Rhythms of Core Clock Genes and Spontaneous Locomotor Activity in Post-Status Epilepticus Model of Mesial Temporal Lobe Epilepsy.

Abstract:

:The interaction of Mesial Temporal Lobe Epilepsy (mTLE) with the circadian system control is apparent from an oscillatory pattern of limbic seizures, daytime's effect on seizure onset and the efficacy of antiepileptic drugs. Moreover, seizures per se can interfere with the biological rhythm output, including circadian oscillation of body temperature, locomotor activity, EEG pattern as well as the transcriptome. However, the molecular mechanisms underlying this cross-talk remain unclear. In this study, we systematically evaluated the temporal expression of seven core circadian transcripts (Bmal1, Clock, Cry1, Cry2, Per1, Per2, and Per3) and the spontaneous locomotor activity (SLA) in post-status epilepticus (SE) model of mTLE. Twenty-four hour oscillating SLA remained intact in post-SE groups although the circadian phase and the amount and intensity of activity were changed in early post-SE and epileptic phases. The acrophase of the SLA rhythm was delayed during epileptogenesis, a fragmented 24 h rhythmicity and extended active phase length appeared in the epileptic phase. The temporal expression of circadian transcripts Bmal1, Cry1, Cry2, Per1, Per2, and Per3 was also substantially altered. The oscillatory expression of Bmal1 was maintained in rats imperiled to SE, but with lower amplitude (A = 0.2) and an advanced acrophase in the epileptic phase. The diurnal rhythm of Cry1 and Cry2 was absent in the early post-SE but was recovered in the epileptic phase. Per1 and Per2 rhythmic expression were disrupted in post-SE groups while Per3 presented an arrhythmic profile in the epileptic phase, only. The expression of Clock did not display rhythmic pattern in any condition. These oscillating patterns of core clock genes may contribute to hippocampal 24 h cycling and, consequently to seizure periodicity. Furthermore, by using a pool of samples collected at 6 different Zeitgeber Times (ZT), we found that all clock transcripts were significantly dysregulated after SE induction, except Per3 and Per2. Collectively, altered SLA rhythm in early post-SE and epileptic phases implies a possible role for seizure as a nonphotic cue, which is likely linked to activation of hippocampal-accumbens pathway. On the other hand, altered temporal expression of the clock genes after SE suggests their involvement in the MTLE.

journal_name

Front Neurol

journal_title

Frontiers in neurology

authors

Matos HC,Koike BDV,Pereira WDS,de Andrade TG,Castro OW,Duzzioni M,Kodali M,Leite JP,Shetty AK,Gitaí DLG

doi

10.3389/fneur.2018.00632

subject

Has Abstract

pub_date

2018-08-02 00:00:00

pages

632

issn

1664-2295

journal_volume

9

pub_type

杂志文章
  • Corrigendum: The Sub-Regional Functional Organization of Neocortical Irritative Epileptic Networks in Pediatric Epilepsy.

    abstract::[This corrects the article DOI: 10.3389/fneur.2018.00184.]. ...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章,已发布勘误

    doi:10.3389/fneur.2019.00631

    authors: Janca R,Krsek P,Jezdik P,Cmejla R,Tomasek M,Komarek V,Marusic P,Jiruska P

    更新日期:2019-06-14 00:00:00

  • The Sub-Classification of Amnestic Mild Cognitive Impairment Using MRI-Based Cortical Thickness Measures.

    abstract:BACKGROUND:Amnestic mild cognitive impairment (aMCI) is considered to be the transitional stage between healthy aging and Alzheimer's disease (AD). Moreover, aMCI individuals with additional impairment in one or more non-memory cognitive domains are at higher risk of conversion to AD. Hence accurate identification of t...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2014.00076

    authors: Raamana PR,Wen W,Kochan NA,Brodaty H,Sachdev PS,Wang L,Beg MF

    更新日期:2014-05-21 00:00:00

  • Embarrassment and Shame in People With Parkinson's Disease: A New Tool for Self-Assessment.

    abstract::Shame and embarrassment related to Parkinson's disease (PD) are rarely addressed in clinical practice nor studied in neuroscience research, partly because no specific tool exists to detect them in PD. Objective: To develop a self-applied assessment tool of shame and embarrassment specifically related to PD or its trea...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2020.00779

    authors: Fleury V,Catalano Chiuvé S,Forjaz MJ,Di Marco M,Messe M,Debove I,Angulo J,Hariz GM,Burkhard PR,Martinez-Martin P,Rodriguez-Blazquez C,Krack P

    更新日期:2020-07-31 00:00:00

  • Increased Circulating Exosomal miRNA-223 Is Associated with Acute Ischemic Stroke.

    abstract::Recent studies have demonstrated that exosomal microRNAs (miRNAs) are novel biomarkers and therapeutic targets for various diseases including vascular disease. However, specific exosomal miRNAs expression in stroke patients has not been reported yet. Here, we explored whether circulating exosomal miRNAs can serve as p...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2017.00057

    authors: Chen Y,Song Y,Huang J,Qu M,Zhang Y,Geng J,Zhang Z,Liu J,Yang GY

    更新日期:2017-02-27 00:00:00

  • Monitoring the Neuroinflammatory Response Following Acute Brain Injury.

    abstract::Traumatic brain injury (TBI) and subarachnoid hemorrhage (SAH) are major contributors to morbidity and mortality. Following the initial insult, patients may deteriorate due to secondary brain damage. The underlying molecular and cellular cascades incorporate components of the innate immune system. There are different ...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章,评审

    doi:10.3389/fneur.2017.00351

    authors: Thelin EP,Tajsic T,Zeiler FA,Menon DK,Hutchinson PJA,Carpenter KLH,Morganti-Kossmann MC,Helmy A

    更新日期:2017-07-20 00:00:00

  • Multiparametric Analysis of Sniff Nasal Inspiratory Pressure Test in Middle Stage Amyotrophic Lateral Sclerosis.

    abstract::The relaxation rates and contractile properties of inspiratory muscles are altered with inspiratory muscle weakness and fatigue. This fact plays an important role in neuromuscular disorders patients and had never been extensively studied in amyotrophic lateral sclerosis (ALS). In this cross-sectional study, these para...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2018.00306

    authors: Sarmento A,Aliverti A,Marques L,Pennati F,Dourado-Júnior ME,Fregonezi G,Resqueti V

    更新日期:2018-05-02 00:00:00

  • Corrigendum: Neuroinflammation and Cytokines in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): A Critical Review of Research Methods.

    abstract::[This corrects the article DOI: 10.3389/fneur.2018.01033.]. ...

    journal_title:Frontiers in neurology

    pub_type: 已发布勘误

    doi:10.3389/fneur.2020.00863

    authors: VanElzakker MB,Brumfield SA,Lara Mejia PS

    更新日期:2020-09-17 00:00:00

  • Lower Functional Connectivity in Vestibular-Limbic Networks in Individuals With Subclinical Agoraphobia.

    abstract::Background: Agoraphobia was described in 1871 as a condition of fear-related alterations in spatial orientation and locomotor control triggered by places or situations that might cause a patient to panic and feel trapped. In contemporary nosology, however, this original concept of agoraphobia was split into two diagno...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2019.00874

    authors: Indovina I,Conti A,Lacquaniti F,Staab JP,Passamonti L,Toschi N

    更新日期:2019-08-13 00:00:00

  • Identification of the Early Stage of Alzheimer's Disease Using Structural MRI and Resting-State fMRI.

    abstract::Accurate prediction of the early stage of Alzheimer's disease (AD) is important but very challenging. The goal of this study was to utilize predictors for diagnosis conversion to AD based on integrating resting-state functional MRI (rs-fMRI) connectivity analysis and structural MRI (sMRI). We included 177 subjects in ...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2019.00904

    authors: Hojjati SH,Ebrahimzadeh A,Babajani-Feremi A

    更新日期:2019-08-30 00:00:00

  • Early-Onset Parkinson's Disease Caused by PLA2G6 Compound Heterozygous Mutation, a Case Report and Literature Review.

    abstract::PLA2G6 has been certified as a causative gene in patients with autosomal recessive early-onset Parkinson's disease (EOPD). We reported an EOPD case caused by PLA2G6 gene mutation, and performed neurological examination, genetic analysis, and multimodal neuroimaging to describe this phenotype. A compound heterozygous m...

    journal_title:Frontiers in neurology

    pub_type:

    doi:10.3389/fneur.2019.00915

    authors: Shen T,Hu J,Jiang Y,Zhao S,Lin C,Yin X,Yan Y,Pu J,Lai HY,Zhang B

    更新日期:2019-08-21 00:00:00

  • Central Nervous System Demyelination Associated With Immune Checkpoint Inhibitors: Review of the Literature.

    abstract::Immune checkpoint inhibitors (ICI) are a novel class of antineoplastic treatment that enhances immunity against tumors. They are associated with immune adverse events, and several neurological syndromes have been described, including multiple sclerosis and atypical demyelination. We performed a systematic literature r...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章,评审

    doi:10.3389/fneur.2020.538695

    authors: Oliveira MCB,de Brito MH,Simabukuro MM

    更新日期:2020-12-11 00:00:00

  • Functional Outcomes at 90 Days in Octogenarians Undergoing Thrombectomy for Acute Ischemic Stroke: A Prospective Cohort Study and Meta-Analysis.

    abstract::Background: Elderly patients account for 30% of acute ischemic stroke (AIS) but are under-represented in randomized controlled trials of endovascular thrombectomy (EVT). Meta-analysis of "real world" studies evaluating 90-day outcomes in elderly patients ≥80 years have been limited to small numbers undergoing EVT with...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2019.00254

    authors: Sharobeam A,Cordato DJ,Manning N,Cheung A,Wenderoth J,Cappelen-Smith C

    更新日期:2019-03-20 00:00:00

  • Blast TBI Models, Neuropathology, and Implications for Seizure Risk.

    abstract::Traumatic brain injury (TBI) due to explosive blast exposure is a leading combat casualty. It is also implicated as a key contributor to war related mental health diseases. A clinically important consequence of all types of TBI is a high risk for development of seizures and epilepsy. Seizures have been reported in pat...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章,评审

    doi:10.3389/fneur.2014.00047

    authors: Kovacs SK,Leonessa F,Ling GS

    更新日期:2014-04-09 00:00:00

  • A Case of Acoustic Shock with Post-trauma Trigeminal-Autonomic Activation.

    abstract::This study reports the case of an acoustic shock injury (ASI), which did not result in a significant hearing loss, but was followed by manifold chronic symptoms both within (tinnitus, otalgia, tingling in the ear, tension in the ear, and red tympanum) and outside the ears (blocked nose, pain in the neck/temporal regio...

    journal_title:Frontiers in neurology

    pub_type:

    doi:10.3389/fneur.2017.00420

    authors: Londero A,Charpentier N,Ponsot D,Fournier P,Pezard L,Noreña AJ

    更新日期:2017-08-16 00:00:00

  • Hypothesis: Etiologic and Molecular Mechanistic Leads for Sporadic Neurodegenerative Diseases Based on Experience With Western Pacific ALS/PDC.

    abstract::Seventy years of research on Western Pacific amyotrophic lateral sclerosis and Parkinsonism-dementia Complex (ALS/PDC) have provided invaluable data on the etiology, molecular pathogenesis and latency of this disappearing, largely environmental neurodegenerative disease. ALS/PDC is linked to genotoxic chemicals (notab...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2019.00754

    authors: Spencer PS

    更新日期:2019-07-31 00:00:00

  • Clinical Profile and Outcome of Pediatric Mitochondrial Myopathy in China.

    abstract::Introduction: Mitochondrial myopathy in children has notable clinical and genetic heterogeneity, but detailed data is lacking. Patients and Methods: In this study, we retrospectively reviewed the clinical presentation, laboratory investigation, genetic and histopathological characteristics, and follow-ups of 21 pediat...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2020.01000

    authors: Hu C,Li X,Zhao L,Shi Y,Zhou S,Wang Y

    更新日期:2020-09-08 00:00:00

  • Camera-Based, Non-Contact, Vital-Signs Monitoring Technology May Provide a Way for the Early Prevention of SIDS in Infants.

    abstract::Sudden infant death syndrome (SIDS) is the unexplained death, usually during sleep, of a baby younger than 1-year-old. Even though researchers have discovered some factors that may put babies at extra risk, SIDS remains unpredictable up until now. One hypothesis is that impaired cardiovascular control may play a role ...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2016.00236

    authors: Zhao F,Li M,Jiang Z,Tsien JZ,Lu Z

    更新日期:2016-12-23 00:00:00

  • Initial Response to Antiepileptic Drugs in Patients with Newly Diagnosed Epilepsy As a Predictor of Long-term Outcome.

    abstract:Objective:To investigate the correlation between initial response to antiepileptic drugs (AEDs) and long-term outcomes after 3 years in patients with newly diagnosed epilepsy. Methods:This prospective study included 204 patients with newly diagnosed epilepsy, who were followed-up for at least 36 months. The long-term ...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2017.00658

    authors: Xia L,Ou S,Pan S

    更新日期:2017-12-08 00:00:00

  • Prolonged Static Whole-Body Roll-Tilt and Optokinetic Stimulation Significantly Bias the Subjective Postural Vertical in Healthy Human Subjects.

    abstract::Background: Prolonged static whole-body roll-tilt has been shown to bias estimates of the direction of gravity when assessed by static paradigms such as the subjective visual vertical and the subjective haptic vertical. Objective: We hypothesized that these shifts are paradigm-independent and thus predicted a post-til...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2020.595975

    authors: Wedtgrube A,Bockisch CJ,Straumann D,Tarnutzer AA

    更新日期:2020-10-15 00:00:00

  • Vitamin K Antagonist Use and Risk for Intracranial Carotid Artery Calcification in Patients With Intracerebral Hemorrhage.

    abstract::Background: Intracranial carotid artery calcification (ICAC) on computed tomography (CT) is a marker of atherosclerosis and an independent predictor of vascular events including stroke. While vitamin K antagonists (VKAs) are used to prevent embolic stroke, they have been shown to increase levels of both coronary and e...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2019.01278

    authors: Peeters MTJ,Houben R,Postma AA,van Oostenbrugge RJ,Schurgers LJ,Staals J

    更新日期:2019-12-20 00:00:00

  • Microscopic Polyangiitis With Selective Involvement of Central and Peripheral Nervous System: A Case Report.

    abstract::Background: Microscopic polyangiitis (MPA) is a necrotizing vasculitis that affects predominantly small-sized vessels in many organ systems. The disease generally causes glomerulonephritis, pulmonary damage, arthritis, and neuropathy. An exclusive involvement of both central nervous system (CNS) and peripheral nervous...

    journal_title:Frontiers in neurology

    pub_type:

    doi:10.3389/fneur.2020.00269

    authors: Arienti F,Franco G,Monfrini E,Santaniello A,Bresolin N,Saetti MC,Di Fonzo A

    更新日期:2020-04-28 00:00:00

  • Spatial Navigation Is Distinctively Impaired in Persistent Postural Perceptual Dizziness.

    abstract::Objective: To determine whether performance in a virtual spatial navigational task is poorer in persistent postural perceptual dizziness (PPPD) patients than in healthy volunteers and patients suffering other vestibular disorders. Methods: Subjects were asked to perform three virtual Morris water maze spatial navigati...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2019.01361

    authors: Breinbauer HA,Contreras MD,Lira JP,Guevara C,Castillo L,Ruëdlinger K,Muñoz D,Delano PH

    更新日期:2020-01-09 00:00:00

  • Association Between Aldehyde dehydrogenase-2 Polymorphisms and Risk of Alzheimer's Disease and Parkinson's Disease: A Meta-Analysis Based on 5,315 Individuals.

    abstract::Objective: A number of studies have reported that aldehyde dehydrogenase-2 (ALDH2) polymorphisms maybe associated with the risk of Alzheimer's disease (AD) and Parkinson's disease (PD). However, the results of such studies are inconsistent. We therefore conducted a meta-analysis to clarify the association between ALDH...

    journal_title:Frontiers in neurology

    pub_type:

    doi:10.3389/fneur.2019.00290

    authors: Chen J,Huang W,Cheng CH,Zhou L,Jiang GB,Hu YY

    更新日期:2019-03-28 00:00:00

  • Spontaneous cervical artery dissection: the borgess classification.

    abstract:BACKGROUND AND PURPOSE:The pathogenesis of spontaneous cervical artery dissections (sCAD) and its best medical treatment are debated. This may be due to a lack of clear classification of sCAD. We propose the new Borgess classification of sCAD, based on the presence or absence of intimal tear as depicted on imaging stud...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章,评审

    doi:10.3389/fneur.2013.00133

    authors: Perry BC,Al-Ali F

    更新日期:2013-09-17 00:00:00

  • Sleep loss in resident physicians: the cause of medical errors?

    abstract::This review begins with the history of the events starting with the death of Libby Zion that lead to the Bell Commission, that the studied her death and made recommendations for improvement that were codified into law in New York state as the 405 law that the ACGME essentially adopted in putting a cap on work hours an...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2010.00128

    authors: Kramer M

    更新日期:2010-10-20 00:00:00

  • Role of intravenous levetiracetam in seizure prophylaxis of severe traumatic brain injury patients.

    abstract::Traumatic brain injury (TBI) can cause seizures and the development of epilepsy. The incidence of seizures varies from 21% in patients with severe brain injuries to 50% in patients with war-related penetrating TBI. In the acute and sub-acute periods following injury, seizures can lead to increased intracranial pressur...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章,评审

    doi:10.3389/fneur.2013.00170

    authors: Kirmani BF,Mungall D,Ling G

    更新日期:2013-11-01 00:00:00

  • The Role of Decompressive Craniectomy in the Context of Severe Traumatic Brain Injury: Summary of Results and Analysis of the Confidence Level of Conclusions From Systematic Reviews and Meta-Analyses.

    abstract::Introduction: Traumatic brain injury (TBI) is a global epidemic. The incidence of TBI in low and middle-income countries (LMICs) is three times greater than in high-income countries (HICs). Decompressive craniectomy (DC) is a surgical procedure to reduce intracranial pressure (ICP) and prevent secondary injury. Multip...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章,评审

    doi:10.3389/fneur.2019.01063

    authors: Rubiano AM,Carney N,Khan AA,Ammirati M

    更新日期:2019-10-10 00:00:00

  • Imaging Mild Cognitive Impairment and Dementia in Parkinson's Disease.

    abstract::Cognitive dysfunction is a significant non-motor feature of Parkinson's disease, with the risk of dementia increasing with prolonged disease duration. Multiple cognitive domains are affected, and the pathophysiology cannot be explained by dopaminergic loss alone. Sophisticated neuroimaging techniques can detect the na...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章,评审

    doi:10.3389/fneur.2020.00047

    authors: Sasikumar S,Strafella AP

    更新日期:2020-01-31 00:00:00

  • Dynamic Alterations of Spontaneous Neural Activity in Parkinson's Disease: A Resting-State fMRI Study.

    abstract::Objective: To investigate the dynamic amplitude of low-frequency fluctuations (dALFFs) in patients with Parkinson's disease (PD) and healthy controls (HCs) and further explore whether dALFF can be used to test the feasibility of differentiating PD from HCs. Methods: Twenty-eight patients with PD and 28 demographically...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2019.01052

    authors: Zhang C,Dou B,Wang J,Xu K,Zhang H,Sami MU,Hu C,Rong Y,Xiao Q,Chen N,Li K

    更新日期:2019-10-01 00:00:00

  • Severe Stroke Patients With Left-Sided Occlusion of the Proximal Anterior Circulation Benefit More From Thrombectomy.

    abstract::Background and Purpose: Endovascular thrombectomy improves the functional independence of patients with proximal anterior circulation occlusion. However, a subset of patients fail to benefit from thrombectomy procedures, the reasons for which remain poorly defined. In this study, we investigated whether the effectiven...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2019.00551

    authors: Li Z,Chu Z,Zhao S,Ma L,Yang Q,Huang X,Zhou Z

    更新日期:2019-05-28 00:00:00