Overall and sex-specific associations between methylation of the ABCG1 and APOE genes and ischemic stroke or other atherosclerosis-related traits in a sibling study of Chinese population.

abstract：BACKGROUND:Cancer treatments have substantially improved childhood cancer survival but are accompanied by long-term complications, notably chronic inflammatory diseases. We hypothesize that cancer treatments could lead to long-term epigenetic changes in immune cells, resulting in increased prevalence of inflammatory di...

journal_title：Clinical epigenetics

authors： Daniel S,Nylander V,Ingerslev LR,Zhong L,Fabre O,Clifford B,Johnston K,Cohn RJ,Barres R,Simar D

更新日期：2018-11-06 00:00:00

abstract：BACKGROUND:The mechanism of action of olanzapine in treating schizophrenia is not clear. This research reports the effects of a therapeutic equivalent treatment of olanzapine on DNA methylation in a rat model in vivo.Genome-wide DNA methylation was assessed using a MeDIP-chip analysis. All methylated DNA immunoprecipit...

journal_title：Clinical epigenetics

authors： Melka MG,Laufer BI,McDonald P,Castellani CA,Rajakumar N,O'Reilly R,Singh SM

更新日期：2014-01-02 00:00:00

abstract：BACKGROUND:Epigenetics changes have been shown to be affected by cigarette smoking. Cigarette smoke (CS)-mediated DNA methylation can potentially affect several cellular and pathophysiological processes, acute exacerbations, and comorbidity in the lungs of patients with chronic obstructive pulmonary disease (COPD). We ...

journal_title：Clinical epigenetics

authors： Sundar IK,Yin Q,Baier BS,Yan L,Mazur W,Li D,Susiarjo M,Rahman I

更新日期：2017-04-14 00:00:00

abstract：BACKGROUND:Goblet cell metaplasia, a common feature of chronic obstructive pulmonary disease (COPD), is associated with mucus hypersecretion which contributes to the morbidity and mortality among patients. Transcription factors SAM-pointed domain-containing Ets-like factor (SPDEF) and forkhead box protein A2 (FOXA2) re...

journal_title：Clinical epigenetics

authors： Song J,Heijink IH,Kistemaker LEM,Reinders-Luinge M,Kooistra W,Noordhoek JA,Gosens R,Brandsma CA,Timens W,Hiemstra PS,Rots MG,Hylkema MN

更新日期：2017-04-24 00:00:00

abstract：BACKGROUND:DNA methylation is a well-studied epigenetic mark that is frequently altered in diseases such as cancer, where specific changes are known to reflect the type and severity of the disease. Therefore, there is a growing interest in assessing the clinical utility of DNA methylation as a biomarker for diagnosing ...

journal_title：Clinical epigenetics

authors： Lam D,Luu PL,Song JZ,Qu W,Risbridger GP,Lawrence MG,Lu J,Trau M,Korbie D,Clark SJ,Pidsley R,Stirzaker C

更新日期：2020-06-22 00:00:00

abstract：BACKGROUND:Tobacco smoking is a risk factor for multiple diseases, including cardiovascular disease and diabetes. Many smoking-associated signals have been detected in the blood methylome, but the extent to which these changes are widespread to metabolically relevant tissues, and impact gene expression or metabolic hea...

journal_title：Clinical epigenetics

authors： Tsai PC,Glastonbury CA,Eliot MN,Bollepalli S,Yet I,Castillo-Fernandez JE,Carnero-Montoro E,Hardiman T,Martin TC,Vickers A,Mangino M,Ward K,Pietiläinen KH,Deloukas P,Spector TD,Viñuela A,Loucks EB,Ollikainen M,Kelsey K

更新日期：2018-10-20 00:00:00

abstract：BACKGROUND:Male obesity has profound effects on morbidity and mortality, but relatively little is known about the impact of obesity on gametes and the potential for adverse effects of male obesity to be passed to the next generation. DNA methylation contributes to gene regulation and is erased and re-established during...

journal_title：Clinical epigenetics

authors： Keyhan S,Burke E,Schrott R,Huang Z,Grenier C,Price T,Raburn D,Corcoran DL,Soubry A,Hoyo C,Murphy SK

更新日期：2021-01-25 00:00:00

abstract：:Interleukin 1 and its receptors are associated with allergic diseases such as asthma. In the present study, we measured DNA methylation at the IL1R1 and IL1R2 gene loci and assessed for associations with asthma-related phenotypes and gene expressions. We found that asthmatic and atopic individuals have higher IL1R2 pr...

journal_title：Clinical epigenetics

authors： Gagné-Ouellet V,Guay SP,Boucher-Lafleur AM,Bouchard L,Laprise C

更新日期：2015-08-05 00:00:00

abstract：BACKGROUND:Numerous pulmonary diseases manifest with upper lobe predominance including cystic fibrosis, smoking-related chronic obstructive pulmonary disease, and tuberculosis. Zonal hypoxia, characteristic of these pulmonary maladies, and oxygen stress in general is known to exert profound effects on various important...

journal_title：Clinical epigenetics

authors： Armstrong DA,Nymon AB,Ringelberg CS,Lesseur C,Hazlett HF,Howard L,Marsit CJ,Ashare A

更新日期：2017-05-30 00:00:00

abstract：Background:Chronic obstructive pulmonary disease (COPD) is a heterogeneous disease of the lungs that is currently the fourth leading cause of death worldwide. Genetic factors account for only a small amount of COPD risk, but epigenetic mechanisms, including DNA methylation, have the potential to mediate the interaction...

journal_title：Clinical epigenetics

authors： Clifford RL,Fishbane N,Patel J,MacIsaac JL,McEwen LM,Fisher AJ,Brandsma CA,Nair P,Kobor MS,Hackett TL,Knox AJ

更新日期：2018-03-05 00:00:00

abstract：BACKGROUND:Colorectal cancer (CRC) is the third most commonly diagnosed human malignancy worldwide. Upregulation of inhibitory immune checkpoints by tumor-infiltrating immune cells (TIICs) or their ligands by tumor cells leads to tumor evasion from host immunosurveillance. Changes in DNA methylation pattern and enrichm...

journal_title：Clinical epigenetics

authors： Sasidharan Nair V,Toor SM,Taha RZ,Shaath H,Elkord E

更新日期：2018-08-06 00:00:00

abstract：BACKGROUND:Human immunodeficiency virus type 1 (HIV-1) latency represents the major barrier to virus eradication in infected individuals because cells harboring latent HIV-1 provirus are not affected by current antiretroviral therapy (ART). We previously demonstrated that DNA methylation of HIV-1 long terminal repeat (...

journal_title：Clinical epigenetics

authors： Trejbalová K,Kovářová D,Blažková J,Machala L,Jilich D,Weber J,Kučerová D,Vencálek O,Hirsch I,Hejnar J

更新日期：2016-02-19 00:00:00

abstract：BACKGROUND:Adiponectin critically contributes to metabolic homeostasis, especially by insulin-sensitizing action. Gestational diabetes mellitus (GDM) is characterized by insulin resistance leading to materno-fetal hyperglycemia and detrimental birth outcomes. By investigating paired subcutaneous (SAT) and visceral adip...

journal_title：Clinical epigenetics

authors： Ott R,Stupin JH,Melchior K,Schellong K,Ziska T,Dudenhausen JW,Henrich W,Rancourt RC,Plagemann A

更新日期：2018-10-24 00:00:00

abstract：: Lower than normal levels of oxygen (hypoxia) is a hallmark of all solid tumours rendering them frequently resistant to both radiotherapy and chemotherapy regimes. Furthermore, tumour hypoxia and activation of the hypoxia inducible factor (HIF) transcriptional pathway is associated with poorer prognosis. Driven by bot...

journal_title：Clinical epigenetics

authors： Thirlwell C,Schulz L,Dibra H,Beck S

更新日期：2011-12-05 00:00:00

abstract：Background:This study was aimed at understanding whether bronchial biopsy specimen can be used as a surrogate for DNA methylation analysis in surgically resected lung cancer. Methods:A genome-wide methylation was analyzed in 42 surgically resected tumor tissues, 136 bronchial washing, 12 sputum, and 8 bronchial biopsy...

journal_title：Clinical epigenetics

authors： Um SW,Kim HK,Kim Y,Lee BB,Kim D,Han J,Kim H,Shim YM,Kim DH

更新日期：2017-12-20 00:00:00

abstract：Background:The dynamic methylation of human papillomavirus (HPV) 16 DNA is thought to be associated with the progression of cervical lesions. Previous studies that did not consider the physical status of HPV 16 may have incorrectly mapped HPV 16 methylomes. In order to identify reliable biomarkers for squamous cervical...

journal_title：Clinical epigenetics

authors： Liu L,Ying C,Zhao Z,Sui L,Zhang X,Qian C,Wang Q,Chen L,Guo Q,Wu J

更新日期：2018-01-23 00:00:00

abstract：Background:Reduced expression of retinoic acid-induced 2 (RAI2) was found in breast cancer. The regulation and function of RAI2 in human colorectal cancer (CRC) remain unclear. Methods:Eight CRC cell lines and 237 cases of primary CRC were analyzed. Methylation-specific PCR (MSP), flow cytometry, xenograft mouse model...

journal_title：Clinical epigenetics

authors： Yan W,Wu K,Herman JG,Xu X,Yang Y,Dai G,Guo M

更新日期：2018-05-23 00:00:00

abstract：INTRODUCTION:DNA methylation of CpG islands within the promoter region of genes is an epigenetic modification with an important role in the development of cancer and it is typically mediated by DNA methyltransferases (DNMTs). In cancer cells, global hypomethylation of the genome as a whole and regional hypermethylation...

journal_title：Clinical epigenetics

authors： Kullmann K,Deryal M,Ong MF,Schmidt W,Mahlknecht U

更新日期：2013-05-02 00:00:00

abstract：Background:Methylation-associated SOX family genes have been proved to be involved in multiple essential processes during carcinogenesis and act as potential biomarkers for cancer diagnosis, staging, prediction of prognosis, and monitoring of response to therapy. Herein, we revealed SOX30 methylation and its clinical i...

journal_title：Clinical epigenetics

authors： Zhou JD,Wang YX,Zhang TJ,Li XX,Gu Y,Zhang W,Ma JC,Lin J,Qian J

更新日期：2018-07-05 00:00:00

abstract：BACKGROUND:Prostate cancer (PCa), a highly incident and heterogeneous malignancy, mostly affects men from developed countries. Increased knowledge of the biological mechanisms underlying PCa onset and progression are critical for improved clinical management. MicroRNAs (miRNAs) deregulation is common in human cancers, ...

journal_title：Clinical epigenetics

authors： Costa-Pinheiro P,Ramalho-Carvalho J,Vieira FQ,Torres-Ferreira J,Oliveira J,Gonçalves CS,Costa BM,Henrique R,Jerónimo C

更新日期：2015-04-10 00:00:00

abstract：:Heterozygous mutation of the transcription factor HNF1B is the most common cause of monogenetic developmental renal disease. Disease-associated mutations fall into two categories: HNF1B intragenic mutations and a 1.3 Mb deletion at chromosome 17q12. An increase in neurodevelopmental disorders has been observed in indi...

journal_title：Clinical epigenetics

authors： Clissold RL,Ashfield B,Burrage J,Hannon E,Bingham C,Mill J,Hattersley A,Dempster EL

更新日期：2018-07-18 00:00:00

abstract：:After publication of the original article [1], authors have requested to add a 'J' as middle name for Richard Gilbertson. Hence, full name should be Richard J Gilbertson. ...

journal_title：Clinical epigenetics

authors： Pienkowska M,Choufani S,Turinsky AL,Guha T,Merino DM,Novokmet A,Brudno M,Weksberg R,Shlien A,Hawkins C,Bouffet E,Tabori U,Gilbertson RJ,Finlay JL,Jabado N,Thomas C,Sill M,Capper D,Hasselblatt M,Malkin D

更新日期：2019-10-21 00:00:00

abstract：BACKGROUND:Type 2 diabetes mellitus (T2D) is highly prevalent in Middle-Eastern and North African Arab populations, but the molecular basis for this susceptibility is unknown. Altered DNA methylation levels were reported in insulin-secreting and responding tissues, but whether methylation in accessible tissues such as ...

journal_title：Clinical epigenetics

authors： Toperoff G,Kark JD,Aran D,Nassar H,Ahmad WA,Sinnreich R,Azaiza D,Glaser B,Hellman A

更新日期：2015-03-28 00:00:00

abstract：BACKGROUND:About half of all prostate cancers harbor the TMPRSS2:ERG (T2E) gene fusion. While T2E-positive and T2E-negative tumors represent specific molecular subtypes of prostate cancer (PCa), previous studies have not yet comprehensively investigated how these tumor subtypes differ at the epigenetic level. We theref...

journal_title：Clinical epigenetics

authors： Geybels MS,Alumkal JJ,Luedeke M,Rinckleb A,Zhao S,Shui IM,Bibikova M,Klotzle B,van den Brandt PA,Ostrander EA,Fan JB,Feng Z,Maier C,Stanford JL

更新日期：2015-12-12 00:00:00

abstract：BACKGROUND:Chronic systemic inflammation has been associated with incident dementia, but its association with age-related cognitive decline is less clear. The acute responses of many inflammatory biomarkers mean they may provide an unreliable picture of the chronicity of inflammation. Recently, a large-scale epigenome-...

journal_title：Clinical epigenetics

authors： Stevenson AJ,McCartney DL,Hillary RF,Campbell A,Morris SW,Bermingham ML,Walker RM,Evans KL,Boutin TS,Hayward C,McRae AF,McColl BW,Spires-Jones TL,McIntosh AM,Deary IJ,Marioni RE

更新日期：2020-07-27 00:00:00

abstract：BACKGROUND:Epigenome-wide association studies using DNA methylation have the potential to uncover novel biomarkers and mechanisms of cardiovascular disease (CVD) risk. However, the direction of causation for these associations is not always clear, and investigations to-date have often failed to replicate at the level o...

journal_title：Clinical epigenetics

authors： Westerman K,Sebastiani P,Jacques P,Liu S,DeMeo D,Ordovás JM

更新日期：2019-10-15 00:00:00

abstract：BACKGROUND:Splicing is more efficient when coupled with transcription and it has been proposed that nucleosomes enriched in exons are important for splice site recognition. Lynch syndrome is a familial cancer syndrome that can be caused by the autosomal dominant inheritance of splice site mutations in the MutL homolog ...

journal_title：Clinical epigenetics

authors： Sloane MA,Hesson LB,Nunez AC,Thompson BA,Ward RL

更新日期：2014-12-13 00:00:00

abstract：BACKGROUND:Compared to healthy individuals, those with stably repressed HIV experience a higher risk of developing insulin resistance, a hallmark of pre-diabetes and a major determinant for cardiometabolic diseases. Although epigenetic processes, including in particular DNA methylation, appear to be dysregulated in ind...

journal_title：Clinical epigenetics

authors： Dye CK,Corley MJ,Li D,Khadka VS,Mitchell BI,Sultana R,Lum-Jones A,Shikuma CM,Ndhlovu LC,Maunakea AK

更新日期：2019-06-28 00:00:00

abstract：: Friedreich ataxia (FRDA) is a debilitating and frequently fatal neurological disorder that is recessively inherited. It belongs to the group of genetic disorders known as the Repeat Expansion Diseases, in which pathology arises from the deleterious consequences of the inheritance of a tandem repeat array whose repeat...

journal_title：Clinical epigenetics

authors： Kumari D,Usdin K

更新日期：2012-01-30 00:00:00

abstract：BACKGROUND:The autoimmune disease systemic lupus erythematosus (SLE) has a modified epigenome with modified tri-methylation of histone H3 lysine 4 (H3K4me3) at specific loci across the genome. H3K4me3 is a canonical chromatin mark of active transcription. Recent studies have suggested that H3K4me3 breadth has an import...

journal_title：Clinical epigenetics

authors： Zhang Z,Shi L,Dawany N,Kelsen J,Petri MA,Sullivan KE

更新日期：2016-02-02 00:00:00