当前位置： SCI文献检索 > Clinical Epigenetics期刊下所有文献 > Characterisation of DNA methylation changes in EBF3 and TBC1D16 associated with tumour progression and metastasis in multiple cancer types.

Characterisation of DNA methylation changes in EBF3 and TBC1D16 associated with tumour progression and metastasis in multiple cancer types.

Abstract：

BACKGROUND:Characteristic DNA methylation differences have been identified between primary and metastatic melanomas at EBF3 and/or TBC1D16 gene loci. To further evaluate whether these epigenetic changes may act more generally as drivers of tumour onset and metastasis, we have investigated DNA methylation changes involving EBF3 and TBC1D16 in additional publicly available data of multiple different tumour types. RESULTS:Promoter hypermethylation and gene body hypomethylation of EBF3 were observed in a number of metastatic tumour types, when compared to normal or primary tumour tissues, as well as in tumour vs normal tissues and in a colorectal primary/metastasis pair, although not all tumour samples or primary/metastasis cancer pairs exhibited altered patterns of EBF3 methylation. In addition, hypomethylation of TBC1D16 was observed in multiple tumours, including a breast cancer primary/metastasis pair, and to a lesser degree in melanoma, although again not all tumours or cancer primary/metastasis pairs exhibited altered patterns of methylation. CONCLUSIONS:These findings suggest characteristic DNA methylation changes in EBF3 and TBC1D16 are relatively common tumour-associated epigenetic events in multiple tumour types, which is consistent with a potential role as more general drivers of tumour progression.

journal_name

Clin Epigenetics

journal_title

Clinical epigenetics

authors

Rodger EJ,Chatterjee A,Stockwell PA,Eccles MR

doi

10.1186/s13148-019-0710-5

subject

Has Abstract

pub_date

2019-08-05 00:00:00

pages

114

issue

1

eissn

1868-7075

issn

1868-7083

pii

10.1186/s13148-019-0710-5

journal_volume

11

pub_type

杂志文章

相关文献

Clinical Epigenetics文献大全
  • Early detection of colorectal cancer based on presence of methylated syndecan-2 (SDC2) in stool DNA.

    abstract：BACKGROUND:Colorectal cancer (CRC) screening can effectively reduce disease-related mortality by detecting CRC at earlier stages. We have previously demonstrated that the presence of SDC2 methylation in stool DNA is significantly associated with the occurrence of CRC regardless of clinical stage. The aim of this study ...

    journal_title：Clinical epigenetics

    pub_type： 临床试验,杂志文章

    doi：10.1186/s13148-019-0642-0

    authors： Han YD,Oh TJ,Chung TH,Jang HW,Kim YN,An S,Kim NK

    更新日期：2019-03-15 00:00:00

  • Identification of reliable biomarkers of human papillomavirus 16 methylation in cervical lesions based on integration status using high-resolution melting analysis.

    abstract：Background:The dynamic methylation of human papillomavirus (HPV) 16 DNA is thought to be associated with the progression of cervical lesions. Previous studies that did not consider the physical status of HPV 16 may have incorrectly mapped HPV 16 methylomes. In order to identify reliable biomarkers for squamous cervical...

    journal_title：Clinical epigenetics

    pub_type： 杂志文章

    doi：10.1186/s13148-018-0445-8

    authors： Liu L,Ying C,Zhao Z,Sui L,Zhang X,Qian C,Wang Q,Chen L,Guo Q,Wu J

    更新日期：2018-01-23 00:00:00

  • What's in a name? Context-dependent significance of 'global' methylation measures in human health and disease.

    abstract：:The study of DNA methylation in development and disease has 'exploded' as a field in recent years, with three major classes of measurement now routine. These encompass (i) locus-specific, (ii) genome-scale/wide and (iii) 'global' methylation approaches. Measures of global methylation refer to the level of 5-methylcyto...

    journal_title：Clinical epigenetics

    pub_type： 杂志文章

    doi：10.1186/s13148-017-0311-0

    authors： Vryer R,Saffery R

    更新日期：2017-01-13 00:00:00

  • Genome-wide DNA methylation profiles of low- and high-grade adenoma reveals potential biomarkers for early detection of colorectal carcinoma.

    abstract：BACKGROUND:Abnormal DNA methylation is a hallmark of human cancers and may be a promising biomarker for early diagnosis of human cancers. However, the majority of DNA methylation biomarkers that have been identified are based on the hypothesis that early differential methylation regions (DMRs) are maintained throughout...

    journal_title：Clinical epigenetics

    pub_type： 杂志文章

    doi：10.1186/s13148-020-00851-3

    authors： Fan J,Li J,Guo S,Tao C,Zhang H,Wang W,Zhang Y,Zhang D,Ding S,Zeng C

    更新日期：2020-04-21 00:00:00

  • Nucleosome positioning is unaltered at MLH1 splice site mutations in cells derived from Lynch syndrome patients.

    abstract：BACKGROUND:Splicing is more efficient when coupled with transcription and it has been proposed that nucleosomes enriched in exons are important for splice site recognition. Lynch syndrome is a familial cancer syndrome that can be caused by the autosomal dominant inheritance of splice site mutations in the MutL homolog ...

    journal_title：Clinical epigenetics

    pub_type： 杂志文章

    doi：10.1186/s13148-014-0032-6

    authors： Sloane MA,Hesson LB,Nunez AC,Thompson BA,Ward RL

    更新日期：2014-12-13 00:00:00

  • The detective, prognostic, and predictive value of DNA methylation in human esophageal squamous cell carcinoma.

    abstract：:Esophageal cancer is one of the most common malignancies in the world. Squamous cell carcinoma accounts for approximately 90 % of esophageal cancer cases. Genetic and epigenetic changes have been found to accumulate during the development of various cancers, including esophageal squamous carcinoma (ESCC). Tobacco smok...

    journal_title：Clinical epigenetics

    pub_type： 杂志文章,评审

    doi：10.1186/s13148-016-0210-9

    authors： Ma K,Cao B,Guo M

    更新日期：2016-04-22 00:00:00

  • Histone deacetylase inhibitors potentiate photodynamic therapy in colon cancer cells marked by chromatin-mediated epigenetic regulation of CDKN1A.

    abstract：BACKGROUND:Hypericin-mediated photodynamic therapy (HY-PDT) has recently captured increased attention as an alternative minimally invasive anticancer treatment, although cancer cells may acquire resistance. Therefore, combination treatments may be necessary to enhance HY-PDT efficacy. Histone deacetylase inhibitors (HD...

    journal_title：Clinical epigenetics

    pub_type： 杂志文章

    doi：10.1186/s13148-017-0359-x

    authors： Halaburková A,Jendželovský R,Kovaľ J,Herceg Z,Fedoročko P,Ghantous A

    更新日期：2017-06-08 00:00:00

  • Vitamin D status and epigenetic-based mortality risk score: strong independent and joint prediction of all-cause mortality in a population-based cohort study.

    abstract：Background:Vitamin D deficiency and insufficiency have been established to be strongly associated with increased overall mortality and deaths from specific aging-related diseases. Recently, an epigenetic "mortality risk score" (MS) based on whole blood DNA methylation at the 10 most prominent mortality-related cytosine...

    journal_title：Clinical epigenetics

    pub_type： 杂志文章

    doi：10.1186/s13148-018-0515-y

    authors： Gao X,Zhang Y,Schöttker B,Brenner H

    更新日期：2018-06-20 00:00:00

  • Gene domain-specific DNA methylation episignatures highlight distinct molecular entities of ADNP syndrome.

    abstract：BACKGROUND:ADNP syndrome is a rare Mendelian disorder characterized by global developmental delay, intellectual disability, and autism. It is caused by truncating mutations in ADNP, which is involved in chromatin regulation. We hypothesized that the disruption of chromatin regulation might result in specific DNA methyl...

    journal_title：Clinical epigenetics

    pub_type： 杂志文章

    doi：10.1186/s13148-019-0658-5

    authors： Bend EG,Aref-Eshghi E,Everman DB,Rogers RC,Cathey SS,Prijoles EJ,Lyons MJ,Davis H,Clarkson K,Gripp KW,Li D,Bhoj E,Zackai E,Mark P,Hakonarson H,Demmer LA,Levy MA,Kerkhof J,Stuart A,Rodenhiser D,Friez MJ,Stevenson

    更新日期：2019-04-27 00:00:00

  • Cooperative effect of chidamide and chemotherapeutic drugs induce apoptosis by DNA damage accumulation and repair defects in acute myeloid leukemia stem and progenitor cells.

    abstract：BACKGROUND:Many conventional chemotherapeutic drugs are known to be involved in DNA damage, thus ultimately leading to apoptosis of leukemic cells. However, they fail to completely eliminate leukemia stem cells (LSCs) due to their higher DNA repair capacity of cancer stem cells than that of bulk cancer cells, which bec...

    journal_title：Clinical epigenetics

    pub_type： 杂志文章

    doi：10.1186/s13148-017-0377-8

    authors： Li Y,Wang Y,Zhou Y,Li J,Chen K,Zhang L,Deng M,Deng S,Li P,Xu B

    更新日期：2017-08-14 00:00:00

  • Is Friedreich ataxia an epigenetic disorder?

    abstract：: Friedreich ataxia (FRDA) is a debilitating and frequently fatal neurological disorder that is recessively inherited. It belongs to the group of genetic disorders known as the Repeat Expansion Diseases, in which pathology arises from the deleterious consequences of the inheritance of a tandem repeat array whose repeat...

    journal_title：Clinical epigenetics

    pub_type： 杂志文章

    doi：10.1186/1868-7083-4-2

    authors： Kumari D,Usdin K

    更新日期：2012-01-30 00:00:00

  • The role of microRNA-1246 in the regulation of B cell activation and the pathogenesis of systemic lupus erythematosus.

    abstract：BACKGROUND:The pathogenesis of systemic lupus erythematosus (SLE) has not yet been completely elucidated. One of the hallmarks of SLE is the production of autoantibodies by uncontrolled over-activated B cells. Early B cell factor 1 (EBF1) contributes to the development, activation, and proliferation of B cells through ...

    journal_title：Clinical epigenetics

    pub_type： 杂志文章

    doi：10.1186/s13148-015-0063-7

    authors： Luo S,Liu Y,Liang G,Zhao M,Wu H,Liang Y,Qiu X,Tan Y,Dai Y,Yung S,Chan TM,Lu Q

    更新日期：2015-03-14 00:00:00

  • DNA methylation and repressive histones in the promoters of PD-1, CTLA-4, TIM-3, LAG-3, TIGIT, PD-L1, and galectin-9 genes in human colorectal cancer.

    abstract：BACKGROUND:Colorectal cancer (CRC) is the third most commonly diagnosed human malignancy worldwide. Upregulation of inhibitory immune checkpoints by tumor-infiltrating immune cells (TIICs) or their ligands by tumor cells leads to tumor evasion from host immunosurveillance. Changes in DNA methylation pattern and enrichm...

    journal_title：Clinical epigenetics

    pub_type： 杂志文章

    doi：10.1186/s13148-018-0539-3

    authors： Sasidharan Nair V,Toor SM,Taha RZ,Shaath H,Elkord E

    更新日期：2018-08-06 00:00:00

  • Association between variation of circulating 25-OH vitamin D and methylation of secreted frizzled-related protein 2 in colorectal cancer.

    abstract：BACKGROUNDS:Colorectal cancer (CRC) results from the accumulation of epigenetic and genetic changes in colon cells during neoplasic transformation, which the activation of Wingless (Wnt) signaling pathway is a common mechanism for CRC initiation. The Wnt pathway is mainly regulated by Wnt antagonists, as secreted frizz...

    journal_title：Clinical epigenetics

    pub_type： 杂志文章

    doi：10.1186/s13148-020-00875-9

    authors： Boughanem H,Cabrera-Mulero A,Hernández-Alonso P,Clemente-Postigo M,Casanueva FF,Tinahones FJ,Morcillo S,Crujeiras AB,Macias-Gonzalez M

    更新日期：2020-06-09 00:00:00

  • The effects of olanzapine on genome-wide DNA methylation in the hippocampus and cerebellum.

    abstract：BACKGROUND:The mechanism of action of olanzapine in treating schizophrenia is not clear. This research reports the effects of a therapeutic equivalent treatment of olanzapine on DNA methylation in a rat model in vivo.Genome-wide DNA methylation was assessed using a MeDIP-chip analysis. All methylated DNA immunoprecipit...

    journal_title：Clinical epigenetics

    pub_type： 杂志文章

    doi：10.1186/1868-7083-6-1

    authors： Melka MG,Laufer BI,McDonald P,Castellani CA,Rajakumar N,O'Reilly R,Singh SM

    更新日期：2014-01-02 00:00:00

  • Epigenetic clocks for gestational age: statistical and study design considerations.

    abstract：:In this letter to the editor, we highlight some concerns with a recently published method to estimate gestational age at delivery from DNA methylation data. We conduct novel analyses to highlight the implications of different choices in study design and statistical methods for the prediction of phenotypes from methyla...

    journal_title：Clinical epigenetics

    pub_type： 信件

    doi：10.1186/s13148-017-0402-y

    authors： Simpkin AJ,Suderman M,Howe LD

    更新日期：2017-09-15 00:00:00

  • Aberrant DNA methylation and expression of SPDEF and FOXA2 in airway epithelium of patients with COPD.

    abstract：BACKGROUND:Goblet cell metaplasia, a common feature of chronic obstructive pulmonary disease (COPD), is associated with mucus hypersecretion which contributes to the morbidity and mortality among patients. Transcription factors SAM-pointed domain-containing Ets-like factor (SPDEF) and forkhead box protein A2 (FOXA2) re...

    journal_title：Clinical epigenetics

    pub_type： 杂志文章

    doi：10.1186/s13148-017-0341-7

    authors： Song J,Heijink IH,Kistemaker LEM,Reinders-Luinge M,Kooistra W,Noordhoek JA,Gosens R,Brandsma CA,Timens W,Hiemstra PS,Rots MG,Hylkema MN

    更新日期：2017-04-24 00:00:00

  • Genetic, epigenetic, and environmental factors controlling oxytocin receptor gene expression.

    abstract：BACKGROUND:The neuropeptide oxytocin regulates mammalian social behavior. Disruptions in oxytocin signaling are a feature of many psychopathologies. One commonly studied biomarker for oxytocin involvement in psychiatric diseases is DNA methylation at the oxytocin receptor gene (OXTR). Such studies focus on DNA methylat...

    journal_title：Clinical epigenetics

    pub_type： 杂志文章

    doi：10.1186/s13148-021-01017-5

    authors： Danoff JS,Wroblewski KL,Graves AJ,Quinn GC,Perkeybile AM,Kenkel WM,Lillard TS,Parikh HI,Golino HF,Gregory SG,Carter CS,Bales KL,Connelly JJ

    更新日期：2021-01-30 00:00:00

  • Genome-wide blood DNA methylation alterations at regulatory elements and heterochromatic regions in monozygotic twins discordant for obesity and liver fat.

    abstract：BACKGROUND:The current epidemic of obesity and associated diseases calls for swift actions to better understand the mechanisms by which genetics and environmental factors affect metabolic health in humans. Monozygotic (MZ) twin pairs showing discordance for obesity suggest that epigenetic influences represent one such ...

    journal_title：Clinical epigenetics

    pub_type： 杂志文章

    doi：10.1186/s13148-015-0073-5

    authors： Ollikainen M,Ismail K,Gervin K,Kyllönen A,Hakkarainen A,Lundbom J,Järvinen EA,Harris JR,Lundbom N,Rissanen A,Lyle R,Pietiläinen KH,Kaprio J

    更新日期：2015-04-02 00:00:00

  • DNMT1 genetic polymorphisms affect breast cancer risk in the central European Caucasian population.

    abstract：INTRODUCTION:DNA methylation of CpG islands within the promoter region of genes is an epigenetic modification with an important role in the development of cancer and it is typically mediated by DNA methyltransferases (DNMTs). In cancer cells, global hypomethylation of the genome as a whole and regional hypermethylation...

    journal_title：Clinical epigenetics

    pub_type： 杂志文章

    doi：10.1186/1868-7083-5-7

    authors： Kullmann K,Deryal M,Ong MF,Schmidt W,Mahlknecht U

    更新日期：2013-05-02 00:00:00

  • Developmental genes targeted for epigenetic variation between twin-twin transfusion syndrome children.

    abstract：BACKGROUND:Epigenetic mechanisms are thought to be critical in mediating the role of the intrauterine environment on lifelong health and disease. Twin-twin transfusion syndrome (TTTS) is a rare condition wherein fetuses share the placenta and develop vascular anastomoses, which allow blood to flow between the fetuses. ...

    journal_title：Clinical epigenetics

    pub_type： 杂志文章

    doi：10.1186/1868-7083-5-18

    authors： Marsit CJ,Koestler DC,Watson-Smith D,Boney CM,Padbury JF,Luks F

    更新日期：2013-10-03 00:00:00

  • H3K4 tri-methylation breadth at transcription start sites impacts the transcriptome of systemic lupus erythematosus.

    abstract：BACKGROUND:The autoimmune disease systemic lupus erythematosus (SLE) has a modified epigenome with modified tri-methylation of histone H3 lysine 4 (H3K4me3) at specific loci across the genome. H3K4me3 is a canonical chromatin mark of active transcription. Recent studies have suggested that H3K4me3 breadth has an import...

    journal_title：Clinical epigenetics

    pub_type： 杂志文章

    doi：10.1186/s13148-016-0179-4

    authors： Zhang Z,Shi L,Dawany N,Kelsen J,Petri MA,Sullivan KE

    更新日期：2016-02-02 00:00:00

  • Differentially methylated loci in NAFLD cirrhosis are associated with key signaling pathways.

    abstract：:Altered DNA methylation events contribute to the pathogenesis and progression of metabolic disorders, including nonalcoholic fatty liver disease (NAFLD). Investigations of global DNA methylation patterns in liver biopsies representing severe NAFLD fibrosis have been limited. We used the HumanMethylation 450K BeadChip ...

    journal_title：Clinical epigenetics

    pub_type： 杂志文章

    doi：10.1186/s13148-018-0525-9

    authors： Gerhard GS,Malenica I,Llaci L,Chu X,Petrick AT,Still CD,DiStefano JK

    更新日期：2018-07-13 00:00:00

  • Dynamic interplay between locus-specific DNA methylation and hydroxymethylation regulates distinct biological pathways in prostate carcinogenesis.

    abstract：BACKGROUND:Despite the significant global loss of DNA hydroxymethylation marks in prostate cancer tissues, the locus-specific role of hydroxymethylation in prostate tumorigenesis is unknown. We characterized hydroxymethylation and methylation marks by performing whole-genome next-generation sequencing in representative...

    journal_title：Clinical epigenetics

    pub_type： 杂志文章

    doi：10.1186/s13148-016-0195-4

    authors： Kamdar SN,Ho LT,Kron KJ,Isserlin R,van der Kwast T,Zlotta AR,Fleshner NE,Bader G,Bapat B

    更新日期：2016-03-15 00:00:00

  • TWIST1 DNA methylation is a cell marker of airway and parenchymal lung fibroblasts that are differentially methylated in asthma.

    abstract：BACKGROUND:Mesenchymal fibroblasts are ubiquitous cells that maintain the extracellular matrix of organs. Within the lung, airway and parenchymal fibroblasts are crucial for lung development and are altered with disease, but it has been difficult to understand their roles due to the lack of distinct molecular markers. ...

    journal_title：Clinical epigenetics

    pub_type： 杂志文章

    doi：10.1186/s13148-020-00931-4

    authors： Clifford RL,Yang CX,Fishbane N,Patel J,MacIsaac JL,McEwen LM,May ST,Castellanos-Uribe M,Nair P,Obeidat M,Kobor MS,Knox AJ,Hackett TL

    更新日期：2020-10-02 00:00:00

  • Epigenomic profiling of prostate cancer identifies differentially methylated genes in TMPRSS2:ERG fusion-positive versus fusion-negative tumors.

    abstract：BACKGROUND:About half of all prostate cancers harbor the TMPRSS2:ERG (T2E) gene fusion. While T2E-positive and T2E-negative tumors represent specific molecular subtypes of prostate cancer (PCa), previous studies have not yet comprehensively investigated how these tumor subtypes differ at the epigenetic level. We theref...

    journal_title：Clinical epigenetics

    pub_type： 杂志文章

    doi：10.1186/s13148-015-0161-6

    authors： Geybels MS,Alumkal JJ,Luedeke M,Rinckleb A,Zhao S,Shui IM,Bibikova M,Klotzle B,van den Brandt PA,Ostrander EA,Fan JB,Feng Z,Maier C,Stanford JL

    更新日期：2015-12-12 00:00:00

  • Genome-wide DNA methylation profiling of CD8+ T cells shows a distinct epigenetic signature to CD4+ T cells in multiple sclerosis patients.

    abstract：BACKGROUND:Multiple sclerosis (MS) is thought to be a T cell-mediated autoimmune disorder. MS pathogenesis is likely due to a genetic predisposition triggered by a variety of environmental factors. Epigenetics, particularly DNA methylation, provide a logical interface for environmental factors to influence the genome. ...

    journal_title：Clinical epigenetics

    pub_type： 杂志文章

    doi：10.1186/s13148-015-0152-7

    authors： Maltby VE,Graves MC,Lea RA,Benton MC,Sanders KA,Tajouri L,Scott RJ,Lechner-Scott J

    更新日期：2015-11-05 00:00:00

  • MicroRNA-375 plays a dual role in prostate carcinogenesis.

    abstract：BACKGROUND:Prostate cancer (PCa), a highly incident and heterogeneous malignancy, mostly affects men from developed countries. Increased knowledge of the biological mechanisms underlying PCa onset and progression are critical for improved clinical management. MicroRNAs (miRNAs) deregulation is common in human cancers, ...

    journal_title：Clinical epigenetics

    pub_type： 杂志文章

    doi：10.1186/s13148-015-0076-2

    authors： Costa-Pinheiro P,Ramalho-Carvalho J,Vieira FQ,Torres-Ferreira J,Oliveira J,Gonçalves CS,Costa BM,Henrique R,Jerónimo C

    更新日期：2015-04-10 00:00:00

  • The tumor suppressor Zinc finger protein 471 suppresses breast cancer growth and metastasis through inhibiting AKT and Wnt/β-catenin signaling.

    abstract：BACKGROUND:Zinc-finger protein 471 (ZNF471) is a member of the Krüppel-associated box domain zinc finger protein (KRAB-ZFP) family. ZNF471 is methylated in squamous cell carcinomas of tongue, stomach and esophageal. However, its role in breast carcinogenesis remains elusive. Here, we studied its expression, functions, ...

    journal_title：Clinical epigenetics

    pub_type： 杂志文章

    doi：10.1186/s13148-020-00959-6

    authors： Tao C,Luo J,Tang J,Zhou D,Feng S,Qiu Z,Putti TC,Xiang T,Tao Q,Li L,Ren G

    更新日期：2020-11-17 00:00:00

  • Identification and validation of SRY-box containing gene family member SOX30 methylation as a prognostic and predictive biomarker in myeloid malignancies.

    abstract：Background:Methylation-associated SOX family genes have been proved to be involved in multiple essential processes during carcinogenesis and act as potential biomarkers for cancer diagnosis, staging, prediction of prognosis, and monitoring of response to therapy. Herein, we revealed SOX30 methylation and its clinical i...

    journal_title：Clinical epigenetics

    pub_type： 杂志文章

    doi：10.1186/s13148-018-0523-y

    authors： Zhou JD,Wang YX,Zhang TJ,Li XX,Gu Y,Zhang W,Ma JC,Lin J,Qian J

    更新日期：2018-07-05 00:00:00