Thyroid Hormones in the Brain and Their Impact in Recovery Mechanisms After Stroke.

abstract：:Background: Educational interventions are needed to overcome knowledge-to-action gaps in clinical care. We previously tested the feasibility and potential efficacy of an educational intervention that facilitates treatment decisions in multiple sclerosis care. A demonstration of the usability of such an intervention is...

journal_title：Frontiers in neurology

authors： Saposnik G,Tobler PN,Caceres F,Terzaghi MA,Ruff C,Maurino J,Fruns Quintana M,Oh J,Montalban X,Mamdani M

更新日期：2018-07-10 00:00:00

abstract：:There is increasing evidence for hippocampal involvement in Amyotrophic Lateral Sclerosis (ALS). Recent neuroimaging studies have been focused on disease-related hippocampal volume alterations while changes in hippocampal shape have been investigated less frequently. Here, we aimed to characterize the patterns of hipp...

journal_title：Frontiers in neurology

authors： Machts J,Vielhaber S,Kollewe K,Petri S,Kaufmann J,Schoenfeld MA

更新日期：2018-07-20 00:00:00

abstract：:Studies of traumatic brain injury from all causes have found evidence of chronic hypopituitarism, defined by deficient production of one or more pituitary hormones at least 1 year after injury, in 25-50% of cases. Most studies found the occurrence of posttraumatic hypopituitarism (PTHP) to be unrelated to injury sever...

journal_title：Frontiers in neurology

authors： Wilkinson CW,Pagulayan KF,Petrie EC,Mayer CL,Colasurdo EA,Shofer JB,Hart KL,Hoff D,Tarabochia MA,Peskind ER

更新日期：2012-02-07 00:00:00

abstract：:Sudden unexpected death in epilepsy (SUDEP) is the most common cause of premature mortality in individuals with epilepsy. Acute and adaptive changes in heart rhythm in epilepsy implicate cardiac dysfunction as a potential pathogenic mechanism in SUDEP. Furthermore, variants in genes associated with Long QT syndrome (L...

journal_title：Frontiers in neurology

authors： Bleakley LE,Soh MS,Bagnall RD,Sadleir LG,Gooley S,Semsarian C,Scheffer IE,Berkovic SF,Reid CA

更新日期：2020-09-08 00:00:00

abstract：:Background: We hypothesized that right and left temporal lobe epilepsy (RTLE and LTLE, respectively) have distinctive spatial patterns of white matter (WM) changes that can be differentiated and interpreted with the use of multiple diffusion parameters. We compared the global microstructure of fiber bundles with regar...

journal_title：Frontiers in neurology

authors： Buksakowska I,Szabó N,Martinkovič L,Faragó P,Király A,Vrána J,Kincses ZT,Meluzín J,Šulc V,Kynčl M,Roček M,Tichý M,Charvát F,Hořínek D,Marusič P

更新日期：2019-10-01 00:00:00

abstract：:Background and Purpose: A large body of literature reported the association of particulate matter (PM) with stroke in high-income countries. Few studies have examined the association between PM and stroke in middle- and low-income countries and considered the types of stroke. In this study, we examined the short-term ...

journal_title：Frontiers in neurology

authors： Zhang R,Liu G,Jiang Y,Li G,Pan Y,Wang Y,Wei Z,Wang J,Wang Y

更新日期：2018-10-02 00:00:00

abstract：:Background: This study aims to investigate the association between blood pressure (BP) at the time of recanalization and hemorrhagic transformation in large vessel occlusion (LVO) patients following mechanical thrombectomy (MT) with general anesthesia. Methods: We retrospectively reviewed our data base for patients wi...

journal_title：Frontiers in neurology

authors： Cheng H,Xu C,Jin X,Chen Y,Zheng X,Shi F,He X,Hao Y,Jiang Y,Zhang J,Chen Z

更新日期：2020-11-17 00:00:00

abstract：:The involvement of the central nervous system (CNS) in Hodgkin lymphoma (HL) has been rarely reported, especially in its primary isolated form. Herein, we present a case of a 33-year-old woman, who received immunosuppressive treatment due to ulcerative colitis (at the beginning azathioprine and sulfasalazine, changed ...

journal_title：Frontiers in neurology

authors： Szczepanek D,Szumiło J,Stoma F,Szymczyk A,Jarosz B,Szczepanek A,Hus M,Trojanowski T,Wasik-Szczepanek E

更新日期：2020-09-08 00:00:00

abstract：:Tadpole pupil is a rare phenomenon in which segmental spasm of the iris dilator muscle results in a tadpole-shaped pupil. The pupillary distortion is usually unilateral, lasts several minutes, and can recur in clusters. Any segment of the iris can be affected; thus, for some patients, a different-shaped tadpole pupil ...

journal_title：Frontiers in neurology

authors： Udry M,Kardon RH,Sadun F,Kawasaki A

更新日期：2019-08-19 00:00:00

abstract：:Hashimoto's encephalopathy (HE) is a rare, clinically heterogeneous condition associated with positive thyroid autoantibodies. It is increasingly recognized as an important and treatable cause of autoimmune encephalopathy. Thyroid-associated antibodies such as thyroperoxidase (TPO) antibody, thyroglobulin (TG) antibod...

journal_title：Frontiers in neurology

authors： Li J,Li F

更新日期：2019-05-08 00:00:00

abstract：:We sought to investigate (1) the characteristics of epileptiform discharge (ED) duration and interdischarge interval (IDI) and (2) the influence of vigilance state on the ED duration and IDI in genetic generalized epilepsy (GGE). In a cohort of patients diagnosed with GGE, 24-h ambulatory EEG recordings were performed...

journal_title：Frontiers in neurology

authors： Seneviratne U,Boston RC,Cook MJ,D'Souza WJ

更新日期：2018-02-19 00:00:00

abstract：:Objective: To investigate an MRI-based etiological classification for acute isolated pontine infarcts and to assess differences in vascular risk factors, clinical characteristics and WMH burden among the etiological subtypes. Methods: All participants from SMART cohort with DWI-proven acute isolated pontine infarcts (...

journal_title：Frontiers in neurology

authors： Zhou L,Yao M,Peng B,Zhu Y,Ni J,Cui L

更新日期：2018-10-09 00:00:00

abstract：:To date, conflicting results about the role of vitamins in amyotrophic lateral sclerosis (ALS) have been reported along with a lack of systematic studies on all types of serum vitamins in patients with ALS. Moreover, extensive studies have been conducted on vitamins in other neurodegenerative diseases; however, whethe...

journal_title：Frontiers in neurology

authors： Wang M,Liu Z,Sun W,Yuan Y,Jiao B,Zhang X,Shen L,Jiang H,Xia K,Tang B,Wang J

更新日期：2020-06-18 00:00:00

abstract：:Severe mercury intoxication is very rare in developed countries, but still occurs as the result of volatile substance abuse, suicide attempts, occupational hazards, or endemic food ingestion as reported in the cases of public health disasters in Iraq and in Minamata Bay, Japan. Here, we describe the dramatic physical ...

journal_title：Frontiers in neurology

authors： Kleffner I,Eichler S,Ruck T,Schüngel L,Pfeuffer S,Polzer P,Dittrich R,Dziewas R,Gross CC,Göbel K,Wiendl H,Kehrel BE,Meuth SG

更新日期：2017-09-28 00:00:00

abstract：:Injuries to the immature optic radiation (OR) are associated with thinning of the retinal nerve fiber layer and corresponding visual field (VF) defects. The aim of the current study was to seek evidence for causal retrograde trans-synaptic degeneration by exploring the correspondence between the localization and exten...

journal_title：Frontiers in neurology

authors： Lennartsson F,Nilsson M,Flodmark O,Jacobson L,Larsson J

更新日期：2018-05-07 00:00:00

abstract：:With the demographic shift of the global population toward longer life expectancy, the number of people living with Alzheimer's disease (AD) has rapidly expanded and is projected to triple by the year 2050. Current treatments provide symptomatic relief but do not affect the underlying pathology of the disease. Therapi...

journal_title：Frontiers in neurology

authors： Ritter A,Cummings J

更新日期：2015-08-31 00:00:00

abstract：:Background: This study's aim was to investigate a large cohort of dystonia patients for pathogenic and rare variants in the ATM gene, making use of a new, cost-efficient enrichment technology for NGS-based screening. Methods: Single molecule Molecular Inversion Probes (smMIPs) were used for targeted enrichment and seq...

journal_title：Frontiers in neurology

authors： Pogoda M,Hilke FJ,Lohmann E,Sturm M,Lenz F,Matthes J,Muyas F,Ossowski S,Hoischen A,Faust U,Sepahi I,Casadei N,Poths S,Riess O,Schroeder C,Grundmann K

更新日期：2019-12-18 00:00:00

abstract：BACKGROUND:To evaluate the efficacy and tolerability of a clonidine transdermal patch in the treatment of children with tic disorders (TD) and to establish a predictive model for patients. METHODS:Forty-one patients who met the inclusion criteria entered into 12 weeks of prospective, open, single-group, self-controlle...

journal_title：Frontiers in neurology

authors： Song PP,Jiang L,Li XJ,Hong SQ,Li SZ,Hu Y

更新日期：2017-02-23 00:00:00

abstract：:Background: Sphingosine 1-phosphate (S1P) is a lipid metabolite that mediates various physiological processes, including vascular endothelial cell function, inflammation, coagulation/thrombosis, and angiogenesis. As a result, S1P may contribute to the pathogenesis of stroke. Objective: This study aimed to evaluate the...

journal_title：Frontiers in neurology

authors： Liu J,Sugimoto K,Cao Y,Mori M,Guo L,Tan G

更新日期：2020-09-08 00:00:00

abstract：:Many neurodegenerative disorders are associated with rapid eye movement sleep (REMS) loss; however, the mechanism was unknown. As REMS loss elevates noradrenaline (NA) level in the brain as well as induces neuronal apoptosis and degeneration, in this study, we have delineated the intracellular molecular pathway involv...

journal_title：Frontiers in neurology

authors： Somarajan BI,Khanday MA,Mallick BN

更新日期：2016-03-07 00:00:00

abstract：:Introduction: Safe driving requires integration of higher-order cognitive and motor functions, which are commonly compromised in patients with antibody-mediated encephalitis (AME) associated with N-methyl-D-aspartate receptors or leucine-rich glioma-inactivated 1 autoantibodies. How these deficits influence the return...

journal_title：Frontiers in neurology

authors： Day GS,Babulal GM,Rajasekar G,Stout S,Roe CM

更新日期：2020-07-28 00:00:00

abstract：:Objective: As a recently defined disease entity, vestibular migraine (VM) is a variant of migraine with broad spectrum of manifestations. We evaluated a prospective cohort of patients with VM in two centers to assess severity of VM attacks and investigate its contributing factors in patients with VM. Methods: Adult pa...

journal_title：Frontiers in neurology

authors： Liu W,Dong H,Yang L,Zhao H,Dong W,Yang Y

更新日期：2020-12-16 00:00:00

abstract：:Huntington's Disease (HD) is a genetic neurodegenerative disease caused by a CAG expansion in the gene encoding Huntingtin (Htt). It is characterized by chorea, cognitive, and psychiatric disorders. The most affected brain region is the striatum, and the clinical symptoms are directly correlated to the rate of striata...

journal_title：Frontiers in neurology

authors： Moumné L,Betuing S,Caboche J

更新日期：2013-10-23 00:00:00

abstract：:Background: Ischemic cerebral infarction is a severe clinical condition that can cause serious mortality. Artesunate, an anti-malarial drug that is widely used in cancer treatment, is known to facilitate accelerated cell apoptosis. The aim of this study is to explore the possible neuroprotective effects of artesunate ...

journal_title：Frontiers in neurology

authors： Shao M,Shen Y,Sun H,Meng D,Huo W,Qi X

更新日期：2018-08-17 00:00:00

abstract：BACKGROUND:Hemiparesis after stroke typically results in a reduced walking speed, an asymmetrical gait pattern and a reduced ability to make gait adjustments. The purpose of this pilot study was to investigate the feasibility and preliminary efficacy of home-based training involving auditory cueing of stepping in place...

journal_title：Frontiers in neurology

authors： Wright RL,Brownless SB,Pratt D,Sackley CM,Wing AM

更新日期：2017-08-22 00:00:00

abstract：BACKGROUND AND PURPOSE:The pathogenesis of spontaneous cervical artery dissections (sCAD) and its best medical treatment are debated. This may be due to a lack of clear classification of sCAD. We propose the new Borgess classification of sCAD, based on the presence or absence of intimal tear as depicted on imaging stud...

journal_title：Frontiers in neurology

authors： Perry BC,Al-Ali F

更新日期：2013-09-17 00:00:00

abstract：:Traumatic brain injury is the leading cause of death in children. Children with severe TBI are in need of neurointensive care where the goal is to prevent secondary brain injury by avoiding secondary insults. Monitoring of cerebral blood flow (CBF) and autoregulation in the injured brain is crucial. However, there are...

journal_title：Frontiers in neurology

authors： Rostami E,Nilsson P,Enblad P

更新日期：2020-04-16 00:00:00

abstract：:Myasthenia gravis (MG) is the most common autoimmune disorder affecting the neuromuscular junction, characterized by skeletal muscle weakness and fatigability. It is caused by autoantibodies targeting proteins of the neuromuscular junction; ~85% of MG patients have autoantibodies against the muscle acetylcholine recep...

journal_title：Frontiers in neurology

authors： Lazaridis K,Tzartos SJ

更新日期：2020-11-30 00:00:00

abstract：:Clinicians are regularly faced with the difficult challenge of diagnosing consciousness after severe brain injury. As such, as many as 40% of minimally conscious patients who demonstrate fluctuations in arousal and awareness are known to be misdiagnosed as unresponsive/vegetative based on clinical consensus. Further, ...

journal_title：Frontiers in neurology

authors： Bareham CA,Allanson J,Roberts N,Hutchinson PJA,Pickard JD,Menon DK,Chennu S

更新日期：2018-08-21 00:00:00

abstract：:Patients with severe mental illnesses may present extrapyramidal symptoms as part of a concomitant neurological disorder or secondary to medications. Extrapyramidal symptoms are frequently unrecognized, have negative consequences for adherence to treatment, negatively affect quality of life and can induce stigma. We e...

journal_title：Frontiers in neurology

authors： Roiter B,Pigato G,Antonini A

更新日期：2020-11-10 00:00:00