DNA methylation signature of interleukin 1 receptor type II in asthma.

abstract：BACKGROUND:The prevalence of type 2 diabetes (T2D) and obesity has dramatically increased within a few generations, reaching epidemic levels. In addition to genetic risk factors, epigenetic mechanisms triggered by changing environment are investigated for their role in the pathogenesis of these complex diseases. Epigen...

journal_title：Clinical epigenetics

authors： Al Muftah WA,Al-Shafai M,Zaghlool SB,Visconti A,Tsai PC,Kumar P,Spector T,Bell J,Falchi M,Suhre K

更新日期：2016-01-28 00:00:00

abstract：BACKGROUND:Identifying subjects with a high risk of ischemic stroke is fundamental for prevention of the disease. Both genetic and environmental risk factors contribute to ischemic stroke, but the underlying epigenetic mechanisms which mediate genetic and environmental risk effects are not fully understood. The aim of ...

journal_title：Clinical epigenetics

authors： Qin X,Li J,Wu T,Wu Y,Tang X,Gao P,Li L,Wang M,Wu Y,Wang X,Chen D,Hu Y

更新日期：2019-12-10 00:00:00

abstract：BACKGROUND:Epigenetic mechanisms may partly explain the persistent effects of adverse childhood experiences (ACEs) on health outcomes in later life. DNA methylation can predict chronological age, and advanced methylation-predicted age beyond chronological age (DNA methylation age acceleration) is associated with ACEs, ...

journal_title：Clinical epigenetics

authors： Tang R,Howe LD,Suderman M,Relton CL,Crawford AA,Houtepen LC

更新日期：2020-04-07 00:00:00

abstract：: Friedreich ataxia (FRDA) is a debilitating and frequently fatal neurological disorder that is recessively inherited. It belongs to the group of genetic disorders known as the Repeat Expansion Diseases, in which pathology arises from the deleterious consequences of the inheritance of a tandem repeat array whose repeat...

journal_title：Clinical epigenetics

authors： Kumari D,Usdin K

更新日期：2012-01-30 00:00:00

abstract：BACKGROUND:Prostate cancer (PCa), a highly incident and heterogeneous malignancy, mostly affects men from developed countries. Increased knowledge of the biological mechanisms underlying PCa onset and progression are critical for improved clinical management. MicroRNAs (miRNAs) deregulation is common in human cancers, ...

journal_title：Clinical epigenetics

authors： Costa-Pinheiro P,Ramalho-Carvalho J,Vieira FQ,Torres-Ferreira J,Oliveira J,Gonçalves CS,Costa BM,Henrique R,Jerónimo C

更新日期：2015-04-10 00:00:00

abstract：BACKGROUND:Splicing is more efficient when coupled with transcription and it has been proposed that nucleosomes enriched in exons are important for splice site recognition. Lynch syndrome is a familial cancer syndrome that can be caused by the autosomal dominant inheritance of splice site mutations in the MutL homolog ...

journal_title：Clinical epigenetics

authors： Sloane MA,Hesson LB,Nunez AC,Thompson BA,Ward RL

更新日期：2014-12-13 00:00:00

abstract：BACKGROUND:Canine mammary tumor (CMT) has long been considered as a good animal model for human breast cancer (HBC) due to their pathological and biological similarities. However, only a few aspects of the epigenome have been explored in both HBC and CMT. Moreover, DNA methylation studies have mainly been limited to th...

journal_title：Clinical epigenetics

authors： Nam AR,Lee KH,Hwang HJ,Schabort JJ,An JH,Won SH,Cho JY

更新日期：2020-07-21 00:00:00

abstract：BACKGROUND:Colorectal cancer (CRC) screening can effectively reduce disease-related mortality by detecting CRC at earlier stages. We have previously demonstrated that the presence of SDC2 methylation in stool DNA is significantly associated with the occurrence of CRC regardless of clinical stage. The aim of this study ...

journal_title：Clinical epigenetics

authors： Han YD,Oh TJ,Chung TH,Jang HW,Kim YN,An S,Kim NK

更新日期：2019-03-15 00:00:00

abstract：BACKGROUND:Chronic systemic inflammation has been associated with incident dementia, but its association with age-related cognitive decline is less clear. The acute responses of many inflammatory biomarkers mean they may provide an unreliable picture of the chronicity of inflammation. Recently, a large-scale epigenome-...

journal_title：Clinical epigenetics

authors： Stevenson AJ,McCartney DL,Hillary RF,Campbell A,Morris SW,Bermingham ML,Walker RM,Evans KL,Boutin TS,Hayward C,McRae AF,McColl BW,Spires-Jones TL,McIntosh AM,Deary IJ,Marioni RE

更新日期：2020-07-27 00:00:00

abstract：BACKGROUND:B vitamins in the one-carbon metabolism pathway (folate, vitamin B6, and vitamin B12) have been implicated in DNA methylation, and their deficiency may contribute to cognitive decline through increased homocysteine (Hcy) levels and subsequent oxidative damage. The aim of this study was to investigate whether...

journal_title：Clinical epigenetics

authors： An Y,Feng L,Zhang X,Wang Y,Wang Y,Tao L,Qin Z,Xiao R

更新日期：2019-10-11 00:00:00

abstract：BACKGROUND:Preeclampsia, a pregnancy complication of placental origin is associated with altered expression of angiogenic factors and their receptors. Recently, there is considerable interest in understanding the role of adverse intrauterine conditions in placental dysfunction and adverse pregnancy outcomes. Since we h...

journal_title：Clinical epigenetics

authors： Sundrani DP,Reddy US,Joshi AA,Mehendale SS,Chavan-Gautam PM,Hardikar AA,Chandak GR,Joshi SR

更新日期：2013-04-26 00:00:00

abstract：BACKGROUND:Human immunodeficiency virus type 1 (HIV-1) latency represents the major barrier to virus eradication in infected individuals because cells harboring latent HIV-1 provirus are not affected by current antiretroviral therapy (ART). We previously demonstrated that DNA methylation of HIV-1 long terminal repeat (...

journal_title：Clinical epigenetics

authors： Trejbalová K,Kovářová D,Blažková J,Machala L,Jilich D,Weber J,Kučerová D,Vencálek O,Hirsch I,Hejnar J

更新日期：2016-02-19 00:00:00

abstract：BACKGROUND:Insufficient specificity of the high-risk human papillomavirus (hrHPV) assay in primary cervical cancer screening results in unnecessary referral. Additional assays to triage hrHPV-positive women are needed to improve molecular cervical cancer screening. DNA methylation is a promising biomarker in cervical c...

journal_title：Clinical epigenetics

authors： Pun PB,Liao YP,Su PH,Wang HC,Chen YC,Hsu YW,Huang RL,Chang CC,Lai HC

更新日期：2015-08-21 00:00:00

abstract：BACKGROUND:Goblet cell metaplasia, a common feature of chronic obstructive pulmonary disease (COPD), is associated with mucus hypersecretion which contributes to the morbidity and mortality among patients. Transcription factors SAM-pointed domain-containing Ets-like factor (SPDEF) and forkhead box protein A2 (FOXA2) re...

journal_title：Clinical epigenetics

authors： Song J,Heijink IH,Kistemaker LEM,Reinders-Luinge M,Kooistra W,Noordhoek JA,Gosens R,Brandsma CA,Timens W,Hiemstra PS,Rots MG,Hylkema MN

更新日期：2017-04-24 00:00:00

abstract：BACKGROUND:Neuroblastoma (NB) is the most common extracranial pediatric solid tumor with a highly variable clinical course, ranging from spontaneous regression to life-threatening disease. Survival rates for high-risk NB patients remain disappointingly low despite multimodal treatment. Thus, there is an urgent clinical...

journal_title：Clinical epigenetics

authors： Yáñez Y,Grau E,Rodríguez-Cortez VC,Hervás D,Vidal E,Noguera R,Hernández M,Segura V,Cañete A,Conesa A,Font de Mora J,Castel V

更新日期：2015-02-27 00:00:00

abstract：:Esophageal cancer is one of the most common malignancies in the world. Squamous cell carcinoma accounts for approximately 90 % of esophageal cancer cases. Genetic and epigenetic changes have been found to accumulate during the development of various cancers, including esophageal squamous carcinoma (ESCC). Tobacco smok...

journal_title：Clinical epigenetics

authors： Ma K,Cao B,Guo M

更新日期：2016-04-22 00:00:00

abstract：BACKGROUND:Many conventional chemotherapeutic drugs are known to be involved in DNA damage, thus ultimately leading to apoptosis of leukemic cells. However, they fail to completely eliminate leukemia stem cells (LSCs) due to their higher DNA repair capacity of cancer stem cells than that of bulk cancer cells, which bec...

journal_title：Clinical epigenetics

authors： Li Y,Wang Y,Zhou Y,Li J,Chen K,Zhang L,Deng M,Deng S,Li P,Xu B

更新日期：2017-08-14 00:00:00

abstract：BACKGROUND:Tobacco smoking is a risk factor for multiple diseases, including cardiovascular disease and diabetes. Many smoking-associated signals have been detected in the blood methylome, but the extent to which these changes are widespread to metabolically relevant tissues, and impact gene expression or metabolic hea...

journal_title：Clinical epigenetics

authors： Tsai PC,Glastonbury CA,Eliot MN,Bollepalli S,Yet I,Castillo-Fernandez JE,Carnero-Montoro E,Hardiman T,Martin TC,Vickers A,Mangino M,Ward K,Pietiläinen KH,Deloukas P,Spector TD,Viñuela A,Loucks EB,Ollikainen M,Kelsey K

更新日期：2018-10-20 00:00:00

abstract：BACKGROUND:The birth weight of Black neonates in the United States is consistently smaller than that of their White counterparts. Epigenetic differences between the races may be involved in such disparities. The goal of these analyses was to model the role of IGF1 methylation in mediating the association between race a...

journal_title：Clinical epigenetics

authors： Straughen JK,Sipahi L,Uddin M,Misra DP,Misra VK

更新日期：2015-04-21 00:00:00

abstract：BACKGROUND:Inadequate maternal nutrition during early fetal development can create permanent alterations in the offspring, leading to poor health outcomes. While nutrients involved in one-carbon cycle metabolism are important to fetal growth, associations with specific nutrients remain inconsistent. This study estimate...

journal_title：Clinical epigenetics

authors： McCullough LE,Miller EE,Mendez MA,Murtha AP,Murphy SK,Hoyo C

更新日期：2016-01-22 00:00:00

abstract：:Researchers have begun to examine epigenetic alterations in the placenta, making key advances in understanding the epigenetic regulatory mechanisms of the placenta that define underlying processes of human development and disease. Examining changes in microRNA (miRNA) expression associated with environmental exposures...

journal_title：Clinical epigenetics

authors： Maccani MA,Marsit CJ

更新日期：2011-08-01 00:00:00

abstract：:Cyclin D1 is a cell cycle machine, a sensor of extracellular signals and plays an important role in G1-S phase progression. The human cyclin D1 promoter contains multiple transcription factor binding sites such as AP-1, NF-қB, E2F, Oct-1, and so on. The extracellular signals functions through the signal transduction p...

journal_title：Clinical epigenetics

authors： Guo ZY,Hao XH,Tan FF,Pei X,Shang LM,Jiang XL,Yang F

更新日期：2011-08-01 00:00:00

abstract：BACKGROUND:Frozen-thawed embryo transfer (FET) is increasingly available for the improvement of the success rate of assisted reproductive technologies other than fresh embryo transfer (ET). There have been numerous findings that FET provides better obstetric and perinatal outcomes. However, the birth weight of infants ...

journal_title：Clinical epigenetics

authors： Hiura H,Hattori H,Kobayashi N,Okae H,Chiba H,Miyauchi N,Kitamura A,Kikuchi H,Yoshida H,Arima T

更新日期：2017-08-03 00:00:00

abstract：BACKGROUND:Kawasaki disease (KD) is a prevalent pediatric disease worldwide and can cause coronary artery aneurysm as a severe complication. Typically, DNA methylation is thought to repress the expression of nearby genes. However, the cases in which DNA methylation promotes gene expression have been reported. In additi...

journal_title：Clinical epigenetics

authors： Huang LH,Kuo HC,Pan CT,Lin YS,Huang YH,Li SC

更新日期：2018-11-01 00:00:00

abstract：BACKGROUND:Although HPV testing and cytology detection are successful for cervical screening in China, additional procedures are urgently required to avoid misdiagnosis and overtreatment. In this multicenter study, we collected cervical samples during screening in clinics. A total of 588 women with HPV16/18+ and/or cyt...

journal_title：Clinical epigenetics

authors： Gu YY,Zhou GN,Wang Q,Ding JX,Hua KQ

更新日期：2020-04-21 00:00:00

abstract：BACKGROUND:Abnormal DNA methylation is a hallmark of human cancers and may be a promising biomarker for early diagnosis of human cancers. However, the majority of DNA methylation biomarkers that have been identified are based on the hypothesis that early differential methylation regions (DMRs) are maintained throughout...

journal_title：Clinical epigenetics

authors： Fan J,Li J,Guo S,Tao C,Zhang H,Wang W,Zhang Y,Zhang D,Ding S,Zeng C

更新日期：2020-04-21 00:00:00

abstract：BACKGROUND:In vitro follicle culture (IFC), as applied in the mouse system, allows the growth and maturation of a large number of immature preantral follicles to become mature and competent oocytes. In the human oncofertility clinic, there is increasing interest in developing this technique as an alternative to ovarian...

journal_title：Clinical epigenetics

authors： Saenz-de-Juano MD,Ivanova E,Billooye K,Herta AC,Smitz J,Kelsey G,Anckaert E

更新日期：2019-12-19 00:00:00

abstract：BACKGROUND:Epigenetic mechanisms have been suggested to play a role in the development of post-traumatic stress disorder (PTSD). Here, blood-derived DNA methylation data (HumanMethylation450 BeadChip) collected prior to and following combat exposure in three cohorts of male military members were analyzed to assess whet...

journal_title：Clinical epigenetics

authors： Snijders C,Maihofer AX,Ratanatharathorn A,Baker DG,Boks MP,Geuze E,Jain S,Kessler RC,Pishva E,Risbrough VB,Stein MB,Ursano RJ,Vermetten E,Vinkers CH,PGC PTSD EWAS Consortium.,Smith AK,Uddin M,Rutten BPF,Nievergelt CM

更新日期：2020-01-13 00:00:00

abstract：:Remodeling of the sperm epigenome by lifestyle factors before conception could account for altered metabolism in the next generation offspring. Here, we hypothesized that endurance training changes the epigenome of human spermatozoa. Using small RNA (sRNA) sequencing and reduced representation bisulfite sequencing (RR...

journal_title：Clinical epigenetics

authors： Ingerslev LR,Donkin I,Fabre O,Versteyhe S,Mechta M,Pattamaprapanont P,Mortensen B,Krarup NT,Barrès R

更新日期：2018-01-25 00:00:00

abstract：:In this letter to the editor, we highlight some concerns with a recently published method to estimate gestational age at delivery from DNA methylation data. We conduct novel analyses to highlight the implications of different choices in study design and statistical methods for the prediction of phenotypes from methyla...

journal_title：Clinical epigenetics

authors： Simpkin AJ,Suderman M,Howe LD

更新日期：2017-09-15 00:00:00