Virulence of invasive Salmonella Typhimurium ST313 in animal models of infection.

abstract：:The chemotherapy of lymphatic filariasis relies upon drugs such as diethylcarbamazine and ivermectin that largely target the microfilarial stages of the parasite, necessitating continued treatment over the long reproductive life span of the adult worm. The identification of compounds that target adult worms has been a...

journal_title：PLoS neglected tropical diseases

authors： Taldone T,Gillan V,Sun W,Rodina A,Patel P,Maitland K,O'Neill K,Chiosis G,Devaney E

更新日期：2010-06-15 00:00:00

abstract：:Due to the large geographical overlap of populations exposed to Zika virus (ZIKV) and human immunodeficiency virus (HIV), understanding the disease pathogenesis of co-infection is urgently needed. This warrants the development of an animal model for HIV-ZIKV co-infection. In this study, we used adult non-pregnant maca...

journal_title：PLoS neglected tropical diseases

authors： Bidokhti MRM,Dutta D,Madduri LSV,Woollard SM,Norgren R Jr,Giavedoni L,Byrareddy SN

更新日期：2018-10-25 00:00:00

abstract：BACKGROUND:Taenia solium cysticercosis/taeniosis is emerging as a serious public health and economic problem in many developing countries. This study was conducted to determine prevalence and risk factors of human T. solium infections in Mbeya Region, Tanzania. METHODS AND FINDINGS:A cross-sectional survey was conduct...

journal_title：PLoS neglected tropical diseases

authors： Mwanjali G,Kihamia C,Kakoko DV,Lekule F,Ngowi H,Johansen MV,Thamsborg SM,Willingham AL 3rd

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:During severe (pneumo)sepsis inflammatory and coagulation pathways become activated as part of the host immune response. Thrombomodulin (TM) is involved in a range of host defense mechanisms during infection and plays a pivotal role in activation of protein C (PC) into active protein C (APC). APC has both an...

journal_title：PLoS neglected tropical diseases

authors： Kager LM,Wiersinga WJ,Roelofs JJ,de Boer OJ,Weiler H,van 't Veer C,van der Poll T

更新日期：2014-04-24 00:00:00

abstract：:Erythema nodosum leprosum (ENL), or type 2 lepra reaction, is a multi-system immune-mediated complication in patients with multibacillary leprosy, frequently associated with chronicity and recurrences. Management of ENL requires high doses of oral corticosteroids, which may not be universally effective and pose seriou...

journal_title：PLoS neglected tropical diseases

authors： Upputuri B,Pallapati MS,Tarwater P,Srikantam A

更新日期：2020-10-09 00:00:00

abstract：:Zika virus was reported in the rainforest city of Iquitos, Peru in 2016. The potential associations between Zika and fetal neurological disorders were reported extensively in the media regarding neighboring Brazil, and led to great concern about the impact Zika could have on people's health in Iquitos when it arrived....

journal_title：PLoS neglected tropical diseases

authors： Weldon CT,Riley-Powell AR,Aguerre IM,Celis Nacimento RA,Morrison AC,Oberhelman RA,Paz-Soldan VA

更新日期：2018-08-30 00:00:00

abstract：BACKGROUND:Enteric fever, a systemic infection caused by the bacteria Salmonella Typhi and Salmonella Paratyphi A, is endemic in Kathmandu, Nepal. Previous work identified proximity to poor quality water sources as a community-level risk for infection. Here, we sought to examine individual-level risk factors related to...

journal_title：PLoS neglected tropical diseases

authors： Karkey A,Thompson CN,Tran Vu Thieu N,Dongol S,Le Thi Phuong T,Voong Vinh P,Arjyal A,Martin LB,Rondini S,Farrar JJ,Dolecek C,Basnyat B,Baker S

更新日期：2013-08-22 00:00:00

abstract：:Mycetoma is a unique neglected tropical disease which is endemic in what is known as the "mycetoma belt". The disease has many devastating impacts on patients and communities in endemic area and is characterised by massive deformity, destruction and disability. Mycetoma is commonly seen in the foot and hand and less f...

journal_title：PLoS neglected tropical diseases

authors： Fahal A,Mahgoub el S,El Hassan AM,Jacoub AO,Hassan D

更新日期：2015-03-13 00:00:00

abstract：BACKGROUND:Cutaneous leishmaniasis (CL) is treated with parenteral drugs for decades with decreasing rate cures. Miltefosine is an oral medication with anti-leishmania activity and may increase the cure rates and improve compliance. METHODOLOGY/PRINCIPAL FINDINGS:This study is a randomized, open-label, controlled clin...

journal_title：PLoS neglected tropical diseases

authors： Machado PR,Ampuero J,Guimarães LH,Villasboas L,Rocha AT,Schriefer A,Sousa RS,Talhari A,Penna G,Carvalho EM

更新日期：2010-12-21 00:00:00

abstract：:We present a general framework which describes the systematic (binary) scenario of individuals either taking treatment or not for any reason, over the course of mass drug administration (MDA)-which we refer to as 'adherence' and 'non-adherence'. The probability models developed can be informed by observed adherence be...

journal_title：PLoS neglected tropical diseases

authors： Hardwick RJ,Truscott JE,Oswald WE,Werkman M,Halliday KE,Pullan RL,Anderson RM

更新日期：2021-01-22 00:00:00

abstract：:The complement cascade in mammalian blood can damage the alimentary tract of haematophagous arthropods. As such, these animals have evolved their own repertoire of complement-inactivating factors, which are inadvertently exploited by blood-borne pathogens to escape complement lysis. Unlike the bloodstream stages, the ...

journal_title：PLoS neglected tropical diseases

authors： Ooi CP,Haines LR,Southern DM,Lehane MJ,Acosta-Serrano A

更新日期：2015-01-08 00:00:00

abstract：:Benzimidazole anthelmintics have long been employed for the control of soil-transmitted helminth infections. Flubendazole (FBZ) was approved in 1980 for the treatment of gastrointestinal nematode infections in both veterinary and human medicine. It has also long been known that parenteral administration of FBZ can lea...

journal_title：PLoS neglected tropical diseases

authors： Geary TG,Mackenzie CD,Silber SA

更新日期：2019-01-16 00:00:00

abstract：BACKGROUND:Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/Cas9 technology has rapidly emerged as a very effective tool for gene editing. Although great advances on gene editing in the medical entomology field have arisen, no attempts of gene editing have been reported in sand flies, the vectors of L...

journal_title：PLoS neglected tropical diseases

authors： Martin-Martin I,Aryan A,Meneses C,Adelman ZN,Calvo E

更新日期：2018-09-04 00:00:00

abstract：:The yellow fever vaccines (YF-17D-204 and 17DD) are considered to be among the safest vaccines and the presence of neutralizing antibodies is correlated with protection, although other immune effector mechanisms are known to be involved. T-cell responses are known to play an important role modulating antibody producti...

journal_title：PLoS neglected tropical diseases

authors： de Melo AB,Nascimento EJ,Braga-Neto U,Dhalia R,Silva AM,Oelke M,Schneck JP,Sidney J,Sette A,Montenegro SM,Marques ET

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Epidemics of meningococcal meningitis (MM) recurrently strike the African Meningitis Belt. This study aimed at investigating factors, still poorly understood, that influence annual incidence of MM serogroup A, the main etiologic agent over 2004-2010, at a fine spatial scale in Niger. METHODOLOGY/PRINCIPAL F...

journal_title：PLoS neglected tropical diseases

authors： Paireau J,Maïnassara HB,Jusot JF,Collard JM,Idi I,Moulia-Pelat JP,Mueller JE,Fontanet A

更新日期：2014-05-22 00:00:00

abstract：:Rift Valley fever virus is an arbovirus that affects both livestock and humans throughout Africa and in the Middle East. Despite its endemicity throughout Africa, it is a rare event to identify an infected individual during the acute phase of the disease and an even rarer event to collect serial blood samples from the...

journal_title：PLoS neglected tropical diseases

authors： de St Maurice A,Harmon J,Nyakarahuka L,Balinandi S,Tumusiime A,Kyondo J,Mulei S,Namutebi A,Knust B,Shoemaker T,Nichol ST,McElroy AK,Spiropoulou CF

更新日期：2018-05-04 00:00:00

abstract：BACKGROUND:French Guiana is a territory that has a decades-long history of dengue outbreaks and more recently, in 2014, a chikungunya outbreak. Zika virus (ZIKV) emerged in late 2015 and subsequently led to an important outbreak. METHODOLOGY/PRINCIPAL FINDINGS:A cross-sectional phone survey was conducted among the gen...

journal_title：PLoS neglected tropical diseases

authors： Fritzell C,Raude J,Kazanji M,Flamand C

更新日期：2018-01-25 00:00:00

abstract：BACKGROUND:Socioeconomically deprived children are at increased risk of ill-health associated with sedentary behavior, malnutrition, and helminth infection. The resulting reduced physical fitness, growth retardation, and impaired cognitive abilities may impede children's capacity to pay attention. The present study exa...

journal_title：PLoS neglected tropical diseases

authors： Gall S,Müller I,Walter C,Seelig H,Steenkamp L,Pühse U,du Randt R,Smith D,Adams L,Nqweniso S,Yap P,Ludyga S,Steinmann P,Utzinger J,Gerber M

更新日期：2017-05-08 00:00:00

abstract：BACKGROUND:Morbidity due to Schistosoma haematobium and hookworm infections is marked in those with intense co-infections by these parasites. The development of a spatial predictive decision-support tool is crucial for targeting the delivery of integrated mass drug administration (MDA) to those most in need. We investi...

journal_title：PLoS neglected tropical diseases

authors： Soares Magalhães RJ,Biritwum NK,Gyapong JO,Brooker S,Zhang Y,Blair L,Fenwick A,Clements AC

更新日期：2011-06-01 00:00:00

abstract：BACKGROUND:African trypanosomosis, primarily transmitted by tsetse flies, remains a serious public health and economic challenge in sub-Saharan Africa. Interventions employing natural repellents from non-preferred hosts of tsetse flies represent a promising management approach. Although zebras have been identified as n...

journal_title：PLoS neglected tropical diseases

authors： Olaide OY,Tchouassi DP,Yusuf AA,Pirk CWW,Masiga DK,Saini RK,Torto B

更新日期：2019-06-10 00:00:00

abstract：:Chromoblastomycosis (CBM) is a chronic, progressive, cutaneous and subcutaneous fungal infection following the traumatic implantation of certain dematiaceous fungi. The disease has worldwide prevalence with predominant cases reported from humid tropical and subtropical regions of America, Asia, and Africa. Diagnosis i...

journal_title：PLoS neglected tropical diseases

authors： Agarwal R,Singh G,Ghosh A,Verma KK,Pandey M,Xess I

更新日期：2017-08-03 00:00:00

abstract：:In this communication, a case of black grain eumycetoma produced by the fungus C. atrobrunneum is reported. The patient was initially misdiagnosed with M. mycetomatis eumycetoma based on the grains' morphological and cytological features. However, further aerobic culture of the black grains generated a melanised fungu...

journal_title：PLoS neglected tropical diseases

authors： Mhmoud NA,Santona A,Fiamma M,Siddig EE,Deligios M,Bakhiet SM,Rubino S,Fahal AH

更新日期：2019-05-30 00:00:00

abstract：BACKGROUND:China has the highest incidence of hemorrhagic fever with renal syndrome (HFRS) worldwide. Reported cases account for 90% of the total number of global cases. By 2010, approximately 1.4 million HFRS cases had been reported in China. This study aimed to explore the effect of the rodent reservoir, and natural ...

journal_title：PLoS neglected tropical diseases

authors： Xiao H,Tian HY,Gao LD,Liu HN,Duan LS,Basta N,Cazelles B,Li XJ,Lin XL,Wu HW,Chen BY,Yang HS,Xu B,Grenfell B

更新日期：2014-01-09 00:00:00

abstract：:Enterotoxigenic Escherichia coli (ETEC) is one of the most common diarrheal pathogens in the low- and middle-income regions of the world, however a systematic examination of the genomic content of isolates from Chile has not yet been undertaken. Whole genome sequencing and comparative analysis of a collection of 125 E...

journal_title：PLoS neglected tropical diseases

authors： Rasko DA,Del Canto F,Luo Q,Fleckenstein JM,Vidal R,Hazen TH

更新日期：2019-11-20 00:00:00

abstract：:Host and parasite gene expression in skin biopsies from Leishmania braziliensis-infected patients were simultaneously analyzed using high throughput RNA-sequencing. Biopsies were taken from 8 patients with early cutaneous leishmaniasis and 17 patients with late cutaneous leishmaniasis. Although parasite DNA was found ...

journal_title：PLoS neglected tropical diseases

authors： Christensen SM,Dillon LA,Carvalho LP,Passos S,Novais FO,Hughitt VK,Beiting DP,Carvalho EM,Scott P,El-Sayed NM,Mosser DM

更新日期：2016-09-15 00:00:00

abstract：BACKGROUND:The parasite Onchocerca volvulus has, until recently, been regarded as the cause of a chronic yet non-fatal condition. Recent analyses, however, have indicated that in addition to blindness, the parasite can also be directly associated with human mortality. Such analyses also suggested that the relationship ...

journal_title：PLoS neglected tropical diseases

authors： Walker M,Little MP,Wagner KS,Soumbey-Alley EW,Boatin BA,Basáñez MG

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Hantaan virus (HTNV) causes a severe lethal haemorrhagic fever with renal syndrome (HFRS) in humans. Despite a limited understanding of the pathogenesis of HFRS, the importance of the abundant production of pro-inflammatory cytokines has been widely recognized. Interleukin 33 (IL-33) has been demonstrated to...

journal_title：PLoS neglected tropical diseases

authors： Zhang Y,Zhang C,Zhuang R,Ma Y,Zhang Y,Yi J,Yang A,Jin B

更新日期：2015-02-06 00:00:00

abstract：:The burden of leptospirosis in humans and animals in Africa is higher than that reported from other parts of the world. However, the disease is not routinely diagnosed in the continent. One of major factors limiting diagnosis is the poor availability of live isolates of locally circulating Leptospira serovars for incl...

journal_title：PLoS neglected tropical diseases

authors： Mgode GF,Machang'u RS,Mhamphi GG,Katakweba A,Mulungu LS,Durnez L,Leirs H,Hartskeerl RA,Belmain SR

更新日期：2015-12-01 00:00:00

abstract：INTRODUCTION:Yaws is endemic in Ghana. The World Health Organization (WHO) has launched a new global eradication campaign based on total community mass treatment with azithromycin. Achieving high coverage of mass treatment will be fundamental to the success of this new strategy; coverage is dependent, in part, on appro...

journal_title：PLoS neglected tropical diseases

authors： Marks M,Kwakye-Maclean C,Doherty R,Adwere P,Aziz Abdulai A,Duah F,Ohene SA,Mitja O,Oguti B,Solomon AW,Mabey DCW,Adu-Sarkodie Y,Asiedu K,Ackumey MM

更新日期：2017-07-31 00:00:00

abstract：:Tick-borne rickettsioses are world-spreading infectious zoonoses. Ticks serve as reservoirs and vectors for Rickettsia and play a key role in transmission of rickettsioses. Most of the Chinese rickettsiosis patients are reported from Northeastern China but the distribution of tick and tick-borne Rickettsia species in ...

journal_title：PLoS neglected tropical diseases

authors： Shao JW,Zhang XL,Li WJ,Huang HL,Yan J

更新日期：2020-06-04 00:00:00