Abstract：
OBJECTIVE:To provide a systematic review of the clinical and radiological features of lesion-induced central positional nystagmus (CPN) and identify salient characteristics that differentiate central from peripheral positional nystagmus (PN). METHODS:Systematic literature search according to the preferred reporting items for systematic reviews and meta-analysis. RESULTS:A total of 82 patients from 28 studies met the participants intervention, comparison, outcomes, and study designs criteria for inclusion. An atypical direction of nystagmus for the stimulated canal was reported in 97.5% patients during Dix-Hallpike (D-H) and 54.5% upon supine roll testing. Five types of CPNs were identified during positional testing: positional horizontal nystagmus (pHN) (36.8%), positional downbeating nystagmus (pDBN) (29.2%), positional torsional nystagmus (pTN) (2.1%), positional upbeating nystagmus (pUBN) (2.1%), and a combination of the four profiles (29.9%). CPN was paroxysmal (<60 s) in 85% patients on straight head hanging (SHH), 63.9% on D-H, and 37.5% on supine roll, and had a latency <3 s upon positioning in 94.7% patients in which it was reported. Concurrent vertigo was reportedly present in 63.4% patients and 48.8% demonstrated other neurological signs. Radiologically, in 74.4%, there was mention of cerebellar involvement, isolated brainstem involvement in 8.5%, and 14.6% involved the fourth ventricle. CONCLUSION:Currently, there is a lack of robust data on the clinical and radiological characteristics of CPN highlighting the need for better phenotyping of CPN to help differentiate this entity from peripheral causes of PN. With increased awareness of CPN, particularly in the acute setting, we may see a change in the estimated prevalence of CPN and improved clinical markers to promptly identify the frequently sinister underlying causes.
journal_name
Front Neuroljournal_title
Frontiers in neurologyauthors
Macdonald NK,Kaski D,Saman Y,Al-Shaikh Sulaiman A,Anwer A,Bamiou DEdoi
10.3389/fneur.2017.00141subject
Has Abstractpub_date
2017-04-20 00:00:00pages
141issn
1664-2295journal_volume
8pub_type
杂志文章,评审abstract：:Humans evolved a symbiotic relationship with their gut microbiome, a complex microbial community composed of bacteria, archaea, protists, and viruses, including bacteriophages. The enteric nervous system (ENS) is a gateway for the bidirectional communication between the brain and the gut, mostly through the vagus nerv...
journal_title：Frontiers in neurology
pub_type： 杂志文章,评审
doi：10.3389/fneur.2019.00574
更新日期：2019-06-04 00:00:00
abstract：:This study was undertaken to demonstrate the vascular protection of exogenous and endogenous hydrogen sulfide (H2S) on cerebral ischemia/reperfusion (I/R) injury. The effect of H2S on cerebrovascular dysfunction in middle cerebral artery (MCA) and neuronal damage were measured after cerebral I/R induced by transient m...
journal_title：Frontiers in neurology
pub_type： 杂志文章
doi：10.3389/fneur.2018.00779
更新日期：2018-10-19 00:00:00
abstract：:Different subtypes of Alzheimer's disease (AD) with characteristic distributions of neurofibrillary tangles and corresponding brain atrophy patterns have been identified using structural magnetic resonance imaging (MRI). However, the underlying biological mechanisms that determine this differential expression of neuro...
journal_title：Frontiers in neurology
pub_type： 杂志文章
doi：10.3389/fneur.2019.00524
更新日期：2019-05-28 00:00:00
abstract：:We report a case of spontaneous intracerebral hemorrhage (sICH) due to delta storage pool disease in a 60-year-old female on a serotonin-norepinephrine reuptake inhibitor (SNRI). Increased susceptibility to SNRI-effects on hemostasis was due to a genetic disposition mediated by a polymorphism of the SLC6A4 gene coding...
journal_title：Frontiers in neurology
pub_type：
doi：10.3389/fneur.2019.01257
更新日期：2019-11-26 00:00:00
abstract：:To investigate the usefulness of pain-related evoked potentials (PREP) elicited by electrical stimulation for the identification of small fiber involvement in patients with mixed fiber neuropathy (MFN). Eleven MFN patients with clinical signs of large fiber impairment and neuropathic pain and ten healthy controls unde...
journal_title：Frontiers in neurology
pub_type： 杂志文章
doi：10.3389/fneur.2015.00244
更新日期：2015-12-07 00:00:00
abstract：:Introduction: Today, half of the American homeless population is older than 50 years of age. This shift in age distribution among people experiencing homelessness has challenged our long-held views of the causes of homelessness. Age-related neurological diseases, especially neurodegenerative diseases of the brain (NDD...
journal_title：Frontiers in neurology
pub_type： 杂志文章
doi：10.3389/fneur.2020.562218
更新日期：2021-01-13 00:00:00
abstract：BACKGROUND:Accurate recognition of stroke symptoms by Emergency Medical Services (EMS) is necessary for timely care of acute stroke patients. We assessed the accuracy of stroke diagnosis by EMS in clinical practice in a major US city. METHODS AND RESULTS:Philadelphia Fire Department data were merged with data from a s...
journal_title：Frontiers in neurology
pub_type： 杂志文章
doi：10.3389/fneur.2017.00466
更新日期：2017-09-14 00:00:00
abstract：:Background and Purpose: Stroke-related functional risk scores are used to predict patients' functional outcomes following a stroke event. We evaluate the predictive accuracy of machine-learning algorithms for predicting functional outcomes in acute ischemic stroke patients after endovascular treatment. Methods: Data w...
journal_title：Frontiers in neurology
pub_type： 杂志文章
doi：10.3389/fneur.2020.00889
更新日期：2020-08-25 00:00:00
abstract：:Epilepsy is a common neurological disorder that affects over 70 million people worldwide. Despite the recent introduction of new antiseizure drugs (ASDs), about one-third of patients with epilepsy have seizures refractory to pharmacotherapy. Early identification of patients who will become refractory to ASDs could hel...
journal_title：Frontiers in neurology
pub_type： 杂志文章,评审
doi：10.3389/fneur.2017.00301
更新日期：2017-07-06 00:00:00
abstract：:Thyroid hormones are of fundamental importance for brain development and essential factors to warrant brain functions throughout life. Their actions are mediated by binding to specific intracellular and membranous receptors regulating genomic and non-genomic mechanisms in neurons and populations of glial cells, respec...
journal_title：Frontiers in neurology
pub_type： 杂志文章,评审
doi：10.3389/fneur.2019.01103
更新日期：2019-10-18 00:00:00
abstract：Background:Visual impairment affects up to 70% of stroke survivors. We designed an app (StrokeVision) to facilitate screening for common post stroke visual issues (acuity, visual fields, and visual inattention). We sought to describe the test time, feasibility, acceptability, and accuracy of our app-based digital visua...
journal_title：Frontiers in neurology
pub_type： 杂志文章
doi：10.3389/fneur.2018.00146
更新日期：2018-03-28 00:00:00
abstract：:Aims: To investigate the relationship between clinical and imaging features of stroke patients with patent foramen ovale (PFO) and those with spontaneous intracranial artery dissection (SIAD). Materials and methods: We retrospectively examined both clinical and imaging results of 40 stroke patients with PFO and 29 wit...
journal_title：Frontiers in neurology
pub_type： 杂志文章
doi：10.3389/fneur.2019.00418
更新日期：2019-04-24 00:00:00
abstract：:Stroke is becoming one of the leading causes of adult disability and death in sub-Saharan African countries. The aim of the present study is to provide an up-to-date account of the clinical and demographic characteristics of patients with stroke admitted to the University of Gondar College of Medicine and Health Scien...
journal_title：Frontiers in neurology
pub_type： 杂志文章
doi：10.3389/fneur.2020.00428
更新日期：2020-05-19 00:00:00
abstract：:Hereditary spastic paraplegias (HSPs) are a heterogeneous group of genetic disorders with spastic paraparesis as the main clinical feature. Complex forms may co-occur with other motor, sensory, and cognitive impairment. A growing number of loci and genes are being identified, but still more than 50% of the patients re...
journal_title：Frontiers in neurology
pub_type：
doi：10.3389/fneur.2020.00041
更新日期：2020-02-14 00:00:00
abstract：:Objective: To determine whether performance in a virtual spatial navigational task is poorer in persistent postural perceptual dizziness (PPPD) patients than in healthy volunteers and patients suffering other vestibular disorders. Methods: Subjects were asked to perform three virtual Morris water maze spatial navigati...
journal_title：Frontiers in neurology
pub_type： 杂志文章
doi：10.3389/fneur.2019.01361
更新日期：2020-01-09 00:00:00
abstract：:Background: There is very limited information on the relationship between non-alcoholic fatty liver disease (NAFLD) and the severity or functional outcomes of ischemic stroke or transient ischemic stroke (TIA). We investigated the correlation between NAFLD and stroke outcomes. Methods: NAFLD was assessed in 321 patien...
journal_title：Frontiers in neurology
pub_type： 杂志文章
doi：10.3389/fneur.2019.00375
更新日期：2019-04-12 00:00:00
abstract：:There is increasing evidence that neuroplastic changes can occur even years after spinal cord injury, leading to reduced disability and better health which should reduce the cost of healthcare. In motor-incomplete spinal cord injury, recovery of leg function may occur if repetitive training causes afferent input to th...
journal_title：Frontiers in neurology
pub_type： 杂志文章,评审
doi：10.3389/fneur.2020.00607
更新日期：2020-06-30 00:00:00
abstract：OBJECTIVE:To perform two scoping systematic reviews of the literature on cytokine measurement in: 1. cerebral microdialysis (CMD) and 2. cerebrospinal fluid (CSF) in severe traumatic brain injury (TBI) patients. METHODS:Two separate systematic reviews were conducted: one for CMD cytokines and the second for CSF cytoki...
journal_title：Frontiers in neurology
pub_type： 杂志文章,评审
doi：10.3389/fneur.2017.00331
更新日期：2017-07-10 00:00:00
abstract：:Spontaneous intracerebral hemorrhage (SICH) is the most lethal type of stroke. Half of these deaths occur within the acute phase. Frequently observed deterioration during the acute phase is often due to rebleeding or peri-hematomal expansion. The exact pathogenesis that leads to rebleeding or peri-hemorrhagic edema re...
journal_title：Frontiers in neurology
pub_type： 杂志文章,评审
doi：10.3389/fneur.2017.00004
更新日期：2017-01-19 00:00:00
abstract：:The interaction of Mesial Temporal Lobe Epilepsy (mTLE) with the circadian system control is apparent from an oscillatory pattern of limbic seizures, daytime's effect on seizure onset and the efficacy of antiepileptic drugs. Moreover, seizures per se can interfere with the biological rhythm output, including circadian...
journal_title：Frontiers in neurology
pub_type： 杂志文章
doi：10.3389/fneur.2018.00632
更新日期：2018-08-02 00:00:00
abstract：:Purpose: Stroke-associated pneumonia (SAP), a common complication in acute ischemic stroke (AIS) patients, is associated with poor prognosis after AIS. Inflammation plays an important role in the development of SAP. In this study, we aimed to explore the association between the monocyte-to-lymphocyte ratio (MLR) and S...
journal_title：Frontiers in neurology
pub_type： 杂志文章
doi：10.3389/fneur.2020.575809
更新日期：2020-10-06 00:00:00
abstract：:Melanopsin retinal ganglion cells (mRGCs) are intrinsically photosensitive RGCs that mediate many relevant non-image forming functions of the eye, including the pupillary light reflex, through the projections to the olivary pretectal nucleus. In particular, the post-illumination pupil response (PIPR), as evaluated by ...
journal_title：Frontiers in neurology
pub_type： 杂志文章,评审
doi：10.3389/fneur.2018.01047
更新日期：2018-12-07 00:00:00
abstract：:Traumatic brain injury (TBI) and subarachnoid hemorrhage (SAH) are major contributors to morbidity and mortality. Following the initial insult, patients may deteriorate due to secondary brain damage. The underlying molecular and cellular cascades incorporate components of the innate immune system. There are different ...
journal_title：Frontiers in neurology
pub_type： 杂志文章,评审
doi：10.3389/fneur.2017.00351
更新日期：2017-07-20 00:00:00
abstract：:The purpose of the study was to test the utility of unique panel of blood biomarkers as a means to reflect one's recovery process after sport-related neurotrauma. We established a panel of biomarkers that reacted positive with CD81 (extracellular vesicle marker) and various neuron- and glia-specific antigens [e.g., ne...
journal_title：Frontiers in neurology
pub_type： 杂志文章
doi：10.3389/fneur.2018.00239
更新日期：2018-04-12 00:00:00
abstract：:Resting-state imaging designs are powerful in modeling functional networks in movement disorders because they eliminate task performance related confounds. However, the most common metric for quantifying functional connectivity, i.e., bivariate magnitude coherence (Coh), can sometimes be contaminated by spurious corre...
journal_title：Frontiers in neurology
pub_type： 杂志文章
doi：10.3389/fneur.2013.00149
更新日期：2013-10-10 00:00:00
abstract：:Previous studies have suggested that the corticoreticular tract (CRT) has an important role in motor function almost next to the corticospinal tract (CST) in the human brain. Herein, the CRT is reviewed with regard to its anatomy, function, and recovery mechanisms after injury, with particular focus on previous diffus...
journal_title：Frontiers in neurology
pub_type： 杂志文章,评审
doi：10.3389/fneur.2019.01188
更新日期：2019-11-12 00:00:00
abstract：:Cerebral venous sinus thrombosis (CVST) is a relatively uncommon cause of stroke more often affecting women and younger individuals. Blockage of the venous outflow rapidly causes edema and space-occupying venous infarctions and it seems intuitive that decompressive craniectomy (DC) can effectively reduce intracranial ...
journal_title：Frontiers in neurology
pub_type： 杂志文章,评审
doi：10.3389/fneur.2019.00511
更新日期：2019-05-15 00:00:00
abstract：:Background: The bidirectional interaction between the gut and brain after stroke through the immune-mediated pathway has been studied. However, the long-term effects of gut microbiota and systemic immune homeostasis after cerebral ischemia remain unclear. We examined long-term changes in the gut microbiota and systemi...
journal_title：Frontiers in neurology
pub_type： 杂志文章
doi：10.3389/fneur.2019.00661
更新日期：2019-06-28 00:00:00
abstract：:Background: Listeria rhombencephalitis, infection of the brainstem with Listeria monocytogenes, occurs mainly in humans and farmed ruminants and is associated with high fatality rates. Small ruminants (goats and sheep) are a large animal model due to neuropathological similarities. The purpose of this study was to def...
journal_title：Frontiers in neurology
pub_type： 杂志文章
doi：10.3389/fneur.2020.518697
更新日期：2020-12-14 00:00:00
abstract：:[This corrects the article DOI: 10.3389/fneur.2019.00129.]. ...
journal_title：Frontiers in neurology
pub_type： 杂志文章,已发布勘误
doi：10.3389/fneur.2019.00371
更新日期：2019-03-27 00:00:00
