Melanopsin Retinal Ganglion Cells and Pupil: Clinical Implications for Neuro-Ophthalmology.


:Melanopsin retinal ganglion cells (mRGCs) are intrinsically photosensitive RGCs that mediate many relevant non-image forming functions of the eye, including the pupillary light reflex, through the projections to the olivary pretectal nucleus. In particular, the post-illumination pupil response (PIPR), as evaluated by chromatic pupillometry, can be used as a reliable marker of mRGC function in vivo. In the last years, pupillometry has become a promising tool to assess mRGC dysfunction in various neurological and neuro-ophthalmological conditions. In this review we will present the most relevant findings of pupillometric studies in glaucoma, hereditary optic neuropathies, ischemic optic neuropathies, idiopathic intracranial hypertension, multiple sclerosis, Parkinson's disease, and mood disorders. The use of PIPR as a marker for mRGC function is also proposed for other neurodegenerative disorders in which circadian dysfunction is documented.


Front Neurol


Frontiers in neurology


La Morgia C,Carelli V,Carbonelli M




Has Abstract


2018-12-07 00:00:00








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    abstract::Alzheimer's disease is the most common neurodegenerative form of dementia that steadily worsens and eventually leads to death. Its set of symptoms include loss of cognitive function and memory decline. Structural and functional imaging methods such as CT, MRI, and PET scans play an essential role in the diagnosis proc...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Gionfrida L,Roginska A

    更新日期:2017-12-07 00:00:00

  • Perturbation-Based Balance Training to Improve Step Quality in the Chronic Phase After Stroke: A Proof-of-Concept Study.

    abstract::Introduction: People with stroke often have impaired stepping responses following balance perturbations, which increases their risk of falling. Computer-controlled movable platforms are promising tools for delivering perturbation-based balance training under safe and standardized circumstances. Purpose: This proof-of-...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: van Duijnhoven HJR,Roelofs JMB,den Boer JJ,Lem FC,Hofman R,van Bon GEA,Geurts ACH,Weerdesteyn V

    更新日期:2018-11-22 00:00:00

  • Stenosis Length and Degree Interact With the Risk of Cerebrovascular Events Related to Internal Carotid Artery Stenosis.

    abstract::Background and Purpose: Internal carotid artery stenosis (ICAS)≥70% is a leading cause of ischemic cerebrovascular events (ICVEs). However, a considerable percentage of stroke survivors with symptomatic ICAS (sICAS) have <70% stenosis with a vulnerable plaque. Whether the length of ICAS is associated with high risk of...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Elhfnawy AM,Heuschmann PU,Pham M,Volkmann J,Fluri F

    更新日期:2019-04-09 00:00:00

  • Patterns of Co-Occurring Gray Matter Concentration Loss across the Huntington Disease Prodrome.

    abstract::Huntington disease (HD) is caused by an abnormally expanded cytosine-adenine-guanine (CAG) trinucleotide repeat in the HTT gene. Age and CAG-expansion number are related to age at diagnosis and can be used to index disease progression. However, observed onset-age variability suggests that other factors also modulate p...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Ciarochi JA,Calhoun VD,Lourens S,Long JD,Johnson HJ,Bockholt HJ,Liu J,Plis SM,Paulsen JS,Turner JA,PREDICT-HD Investigators and Coordinators of the Huntington Study Group.

    更新日期:2016-09-21 00:00:00

  • Kinematic Components of the Reach-to-Target Movement After Stroke for Focused Rehabilitation Interventions: Systematic Review and Meta-Analysis.

    abstract::Background: Better upper limb recovery after stroke could be achieved through tailoring rehabilitation interventions directly at movement deficits. Aim: To identify potential; targets for therapy by synthesizing findings of differences in kinematics and muscle activity between stroke survivors and healthy adults perfo...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Collins KC,Kennedy NC,Clark A,Pomeroy VM

    更新日期:2018-06-25 00:00:00

  • Patient Benefit Following Bimodal CI-provision: Self-reported Abilities vs. Hearing Status.

    abstract::Objectives: Patient-reported outcomes gain importance for the assessment of auditory abilities in cochlear implant users and for the evaluation of auditory rehabilitation. Aims of the study were to explore the interrelation of self-reported improvements in auditory ability with improvements in speech comprehension and...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Wallhäusser-Franke E,Balkenhol T,Hetjens S,Rotter N,Servais JJ

    更新日期:2018-09-10 00:00:00

  • Association of Blood Pressure at Successful Recanalization and Parenchymal Hemorrhage After Mechanical Thrombectomy With General Anesthesia.

    abstract::Background: This study aims to investigate the association between blood pressure (BP) at the time of recanalization and hemorrhagic transformation in large vessel occlusion (LVO) patients following mechanical thrombectomy (MT) with general anesthesia. Methods: We retrospectively reviewed our data base for patients wi...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Cheng H,Xu C,Jin X,Chen Y,Zheng X,Shi F,He X,Hao Y,Jiang Y,Zhang J,Chen Z

    更新日期:2020-11-17 00:00:00

  • Fatigue and Cognitive Fatigability in Mild Traumatic Brain Injury are Correlated with Altered Neural Activity during Vigilance Test Performance.

    abstract:INTRODUCTION:Fatigue is the most frequently reported persistent symptom following a mild traumatic brain injury (mTBI), but the explanations for the persisting fatigue symptoms in mTBI remain controversial. In this study, we investigated the change of cerebral blood flow during the performance of a psychomotor vigilanc...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Möller MC,Nordin LE,Bartfai A,Julin P,Li TQ

    更新日期:2017-09-21 00:00:00

  • Corrigendum: Contributing Factors and Evolution of Impulse Control Disorder in the Luxembourg Parkinson Cohort.

    abstract::[This corrects the article DOI: 10.3389/fneur.2020.578924.]. ...

    journal_title:Frontiers in neurology

    pub_type: 已发布勘误


    authors: Binck S,Pauly C,Vaillant M,Hipp G,Gantenbein M,Krueger R,Diederich NJ

    更新日期:2021-01-12 00:00:00

  • Grafting Neural Stem and Progenitor Cells Into the Hippocampus of Juvenile, Irradiated Mice Normalizes Behavior Deficits.

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    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Sato Y,Shinjyo N,Sato M,Nilsson MKL,Osato K,Zhu C,Pekna M,Kuhn HG,Blomgren K

    更新日期:2018-09-11 00:00:00

  • Conscious While Being Considered in an Unresponsive Wakefulness Syndrome for 20 Years.

    abstract::Despite recent advances in our understanding of consciousness disorders, accurate diagnosis of severely brain-damaged patients is still a major clinical challenge. We here present the case of a patient who was considered in an unresponsive wakefulness syndrome/vegetative state for 20 years. Repeated standardized behav...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Vanhaudenhuyse A,Charland-Verville V,Thibaut A,Chatelle C,Tshibanda JL,Maudoux A,Faymonville ME,Laureys S,Gosseries O

    更新日期:2018-08-28 00:00:00

  • Case Series: Myelin Oligodendrocyte Glycoprotein-Immunoglobulin G-Related Disease Spectrum.

    abstract::Introduction: Myelin oligodendrocyte glycoprotein-immunoglobulin G (MOG-IgG)-related disease was initially described as a subtype of neuromyelitis optica spectrum disorder (NMOSD) with antibodies against MOG. However, it has recently been described as a separate disease entity with clinical and radiological features t...

    journal_title:Frontiers in neurology



    authors: Alshamrani F,Alnajashi H,Shosha E,Casserly C,Morrow SA

    更新日期:2020-02-26 00:00:00

  • Vascular Protection of Hydrogen Sulfide on Cerebral Ischemia/Reperfusion Injury in Rats.

    abstract::This study was undertaken to demonstrate the vascular protection of exogenous and endogenous hydrogen sulfide (H2S) on cerebral ischemia/reperfusion (I/R) injury. The effect of H2S on cerebrovascular dysfunction in middle cerebral artery (MCA) and neuronal damage were measured after cerebral I/R induced by transient m...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Wen JY,Wang M,Li YN,Jiang HH,Sun XJ,Chen ZW

    更新日期:2018-10-19 00:00:00

  • Use of Surface EMG in Clinical Rehabilitation of Individuals With SCI: Barriers and Future Considerations.

    abstract::Surface electromyography (sEMG) is a widely used technology in rehabilitation research and provides quantifiable information on the myoelectric output of a muscle. In this perspective, we discuss the barriers which have restricted the wide-spread use of sEMG in clinical rehabilitation of individuals with spinal cord i...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Pilkar R,Momeni K,Ramanujam A,Ravi M,Garbarini E,Forrest GF

    更新日期:2020-12-18 00:00:00

  • Glucocerebrosidase involvement in Parkinson disease and other synucleinopathies.

    abstract::Mutations in both copies (homozygous or compound heterozygous) of the gene encoding the lysosomal enzyme glucocerebrosidase, which cleaves the glycolipid glucocerebroside into glucose and ceramide cause Gaucher disease. However, multiple independent studies have also reported an association between GBA mutations and P...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Almeida Mdo R

    更新日期:2012-04-27 00:00:00

  • Microvascular Parameters Help to Predict Stroke Risk in the Asian Diabetic Population in Taiwan: A Population Based Case-Control Study.

    abstract::Intensive glycemic control has not shown consistent findings in stroke prevention for diabetes patients, particularly for those with microvascular complications. This case-control study evaluates the risks of stroke in Asian diabetic population with microvascular complications. From the insurance claims of Taiwan, we ...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Lo SF,Chen WL,Muo CH,Chen PC,Chen SY,Kuo CL,Sung FC

    更新日期:2018-08-29 00:00:00

  • Correlative Magnetic Resonance Imaging and Histopathology in Small Ruminant Listeria Rhombencephalitis.

    abstract::Background: Listeria rhombencephalitis, infection of the brainstem with Listeria monocytogenes, occurs mainly in humans and farmed ruminants and is associated with high fatality rates. Small ruminants (goats and sheep) are a large animal model due to neuropathological similarities. The purpose of this study was to def...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Precht C,Vermathen P,Henke D,Staudacher A,Lauper J,Seuberlich T,Oevermann A,Schweizer-Gorgas D

    更新日期:2020-12-14 00:00:00

  • Erratum: Standards in Pupillography.

    abstract::[This corrects the article DOI: 10.3389/fneur.2019.00129.]. ...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章,已发布勘误


    authors: Frontiers Production Office.

    更新日期:2019-03-27 00:00:00

  • Artificial balance: restoration of the vestibulo-ocular reflex in humans with a prototype vestibular neuroprosthesis.

    abstract::The vestibular system plays a crucial role in the multisensory control of balance. When vestibular function is lost, essential tasks such as postural control, gaze stabilization, and spatial orientation are limited and the quality of life of patients is significantly impaired. Currently, there is no effective treatmen...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Perez Fornos A,Guinand N,van de Berg R,Stokroos R,Micera S,Kingma H,Pelizzone M,Guyot JP

    更新日期:2014-04-29 00:00:00

  • High Monocyte-To-Lymphocyte Ratio Is Associated With Stroke-Associated Pneumonia.

    abstract::Purpose: Stroke-associated pneumonia (SAP), a common complication in acute ischemic stroke (AIS) patients, is associated with poor prognosis after AIS. Inflammation plays an important role in the development of SAP. In this study, we aimed to explore the association between the monocyte-to-lymphocyte ratio (MLR) and S...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Cheng HR,Song JY,Zhang YN,Chen YB,Lin GQ,Huang GQ,He JC,Wang Z

    更新日期:2020-10-06 00:00:00

  • Analysis of the Skew Deviation to Evaluate the Period of Onset of a Canalolithiasis After Macular Damage.

    abstract::Benign paroxysmal positional vertigo (BPPV) is the most common peripheral vestibular end-organ disease, and it is one of the first causes of access to the emergency room. The moment of migration of the otoconial debris in a semicircular canal does not necessarily coincide with the moment of detachment of the debris th...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Gufoni M,Vianini M,Casani AP

    更新日期:2020-10-23 00:00:00

  • Conveniently-Grasped Field Assessment Stroke Triage (CG-FAST): A Modified Scale to Detect Large Vessel Occlusion Stroke.

    abstract::Background and Purpose: Patients with large vessel occlusion stroke (LVOS) need to be rapidly identified and transferred to comprehensive stroke centers (CSC). However, previous pre-hospital strategy remains challenging. We aimed to develop a modified scale to better predict LVOS. Methods: We retrospectively reviewed ...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Gong X,Chen Z,Shi F,Zhang M,Xu C,Zhang R,Lou M

    更新日期:2019-04-17 00:00:00

  • Optical Coherence Tomography and Optical Coherence Tomography Angiography Findings After Optic Neuritis in Multiple Sclerosis.

    abstract::Background: In people with multiple sclerosis (MS), optic neuritis (ON) results in inner retinal layer thinning, and reduced density of the retinal microvasculature. Objective: To compare inter-eye differences (IEDs) in macular optical coherence tomography (OCT) and OCT angiography (OCTA) measures in MS patients with ...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Murphy OC,Kalaitzidis G,Vasileiou E,Filippatou AG,Lambe J,Ehrhardt H,Pellegrini N,Sotirchos ES,Luciano NJ,Liu Y,Fitzgerald KC,Prince JL,Calabresi PA,Saidha S

    更新日期:2020-12-15 00:00:00

  • Microbial Neuraminidase Induces a Moderate and Transient Myelin Vacuolation Independent of Complement System Activation.

    abstract:AIMS:Some central nervous system pathogens express neuraminidase (NA) on their surfaces. In the rat brain, a single intracerebroventricular (ICV) injection of NA induces myelin vacuolation in axonal tracts. Here, we explore the nature, the time course, and the role of the complement system in this damage. METHODS:The ...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Granados-Durán P,López-Ávalos MD,Cifuentes M,Pérez-Martín M,Fernández-Arjona MD,Hughes TR,Johnson K,Morgan BP,Fernández-Llebrez P,Grondona JM

    更新日期:2017-03-07 00:00:00

  • Risk Factors of External Ventricular Drain Infection: Proposing a Model for Future Studies.

    abstract::Background: External ventricular drain (EVD) has a major role in the management and monitoring of intracranial pressure (ICP) and its major complication is EVD infection. The risk factors for EVD infection are still a major topic of controversy, hence the need for further research. Objective: The objective of this rev...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章,评审


    authors: Sorinola A,Buki A,Sandor J,Czeiter E

    更新日期:2019-03-15 00:00:00

  • Quality of Life in Newly Diagnosed Patients With Parkin-Related Parkinson's Disease.

    abstract::Introduction: Mutations in the Parkin gene are the most common cause of autosomal recessive early-onset Parkinson's disease (PD). However, little is known about the quality of life (QoL) in Parkin-related PD. Here, we investigated the patterns of QoL in newly diagnosed Parkin-related PD patients. Methods: Newly diagno...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Zhou XY,Liu FT,Chen C,Luo SS,Zhao J,Tang YL,Shen B,Yu WB,Zuo CT,Wu JJ,Ding ZT,Wang J,Sun YM

    更新日期:2020-12-18 00:00:00

  • Neurological Emergencies in Refugees.

    abstract::Objective: Health care personnel in Europe is increasingly involved in care of displaced persons from non-European countries; we investigated the spectrum of neurological disorders and medical management in refugees presenting to the emergency room (ER) of a German university hospital. Methods: We retrospectively stud...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Brinckmann MP,van Noort BM,Leithner C,Ploner CJ

    更新日期:2018-12-11 00:00:00

  • Aging Increases Hippocampal DUSP2 by a Membrane Cholesterol Loss-Mediated RTK/p38MAPK Activation Mechanism.

    abstract::Numerous studies suggest that the increased activity of p38MAPK plays an important role in the abnormal immune and inflammatory response observed in the course of neurodegenerative diseases such as Alzheimer's disease. On the other hand, high levels of p38MAPK are present in the brain during normal aging, suggesting t...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Martín-Segura A,Casadomé-Perales Á,Fazzari P,Mas JM,Artigas L,Valls R,Nebreda AR,Dotti CG

    更新日期:2019-06-25 00:00:00

  • Follow-up Analysis of Serum TNF-Related Apoptosis-Inducing Ligand Protein and mRNA Expression in Peripheral Blood Mononuclear Cells from Patients with Ischemic Stroke.

    abstract::Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL), which is TNF receptor superfamily member, contributes to several diseases pathogenesis. The aim of this research was to investigate the relevance of serum TRAIL protein levels and mRNA expression in peripheral blood mononuclear cells (PBMC) of pati...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Tufekci KU,Vurgun U,Yigitaslan O,Keskinoglu P,Yaka E,Kutluk K,Genc S

    更新日期:2018-03-05 00:00:00

  • A Case-Controlled Pilot Study on Rhythmic Auditory Stimulation-Assisted Gait Training and Conventional Physiotherapy in Patients With Parkinson's Disease Submitted to Deep Brain Stimulation.

    abstract::Deep brain stimulation (DBS) is indicated when motor disturbances in patients with idiopathic Parkinson's disease (PD) are refractory to current treatment options and significantly impair quality of life. However, post-DBS rehabilitation is essential, with particular regard to gait. Rhythmic auditory stimulation (RAS)...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Naro A,Pignolo L,Sorbera C,Latella D,Billeri L,Manuli A,Portaro S,Bruschetta D,Calabrò RS

    更新日期:2020-08-04 00:00:00