Epigenetic management of major psychosis.


:Epigenetic mechanisms are thought to play a major role in the pathogenesis of the major psychoses (schizophrenia and bipolar disorder), and they may be the link between the environment and the genome in the pathogenesis of these disorders. This paper discusses the role of epigenetics in the management of major psychosis: (1) the role of epigenetic drugs in treating these disorders. At present, there are three categories of epigenetic drugs that are being actively investigated for their ability to treat psychosis: drugs inhibiting histone deacetylation; drugs decreasing DNA methylation; and drugs targeting microRNAs; and (2) the role of epigenetic mechanisms in electroconvulsive therapy in these disorders.


Clin Epigenetics


Clinical epigenetics


Peedicayil J




Has Abstract


2011-08-01 00:00:00














  • Cooperative effect of chidamide and chemotherapeutic drugs induce apoptosis by DNA damage accumulation and repair defects in acute myeloid leukemia stem and progenitor cells.

    abstract:BACKGROUND:Many conventional chemotherapeutic drugs are known to be involved in DNA damage, thus ultimately leading to apoptosis of leukemic cells. However, they fail to completely eliminate leukemia stem cells (LSCs) due to their higher DNA repair capacity of cancer stem cells than that of bulk cancer cells, which bec...

    journal_title:Clinical epigenetics

    pub_type: 杂志文章


    authors: Li Y,Wang Y,Zhou Y,Li J,Chen K,Zhang L,Deng M,Deng S,Li P,Xu B

    更新日期:2017-08-14 00:00:00

  • Altered DNA methylation is associated with aberrant gene expression in parenchymal but not airway fibroblasts isolated from individuals with COPD.

    abstract:Background:Chronic obstructive pulmonary disease (COPD) is a heterogeneous disease of the lungs that is currently the fourth leading cause of death worldwide. Genetic factors account for only a small amount of COPD risk, but epigenetic mechanisms, including DNA methylation, have the potential to mediate the interaction...

    journal_title:Clinical epigenetics

    pub_type: 杂志文章


    authors: Clifford RL,Fishbane N,Patel J,MacIsaac JL,McEwen LM,Fisher AJ,Brandsma CA,Nair P,Kobor MS,Hackett TL,Knox AJ

    更新日期:2018-03-05 00:00:00

  • DNA hydroxymethylation age of human blood determined by capillary hydrophilic-interaction liquid chromatography/mass spectrometry.

    abstract:BACKGROUND:Aging is a complex phenomenon and characterized by a progressive decline in physiology and function of adult tissues. However, it hasn't been well established of the correlation between aging and global DNA methylation and hydroxymethylation that regulate the growth and development of higher organisms. RESU...

    journal_title:Clinical epigenetics

    pub_type: 杂志文章


    authors: Xiong J,Jiang HP,Peng CY,Deng QY,Lan MD,Zeng H,Zheng F,Feng YQ,Yuan BF

    更新日期:2015-07-23 00:00:00

  • Evaluation of a methylation classifier for predicting pre-cancer lesion among women with abnormal results between HPV16/18 and cytology.

    abstract:BACKGROUND:Although HPV testing and cytology detection are successful for cervical screening in China, additional procedures are urgently required to avoid misdiagnosis and overtreatment. In this multicenter study, we collected cervical samples during screening in clinics. A total of 588 women with HPV16/18+ and/or cyt...

    journal_title:Clinical epigenetics

    pub_type: 杂志文章


    authors: Gu YY,Zhou GN,Wang Q,Ding JX,Hua KQ

    更新日期:2020-04-21 00:00:00

  • Epigenetic modifications in muscle regeneration and progression of Duchenne muscular dystrophy.

    abstract::Duchenne muscular dystrophy (DMD) is a multisystemic disorder that affects 1:5000 boys. The severity of the phenotype varies dependent on the mutation site in the DMD gene and the resultant dystrophin expression profile. In skeletal muscle, dystrophin loss is associated with the disintegration of myofibers and their i...

    journal_title:Clinical epigenetics

    pub_type: 杂志文章,评审


    authors: Rugowska A,Starosta A,Konieczny P

    更新日期:2021-01-19 00:00:00

  • Reduced mitochondrial D-loop methylation levels in sporadic amyotrophic lateral sclerosis.

    abstract:BACKGROUND:Mitochondrial dysregulation and aberrant epigenetic mechanisms have been frequently reported in neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS), and several researchers suggested that epigenetic dysregulation in mitochondrial DNA (mtDNA) could contribute to the neurodegenerative pro...

    journal_title:Clinical epigenetics

    pub_type: 杂志文章


    authors: Stoccoro A,Smith AR,Mosca L,Marocchi A,Gerardi F,Lunetta C,Cereda C,Gagliardi S,Lunnon K,Migliore L,Coppedè F

    更新日期:2020-09-11 00:00:00

  • MUC1 is associated with TFF2 methylation in gastric cancer.

    abstract:BACKGROUND:Emerging evidence has shown that MUC1 and TFF2 play crucial roles in the H. pylori-infected pathogenesis of gastric cancer (GC). A recent study revealed that H. pylori infection induced obviously increased Tff2 methylation levels in Muc1-/- mice compared with controls. However, little is known of the molecul...

    journal_title:Clinical epigenetics

    pub_type: 杂志文章


    authors: Ge Y,Ma G,Liu H,Lin Y,Zhang G,Du M,Wang M,Chu H,Zhang H,Zhang Z

    更新日期:2020-03-02 00:00:00

  • DNA methylation and repressive histones in the promoters of PD-1, CTLA-4, TIM-3, LAG-3, TIGIT, PD-L1, and galectin-9 genes in human colorectal cancer.

    abstract:BACKGROUND:Colorectal cancer (CRC) is the third most commonly diagnosed human malignancy worldwide. Upregulation of inhibitory immune checkpoints by tumor-infiltrating immune cells (TIICs) or their ligands by tumor cells leads to tumor evasion from host immunosurveillance. Changes in DNA methylation pattern and enrichm...

    journal_title:Clinical epigenetics

    pub_type: 杂志文章


    authors: Sasidharan Nair V,Toor SM,Taha RZ,Shaath H,Elkord E

    更新日期:2018-08-06 00:00:00

  • Genome-wide blood DNA methylation alterations at regulatory elements and heterochromatic regions in monozygotic twins discordant for obesity and liver fat.

    abstract:BACKGROUND:The current epidemic of obesity and associated diseases calls for swift actions to better understand the mechanisms by which genetics and environmental factors affect metabolic health in humans. Monozygotic (MZ) twin pairs showing discordance for obesity suggest that epigenetic influences represent one such ...

    journal_title:Clinical epigenetics

    pub_type: 杂志文章


    authors: Ollikainen M,Ismail K,Gervin K,Kyllönen A,Hakkarainen A,Lundbom J,Järvinen EA,Harris JR,Lundbom N,Rissanen A,Lyle R,Pietiläinen KH,Kaprio J

    更新日期:2015-04-02 00:00:00

  • Epigenetic stratification of head and neck cancer survivors reveals differences in lycopene levels, alcohol consumption, and methylation of immune regulatory genes.

    abstract:BACKGROUND:Inflammation has been associated with higher rates of recurrence and mortality in head and neck cancer (HNC). While the biological mechanisms predisposing patients to heightened inflammatory states remain largely unknown, DNA methylation has been proposed to reflect systemic inflammation. In this analysis, w...

    journal_title:Clinical epigenetics

    pub_type: 杂志文章


    authors: Moody L,Crowder SL,Fruge AD,Locher JL,Demark-Wahnefried W,Rogers LQ,Delk-Licata A,Carroll WR,Spencer SA,Black M,Erdman JW Jr,Chen H,Pan YX,Arthur AE

    更新日期:2020-09-11 00:00:00

  • Developmental genes targeted for epigenetic variation between twin-twin transfusion syndrome children.

    abstract:BACKGROUND:Epigenetic mechanisms are thought to be critical in mediating the role of the intrauterine environment on lifelong health and disease. Twin-twin transfusion syndrome (TTTS) is a rare condition wherein fetuses share the placenta and develop vascular anastomoses, which allow blood to flow between the fetuses. ...

    journal_title:Clinical epigenetics

    pub_type: 杂志文章


    authors: Marsit CJ,Koestler DC,Watson-Smith D,Boney CM,Padbury JF,Luks F

    更新日期:2013-10-03 00:00:00

  • Genome-wide DNA methylation profiles of low- and high-grade adenoma reveals potential biomarkers for early detection of colorectal carcinoma.

    abstract:BACKGROUND:Abnormal DNA methylation is a hallmark of human cancers and may be a promising biomarker for early diagnosis of human cancers. However, the majority of DNA methylation biomarkers that have been identified are based on the hypothesis that early differential methylation regions (DMRs) are maintained throughout...

    journal_title:Clinical epigenetics

    pub_type: 杂志文章


    authors: Fan J,Li J,Guo S,Tao C,Zhang H,Wang W,Zhang Y,Zhang D,Ding S,Zeng C

    更新日期:2020-04-21 00:00:00

  • Individual epigenetic status of the pathogenic D4Z4 macrosatellite correlates with disease in facioscapulohumeral muscular dystrophy.

    abstract:BACKGROUND:Both forms of facioscapulohumeral muscular dystrophy (FSHD) are associated with aberrant epigenetic regulation of the chromosome 4q35 D4Z4 macrosatellite. Chromatin changes due to large deletions of heterochromatin (FSHD1) or mutations in chromatin regulatory proteins (FSHD2) lead to relaxation of epigenetic...

    journal_title:Clinical epigenetics

    pub_type: 杂志文章


    authors: Jones TI,King OD,Himeda CL,Homma S,Chen JC,Beermann ML,Yan C,Emerson CP Jr,Miller JB,Wagner KR,Jones PL

    更新日期:2015-03-29 00:00:00

  • Correction to: DNA methylation signature is prognostic of choroid plexus tumor aggressiveness.

    abstract::After publication of the original article [1], authors have requested to add a 'J' as middle name for Richard Gilbertson. Hence, full name should be Richard J Gilbertson. ...

    journal_title:Clinical epigenetics

    pub_type: 已发布勘误


    authors: Pienkowska M,Choufani S,Turinsky AL,Guha T,Merino DM,Novokmet A,Brudno M,Weksberg R,Shlien A,Hawkins C,Bouffet E,Tabori U,Gilbertson RJ,Finlay JL,Jabado N,Thomas C,Sill M,Capper D,Hasselblatt M,Malkin D

    更新日期:2019-10-21 00:00:00

  • Differences in DNA methylation profile of Th1 and Th2 cytokine genes are associated with tolerance acquisition in children with IgE-mediated cow's milk allergy.

    abstract:BACKGROUND:Epigenetic changes in DNA methylation could regulate the expression of several allergy-related genes. We investigated whether tolerance acquisition in children with immunoglobulin E (IgE)-mediated cow's milk allergy (CMA) is characterized by a specific DNA methylation profile of Th2 (IL-4, IL-5) and Th1 (IL-...

    journal_title:Clinical epigenetics

    pub_type: 杂志文章


    authors: Berni Canani R,Paparo L,Nocerino R,Cosenza L,Pezzella V,Di Costanzo M,Capasso M,Del Monaco V,D'Argenio V,Greco L,Salvatore F

    更新日期:2015-03-31 00:00:00

  • Apabetalone (RVX-208) reduces vascular inflammation in vitro and in CVD patients by a BET-dependent epigenetic mechanism.

    abstract:BACKGROUND:Apabetalone (RVX-208) is a bromodomain and extraterminal protein inhibitor (BETi) that in phase II trials reduced the relative risk (RR) of major adverse cardiac events (MACE) in patients with cardiovascular disease (CVD) by 44% and in diabetic CVD patients by 57% on top of statins. A phase III trial, BETonM...

    journal_title:Clinical epigenetics

    pub_type: 杂志文章


    authors: Tsujikawa LM,Fu L,Das S,Halliday C,Rakai BD,Stotz SC,Sarsons CD,Gilham D,Daze E,Wasiak S,Studer D,Rinker KD,Sweeney M,Johansson JO,Wong NCW,Kulikowski E

    更新日期:2019-07-12 00:00:00

  • Single-molecule quantification of 5-hydroxymethylcytosine for diagnosis of blood and colon cancers.

    abstract:BACKGROUND:The DNA modification 5-hydroxymethylcytosine (5hmC) is now referred to as the sixth base of DNA with evidence of tissue-specific patterns and correlation with gene regulation and expression. This epigenetic mark was recently reported as a potential biomarker for multiple types of cancer, but its application ...

    journal_title:Clinical epigenetics

    pub_type: 杂志文章


    authors: Gilat N,Tabachnik T,Shwartz A,Shahal T,Torchinsky D,Michaeli Y,Nifker G,Zirkin S,Ebenstein Y

    更新日期:2017-07-14 00:00:00

  • SLCO4C1 promoter methylation is a potential biomarker for prognosis associated with biochemical recurrence-free survival after radical prostatectomy.

    abstract:BACKGROUND:Prostate cancer (PC) is a commonly diagnosed malignancy in males, especially in the western hemisphere. The extensive use of multiple biomarkers plays an important role in the diagnosis and prognosis of PC. However, the accuracy of biomarkers for PC prognosis needs to be urgently improved. This study aimed t...

    journal_title:Clinical epigenetics

    pub_type: 杂志文章


    authors: Li X,Zhang W,Song J,Zhang X,Ran L,He Y

    更新日期:2019-07-09 00:00:00

  • Maternal diabetes and obesity influence the fetal epigenome in a largely Hispanic population.

    abstract:BACKGROUND:Obesity and diabetes mellitus are directly implicated in many adverse health consequences in adults as well as in the offspring of obese and diabetic mothers. Hispanic Americans are particularly at risk for obesity, diabetes, and end-stage renal disease. Maternal obesity and/or diabetes through prenatal prog...

    journal_title:Clinical epigenetics

    pub_type: 杂志文章


    authors: Rizzo HE,Escaname EN,Alana NB,Lavender E,Gelfond J,Fernandez R,Hibbs MA,King JM,Carr NR,Blanco CL

    更新日期:2020-02-19 00:00:00

  • Genome-scale hypomethylation in the cord blood DNAs associated with early onset preeclampsia.

    abstract:BACKGROUND:Preeclampsia is one of the leading causes of fetal and maternal morbidity and mortality worldwide. Preterm babies of mothers with early onset preeclampsia (EOPE) are at higher risks for various diseases later on in life, including cardiovascular diseases. We hypothesized that genome-wide epigenetic alteratio...

    journal_title:Clinical epigenetics

    pub_type: 杂志文章


    authors: Ching T,Ha J,Song MA,Tiirikainen M,Molnar J,Berry MJ,Towner D,Garmire LX

    更新日期:2015-03-13 00:00:00

  • Alterations of adiponectin gene expression and DNA methylation in adipose tissues and blood cells are associated with gestational diabetes and neonatal outcome.

    abstract:BACKGROUND:Adiponectin critically contributes to metabolic homeostasis, especially by insulin-sensitizing action. Gestational diabetes mellitus (GDM) is characterized by insulin resistance leading to materno-fetal hyperglycemia and detrimental birth outcomes. By investigating paired subcutaneous (SAT) and visceral adip...

    journal_title:Clinical epigenetics

    pub_type: 杂志文章


    authors: Ott R,Stupin JH,Melchior K,Schellong K,Ziska T,Dudenhausen JW,Henrich W,Rancourt RC,Plagemann A

    更新日期:2018-10-24 00:00:00

  • Identification of reliable biomarkers of human papillomavirus 16 methylation in cervical lesions based on integration status using high-resolution melting analysis.

    abstract:Background:The dynamic methylation of human papillomavirus (HPV) 16 DNA is thought to be associated with the progression of cervical lesions. Previous studies that did not consider the physical status of HPV 16 may have incorrectly mapped HPV 16 methylomes. In order to identify reliable biomarkers for squamous cervical...

    journal_title:Clinical epigenetics

    pub_type: 杂志文章


    authors: Liu L,Ying C,Zhao Z,Sui L,Zhang X,Qian C,Wang Q,Chen L,Guo Q,Wu J

    更新日期:2018-01-23 00:00:00

  • MicroRNA-375 plays a dual role in prostate carcinogenesis.

    abstract:BACKGROUND:Prostate cancer (PCa), a highly incident and heterogeneous malignancy, mostly affects men from developed countries. Increased knowledge of the biological mechanisms underlying PCa onset and progression are critical for improved clinical management. MicroRNAs (miRNAs) deregulation is common in human cancers, ...

    journal_title:Clinical epigenetics

    pub_type: 杂志文章


    authors: Costa-Pinheiro P,Ramalho-Carvalho J,Vieira FQ,Torres-Ferreira J,Oliveira J,Gonçalves CS,Costa BM,Henrique R,Jerónimo C

    更新日期:2015-04-10 00:00:00

  • Maternal B vitamins: effects on offspring weight and DNA methylation at genomically imprinted domains.

    abstract:BACKGROUND:Inadequate maternal nutrition during early fetal development can create permanent alterations in the offspring, leading to poor health outcomes. While nutrients involved in one-carbon cycle metabolism are important to fetal growth, associations with specific nutrients remain inconsistent. This study estimate...

    journal_title:Clinical epigenetics

    pub_type: 杂志文章


    authors: McCullough LE,Miller EE,Mendez MA,Murtha AP,Murphy SK,Hoyo C

    更新日期:2016-01-22 00:00:00

  • Development of 5' LTR DNA methylation of latent HIV-1 provirus in cell line models and in long-term-infected individuals.

    abstract:BACKGROUND:Human immunodeficiency virus type 1 (HIV-1) latency represents the major barrier to virus eradication in infected individuals because cells harboring latent HIV-1 provirus are not affected by current antiretroviral therapy (ART). We previously demonstrated that DNA methylation of HIV-1 long terminal repeat (...

    journal_title:Clinical epigenetics

    pub_type: 杂志文章


    authors: Trejbalová K,Kovářová D,Blažková J,Machala L,Jilich D,Weber J,Kučerová D,Vencálek O,Hirsch I,Hejnar J

    更新日期:2016-02-19 00:00:00

  • Multiomics analyses identified epigenetic modulation of the S100A gene family in Kawasaki disease and their significant involvement in neutrophil transendothelial migration.

    abstract:BACKGROUND:Kawasaki disease (KD) is a prevalent pediatric disease worldwide and can cause coronary artery aneurysm as a severe complication. Typically, DNA methylation is thought to repress the expression of nearby genes. However, the cases in which DNA methylation promotes gene expression have been reported. In additi...

    journal_title:Clinical epigenetics

    pub_type: 杂志文章


    authors: Huang LH,Kuo HC,Pan CT,Lin YS,Huang YH,Li SC

    更新日期:2018-11-01 00:00:00

  • Characterisation of DNA methylation changes in EBF3 and TBC1D16 associated with tumour progression and metastasis in multiple cancer types.

    abstract:BACKGROUND:Characteristic DNA methylation differences have been identified between primary and metastatic melanomas at EBF3 and/or TBC1D16 gene loci. To further evaluate whether these epigenetic changes may act more generally as drivers of tumour onset and metastasis, we have investigated DNA methylation changes involv...

    journal_title:Clinical epigenetics

    pub_type: 杂志文章


    authors: Rodger EJ,Chatterjee A,Stockwell PA,Eccles MR

    更新日期:2019-08-05 00:00:00

  • RFX1 downregulation contributes to TLR4 overexpression in CD14+ monocytes via epigenetic mechanisms in coronary artery disease.

    abstract:BACKGROUND:Toll-like receptor 4 (TLR4) expression is increased in activated monocytes, which play a critical role in the pathogenesis of coronary artery disease (CAD). However, the mechanism remains unclear. Regulatory factor X1 (RFX1) is a critical transcription factor regulating epigenetic modifications. In this stud...

    journal_title:Clinical epigenetics

    pub_type: 杂志文章


    authors: Du P,Gao K,Cao Y,Yang S,Wang Y,Guo R,Zhao M,Jia S

    更新日期:2019-03-11 00:00:00

  • Epigenomic profiling of archived FFPE tissues by enhanced PAT-ChIP (EPAT-ChIP) technology.

    abstract:BACKGROUND:The introduction of pathology tissue-chromatin immunoprecipitation (PAT-ChIP), a technique allowing chromatin immunoprecipitation (ChIP) from formalin-fixed paraffin-embedded (FFPE) tissues, has extended the application of chromatin studies to clinical patient samples. However, extensive crosslinking introdu...

    journal_title:Clinical epigenetics

    pub_type: 杂志文章


    authors: Amatori S,Persico G,Paolicelli C,Hillje R,Sahnane N,Corini F,Furlan D,Luzi L,Minucci S,Giorgio M,Pelicci PG,Fanelli M

    更新日期:2018-11-16 00:00:00

  • Cell-free DNA promoter hypermethylation in plasma as a diagnostic marker for pancreatic adenocarcinoma.

    abstract:BACKGROUND:Pancreatic cancer has a 5-year survival rate of only 5-7%. Difficulties in detecting pancreatic cancer at early stages results in the high mortality and substantiates the need for additional diagnostic tools. Surgery is the only curative treatment and unfortunately only possible in localized tumours. A diagn...

    journal_title:Clinical epigenetics

    pub_type: 临床试验,杂志文章


    authors: Henriksen SD,Madsen PH,Larsen AC,Johansen MB,Drewes AM,Pedersen IS,Krarup H,Thorlacius-Ussing O

    更新日期:2016-11-16 00:00:00