Alterations of adiponectin gene expression and DNA methylation in adipose tissues and blood cells are associated with gestational diabetes and neonatal outcome.

abstract：BACKGROUND:ADNP syndrome is a rare Mendelian disorder characterized by global developmental delay, intellectual disability, and autism. It is caused by truncating mutations in ADNP, which is involved in chromatin regulation. We hypothesized that the disruption of chromatin regulation might result in specific DNA methyl...

journal_title：Clinical epigenetics

authors： Bend EG,Aref-Eshghi E,Everman DB,Rogers RC,Cathey SS,Prijoles EJ,Lyons MJ,Davis H,Clarkson K,Gripp KW,Li D,Bhoj E,Zackai E,Mark P,Hakonarson H,Demmer LA,Levy MA,Kerkhof J,Stuart A,Rodenhiser D,Friez MJ,Stevenson

更新日期：2019-04-27 00:00:00

abstract：:Cyclin D1 is a cell cycle machine, a sensor of extracellular signals and plays an important role in G1-S phase progression. The human cyclin D1 promoter contains multiple transcription factor binding sites such as AP-1, NF-қB, E2F, Oct-1, and so on. The extracellular signals functions through the signal transduction p...

journal_title：Clinical epigenetics

authors： Guo ZY,Hao XH,Tan FF,Pei X,Shang LM,Jiang XL,Yang F

更新日期：2011-08-01 00:00:00

abstract：BACKGROUND:Testicular germ cell tumor such as seminoma is strongly associated with male reproductive problems commonly associated with the alteration of sperm parameters as described in testicular dysgenesis syndrome. Interestingly, numerous studies have reported that the precursor of germ cell cancer, germ cell neopla...

journal_title：Clinical epigenetics

authors： Bruno C,Blagoskonov O,Barberet J,Guilleman M,Daniel S,Tournier B,Binquet C,Choux C,Fauque P

更新日期：2018-10-19 00:00:00

abstract：BACKGROUND:Smoking is the largest preventable cause of morbidity and mortality in the United States. In previous work, we demonstrated that altered DNA methylation at the aryl hydrocarbon receptor repressor (AHRR) is correlated with self-reported smoking in 19-year-old African Americans with relatively low levels of sm...

journal_title：Clinical epigenetics

authors： Philibert RA,Beach SR,Lei MK,Brody GH

更新日期：2013-10-11 00:00:00

abstract：BACKGROUND:The transcription factor Snail2 is a repressor of E-cadherin expression during carcinogenesis; however, the specific mechanisms involved in this process in human colorectal cancer (CRC) remain largely unknown. METHOD:We checked the expression of Snail2 in several clinical CRC specimens. Then, we established...

journal_title：Clinical epigenetics

authors： Hu Y,Dai M,Zheng Y,Wu J,Yu B,Zhang H,Kong W,Wu H,Yu X

更新日期：2018-12-12 00:00:00

abstract：BACKGROUND:Despite the significant global loss of DNA hydroxymethylation marks in prostate cancer tissues, the locus-specific role of hydroxymethylation in prostate tumorigenesis is unknown. We characterized hydroxymethylation and methylation marks by performing whole-genome next-generation sequencing in representative...

journal_title：Clinical epigenetics

authors： Kamdar SN,Ho LT,Kron KJ,Isserlin R,van der Kwast T,Zlotta AR,Fleshner NE,Bader G,Bapat B

更新日期：2016-03-15 00:00:00

abstract：:Duchenne muscular dystrophy (DMD) is a multisystemic disorder that affects 1:5000 boys. The severity of the phenotype varies dependent on the mutation site in the DMD gene and the resultant dystrophin expression profile. In skeletal muscle, dystrophin loss is associated with the disintegration of myofibers and their i...

journal_title：Clinical epigenetics

authors： Rugowska A,Starosta A,Konieczny P

更新日期：2021-01-19 00:00:00

abstract：BACKGROUND:Preeclampsia is one of the leading causes of fetal and maternal morbidity and mortality worldwide. Preterm babies of mothers with early onset preeclampsia (EOPE) are at higher risks for various diseases later on in life, including cardiovascular diseases. We hypothesized that genome-wide epigenetic alteratio...

journal_title：Clinical epigenetics

authors： Ching T,Ha J,Song MA,Tiirikainen M,Molnar J,Berry MJ,Towner D,Garmire LX

更新日期：2015-03-13 00:00:00

abstract：BACKGROUND:Pancreatic cancer has a 5-year survival rate of only 5-7%. Difficulties in detecting pancreatic cancer at early stages results in the high mortality and substantiates the need for additional diagnostic tools. Surgery is the only curative treatment and unfortunately only possible in localized tumours. A diagn...

journal_title：Clinical epigenetics

authors： Henriksen SD,Madsen PH,Larsen AC,Johansen MB,Drewes AM,Pedersen IS,Krarup H,Thorlacius-Ussing O

更新日期：2016-11-16 00:00:00

abstract：BACKGROUND:The autoimmune disease systemic lupus erythematosus (SLE) has a modified epigenome with modified tri-methylation of histone H3 lysine 4 (H3K4me3) at specific loci across the genome. H3K4me3 is a canonical chromatin mark of active transcription. Recent studies have suggested that H3K4me3 breadth has an import...

journal_title：Clinical epigenetics

authors： Zhang Z,Shi L,Dawany N,Kelsen J,Petri MA,Sullivan KE

更新日期：2016-02-02 00:00:00

abstract：:In this letter to the editor, we highlight some concerns with a recently published method to estimate gestational age at delivery from DNA methylation data. We conduct novel analyses to highlight the implications of different choices in study design and statistical methods for the prediction of phenotypes from methyla...

journal_title：Clinical epigenetics

authors： Simpkin AJ,Suderman M,Howe LD

更新日期：2017-09-15 00:00:00

abstract：BACKGROUND:Epigenetic mechanisms have been suggested to play a role in the development of post-traumatic stress disorder (PTSD). Here, blood-derived DNA methylation data (HumanMethylation450 BeadChip) collected prior to and following combat exposure in three cohorts of male military members were analyzed to assess whet...

journal_title：Clinical epigenetics

authors： Snijders C,Maihofer AX,Ratanatharathorn A,Baker DG,Boks MP,Geuze E,Jain S,Kessler RC,Pishva E,Risbrough VB,Stein MB,Ursano RJ,Vermetten E,Vinkers CH,PGC PTSD EWAS Consortium.,Smith AK,Uddin M,Rutten BPF,Nievergelt CM

更新日期：2020-01-13 00:00:00

abstract：BACKGROUND:Hypericin-mediated photodynamic therapy (HY-PDT) has recently captured increased attention as an alternative minimally invasive anticancer treatment, although cancer cells may acquire resistance. Therefore, combination treatments may be necessary to enhance HY-PDT efficacy. Histone deacetylase inhibitors (HD...

journal_title：Clinical epigenetics

authors： Halaburková A,Jendželovský R,Kovaľ J,Herceg Z,Fedoročko P,Ghantous A

更新日期：2017-06-08 00:00:00

abstract：BACKGROUND:Male obesity has profound effects on morbidity and mortality, but relatively little is known about the impact of obesity on gametes and the potential for adverse effects of male obesity to be passed to the next generation. DNA methylation contributes to gene regulation and is erased and re-established during...

journal_title：Clinical epigenetics

authors： Keyhan S,Burke E,Schrott R,Huang Z,Grenier C,Price T,Raburn D,Corcoran DL,Soubry A,Hoyo C,Murphy SK

更新日期：2021-01-25 00:00:00

abstract：Background:AXL is one of the TAM (TYRO3, AXL and MERTK) receptor tyrosine kinases and may affect numerous immune-related health conditions. However, the role for AXL in asthma, including its epigenetic regulation, has not been extensively studied. Methods:We investigated the association between AXL DNA methylation at ...

journal_title：Clinical epigenetics

authors： Gao L,Millstein J,Siegmund KD,Dubeau L,Maguire R,Gilliland FD,Murphy SK,Hoyo C,Breton CV

更新日期：2017-11-07 00:00:00

abstract：BACKGROUND:The DNA modification 5-hydroxymethylcytosine (5hmC) is now referred to as the sixth base of DNA with evidence of tissue-specific patterns and correlation with gene regulation and expression. This epigenetic mark was recently reported as a potential biomarker for multiple types of cancer, but its application ...

journal_title：Clinical epigenetics

authors： Gilat N,Tabachnik T,Shwartz A,Shahal T,Torchinsky D,Michaeli Y,Nifker G,Zirkin S,Ebenstein Y

更新日期：2017-07-14 00:00:00

abstract：BACKGROUND:Preeclampsia, a pregnancy complication of placental origin is associated with altered expression of angiogenic factors and their receptors. Recently, there is considerable interest in understanding the role of adverse intrauterine conditions in placental dysfunction and adverse pregnancy outcomes. Since we h...

journal_title：Clinical epigenetics

authors： Sundrani DP,Reddy US,Joshi AA,Mehendale SS,Chavan-Gautam PM,Hardikar AA,Chandak GR,Joshi SR

更新日期：2013-04-26 00:00:00

abstract：BACKGROUND:Colorectal cancer (CRC) is the third most commonly diagnosed human malignancy worldwide. Upregulation of inhibitory immune checkpoints by tumor-infiltrating immune cells (TIICs) or their ligands by tumor cells leads to tumor evasion from host immunosurveillance. Changes in DNA methylation pattern and enrichm...

journal_title：Clinical epigenetics

authors： Sasidharan Nair V,Toor SM,Taha RZ,Shaath H,Elkord E

更新日期：2018-08-06 00:00:00

abstract：BACKGROUND:Tobacco smoking is a risk factor for multiple diseases, including cardiovascular disease and diabetes. Many smoking-associated signals have been detected in the blood methylome, but the extent to which these changes are widespread to metabolically relevant tissues, and impact gene expression or metabolic hea...

journal_title：Clinical epigenetics

authors： Tsai PC,Glastonbury CA,Eliot MN,Bollepalli S,Yet I,Castillo-Fernandez JE,Carnero-Montoro E,Hardiman T,Martin TC,Vickers A,Mangino M,Ward K,Pietiläinen KH,Deloukas P,Spector TD,Viñuela A,Loucks EB,Ollikainen M,Kelsey K

更新日期：2018-10-20 00:00:00

abstract：:Heterozygous mutation of the transcription factor HNF1B is the most common cause of monogenetic developmental renal disease. Disease-associated mutations fall into two categories: HNF1B intragenic mutations and a 1.3 Mb deletion at chromosome 17q12. An increase in neurodevelopmental disorders has been observed in indi...

journal_title：Clinical epigenetics

authors： Clissold RL,Ashfield B,Burrage J,Hannon E,Bingham C,Mill J,Hattersley A,Dempster EL

更新日期：2018-07-18 00:00:00

abstract：:[This corrects the article DOI: 10.1186/s13148-016-0190-9.]. ...

journal_title：Clinical epigenetics

authors： Pandey RV,Pulverer W,Kallmeyer R,Beikircher G,Pabinger S,Kriegner A,Weinhäusel A

更新日期：2016-08-04 00:00:00

abstract：BACKGROUND:B vitamins in the one-carbon metabolism pathway (folate, vitamin B6, and vitamin B12) have been implicated in DNA methylation, and their deficiency may contribute to cognitive decline through increased homocysteine (Hcy) levels and subsequent oxidative damage. The aim of this study was to investigate whether...

journal_title：Clinical epigenetics

authors： An Y,Feng L,Zhang X,Wang Y,Wang Y,Tao L,Qin Z,Xiao R

更新日期：2019-10-11 00:00:00

abstract：:Interleukin 1 and its receptors are associated with allergic diseases such as asthma. In the present study, we measured DNA methylation at the IL1R1 and IL1R2 gene loci and assessed for associations with asthma-related phenotypes and gene expressions. We found that asthmatic and atopic individuals have higher IL1R2 pr...

journal_title：Clinical epigenetics

authors： Gagné-Ouellet V,Guay SP,Boucher-Lafleur AM,Bouchard L,Laprise C

更新日期：2015-08-05 00:00:00

abstract：BACKGROUND:Identifying subjects with a high risk of ischemic stroke is fundamental for prevention of the disease. Both genetic and environmental risk factors contribute to ischemic stroke, but the underlying epigenetic mechanisms which mediate genetic and environmental risk effects are not fully understood. The aim of ...

journal_title：Clinical epigenetics

authors： Qin X,Li J,Wu T,Wu Y,Tang X,Gao P,Li L,Wang M,Wu Y,Wang X,Chen D,Hu Y

更新日期：2019-12-10 00:00:00

abstract：BACKGROUND:The pathogenesis of systemic lupus erythematosus (SLE) has not yet been completely elucidated. One of the hallmarks of SLE is the production of autoantibodies by uncontrolled over-activated B cells. Early B cell factor 1 (EBF1) contributes to the development, activation, and proliferation of B cells through ...

journal_title：Clinical epigenetics

authors： Luo S,Liu Y,Liang G,Zhao M,Wu H,Liang Y,Qiu X,Tan Y,Dai Y,Yung S,Chan TM,Lu Q

更新日期：2015-03-14 00:00:00

abstract：:After publication of the original article [1], authors have requested to add a 'J' as middle name for Richard Gilbertson. Hence, full name should be Richard J Gilbertson. ...

journal_title：Clinical epigenetics

authors： Pienkowska M,Choufani S,Turinsky AL,Guha T,Merino DM,Novokmet A,Brudno M,Weksberg R,Shlien A,Hawkins C,Bouffet E,Tabori U,Gilbertson RJ,Finlay JL,Jabado N,Thomas C,Sill M,Capper D,Hasselblatt M,Malkin D

更新日期：2019-10-21 00:00:00

abstract：: Lower than normal levels of oxygen (hypoxia) is a hallmark of all solid tumours rendering them frequently resistant to both radiotherapy and chemotherapy regimes. Furthermore, tumour hypoxia and activation of the hypoxia inducible factor (HIF) transcriptional pathway is associated with poorer prognosis. Driven by bot...

journal_title：Clinical epigenetics

authors： Thirlwell C,Schulz L,Dibra H,Beck S

更新日期：2011-12-05 00:00:00

abstract：BACKGROUND:The birth weight of Black neonates in the United States is consistently smaller than that of their White counterparts. Epigenetic differences between the races may be involved in such disparities. The goal of these analyses was to model the role of IGF1 methylation in mediating the association between race a...

journal_title：Clinical epigenetics

authors： Straughen JK,Sipahi L,Uddin M,Misra DP,Misra VK

更新日期：2015-04-21 00:00:00

abstract：BACKGROUND:Prostate cancer (PCa), a highly incident and heterogeneous malignancy, mostly affects men from developed countries. Increased knowledge of the biological mechanisms underlying PCa onset and progression are critical for improved clinical management. MicroRNAs (miRNAs) deregulation is common in human cancers, ...

journal_title：Clinical epigenetics

authors： Costa-Pinheiro P,Ramalho-Carvalho J,Vieira FQ,Torres-Ferreira J,Oliveira J,Gonçalves CS,Costa BM,Henrique R,Jerónimo C

更新日期：2015-04-10 00:00:00

abstract：BACKGROUND:Many conventional chemotherapeutic drugs are known to be involved in DNA damage, thus ultimately leading to apoptosis of leukemic cells. However, they fail to completely eliminate leukemia stem cells (LSCs) due to their higher DNA repair capacity of cancer stem cells than that of bulk cancer cells, which bec...

journal_title：Clinical epigenetics

authors： Li Y,Wang Y,Zhou Y,Li J,Chen K,Zhang L,Deng M,Deng S,Li P,Xu B

更新日期：2017-08-14 00:00:00