protein A2 (FOXA2) regulate goblet cell differentiation. This study aimed to (1) investigate DNA methylation and expression of SPDEF and FOXA2 during goblet cell differentiation and (2) compare this in airway epithelial cells from patients with COPD and controls during mucociliary differentiation. METHODS:To assess DNA methylation and expression of SPDEF and FOXA2 during goblet cell differentiation, primary airway epithelial cells, isolated from trachea (non-COPD controls) and bronchial tissue (patients with COPD), were differentiated by culture at the air-liquid interface (ALI) in the presence of cytokine interleukin (IL)-13 to promote goblet cell differentiation. RESULTS:We found that SPDEF expression was induced during goblet cell differentiation, while FOXA2 expression was decreased. Importantly, CpG number 8 in the SPDEF promoter was hypermethylated upon differentiation, whereas DNA methylation of FOXA2 promoter was not changed. In the absence of IL-13, COPD-derived ALI-cultured cells displayed higher SPDEF expression than control-derived ALI cultures, whereas no difference was found for FOXA2 expression. This was accompanied with hypomethylation of CpG number 6 in the SPDEF promoter and also hypomethylation of CpG numbers 10 and 11 in the FOXA2 promoter. CONCLUSIONS:These findings suggest that aberrant DNA methylation of SPDEF and FOXA2 is one of the factors underlying mucus hypersecretion in COPD, opening new avenues for epigenetic-based inhibition of mucus hypersecretion.

journal_name

Clin Epigenetics

journal_title

Clinical epigenetics

authors

Song J,Heijink IH,Kistemaker LEM,Reinders-Luinge M,Kooistra W,Noordhoek JA,Gosens R,Brandsma CA,Timens W,Hiemstra PS,Rots MG,Hylkema MN

doi

10.1186/s13148-017-0341-7

subject

Has Abstract

pub_date

2017-04-24 00:00:00

pages

42

eissn

1868-7075

issn

1868-7083

pii

341

journal_volume

9

pub_type

杂志文章

相关文献

Clinical Epigenetics文献大全
  • Maternal B vitamins: effects on offspring weight and DNA methylation at genomically imprinted domains.

    abstract：BACKGROUND:Inadequate maternal nutrition during early fetal development can create permanent alterations in the offspring, leading to poor health outcomes. While nutrients involved in one-carbon cycle metabolism are important to fetal growth, associations with specific nutrients remain inconsistent. This study estimate...

    journal_title：Clinical epigenetics

    pub_type： 杂志文章

    doi：10.1186/s13148-016-0174-9

    authors： McCullough LE,Miller EE,Mendez MA,Murtha AP,Murphy SK,Hoyo C

    更新日期：2016-01-22 00:00:00

  • Exploring the unique function of imprinting control centers in the PWS/AS-responsible region: finding from array-based methylation analysis in cases with variously sized microdeletions.

    abstract：BACKGROUND:Human 15q11-13 is responsible for Prader-Willi syndrome (PWS) and Angelman syndrome (AS) and includes several imprinted genes together with bipartite elements named AS-IC (imprinting center) and PWS-IC. These concertedly confer allele specificity on 15q11-13. Here, we report DNA methylation status of 15q11-1...

    journal_title：Clinical epigenetics

    pub_type： 杂志文章

    doi：10.1186/s13148-019-0633-1

    authors： Matsubara K,Itoh M,Shimizu K,Saito S,Enomoto K,Nakabayashi K,Hata K,Kurosawa K,Ogata T,Fukami M,Kagami M

    更新日期：2019-02-28 00:00:00

  • Adverse childhood experiences, DNA methylation age acceleration, and cortisol in UK children: a prospective population-based cohort study.

    abstract：BACKGROUND:Epigenetic mechanisms may partly explain the persistent effects of adverse childhood experiences (ACEs) on health outcomes in later life. DNA methylation can predict chronological age, and advanced methylation-predicted age beyond chronological age (DNA methylation age acceleration) is associated with ACEs, ...

    journal_title：Clinical epigenetics

    pub_type： 杂志文章

    doi：10.1186/s13148-020-00844-2

    authors： Tang R,Howe LD,Suderman M,Relton CL,Crawford AA,Houtepen LC

    更新日期：2020-04-07 00:00:00

  • Characterisation of DNA methylation changes in EBF3 and TBC1D16 associated with tumour progression and metastasis in multiple cancer types.

    abstract：BACKGROUND:Characteristic DNA methylation differences have been identified between primary and metastatic melanomas at EBF3 and/or TBC1D16 gene loci. To further evaluate whether these epigenetic changes may act more generally as drivers of tumour onset and metastasis, we have investigated DNA methylation changes involv...

    journal_title：Clinical epigenetics

    pub_type： 杂志文章

    doi：10.1186/s13148-019-0710-5

    authors： Rodger EJ,Chatterjee A,Stockwell PA,Eccles MR

    更新日期：2019-08-05 00:00:00

  • Epigenomic profiling of prostate cancer identifies differentially methylated genes in TMPRSS2:ERG fusion-positive versus fusion-negative tumors.

    abstract：BACKGROUND:About half of all prostate cancers harbor the TMPRSS2:ERG (T2E) gene fusion. While T2E-positive and T2E-negative tumors represent specific molecular subtypes of prostate cancer (PCa), previous studies have not yet comprehensively investigated how these tumor subtypes differ at the epigenetic level. We theref...

    journal_title：Clinical epigenetics

    pub_type： 杂志文章

    doi：10.1186/s13148-015-0161-6

    authors： Geybels MS,Alumkal JJ,Luedeke M,Rinckleb A,Zhao S,Shui IM,Bibikova M,Klotzle B,van den Brandt PA,Ostrander EA,Fan JB,Feng Z,Maier C,Stanford JL

    更新日期：2015-12-12 00:00:00

  • Retinoic acid-induced 2 (RAI2) is a novel tumor suppressor, and promoter region methylation of RAI2 is a poor prognostic marker in colorectal cancer.

    abstract：Background:Reduced expression of retinoic acid-induced 2 (RAI2) was found in breast cancer. The regulation and function of RAI2 in human colorectal cancer (CRC) remain unclear. Methods:Eight CRC cell lines and 237 cases of primary CRC were analyzed. Methylation-specific PCR (MSP), flow cytometry, xenograft mouse model...

    journal_title：Clinical epigenetics

    pub_type： 杂志文章

    doi：10.1186/s13148-018-0501-4

    authors： Yan W,Wu K,Herman JG,Xu X,Yang Y,Dai G,Guo M

    更新日期：2018-05-23 00:00:00

  • DNA hydroxymethylation age of human blood determined by capillary hydrophilic-interaction liquid chromatography/mass spectrometry.

    abstract：BACKGROUND:Aging is a complex phenomenon and characterized by a progressive decline in physiology and function of adult tissues. However, it hasn't been well established of the correlation between aging and global DNA methylation and hydroxymethylation that regulate the growth and development of higher organisms. RESU...

    journal_title：Clinical epigenetics

    pub_type： 杂志文章

    doi：10.1186/s13148-015-0109-x

    authors： Xiong J,Jiang HP,Peng CY,Deng QY,Lan MD,Zeng H,Zheng F,Feng YQ,Yuan BF

    更新日期：2015-07-23 00:00:00

  • Racial differences in IGF1 methylation and birth weight.

    abstract：BACKGROUND:The birth weight of Black neonates in the United States is consistently smaller than that of their White counterparts. Epigenetic differences between the races may be involved in such disparities. The goal of these analyses was to model the role of IGF1 methylation in mediating the association between race a...

    journal_title：Clinical epigenetics

    pub_type： 杂志文章

    doi：10.1186/s13148-015-0080-6

    authors： Straughen JK,Sipahi L,Uddin M,Misra DP,Misra VK

    更新日期：2015-04-21 00:00:00

  • Erratum to: MSRE-HTPrimer: a high-throughput and genome-wide primer design pipeline optimized for epigenetic research.

    abstract：:[This corrects the article DOI: 10.1186/s13148-016-0190-9.]. ...

    journal_title：Clinical epigenetics

    pub_type： 已发布勘误

    doi：10.1186/s13148-016-0250-1

    authors： Pandey RV,Pulverer W,Kallmeyer R,Beikircher G,Pabinger S,Kriegner A,Weinhäusel A

    更新日期：2016-08-04 00:00:00

  • Identification and validation of SRY-box containing gene family member SOX30 methylation as a prognostic and predictive biomarker in myeloid malignancies.

    abstract：Background:Methylation-associated SOX family genes have been proved to be involved in multiple essential processes during carcinogenesis and act as potential biomarkers for cancer diagnosis, staging, prediction of prognosis, and monitoring of response to therapy. Herein, we revealed SOX30 methylation and its clinical i...

    journal_title：Clinical epigenetics

    pub_type： 杂志文章

    doi：10.1186/s13148-018-0523-y

    authors： Zhou JD,Wang YX,Zhang TJ,Li XX,Gu Y,Zhang W,Ma JC,Lin J,Qian J

    更新日期：2018-07-05 00:00:00

  • The tumor suppressor Zinc finger protein 471 suppresses breast cancer growth and metastasis through inhibiting AKT and Wnt/β-catenin signaling.

    abstract：BACKGROUND:Zinc-finger protein 471 (ZNF471) is a member of the Krüppel-associated box domain zinc finger protein (KRAB-ZFP) family. ZNF471 is methylated in squamous cell carcinomas of tongue, stomach and esophageal. However, its role in breast carcinogenesis remains elusive. Here, we studied its expression, functions, ...

    journal_title：Clinical epigenetics

    pub_type： 杂志文章

    doi：10.1186/s13148-020-00959-6

    authors： Tao C,Luo J,Tang J,Zhou D,Feng S,Qiu Z,Putti TC,Xiang T,Tao Q,Li L,Ren G

    更新日期：2020-11-17 00:00:00

  • Alternative methylation of intron motifs is associated with cancer-related gene expression in both canine mammary tumor and human breast cancer.

    abstract：BACKGROUND:Canine mammary tumor (CMT) has long been considered as a good animal model for human breast cancer (HBC) due to their pathological and biological similarities. However, only a few aspects of the epigenome have been explored in both HBC and CMT. Moreover, DNA methylation studies have mainly been limited to th...

    journal_title：Clinical epigenetics

    pub_type： 杂志文章

    doi：10.1186/s13148-020-00888-4

    authors： Nam AR,Lee KH,Hwang HJ,Schabort JJ,An JH,Won SH,Cho JY

    更新日期：2020-07-21 00:00:00

  • High-resolution analysis of germ cells from men with sex chromosomal aneuploidies reveals normal transcriptome but impaired imprinting.

    abstract：BACKGROUND:The most common sex chromosomal aneuploidy in males is Klinefelter syndrome, which is characterized by at least one supernumerary X chromosome. While these men have long been considered infertile, focal spermatogenesis can be observed in some patients, and sperm can be surgically retrieved and used for artif...

    journal_title：Clinical epigenetics

    pub_type： 杂志文章

    doi：10.1186/s13148-019-0720-3

    authors： Laurentino S,Heckmann L,Di Persio S,Li X,Meyer Zu Hörste G,Wistuba J,Cremers JF,Gromoll J,Kliesch S,Schlatt S,Neuhaus N

    更新日期：2019-08-28 00:00:00

  • Genome-wide DNA methylation profiling of CD8+ T cells shows a distinct epigenetic signature to CD4+ T cells in multiple sclerosis patients.

    abstract：BACKGROUND:Multiple sclerosis (MS) is thought to be a T cell-mediated autoimmune disorder. MS pathogenesis is likely due to a genetic predisposition triggered by a variety of environmental factors. Epigenetics, particularly DNA methylation, provide a logical interface for environmental factors to influence the genome. ...

    journal_title：Clinical epigenetics

    pub_type： 杂志文章

    doi：10.1186/s13148-015-0152-7

    authors： Maltby VE,Graves MC,Lea RA,Benton MC,Sanders KA,Tajouri L,Scott RJ,Lechner-Scott J

    更新日期：2015-11-05 00:00:00

  • DNA methylation and socioeconomic status in a Mexican-American birth cohort.

    abstract：Background:Maternal social environmental stressors during pregnancy are associated with adverse birth and child developmental outcomes, and epigenetics has been proposed as a possible mechanism for such relationships. Methods:In a Mexican-American birth cohort of 241 maternal-infant pairs, cord blood samples were meas...

    journal_title：Clinical epigenetics

    pub_type： 杂志文章

    doi：10.1186/s13148-018-0494-z

    authors： Coker ES,Gunier R,Huen K,Holland N,Eskenazi B

    更新日期：2018-05-08 00:00:00

  • Developmental genes targeted for epigenetic variation between twin-twin transfusion syndrome children.

    abstract：BACKGROUND:Epigenetic mechanisms are thought to be critical in mediating the role of the intrauterine environment on lifelong health and disease. Twin-twin transfusion syndrome (TTTS) is a rare condition wherein fetuses share the placenta and develop vascular anastomoses, which allow blood to flow between the fetuses. ...

    journal_title：Clinical epigenetics

    pub_type： 杂志文章

    doi：10.1186/1868-7083-5-18

    authors： Marsit CJ,Koestler DC,Watson-Smith D,Boney CM,Padbury JF,Luks F

    更新日期：2013-10-03 00:00:00

  • Smoking induces coordinated DNA methylation and gene expression changes in adipose tissue with consequences for metabolic health.

    abstract：BACKGROUND:Tobacco smoking is a risk factor for multiple diseases, including cardiovascular disease and diabetes. Many smoking-associated signals have been detected in the blood methylome, but the extent to which these changes are widespread to metabolically relevant tissues, and impact gene expression or metabolic hea...

    journal_title：Clinical epigenetics

    pub_type： 杂志文章

    doi：10.1186/s13148-018-0558-0

    authors： Tsai PC,Glastonbury CA,Eliot MN,Bollepalli S,Yet I,Castillo-Fernandez JE,Carnero-Montoro E,Hardiman T,Martin TC,Vickers A,Mangino M,Ward K,Pietiläinen KH,Deloukas P,Spector TD,Viñuela A,Loucks EB,Ollikainen M,Kelsey K

    更新日期：2018-10-20 00:00:00

  • Longitudinal epigenome-wide association studies of three male military cohorts reveal multiple CpG sites associated with post-traumatic stress disorder.

    abstract：BACKGROUND:Epigenetic mechanisms have been suggested to play a role in the development of post-traumatic stress disorder (PTSD). Here, blood-derived DNA methylation data (HumanMethylation450 BeadChip) collected prior to and following combat exposure in three cohorts of male military members were analyzed to assess whet...

    journal_title：Clinical epigenetics

    pub_type： 杂志文章

    doi：10.1186/s13148-019-0798-7

    authors： Snijders C,Maihofer AX,Ratanatharathorn A,Baker DG,Boks MP,Geuze E,Jain S,Kessler RC,Pishva E,Risbrough VB,Stein MB,Ursano RJ,Vermetten E,Vinkers CH,PGC PTSD EWAS Consortium.,Smith AK,Uddin M,Rutten BPF,Nievergelt CM

    更新日期：2020-01-13 00:00:00

  • Exposure and fetal growth-associated miRNA alterations in the human placenta.

    abstract：:Researchers have begun to examine epigenetic alterations in the placenta, making key advances in understanding the epigenetic regulatory mechanisms of the placenta that define underlying processes of human development and disease. Examining changes in microRNA (miRNA) expression associated with environmental exposures...

    journal_title：Clinical epigenetics

    pub_type： 杂志文章

    doi：10.1007/s13148-011-0046-2

    authors： Maccani MA,Marsit CJ

    更新日期：2011-08-01 00:00:00

  • The hyper-activation of transcriptional enhancers in breast cancer.

    abstract：BACKGROUND:Activation of transcription enhancers, especially super-enhancers, is one of the critical epigenetic features of tumorigenesis. However, very few studies have systematically identified the enhancers specific in cancer tissues. METHODS:Here, we studied the change of histone modifications in MMTV-PyVT breast ...

    journal_title：Clinical epigenetics

    pub_type： 杂志文章

    doi：10.1186/s13148-019-0645-x

    authors： Li QL,Wang DY,Ju LG,Yao J,Gao C,Lei PJ,Li LY,Zhao XL,Wu M

    更新日期：2019-03-12 00:00:00

  • Dynamic changes in chromatin accessibility, altered adipogenic gene expression, and total versus de novo fatty acid synthesis in subcutaneous adipose stem cells of normal-weight polycystic ovary syndrome (PCOS) women during adipogenesis: evidence of cellu

    abstract：BACKGROUND:Normal-weight polycystic ovary syndrome (PCOS) women exhibit adipose resistance in vivo accompanied by enhanced subcutaneous (SC) abdominal adipose stem cell (ASC) development to adipocytes with accelerated lipid accumulation per cell in vitro. The present study examines chromatin accessibility, RNA expressi...

    journal_title：Clinical epigenetics

    pub_type： 杂志文章

    doi：10.1186/s13148-020-00970-x

    authors： Leung KL,Sanchita S,Pham CT,Davis BA,Okhovat M,Ding X,Dumesic P,Grogan TR,Williams KJ,Morselli M,Ma F,Carbone L,Li X,Pellegrini M,Dumesic DA,Chazenbalk GD

    更新日期：2020-11-23 00:00:00

  • Cooperative effect of chidamide and chemotherapeutic drugs induce apoptosis by DNA damage accumulation and repair defects in acute myeloid leukemia stem and progenitor cells.

    abstract：BACKGROUND:Many conventional chemotherapeutic drugs are known to be involved in DNA damage, thus ultimately leading to apoptosis of leukemic cells. However, they fail to completely eliminate leukemia stem cells (LSCs) due to their higher DNA repair capacity of cancer stem cells than that of bulk cancer cells, which bec...

    journal_title：Clinical epigenetics

    pub_type： 杂志文章

    doi：10.1186/s13148-017-0377-8

    authors： Li Y,Wang Y,Zhou Y,Li J,Chen K,Zhang L,Deng M,Deng S,Li P,Xu B

    更新日期：2017-08-14 00:00:00

  • Premature aging of leukocyte DNA methylation is associated with type 2 diabetes prevalence.

    abstract：BACKGROUND:Type 2 diabetes mellitus (T2D) is highly prevalent in Middle-Eastern and North African Arab populations, but the molecular basis for this susceptibility is unknown. Altered DNA methylation levels were reported in insulin-secreting and responding tissues, but whether methylation in accessible tissues such as ...

    journal_title：Clinical epigenetics

    pub_type： 杂志文章

    doi：10.1186/s13148-015-0069-1

    authors： Toperoff G,Kark JD,Aran D,Nassar H,Ahmad WA,Sinnreich R,Azaiza D,Glaser B,Hellman A

    更新日期：2015-03-28 00:00:00

  • Sperm imprinting integrity in seminoma patients?

    abstract：BACKGROUND:Testicular germ cell tumor such as seminoma is strongly associated with male reproductive problems commonly associated with the alteration of sperm parameters as described in testicular dysgenesis syndrome. Interestingly, numerous studies have reported that the precursor of germ cell cancer, germ cell neopla...

    journal_title：Clinical epigenetics

    pub_type： 杂志文章

    doi：10.1186/s13148-018-0559-z

    authors： Bruno C,Blagoskonov O,Barberet J,Guilleman M,Daniel S,Tournier B,Binquet C,Choux C,Fauque P

    更新日期：2018-10-19 00:00:00

  • Genome-wide microRNA expression profiling in placentae from frozen-thawed blastocyst transfer.

    abstract：BACKGROUND:Frozen-thawed embryo transfer (FET) is increasingly available for the improvement of the success rate of assisted reproductive technologies other than fresh embryo transfer (ET). There have been numerous findings that FET provides better obstetric and perinatal outcomes. However, the birth weight of infants ...

    journal_title：Clinical epigenetics

    pub_type： 杂志文章

    doi：10.1186/s13148-017-0379-6

    authors： Hiura H,Hattori H,Kobayashi N,Okae H,Chiba H,Miyauchi N,Kitamura A,Kikuchi H,Yoshida H,Arima T

    更新日期：2017-08-03 00:00:00

  • Genome-wide assessment of DNA methylation in mouse oocytes reveals effects associated with in vitro growth, superovulation, and sexual maturity.

    abstract：BACKGROUND:In vitro follicle culture (IFC), as applied in the mouse system, allows the growth and maturation of a large number of immature preantral follicles to become mature and competent oocytes. In the human oncofertility clinic, there is increasing interest in developing this technique as an alternative to ovarian...

    journal_title：Clinical epigenetics

    pub_type： 杂志文章

    doi：10.1186/s13148-019-0794-y

    authors： Saenz-de-Juano MD,Ivanova E,Billooye K,Herta AC,Smitz J,Kelsey G,Anckaert E

    更新日期：2019-12-19 00:00:00

  • Endurance training remodels sperm-borne small RNA expression and methylation at neurological gene hotspots.

    abstract：:Remodeling of the sperm epigenome by lifestyle factors before conception could account for altered metabolism in the next generation offspring. Here, we hypothesized that endurance training changes the epigenome of human spermatozoa. Using small RNA (sRNA) sequencing and reduced representation bisulfite sequencing (RR...

    journal_title：Clinical epigenetics

    pub_type： 杂志文章

    doi：10.1186/s13148-018-0446-7

    authors： Ingerslev LR,Donkin I,Fabre O,Versteyhe S,Mechta M,Pattamaprapanont P,Mortensen B,Krarup NT,Barrès R

    更新日期：2018-01-25 00:00:00

  • Epigenetic management of major psychosis.

    abstract：:Epigenetic mechanisms are thought to play a major role in the pathogenesis of the major psychoses (schizophrenia and bipolar disorder), and they may be the link between the environment and the genome in the pathogenesis of these disorders. This paper discusses the role of epigenetics in the management of major psychos...

    journal_title：Clinical epigenetics

    pub_type： 杂志文章

    doi：10.1007/s13148-011-0038-2

    authors： Peedicayil J

    更新日期：2011-08-01 00:00:00

  • Epigenetic clocks for gestational age: statistical and study design considerations.

    abstract：:In this letter to the editor, we highlight some concerns with a recently published method to estimate gestational age at delivery from DNA methylation data. We conduct novel analyses to highlight the implications of different choices in study design and statistical methods for the prediction of phenotypes from methyla...

    journal_title：Clinical epigenetics

    pub_type： 信件

    doi：10.1186/s13148-017-0402-y

    authors： Simpkin AJ,Suderman M,Howe LD

    更新日期：2017-09-15 00:00:00

  • Increased epigenetic age in normal breast tissue from luminal breast cancer patients.

    abstract：BACKGROUND:Age is one of the most important risk factors for developing breast cancer. However, age-related changes in normal breast tissue that potentially lead to breast cancer are incompletely understood. Quantifying tissue-level DNA methylation can contribute to understanding these processes. We hypothesized that o...

    journal_title：Clinical epigenetics

    pub_type： 杂志文章,多中心研究

    doi：10.1186/s13148-018-0534-8

    authors： Hofstatter EW,Horvath S,Dalela D,Gupta P,Chagpar AB,Wali VB,Bossuyt V,Storniolo AM,Hatzis C,Patwardhan G,Von Wahlde MK,Butler M,Epstein L,Stavris K,Sturrock T,Au A,Kwei S,Pusztai L

    更新日期：2018-08-29 00:00:00