Persistence of Gut Microbiota Dysbiosis and Chronic Systemic Inflammation After Cerebral Infarction in Cynomolgus Monkeys.

abstract：:Tau accumulation is a prominent feature in a variety of neurodegenerative disorders and remarkable effort has been expended working out the biochemistry and cell biology of this cytoplasmic protein. Tau's wayward properties may derive from germline mutations in the case of frontotemporal lobar degeneration (FTLD-MAPT)...

journal_title：Frontiers in neurology

authors： Kang SG,Eskandari-Sedighi G,Hromadkova L,Safar JG,Westaway D

更新日期：2020-11-12 00:00:00

abstract：:Introduction: Myelin oligodendrocyte glycoprotein-immunoglobulin G (MOG-IgG)-related disease was initially described as a subtype of neuromyelitis optica spectrum disorder (NMOSD) with antibodies against MOG. However, it has recently been described as a separate disease entity with clinical and radiological features t...

journal_title：Frontiers in neurology

authors： Alshamrani F,Alnajashi H,Shosha E,Casserly C,Morrow SA

更新日期：2020-02-26 00:00:00

abstract：:Objectives: Elevated neurofilament light chain (NFL) levels within the cerebrospinal fluid (CSF) are a biomarker representing axonal neurodegeneration in rapid progressive neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS). It is unclear to what extent the levels of NFL increase in the CSF (CSF-NFL...

journal_title：Frontiers in neurology

authors： Pawlitzki M,Schreiber S,Bittner D,Kreipe J,Leypoldt F,Rupprecht K,Carare RO,Meuth SG,Vielhaber S,Körtvélyessy P

更新日期：2018-12-14 00:00:00

abstract：:Thalamotomy at the ventralis intermedius nucleus has been an effective treatment method for essential tremor, but how the brain network changes immediately responding to this deliberate lesion and then reorganizes afterwards are not clear. Taking advantage of a non-cranium-opening MRI-guided focused ultrasound ablatio...

journal_title：Frontiers in neurology

authors： Jang C,Park HJ,Chang WS,Pae C,Chang JW

更新日期：2016-10-24 00:00:00

abstract：:The dopamine (DA) precursor l-DOPA has been the most effective treatment for Parkinson's disease (PD) for over 40 years. However, the response to this treatment changes with disease progression, and most patients develop dyskinesias (abnormal involuntary movements) and motor fluctuations within a few years of l-DOPA t...

journal_title：Frontiers in neurology

authors： Cenci MA

更新日期：2014-12-15 00:00:00

abstract：:Objective: The platelet-to-lymphocyte ratio (PLR) is a new marker of atherosclerotic inflammation and has been identified as a predictive factor in cardiovascular diseases, but its significance in patients with acute ischaemic stroke (AIS) who have undergone intravenous thrombolysis (IVT) is still unknown. Methods: Co...

journal_title：Frontiers in neurology

authors： Xu JH,He XW,Li Q,Liu JR,Zhuang MT,Huang FF,Bao GS

更新日期：2019-11-13 00:00:00

abstract：:The developmental vulnerability of different classes of axonal pathways in preterm white matter is not known. We propose that laminar compartments of the developing cerebral wall serve as spatial framework for axonal growth and evaluate potential of anatomical landmarks for understanding reorganization of the cerebral...

journal_title：Frontiers in neurology

authors： Kostović I,Kostović-Srzentić M,Benjak V,Jovanov-Milošević N,Radoš M

更新日期：2014-07-29 00:00:00

abstract：:Background: Overweight contributes to type 2 diabetes mellitus (T2DM) development. Although the obesity paradox has been suggested in many vascular diseases, little information is available about stroke patients with T2DM. We investigated whether body mass index (BMI) has a differential impact on the incidence of majo...

journal_title：Frontiers in neurology

authors： Park H,Lee HW,Yoo J,Lee HS,Nam HS,Kim YD,Heo JH

更新日期：2019-06-05 00:00:00

abstract：:Objective: Lipohyalinosis or atherosclerosis might be responsible for single subcortical infarctions (SSIs); however, ways of differentiating between the two clinically remain uncertain. We aimed to investigate whether consecutive slides on axial view or transversal diameter is more effective to differentiate mechanis...

journal_title：Frontiers in neurology

authors： Cao Y,Zhang M,Zhou L,Yao M,Peng B,Zhu Y,Ni J,Cui L

更新日期：2019-04-09 00:00:00

abstract：:Cerebral ischemia is the leading cause of morbidity and mortality following aneurysmal subarachnoid hemorrhage (SAH). Although 70% of the patients show angiographic vasospasm only 30% develop symptomatic vasospasm defined as delayed cerebral ischemia (DCI). Early detection and management of reversible ischemia is of c...

journal_title：Frontiers in neurology

authors： Rostami E,Engquist H,Johnson U,Howells T,Ronne-Engström E,Nilsson P,Hillered L,Lewén A,Enblad P

更新日期：2014-06-02 00:00:00

abstract：:Cocaine use is associated with the transmission of human immunodeficiency (HIV) virus through risky sexual behavior. In HIV+ individuals, cocaine use is linked with poor health outcomes, including HIV-medication non-adherence and faster disease progression. Both HIV and cocaine dependence are associated with reduced i...

journal_title：Frontiers in neurology

authors： Wakim KM,Molloy CJ,Bell RP,Ross LA,Foxe JJ

更新日期：2017-10-31 00:00:00

abstract：:Here, we describe a 79-year-old man, admitted to our unit for worsening diplopia and fatigue, started a few weeks after an episode of bronchitis and flu vaccination. Past medical history includes myasthenia gravis (MG), well-controlled by Pyridostigmine, Azathioprine, and Prednisone. During the first days, the patient...

journal_title：Frontiers in neurology

authors： Brusa R,Faravelli I,Gagliardi D,Magri F,Cogiamanian F,Saccomanno D,Cinnante C,Mauri E,Abati E,Bresolin N,Corti S,Comi GP

更新日期：2019-08-13 00:00:00

abstract：:This study describes two experiments that were conducted in search for a behavioral paradigm to test for tinnitus in guinea pigs. Conditioning paradigms are available to determine the presence of tinnitus in animals and are based on the assumption that tinnitus impairs their ability to detect silent intervals in conti...

journal_title：Frontiers in neurology

authors： Heeringa AN,Agterberg MJ,van Dijk P

更新日期：2014-10-15 00:00:00

abstract：OBJECTIVE:Evaluate medical students' communication and professionalism skills from the perspective of the ambulatory patient and later compare these skills in their first year of residency. METHODS:Students in third year neurology clerkship clinics see patients alone followed by a revisit with an attending neurologist...

journal_title：Frontiers in neurology

authors： Davis LE,King MK,Wayne SJ,Kalishman SG

更新日期：2012-06-20 00:00:00

abstract：OBJECTIVE:To perform two scoping systematic reviews of the literature on cytokine measurement in: 1. cerebral microdialysis (CMD) and 2. cerebrospinal fluid (CSF) in severe traumatic brain injury (TBI) patients. METHODS:Two separate systematic reviews were conducted: one for CMD cytokines and the second for CSF cytoki...

journal_title：Frontiers in neurology

authors： Zeiler FA,Thelin EP,Czosnyka M,Hutchinson PJ,Menon DK,Helmy A

更新日期：2017-07-10 00:00:00

abstract：:Background: The causal relationship between serum lipid levels and the risk of Parkinson's disease (PD) remains largely uncertain. We summarized the existing controversial evidence on this topic. Methods: We searched the electronic databases for observational studies from January 1988 to March 2020. We applied random-...

journal_title：Frontiers in neurology

authors： Jiang Z,Xu X,Gu X,Ou R,Luo X,Shang H,Song W

更新日期：2020-06-26 00:00:00

abstract：:Objective: To report a rare case of brainstem encephalitis with low-titer acetylcholine receptor antibodies mimicking myasthenia gravis. Methods: The patient was investigated with repeated brain MRI, CSF examination, repetitive nerve stimulation, thoracic CT, and serologic screening. Our patient passed away and finall...

journal_title：Frontiers in neurology

authors： Ayzenberg I,Ellrichmann G,Schroeder C,Tönges L,Klasing A,Pappa V,Brück W,Gold R

更新日期：2019-08-02 00:00:00

abstract：:Traumatic brain injury is the leading cause of death in children. Children with severe TBI are in need of neurointensive care where the goal is to prevent secondary brain injury by avoiding secondary insults. Monitoring of cerebral blood flow (CBF) and autoregulation in the injured brain is crucial. However, there are...

journal_title：Frontiers in neurology

authors： Rostami E,Nilsson P,Enblad P

更新日期：2020-04-16 00:00:00

abstract：:Background: Spinocerebellar ataxia type 3/Machado-Joseph disease (SCA3/MJD) is one of the nine polyglutamine (polyQ) diseases and is caused by a CAG repeat expansion within the coding sequence of the ATXN3 gene. Few multimodal imaging analyses of the macro- and micro-structural changes have been performed. Methods: In...

journal_title：Frontiers in neurology

authors： Peng H,Liang X,Long Z,Chen Z,Shi Y,Xia K,Meng L,Tang B,Qiu R,Jiang H

更新日期：2019-09-24 00:00:00

abstract：:Introduction: Mutations in the Parkin gene are the most common cause of autosomal recessive early-onset Parkinson's disease (PD). However, little is known about the quality of life (QoL) in Parkin-related PD. Here, we investigated the patterns of QoL in newly diagnosed Parkin-related PD patients. Methods: Newly diagno...

journal_title：Frontiers in neurology

authors： Zhou XY,Liu FT,Chen C,Luo SS,Zhao J,Tang YL,Shen B,Yu WB,Zuo CT,Wu JJ,Ding ZT,Wang J,Sun YM

更新日期：2020-12-18 00:00:00

abstract：:Ictal fear-a relatively rare phenomenon-is a semiological characteristic of epilepsy. Most patients with epilepsy with ictal fear have an epileptic zone in the mesial temporal lobe, which is the classical brain area involved in emotion processing. Herein, we report a case of epilepsy with ictal fear as the first manif...

journal_title：Frontiers in neurology

authors： Wang J,Wang Q,Wang M,Luan G,Zhou J,Guan Y,Yan Z

更新日期：2018-08-07 00:00:00

abstract：:Background: Ischemic cerebral infarction is a severe clinical condition that can cause serious mortality. Artesunate, an anti-malarial drug that is widely used in cancer treatment, is known to facilitate accelerated cell apoptosis. The aim of this study is to explore the possible neuroprotective effects of artesunate ...

journal_title：Frontiers in neurology

authors： Shao M,Shen Y,Sun H,Meng D,Huo W,Qi X

更新日期：2018-08-17 00:00:00

abstract：:Objective: To investigate the effects of low frequency transcranial magnetic stimulation (LF-rTMS) combined with motor imagery (MI) on upper limb motor function during stroke rehabilitation. Background: Hemiplegic upper extremity activity obstacle is a common movement disorder after stroke. Compared with a single inte...

journal_title：Frontiers in neurology

authors： Pan W,Wang P,Song X,Sun X,Xie Q

更新日期：2019-02-19 00:00:00

abstract：:Functional magnetic resonance imaging studies suggest that different subcortico-cortical circuits control different aspects of Parkinsonian rest tremor. The basal ganglia were proposed to drive tremor onset, and the cerebellum was suggested to be responsible for tremor maintenance ("dimmer-switch" hypothesis). Althoug...

journal_title：Frontiers in neurology

authors： Hirschmann J,Abbasi O,Storzer L,Butz M,Hartmann CJ,Wojtecki L,Schnitzler A

更新日期：2019-03-07 00:00:00

abstract：:Background: Recent studies have shown that renal disease is associated with magnetic resonance imaging (MRI) markers of cerebral small vessel disease (CSVD), independent of traditional vascular risk factors. Although large artery lesions might be involved in the cerebrorenal association, evidence has been lacking. Met...

journal_title：Frontiers in neurology

authors： Ao DH,Zhai FF,Han F,Zhou LX,Ni J,Yao M,Zhang DD,Li ML,Fan XH,Jin ZY,Cui LY,Zhang SY,Zhu YC

更新日期：2018-06-26 00:00:00

abstract：:Hemiconvulsion-hemiplegia-epilepsy syndrome (HHE) is a rare outcome of prolonged hemiconvulsion that is followed by diffuse unilateral hemispheric edema, hemiplegia, and ultimately hemiatrophy of the affected hemisphere and epilepsy. Here, we describe the case of a 3-year-old male with a 1;3 translocation leading to a...

journal_title：Frontiers in neurology

authors： Robinson JE,Wolfe SM,Kaiser-Rogers K,Greenwood RS

更新日期：2016-05-04 00:00:00

abstract：:Introduction: Although patients with Parkinson's disease (PD) often suffer from oropharyngeal dysphagia, knowledge about the underlying pathophysiological mechanisms is limited. Substance P (SP) is a localization-independent neurotransmitter of the entire nervous system. Reduced levels of SP were found in saliva of pa...

journal_title：Frontiers in neurology

authors： Schröder JB,Marian T,Claus I,Muhle P,Pawlowski M,Wiendl H,Suntrup-Krueger S,Meuth SG,Dziewas R,Ruck T,Warnecke T

更新日期：2019-04-16 00:00:00

abstract：:Multiple sclerosis (MS) pathology progressively affects multiple central nervous system (CNS) areas. Due to this fact, MS produces a wide array of symptoms. Symptomatic therapy of one MS symptom can cause or worsen other unwanted symptoms (anticholinergics used for bladder dysfunction produce impairment of cognition, ...

journal_title：Frontiers in neurology

authors： Fernández Ó,Costa-Frossard L,Martínez-Ginés M,Montero P,Prieto JM,Ramió L

更新日期：2020-03-17 00:00:00

abstract：Background:Wernicke's encephalopathy (WE), a metabolic disorder due to thiamine deficiency, manifests with various neurological symptoms and signs. It has been known as a cause of vestibular dysfunction. Preliminary reports have proposed predominant involvement of the horizontal semicircular canals (HSCs). Objective:T...

journal_title：Frontiers in neurology

authors： Lee SH,Kim SH,Kim JM,Tarnutzer AA

更新日期：2018-03-12 00:00:00

abstract：:Neurosyphilis, which is caused by Treponema pallidum, is a rare sexually transmitted disease involving the central nervous system (CNS). Among all the sub-categories, spinal syphilitic gumma is extremely rare. In previous literature, limited cases of spinal syphilitic gumma have been reported, most of which underwent ...

journal_title：Frontiers in neurology

authors： Cui L,Xu Z,Hou H

更新日期：2020-01-15 00:00:00