当前位置： SCI文献检索 > Clinical Epigenetics期刊下所有文献 > Epigenetic analyses in blood cells of men suspected of prostate cancer predict the outcome of biopsy better than serum PSA levels.

Epigenetic analyses in blood cells of men suspected of prostate cancer predict the outcome of biopsy better than serum PSA levels.

Abstract：

:Lymphocytes from the peripheral blood of patients with prostate cancer-the most frequent (noncutaneous) tumor in men-display epigenetic aberrations (altered modes of allelic replication) characteristic of the malignant phenotype. The present study aims to determine whether replication aberrations add certainty to the suspicion of prostate cancer provided by the prostate-specific antigen (PSA) blood test. The allelic replication mode (whether synchronous or asynchronous) was exemplified for RB1 and AML1. These two genes normally exhibit a synchronous mode of allelic replication. Fluorescence in situ hybridization (FISH) replication assay was used for replication analyses. The FISH assays were applied to PHA-stimulated lymphocytes, established from peripheral blood samples of 35 men referred to biopsy due to suspected prostate cancer. Following biopsy 13 out of these 35 men were found positive for prostate malignancy. The FISH assay-showing asynchronous or synchronous RB1 and AML1 replication-was able to predict, respectively, the results of all biopsy-positive men and in 18 out of the 22 biopsy-negative ones. These measurements, distinguishing biopsy-positive from biopsy-negative men, were highly significant (P < 10(-8); 100% sensitivity and 81.8% specificity). Yet, distinguishing between the two groups of men based on the PSA measurements was nonsignificant (P > 0.70). The FISH replication assay applied to peripheral blood lymphocytes of 35 men referred for biopsy significantly predicted the outcome of the pathological examination, more precisely than the serum PSA test. As such, the epigenetic alteration offers a potential noninvasive blood marker, complementary to the PSA, for a preliminary prostate cancer diagnosis.

journal_name

Clin Epigenetics

journal_title

Clinical epigenetics

authors

Cytron S,Stepnov E,Bounkin I,Mashevich M,Dotan A,Avivi L

doi

10.1007/s13148-011-0029-3

subject

Has Abstract

pub_date

2011-08-01 00:00:00

pages

383-388

issue

2

eissn

1868-7075

issn

1868-7083

pii

29

journal_volume

2

pub_type

杂志文章

相关文献

Clinical Epigenetics文献大全
  • Alternative methylation of intron motifs is associated with cancer-related gene expression in both canine mammary tumor and human breast cancer.

    abstract：BACKGROUND:Canine mammary tumor (CMT) has long been considered as a good animal model for human breast cancer (HBC) due to their pathological and biological similarities. However, only a few aspects of the epigenome have been explored in both HBC and CMT. Moreover, DNA methylation studies have mainly been limited to th...

    journal_title：Clinical epigenetics

    pub_type： 杂志文章

    doi：10.1186/s13148-020-00888-4

    authors： Nam AR,Lee KH,Hwang HJ,Schabort JJ,An JH,Won SH,Cho JY

    更新日期：2020-07-21 00:00:00

  • The elements of human cyclin D1 promoter and regulation involved.

    abstract：:Cyclin D1 is a cell cycle machine, a sensor of extracellular signals and plays an important role in G1-S phase progression. The human cyclin D1 promoter contains multiple transcription factor binding sites such as AP-1, NF-қB, E2F, Oct-1, and so on. The extracellular signals functions through the signal transduction p...

    journal_title：Clinical epigenetics

    pub_type： 杂志文章

    doi：10.1007/s13148-010-0018-y

    authors： Guo ZY,Hao XH,Tan FF,Pei X,Shang LM,Jiang XL,Yang F

    更新日期：2011-08-01 00:00:00

  • Altered DNA methylation is associated with aberrant gene expression in parenchymal but not airway fibroblasts isolated from individuals with COPD.

    abstract：Background:Chronic obstructive pulmonary disease (COPD) is a heterogeneous disease of the lungs that is currently the fourth leading cause of death worldwide. Genetic factors account for only a small amount of COPD risk, but epigenetic mechanisms, including DNA methylation, have the potential to mediate the interaction...

    journal_title：Clinical epigenetics

    pub_type： 杂志文章

    doi：10.1186/s13148-018-0464-5

    authors： Clifford RL,Fishbane N,Patel J,MacIsaac JL,McEwen LM,Fisher AJ,Brandsma CA,Nair P,Kobor MS,Hackett TL,Knox AJ

    更新日期：2018-03-05 00:00:00

  • RRx-001, an epigenetic-based radio- and chemosensitizer, has vascular normalizing effects on SCCVII and U87 tumors.

    abstract：BACKGROUND:The tumor-specific microregional effects of the anticancer agent RRx-001, a novel epigenetic-based radio/chemosensitizer with nitrogen oxide-donating properties in phase II clinical trials, were investigated with whole tissue section quantitative immunohistological staining in mouse SCCVII and human U87 tumo...

    journal_title：Clinical epigenetics

    pub_type： 杂志文章

    doi：10.1186/s13148-016-0220-7

    authors： Oronsky B,Scicinski J,Cabrales P,Minchinton A

    更新日期：2016-05-11 00:00:00

  • Epigenetic management of major psychosis.

    abstract：:Epigenetic mechanisms are thought to play a major role in the pathogenesis of the major psychoses (schizophrenia and bipolar disorder), and they may be the link between the environment and the genome in the pathogenesis of these disorders. This paper discusses the role of epigenetics in the management of major psychos...

    journal_title：Clinical epigenetics

    pub_type： 杂志文章

    doi：10.1007/s13148-011-0038-2

    authors： Peedicayil J

    更新日期：2011-08-01 00:00:00

  • Genome-wide blood DNA methylation alterations at regulatory elements and heterochromatic regions in monozygotic twins discordant for obesity and liver fat.

    abstract：BACKGROUND:The current epidemic of obesity and associated diseases calls for swift actions to better understand the mechanisms by which genetics and environmental factors affect metabolic health in humans. Monozygotic (MZ) twin pairs showing discordance for obesity suggest that epigenetic influences represent one such ...

    journal_title：Clinical epigenetics

    pub_type： 杂志文章

    doi：10.1186/s13148-015-0073-5

    authors： Ollikainen M,Ismail K,Gervin K,Kyllönen A,Hakkarainen A,Lundbom J,Järvinen EA,Harris JR,Lundbom N,Rissanen A,Lyle R,Pietiläinen KH,Kaprio J

    更新日期：2015-04-02 00:00:00

  • Single-molecule quantification of 5-hydroxymethylcytosine for diagnosis of blood and colon cancers.

    abstract：BACKGROUND:The DNA modification 5-hydroxymethylcytosine (5hmC) is now referred to as the sixth base of DNA with evidence of tissue-specific patterns and correlation with gene regulation and expression. This epigenetic mark was recently reported as a potential biomarker for multiple types of cancer, but its application ...

    journal_title：Clinical epigenetics

    pub_type： 杂志文章

    doi：10.1186/s13148-017-0368-9

    authors： Gilat N,Tabachnik T,Shwartz A,Shahal T,Torchinsky D,Michaeli Y,Nifker G,Zirkin S,Ebenstein Y

    更新日期：2017-07-14 00:00:00

  • Genetic, epigenetic, and environmental factors controlling oxytocin receptor gene expression.

    abstract：BACKGROUND:The neuropeptide oxytocin regulates mammalian social behavior. Disruptions in oxytocin signaling are a feature of many psychopathologies. One commonly studied biomarker for oxytocin involvement in psychiatric diseases is DNA methylation at the oxytocin receptor gene (OXTR). Such studies focus on DNA methylat...

    journal_title：Clinical epigenetics

    pub_type： 杂志文章

    doi：10.1186/s13148-021-01017-5

    authors： Danoff JS,Wroblewski KL,Graves AJ,Quinn GC,Perkeybile AM,Kenkel WM,Lillard TS,Parikh HI,Golino HF,Gregory SG,Carter CS,Bales KL,Connelly JJ

    更新日期：2021-01-30 00:00:00

  • Comparative DNA methylomic analyses reveal potential origins of novel epigenetic biomarkers of insulin resistance in monocytes from virally suppressed HIV-infected adults.

    abstract：BACKGROUND:Compared to healthy individuals, those with stably repressed HIV experience a higher risk of developing insulin resistance, a hallmark of pre-diabetes and a major determinant for cardiometabolic diseases. Although epigenetic processes, including in particular DNA methylation, appear to be dysregulated in ind...

    journal_title：Clinical epigenetics

    pub_type： 杂志文章

    doi：10.1186/s13148-019-0694-1

    authors： Dye CK,Corley MJ,Li D,Khadka VS,Mitchell BI,Sultana R,Lum-Jones A,Shikuma CM,Ndhlovu LC,Maunakea AK

    更新日期：2019-06-28 00:00:00

  • Longitudinal epigenome-wide association studies of three male military cohorts reveal multiple CpG sites associated with post-traumatic stress disorder.

    abstract：BACKGROUND:Epigenetic mechanisms have been suggested to play a role in the development of post-traumatic stress disorder (PTSD). Here, blood-derived DNA methylation data (HumanMethylation450 BeadChip) collected prior to and following combat exposure in three cohorts of male military members were analyzed to assess whet...

    journal_title：Clinical epigenetics

    pub_type： 杂志文章

    doi：10.1186/s13148-019-0798-7

    authors： Snijders C,Maihofer AX,Ratanatharathorn A,Baker DG,Boks MP,Geuze E,Jain S,Kessler RC,Pishva E,Risbrough VB,Stein MB,Ursano RJ,Vermetten E,Vinkers CH,PGC PTSD EWAS Consortium.,Smith AK,Uddin M,Rutten BPF,Nievergelt CM

    更新日期：2020-01-13 00:00:00

  • Male obesity impacts DNA methylation reprogramming in sperm.

    abstract：BACKGROUND:Male obesity has profound effects on morbidity and mortality, but relatively little is known about the impact of obesity on gametes and the potential for adverse effects of male obesity to be passed to the next generation. DNA methylation contributes to gene regulation and is erased and re-established during...

    journal_title：Clinical epigenetics

    pub_type： 杂志文章

    doi：10.1186/s13148-020-00997-0

    authors： Keyhan S,Burke E,Schrott R,Huang Z,Grenier C,Price T,Raburn D,Corcoran DL,Soubry A,Hoyo C,Murphy SK

    更新日期：2021-01-25 00:00:00

  • Increased epigenetic age in normal breast tissue from luminal breast cancer patients.

    abstract：BACKGROUND:Age is one of the most important risk factors for developing breast cancer. However, age-related changes in normal breast tissue that potentially lead to breast cancer are incompletely understood. Quantifying tissue-level DNA methylation can contribute to understanding these processes. We hypothesized that o...

    journal_title：Clinical epigenetics

    pub_type： 杂志文章,多中心研究

    doi：10.1186/s13148-018-0534-8

    authors： Hofstatter EW,Horvath S,Dalela D,Gupta P,Chagpar AB,Wali VB,Bossuyt V,Storniolo AM,Hatzis C,Patwardhan G,Von Wahlde MK,Butler M,Epstein L,Stavris K,Sturrock T,Au A,Kwei S,Pusztai L

    更新日期：2018-08-29 00:00:00

  • Exposure and fetal growth-associated miRNA alterations in the human placenta.

    abstract：:Researchers have begun to examine epigenetic alterations in the placenta, making key advances in understanding the epigenetic regulatory mechanisms of the placenta that define underlying processes of human development and disease. Examining changes in microRNA (miRNA) expression associated with environmental exposures...

    journal_title：Clinical epigenetics

    pub_type： 杂志文章

    doi：10.1007/s13148-011-0046-2

    authors： Maccani MA,Marsit CJ

    更新日期：2011-08-01 00:00:00

  • The hyper-activation of transcriptional enhancers in breast cancer.

    abstract：BACKGROUND:Activation of transcription enhancers, especially super-enhancers, is one of the critical epigenetic features of tumorigenesis. However, very few studies have systematically identified the enhancers specific in cancer tissues. METHODS:Here, we studied the change of histone modifications in MMTV-PyVT breast ...

    journal_title：Clinical epigenetics

    pub_type： 杂志文章

    doi：10.1186/s13148-019-0645-x

    authors： Li QL,Wang DY,Ju LG,Yao J,Gao C,Lei PJ,Li LY,Zhao XL,Wu M

    更新日期：2019-03-12 00:00:00

  • High-resolution analysis of germ cells from men with sex chromosomal aneuploidies reveals normal transcriptome but impaired imprinting.

    abstract：BACKGROUND:The most common sex chromosomal aneuploidy in males is Klinefelter syndrome, which is characterized by at least one supernumerary X chromosome. While these men have long been considered infertile, focal spermatogenesis can be observed in some patients, and sperm can be surgically retrieved and used for artif...

    journal_title：Clinical epigenetics

    pub_type： 杂志文章

    doi：10.1186/s13148-019-0720-3

    authors： Laurentino S,Heckmann L,Di Persio S,Li X,Meyer Zu Hörste G,Wistuba J,Cremers JF,Gromoll J,Kliesch S,Schlatt S,Neuhaus N

    更新日期：2019-08-28 00:00:00

  • Genome-wide microRNA expression profiling in placentae from frozen-thawed blastocyst transfer.

    abstract：BACKGROUND:Frozen-thawed embryo transfer (FET) is increasingly available for the improvement of the success rate of assisted reproductive technologies other than fresh embryo transfer (ET). There have been numerous findings that FET provides better obstetric and perinatal outcomes. However, the birth weight of infants ...

    journal_title：Clinical epigenetics

    pub_type： 杂志文章

    doi：10.1186/s13148-017-0379-6

    authors： Hiura H,Hattori H,Kobayashi N,Okae H,Chiba H,Miyauchi N,Kitamura A,Kikuchi H,Yoshida H,Arima T

    更新日期：2017-08-03 00:00:00

  • Correction to: DNA methylation signature is prognostic of choroid plexus tumor aggressiveness.

    abstract：:After publication of the original article [1], authors have requested to add a 'J' as middle name for Richard Gilbertson. Hence, full name should be Richard J Gilbertson. ...

    journal_title：Clinical epigenetics

    pub_type： 已发布勘误

    doi：10.1186/s13148-019-0737-7

    authors： Pienkowska M,Choufani S,Turinsky AL,Guha T,Merino DM,Novokmet A,Brudno M,Weksberg R,Shlien A,Hawkins C,Bouffet E,Tabori U,Gilbertson RJ,Finlay JL,Jabado N,Thomas C,Sill M,Capper D,Hasselblatt M,Malkin D

    更新日期：2019-10-21 00:00:00

  • RFX1 downregulation contributes to TLR4 overexpression in CD14+ monocytes via epigenetic mechanisms in coronary artery disease.

    abstract：BACKGROUND:Toll-like receptor 4 (TLR4) expression is increased in activated monocytes, which play a critical role in the pathogenesis of coronary artery disease (CAD). However, the mechanism remains unclear. Regulatory factor X1 (RFX1) is a critical transcription factor regulating epigenetic modifications. In this stud...

    journal_title：Clinical epigenetics

    pub_type： 杂志文章

    doi：10.1186/s13148-019-0646-9

    authors： Du P,Gao K,Cao Y,Yang S,Wang Y,Guo R,Zhao M,Jia S

    更新日期：2019-03-11 00:00:00

  • Epigenetic associations of type 2 diabetes and BMI in an Arab population.

    abstract：BACKGROUND:The prevalence of type 2 diabetes (T2D) and obesity has dramatically increased within a few generations, reaching epidemic levels. In addition to genetic risk factors, epigenetic mechanisms triggered by changing environment are investigated for their role in the pathogenesis of these complex diseases. Epigen...

    journal_title：Clinical epigenetics

    pub_type： 杂志文章

    doi：10.1186/s13148-016-0177-6

    authors： Al Muftah WA,Al-Shafai M,Zaghlool SB,Visconti A,Tsai PC,Kumar P,Spector T,Bell J,Falchi M,Suhre K

    更新日期：2016-01-28 00:00:00

  • Early detection of colorectal cancer based on presence of methylated syndecan-2 (SDC2) in stool DNA.

    abstract：BACKGROUND:Colorectal cancer (CRC) screening can effectively reduce disease-related mortality by detecting CRC at earlier stages. We have previously demonstrated that the presence of SDC2 methylation in stool DNA is significantly associated with the occurrence of CRC regardless of clinical stage. The aim of this study ...

    journal_title：Clinical epigenetics

    pub_type： 临床试验,杂志文章

    doi：10.1186/s13148-019-0642-0

    authors： Han YD,Oh TJ,Chung TH,Jang HW,Kim YN,An S,Kim NK

    更新日期：2019-03-15 00:00:00

  • Dynamic changes in chromatin accessibility, altered adipogenic gene expression, and total versus de novo fatty acid synthesis in subcutaneous adipose stem cells of normal-weight polycystic ovary syndrome (PCOS) women during adipogenesis: evidence of cellu

    abstract：BACKGROUND:Normal-weight polycystic ovary syndrome (PCOS) women exhibit adipose resistance in vivo accompanied by enhanced subcutaneous (SC) abdominal adipose stem cell (ASC) development to adipocytes with accelerated lipid accumulation per cell in vitro. The present study examines chromatin accessibility, RNA expressi...

    journal_title：Clinical epigenetics

    pub_type： 杂志文章

    doi：10.1186/s13148-020-00970-x

    authors： Leung KL,Sanchita S,Pham CT,Davis BA,Okhovat M,Ding X,Dumesic P,Grogan TR,Williams KJ,Morselli M,Ma F,Carbone L,Li X,Pellegrini M,Dumesic DA,Chazenbalk GD

    更新日期：2020-11-23 00:00:00

  • Individual epigenetic status of the pathogenic D4Z4 macrosatellite correlates with disease in facioscapulohumeral muscular dystrophy.

    abstract：BACKGROUND:Both forms of facioscapulohumeral muscular dystrophy (FSHD) are associated with aberrant epigenetic regulation of the chromosome 4q35 D4Z4 macrosatellite. Chromatin changes due to large deletions of heterochromatin (FSHD1) or mutations in chromatin regulatory proteins (FSHD2) lead to relaxation of epigenetic...

    journal_title：Clinical epigenetics

    pub_type： 杂志文章

    doi：10.1186/s13148-015-0072-6

    authors： Jones TI,King OD,Himeda CL,Homma S,Chen JC,Beermann ML,Yan C,Emerson CP Jr,Miller JB,Wagner KR,Jones PL

    更新日期：2015-03-29 00:00:00

  • Exploring the unique function of imprinting control centers in the PWS/AS-responsible region: finding from array-based methylation analysis in cases with variously sized microdeletions.

    abstract：BACKGROUND:Human 15q11-13 is responsible for Prader-Willi syndrome (PWS) and Angelman syndrome (AS) and includes several imprinted genes together with bipartite elements named AS-IC (imprinting center) and PWS-IC. These concertedly confer allele specificity on 15q11-13. Here, we report DNA methylation status of 15q11-1...

    journal_title：Clinical epigenetics

    pub_type： 杂志文章

    doi：10.1186/s13148-019-0633-1

    authors： Matsubara K,Itoh M,Shimizu K,Saito S,Enomoto K,Nakabayashi K,Hata K,Kurosawa K,Ogata T,Fukami M,Kagami M

    更新日期：2019-02-28 00:00:00

  • Retinoic acid-induced 2 (RAI2) is a novel tumor suppressor, and promoter region methylation of RAI2 is a poor prognostic marker in colorectal cancer.

    abstract：Background:Reduced expression of retinoic acid-induced 2 (RAI2) was found in breast cancer. The regulation and function of RAI2 in human colorectal cancer (CRC) remain unclear. Methods:Eight CRC cell lines and 237 cases of primary CRC were analyzed. Methylation-specific PCR (MSP), flow cytometry, xenograft mouse model...

    journal_title：Clinical epigenetics

    pub_type： 杂志文章

    doi：10.1186/s13148-018-0501-4

    authors： Yan W,Wu K,Herman JG,Xu X,Yang Y,Dai G,Guo M

    更新日期：2018-05-23 00:00:00

  • Comprehensive evaluation of targeted multiplex bisulphite PCR sequencing for validation of DNA methylation biomarker panels.

    abstract：BACKGROUND:DNA methylation is a well-studied epigenetic mark that is frequently altered in diseases such as cancer, where specific changes are known to reflect the type and severity of the disease. Therefore, there is a growing interest in assessing the clinical utility of DNA methylation as a biomarker for diagnosing ...

    journal_title：Clinical epigenetics

    pub_type： 杂志文章

    doi：10.1186/s13148-020-00880-y

    authors： Lam D,Luu PL,Song JZ,Qu W,Risbridger GP,Lawrence MG,Lu J,Trau M,Korbie D,Clark SJ,Pidsley R,Stirzaker C

    更新日期：2020-06-22 00:00:00

  • Endurance training remodels sperm-borne small RNA expression and methylation at neurological gene hotspots.

    abstract：:Remodeling of the sperm epigenome by lifestyle factors before conception could account for altered metabolism in the next generation offspring. Here, we hypothesized that endurance training changes the epigenome of human spermatozoa. Using small RNA (sRNA) sequencing and reduced representation bisulfite sequencing (RR...

    journal_title：Clinical epigenetics

    pub_type： 杂志文章

    doi：10.1186/s13148-018-0446-7

    authors： Ingerslev LR,Donkin I,Fabre O,Versteyhe S,Mechta M,Pattamaprapanont P,Mortensen B,Krarup NT,Barrès R

    更新日期：2018-01-25 00:00:00

  • Characterisation of DNA methylation changes in EBF3 and TBC1D16 associated with tumour progression and metastasis in multiple cancer types.

    abstract：BACKGROUND:Characteristic DNA methylation differences have been identified between primary and metastatic melanomas at EBF3 and/or TBC1D16 gene loci. To further evaluate whether these epigenetic changes may act more generally as drivers of tumour onset and metastasis, we have investigated DNA methylation changes involv...

    journal_title：Clinical epigenetics

    pub_type： 杂志文章

    doi：10.1186/s13148-019-0710-5

    authors： Rodger EJ,Chatterjee A,Stockwell PA,Eccles MR

    更新日期：2019-08-05 00:00:00

  • The detective, prognostic, and predictive value of DNA methylation in human esophageal squamous cell carcinoma.

    abstract：:Esophageal cancer is one of the most common malignancies in the world. Squamous cell carcinoma accounts for approximately 90 % of esophageal cancer cases. Genetic and epigenetic changes have been found to accumulate during the development of various cancers, including esophageal squamous carcinoma (ESCC). Tobacco smok...

    journal_title：Clinical epigenetics

    pub_type： 杂志文章,评审

    doi：10.1186/s13148-016-0210-9

    authors： Ma K,Cao B,Guo M

    更新日期：2016-04-22 00:00:00

  • Analysis of two birth tissues provides new insights into the epigenetic landscape of neonates born preterm.

    abstract：BACKGROUND:Preterm birth (PTB), defined as child birth before completion of 37 weeks of gestation, is a major challenge in perinatal health care and can bear long-term medical and financial burden. Over a million children die each year due to PTB complications, and those who survive can face developmental delays. Unfor...

    journal_title：Clinical epigenetics

    pub_type： 杂志文章

    doi：10.1186/s13148-018-0599-4

    authors： Wu Y,Lin X,Lim IY,Chen L,Teh AL,MacIsaac JL,Tan KH,Kobor MS,Chong YS,Gluckman PD,Karnani N

    更新日期：2019-02-11 00:00:00

  • Development of 5' LTR DNA methylation of latent HIV-1 provirus in cell line models and in long-term-infected individuals.

    abstract：BACKGROUND:Human immunodeficiency virus type 1 (HIV-1) latency represents the major barrier to virus eradication in infected individuals because cells harboring latent HIV-1 provirus are not affected by current antiretroviral therapy (ART). We previously demonstrated that DNA methylation of HIV-1 long terminal repeat (...

    journal_title：Clinical epigenetics

    pub_type： 杂志文章

    doi：10.1186/s13148-016-0185-6

    authors： Trejbalová K,Kovářová D,Blažková J,Machala L,Jilich D,Weber J,Kučerová D,Vencálek O,Hirsch I,Hejnar J

    更新日期：2016-02-19 00:00:00